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1. 发明申请

WO2011119887A1 RNA INTERFERENCE IN DERMAL AND FIBROTIC INDICATIONS 审中-公开
标题翻译： RNA干扰在纤维和纤维中的作用
公开(公告)号：WO2011119887A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029867
申请日：2011-03-24
申请人： RXI PHARMACEUTICALS CORPORATION , KHVOROVA, Anastasia , SALOMON, William , KAMENS, Joanne , SAMARSKY, Dmitry , WOOLF, Tod, M. , PAVCO, Pamela, A. , LIBERTINE, Lyn , CARDIA, James
发明人： KHVOROVA, Anastasia , SALOMON, William , KAMENS, Joanne , SAMARSKY, Dmitry , WOOLF, Tod, M. , PAVCO, Pamela, A. , LIBERTINE, Lyn , CARDIA, James
IPC分类号： A61K31/713 , C07H21/02
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/3341 , C12N2310/351 , C12N2310/3515 , C12N2320/32 , C12N2320/52 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
摘要： The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal and fibrotic applications.
摘要翻译：本发明涉及具有改善的组织和细胞摄取特性的RNAi构建体以及在真皮和纤维化应用中使用这些化合物的方法。

2. 发明申请

WO2010090762A1 RNA DUPLEXES WITH SINGLE STRANDED PHOSPHOROTHIOATE NUCLEOTIDE REGIONS FOR ADDITIONAL FUNCTIONALITY 审中-公开
标题翻译：具有单链磷酸核苷酸核酸区域的RNA双链体作为附加功能
公开(公告)号：WO2010090762A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/000348
申请日：2010-02-04
申请人： RXI PHARMACEUTICALS CORPORATION , WOOLF, Tod, M. , KAMENS, Joanne , SALOMON, William , KHVOROVA, Anastasia
发明人： WOOLF, Tod, M. , KAMENS, Joanne , SALOMON, William , KHVOROVA, Anastasia
IPC分类号： C12N15/113 , C07H21/00 , A61K31/713
CPC分类号： C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2310/3519 , C12N2310/533 , C12N2320/51 , C12N2310/3521 , C12N2310/3533
摘要： The present invention relates to RNAi constructs and their use in gene silencing. RNAi constructs associated with the invention contain a double stranded region connected to a single stranded region of phosphorothioate modified nucleotides.
摘要翻译：本发明涉及RNAi构建体及其在基因沉默中的用途。与本发明相关的RNAi构建体含有连接到硫代磷酸酯修饰的核苷酸的单链区域的双链区域。

3. 发明申请

WO2010033246A1 RNA INTERFERENCE IN SKIN INDICATIONS 审中-公开
标题翻译：皮肤干燥RNA干扰
公开(公告)号：WO2010033246A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/005246
申请日：2009-09-22
申请人： RXI PHARMACEUTICALS CORPORATION , KHVOROVA, Anastasia , SALOMON, William , KAMENS, Joanne , SAMARSKY, Dmitry , WOOLF, Tod, M. , PAVCO, Pamela, A.
发明人： KHVOROVA, Anastasia , SALOMON, William , KAMENS, Joanne , SAMARSKY, Dmitry , WOOLF, Tod, M. , PAVCO, Pamela, A.
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/1136 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/3515 , C12N2310/3519 , C12N2310/3521 , C12N2320/32 , C12N2320/51 , C12N2320/53
摘要： The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.
摘要翻译：本发明涉及具有改善的组织和细胞摄取特性的RNAi构建体以及在真皮应用中使用这些化合物的方法。

4. 发明申请

WO2007016704A3 INPUT DEVICE HAVING MULTIFUNCTIONAL KEYS 审中-公开
标题翻译：具有多功能键的输入装置
公开(公告)号：WO2007016704A3
公开(公告)日：2007-05-10
申请号：PCT/US2006030571
申请日：2006-08-01
申请人： IPIFINI INC , WOOLF TOD M , MARKS ANDREW S
发明人： WOOLF TOD M , MARKS ANDREW S
IPC分类号： G09G5/00
CPC分类号： G06F3/0233 , G06F3/0234 , G06F3/0362 , H01H13/64 , H01H2215/05 , H01H2225/018
摘要： The invention relates to an input device having multifunctional keys, wherein the different functions are triggered by varying the pressure on the keys or by varying the depth to which the key is depressed or the distance it is moved (see figure 3). The input device requires substantially fewer keys than a standard qwerty keyboard to input data and requires less physical space. In certain instances the keyboard can be operated with one hand.
摘要翻译：本发明涉及具有多功能键的输入装置，其中通过改变键上的压力或通过改变按键被压下的深度或其移动距离来触发不同的功能（见图3）。输入设备需要比标准键盘更少的键输入数据并且需要较少的物理空间。在某些情况下，键盘可以用一只手操作。

