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    • 3. 发明申请
    • METHOD FOR DIFFERENTIATING CARTILAGE CELLS, BONE CELLS, NERVE CELLS OR FAT CELLS FROM HUMAN INFERIOR TURBINATE MESENCHYMAL STROMAL CELLS
    • 用于区分来自人类不良的转动中间质基质细胞的软骨细胞,骨细胞,神经细胞或脂肪细胞的方法
    • WO2011118954A9
    • 2011-11-17
    • PCT/KR2011001947
    • 2011-03-22
    • CATHOLIC UNIV IND ACAD COOPKIM SUNG WON
    • KIM SUNG WON
    • C12N5/077A61F2/30A61K35/32A61P19/00C07K14/495C12N5/02
    • C12N5/0668A61K35/12
    • The present invention relates to a method for inducing differentiation of human inferior turbinate mesenchymal stromal cells to bone cells, cartilage cells or nerve cells. More particularly, the present invention relates to a method for inducing differentiation of human inferior turbinate mesenchymal stromal cells to bone cells, cartilage cells, nerve cells or fat cells, wherein the method comprises the step of culturing the mesenchymal stromal cells that are isolated from human inferior turbinate tissues in a medium containing growth factors. The present invention also relates to a composition for prevention or treatment of cartilage injury or disease, bone injury or osseous metabolic disease, or nerve injury or disease that contain cells differentiated by said method as active ingredients. The bone cells, cartilage cells, nerve cells or fat cells differentiated from human inferior turbinate mesenchymal stromal cells according to the present invention can be used in the fields of cell replacement therapy and regenerative medicine for treating diseases caused by the damage of said cells, and the human inferior turbinate tissues used in the present invention can be easily obtained as the source of the cells from the discarded tissues during inferior turbinate surgery.
    • 本发明涉及诱导人下鼻甲骨间质基质细胞分化成骨细胞,软骨细胞或神经细胞的方法。 更具体地,本发明涉及用于诱导人下鼻甲骨间质基质细胞分化成骨细胞,软骨细胞,神经细胞或脂肪细胞的方法,其中所述方法包括培养从人分离的间充质基质细胞的步骤 在含有生长因子的培养基中下鼻甲组织。 本发明还涉及用于预防或治疗软骨损伤或疾病,骨损伤或骨代谢疾病或神经损伤或疾病的组合物,其含有通过所述方法分化的细胞作为活性成分。 根据本发明的从人下鼻甲间质基质细胞分化的骨细胞,软骨细胞,神经细胞或脂肪细胞可以用于细胞替代疗法和再生医学领域,用于治疗由所述细胞的损伤引起的疾病,以及 在下鼻甲手术期间,本发明中使用的人下鼻甲组织可以容易地作为来自丢弃组织的细胞来源获得。
    • 4. 发明申请
    • METHOD FOR DIFFERENTIATING CARTILAGE CELLS, BONE CELLS, NERVE CELLS OR FAT CELLS FROM HUMAN INFERIOR TURBINATE MESENCHYMAL STROMAL CELLS
    • 用于分化人源细胞,骨髓细胞,神经细胞或脂肪细胞的方法,用于人源性涡轮发育蛋白质细胞
    • WO2011118954A2
    • 2011-09-29
    • PCT/KR2011001947
    • 2011-03-22
    • CATHOLIC UNIV IND ACAD COOPKIM SUNG WON
    • KIM SUNG WON
    • C12N5/077A61F2/30A61K35/32A61P19/00C07K14/495C12N5/02
    • C12N5/0668A61K35/12
    • The present invention relates to a method for inducing differentiation of human inferior turbinate mesenchymal stromal cells to bone cells, cartilage cells or nerve cells. More particularly, the present invention relates to a method for inducing differentiation of human inferior turbinate mesenchymal stromal cells to bone cells, cartilage cells, nerve cells or fat cells, wherein the method comprises the step of culturing the mesenchymal stromal cells that are isolated from human inferior turbinate tissues in a medium containing growth factors. The present invention also relates to a composition for prevention or treatment of cartilage injury or disease, bone injury or osseous metabolic disease, or nerve injury or disease that contain cells differentiated by said method as active ingredients. The bone cells, cartilage cells, nerve cells or fat cells differentiated from human inferior turbinate mesenchymal stromal cells according to the present invention can be used in the fields of cell replacement therapy and regenerative medicine for treating diseases caused by the damage of said cells, and the human inferior turbinate tissues used in the present invention can be easily obtained as the source of the cells from the discarded tissues during inferior turbinate surgery.
    • 本发明涉及诱导人类下鼻甲间充质基质细胞分化为骨细胞,软骨细胞或神经细胞的方法。 更具体地,本发明涉及诱导人类下鼻甲间充质基质细胞分化为骨细胞,软骨细胞,神经细胞或脂肪细胞的方法,其中所述方法包括培养从人体分离的间充质基质细胞的步骤 含有生长因子的培养基中的下鼻甲组织。 本发明还涉及用于预防或治疗软骨损伤或疾病,骨损伤或骨代谢疾病或包含通过所述方法分化的细胞作为活性成分的神经损伤或疾病的组合物。 根据本发明的从人类下鼻甲间充质基质细胞分化的骨细胞,软骨细胞,神经细胞或脂肪细胞可用于细胞替代疗法和再生医学领域,用于治疗由所述细胞的损伤引起的疾病,以及 在下鼻甲手术期间,可以容易地获得本发明中使用的人类下鼻甲组织作为来自废弃组织的细胞源。
    • 7. 发明申请
    • SURFACE TREATMENT METHOD FOR AN ORTHODONTIC SCREW, AND ORTHODONTIC SCREW
    • 正交螺钉的表面处理方法和正交螺丝
    • WO2010143830A3
    • 2011-04-14
    • PCT/KR2010003392
    • 2010-05-28
    • JEIL MEDICAL CORPKIM SUNG WON
    • KIM SUNG WON
    • A61C7/12A61L27/28
    • A61C8/0012A61C8/0096A61L31/14A61L2400/18
    • The present invention relates to a surface treatment method for an orthodontic screw and to an orthodontic screw, which prevent the screw from fracturing during the implantation of the screw, and increase osseointegration between the implanted screw and alveolar bone. The screw of the present invention includes a head portion, as well as an implanting portion which extends from the head portion and which has a threaded outer surface. The surface treatment method for an orthodontic screw involves performing a masking process on the head portion using a masking material. The method comprises a surface treatment step of treating the surface of the implanting portion to increase the surface roughness thereof, and a removal step of removing the masking material.
    • 本发明涉及一种用于正畸螺钉和正畸螺钉的表面处理方法,其在螺钉植入期间防止螺钉压裂,并增加植入的螺钉和牙槽骨之间的骨整合。 本发明的螺钉包括头部,以及从头部延伸并具有螺纹外表面的植入部分。 用于正畸螺钉的表面处理方法包括使用掩模材料对头部进行掩模处理。 该方法包括处理植入部分的表面以增加其表面粗糙度的表面处理步骤,以及去除掩模材料的去除步骤。