5. 发明申请

WO2011119871A1 RNA INTERFERENCE IN OCULAR INDICATIONS 审中-公开
标题翻译： RNA干扰在眼睛适应症
公开(公告)号：WO2011119871A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029849
申请日：2011-03-24
申请人： RXI PHRMACEUTICALS CORPORATION , LIBERTINE, Lyn , KHVOROVA, Anastasia , SALOMON, William , KAMENS, Joanne , SAMARSKY, Dmitry , WOOLF, Tod, M. , CARDIA, James
发明人： LIBERTINE, Lyn , KHVOROVA, Anastasia , SALOMON, William , KAMENS, Joanne , SAMARSKY, Dmitry , WOOLF, Tod, M. , CARDIA, James
IPC分类号： A61K31/713 , C07H21/02
CPC分类号： C12N15/1136 , A61K9/0048 , A61K9/0051 , A61K31/713 , A61K45/06 , A61K47/554 , C12N2310/14 , C12N2310/313 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2320/31 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to ocular administration of sd-rxRNA and rxRNAori molecules.
摘要翻译：本发明涉及sd-rxRNA和rxRNAori分子的眼部给药。

6. 发明申请

WO2010059226A3 INHIBITION OF MAP4K4 THROUGH RNAI 审中-公开
标题翻译：通过RNAi抑制MAP4K4
公开(公告)号：WO2010059226A3
公开(公告)日：2010-07-15
申请号：PCT/US2009006211
申请日：2009-11-19
申请人： RXI PHARMACEUTICALS CORP , WOOLF TOD M , KAMENS JOANNE , KHVOROVA ANASTASIA , SALOMON WILLIAM
发明人： WOOLF TOD M , KAMENS JOANNE , KHVOROVA ANASTASIA , SALOMON WILLIAM
IPC分类号： C07H21/02 , A61K31/7088
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/321 , C12N2320/11 , C12N2320/30 , C12Y207/01037
摘要： RNAi constructs directed to MAP4K4 that demonstrate unexpectedly high gene silencing activities, and uses thereof are disclosed. The blunt-ended constructs have a double-stranded region of 19-49 nucleotides. The constructs have selective minimal modifications to confer an optimal balance of biological activity, toxicity, stability, and target gene specificity. For example, the strands may be modified (e g., one or both ends of the sense strand is modified by 2'-O-methyl groups), such that the construct is not cleaved by Dicer or other RNAse III, the antisense strand may also be modified by a 2'-O-methyl group at the penultimate 5'-end nucleotide to greatly reduce off- target silencing.
摘要翻译：公开了针对表达意想不到的高基因沉默活性的MAP4K4的RNAi构建体及其用途。平端构建体具有19-49个核苷酸的双链区域。该构建体具有选择性的最小修饰以赋予生物活性，毒性，稳定性和靶基因特异性的最佳平衡。例如，可以修饰链（例如，有义链的一个或两个末端被2'-O-甲基修饰），使得构建体不被Dicer或其他RNA酶III切割，反义链也可以在倒数第二个5'-末端核苷酸处被2'-O-甲基修饰，以大大减少脱靶沉默。

7. 发明申请

WO2010033247A3 REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS 审中-公开
标题翻译：减少尺寸自交RNAi化合物
公开(公告)号：WO2010033247A3
公开(公告)日：2010-06-03
申请号：PCT/US2009005247
申请日：2009-09-22
申请人： RXI PHARMACEUTICALS CORP , KHVOROVA ANASTASIA , SALOMON WILLIAM , KAMENS JOANNE , SAMARSKY DMITRY , WOOLF TOD M , CARDIA JAMES
发明人： KHVOROVA ANASTASIA , SALOMON WILLIAM , KAMENS JOANNE , SAMARSKY DMITRY , WOOLF TOD M , CARDIA JAMES
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/1136 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/3515 , C12N2310/3519 , C12N2320/32 , C12N2320/51 , C12N2310/3521
摘要： The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing.
摘要翻译：本发明涉及具有最小双链区的RNAi构建体及其在基因沉默中的应用。与本发明相关的RNAi构建体包括8-14个核苷酸的双链区域和各种化学修饰，并且在基因沉默中是非常有效的。

8. 发明申请

WO2010059226A2 INHIBITION OF MAP4K4 THROUGH RNAI 审中-公开
标题翻译：通过RNAi抑制MAP4K4
公开(公告)号：WO2010059226A2
公开(公告)日：2010-05-27
申请号：PCT/US2009/006211
申请日：2009-11-19
申请人： RXI PHARMACEUTICALS CORPORATION , WOOLF, Tod, M. , KAMENS, Joanne , KHVOROVA, Anastasia , SALOMON, William
发明人： WOOLF, Tod, M. , KAMENS, Joanne , KHVOROVA, Anastasia , SALOMON, William
IPC分类号： A61M5/31
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/321 , C12N2320/11 , C12N2320/30 , C12Y207/01037
摘要： The invention relates to various MAP4K4 RNAi constructs with unexpectedly high gene silencing activities, and uses thereof. The construct has a double-stranded region of 19-49 nucleotides, preferably 25, 26, or 27 nucleotides, and preferably blunt-ended. The construct has selective minimal modifications to confer an optimal balance of biological activity, toxicity, stability, and target gene specificity. For example, the sense strand may be modified ( e.g ., one or both ends of the sense strand is/are modified by four 2'-O-methyl groups), such that the construct is not cleaved by Dicer or other RNAse III, and the entire length of the antisense strand is loaded into RISC. In addition, the antisense strand may also be modified by 2'-O-methyl group at the 2nd 5'-end nucleotide to greatly reduce off-target silencing. The constructs of the invention largely avoids the interferon response and sequence-independent apoptosis in mammalian cells, exhibits better serum stability, and enhanced target specificity.
摘要翻译：本发明涉及具有意想不到的高基因沉默活性的各种MAP4K4 RNAi构建体及其用途。该构建体具有19-49个核苷酸，优选25,26或27个核苷酸的双链区域，并且优选是平端的。该构建体具有选择性的最小修饰以赋予生物活性，毒性，稳定性和靶基因特异性的最佳平衡。例如，有义链可以被修饰（例如，有义链的一个或两个末端被四个2'-O-甲基修饰），使得该构建体不被Dicer或其他RNA酶III切割，以及反义链的整个长度被加载到RISC中。此外，反义链也可以通过2'-O-甲基在第二个5'-末端核苷酸修饰，以大大减少脱靶沉默。本发明的构建体大大避免了哺乳动物细胞中的干扰素反应和序列无关的凋亡，表现出更好的血清稳定性和增强的靶特异性。

9. 发明申请

WO2009045457A3 TRIPARTITE RNAI CONSTRUCTS 审中-公开
公开(公告)号：WO2009045457A3
公开(公告)日：2009-04-09
申请号：PCT/US2008/011394
申请日：2008-10-02
申请人： RXI PHARMACEUTICALS CORP. , WOOLF, Tod, M. , WAGNER, Rick , PAVCO, Pam , SALOMON, William , USMAN, Nassim , SAMARSKY, Dmitry
发明人： WOOLF, Tod, M. , WAGNER, Rick , PAVCO, Pam , SALOMON, William , USMAN, Nassim , SAMARSKY, Dmitry
IPC分类号： C12N15/11 , C07H21/00 , A61K31/713 , C12P19/34 , C07H21/02 , C07H21/04 , A01N43/04
摘要： The present invention provides compositions and methods for inhibiting expression of a target gene in a cell. The process comprises introduction of double-stranded tripartite RNAi constructs into the cells and reducing the expression of the corresponding messenger RNA in the cells. The constructs, which may be packaged in or delivered as sequestered RNAi constructs, differ from the canonical siRNA in that they comprise a tripartite structure which follows the general formula of having (1) an RNAi core (either native or abbreviated), (2) one or more terminal moieties attached to the RNAi core and optionally (3) a linker between the RNAi core and the terminal moiety. Once packaged into sequestration vehicles, the constructs are activated for gene regulation by the application of certain forms of energy.

10. 发明申请

WO2006130612A3 COMPUTER PROGRAM FOR IDENTIFYING AND AUTOMATING REPETITIVE USER INPUTS 审中-公开
公开(公告)号：WO2006130612A3
公开(公告)日：2006-12-07
申请号：PCT/US2006/020980
申请日：2006-05-30
申请人： IPIFINI , WOOLF, Tod, M. , MARKS, Andrew, S.
发明人： WOOLF, Tod, M. , MARKS, Andrew, S.
IPC分类号： G06F15/00
摘要： The invention relates to machine-readable code that tracks user input and associated computer output during use of a computer programmed with the code, identifies repetitive patterns and automates the user input portion of those identified repetitive patterns when they occur again.

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