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1. 发明申请

WO2015200178A1 ASSAYS FOR VITAMIN D EPIMERS 审中-公开
标题翻译： VITAMIN D EPIMERS的测定
公开(公告)号：WO2015200178A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/036900
申请日：2015-06-22
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： WEI, Tie Quan , TENG, Zhu , MAREEVA, Tatiana , LI, Jie , DRINAN, Martin A. , BAHAR, Izak , SHARMA, Manoj
IPC分类号： C07K16/44
CPC分类号： G01N33/82 , A61K39/385 , C07C401/00 , C07K16/44 , G01N21/76 , G01N33/532
摘要： Methods include determining an amount of an epimeric vitamin D analyte in a sample suspected of containing the epimeric vitamin D analyte. A combination is provided in an assay medium that includes the sample and a vitamin D epimer antibody that is specific for the epimeric vitamin D analyte. The assay medium is incubated under conditions for binding of the vitamin D epimer antibody to the epimeric vitamin D analyte to form an epimeric vitamin D antibody-bound complex. The amount of the epimeric vitamin D antibody-bound complex is determined and related to the amount of epimeric vitamin D analyte in the sample.
摘要翻译：方法包括确定怀疑含有差向异构维生素D分析物的样品中差向异构维生素D分析物的量。在包含样品和对于差向异构维生素D分析物特异的维生素D差向异构体抗体的测定培养基中提供了组合。将测定培养基在维生素D差向异构体抗体与差向异构维生素D分析物的结合条件下孵育以形成差向异构维生素D抗体结合复合物。测定差向异构维生素D抗体结合复合物的量，并与样品中差向异构维生素D分析物的量相关。

2. 发明申请

WO2021030166A1 ANTI-HOG TCN1 MONOCLONAL ANTIBODIES AND METHODS OF PRODUCTION AND USE THEREOF 审中-公开
公开(公告)号：WO2021030166A1
公开(公告)日：2021-02-18
申请号：PCT/US2020/045318
申请日：2020-08-07
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： SHARMA, Manoj , MAREEVA, Tatiana , SMIRNOV, Yuriy , SINGH, Pratap , BEDZYK, William
IPC分类号： A61K38/00 , A61K39/00 , A61K39/395 , C07K16/18 , C07K16/46 , C07K19/00
摘要： Anti-hog TCN1 monoclonal antibodies are disclosed, along with epitopes recognized by same. Also disclosed are kits containing the monoclonal antibodies and methods of producing the antibodies. Further disclosed are methods of using the monoclonal antibodies, such as (but not limited to) in methods of estimating and/or removing TCN1 from hog intrinsic factor preparations.

3. 发明申请

WO2015200186A1 BINDING PARTNERS SPECIFIC FOR VITAMIN D EPIMERS IN VITAMIN D ASSAYS 审中-公开
标题翻译：维生素D测定中VITAMIN D EPIMERS的具体合作伙伴
公开(公告)号：WO2015200186A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/036912
申请日：2015-06-22
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： WEI, Tie, Quan , LI, Jie , SHARMA, Manoj , TENG, Zhu
IPC分类号： C07K16/44
CPC分类号： G01N33/82 , A61K39/385 , C07C401/00 , C07K16/44 , G01N21/76 , G01N33/532
摘要： Methods include determining an amount of vitamin D analyte in a sample suspected of containing the vitamin D analyte. A combination is provided in an assay medium that includes the sample, a vitamin D epimer antibody that is specific for epimers of the vitamin D analyte wherein the vitamin D epimer antibody does not bind to any detectable degree to the vitamin D analyte, and a vitamin D antibody that is specific for the vitamin D analyte, and. The assay medium is incubated under conditions for binding of the vitamin D epimer antibody to the epimers of the vitamin D analyte and for binding of the vitamin D antibody to the vitamin D analyte to form a vitamin D antibody-bound complex. The amount of vitamin D antibody-bound complex is determined and related to the amount of vitamin D analyte in the sample.
摘要翻译：方法包括确定怀疑含有维生素D分析物的样品中的维生素D分析物的量。在包含样品的测定培养基中提供组合，所述样品是维生素D分析物的差向异构体的维生素D差向异构体抗体，其中维生素D差向异构体抗体不与维生素D分析物的任何可检测度结合， D抗体对维生素D分析物具有特异性，将测定培养基在维生素D差向异构体抗体与维生素D分析物的差向异构体结合的条件下孵育，并将维生素D抗体与维生素D分析物结合以形成维生素D抗体结合复合物。测定维生素D抗体结合复合物的量并与样品中维生素D分析物的量相关。

4. 发明申请

WO2015200182A1 BINDING PARTNERS SPECIFIC FOR VITAMIN D EPIMERS 审中-公开
标题翻译： VITAMIN D EPIMERS的具体合作伙伴
公开(公告)号：WO2015200182A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/036907
申请日：2015-06-22
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： SHARMA, Manoj , MAREEVA, Tatiana , SMIRNOV, Yuriy , BEDZYK, William D. , TENG, Zhu , WEI, Tie Quan
IPC分类号： C07K16/44
CPC分类号： C07K16/44 , B01D15/3809 , C07K16/26 , C07K2317/33 , G01N33/82
摘要： Antibodies are raised against compounds of Formula (I) where Z is an immunogenic carrier. These compounds are capable of binding specifically to corresponding antibodies. The antibodies are specific for epimers of vitamin D. Antibodies in accordance with the principles described herein may be employed to minimize or eliminate 3-epimer cross-reactivity in assays for non-epimeric forms of vitamin D analytes. Over-estimation of total non-epimeric vitamin D analyte caused by the cross-reactivity of 3-epimer vitamin D with an antibody for vitamin D analyte can be substantially avoided employing, as blocking agents, antibodies prepared against immunogens that are a compound of the Formula (I) wherein Z is an immunogenic carrier.
摘要翻译：针对其中Z是免疫原性载体的式（I）化合物产生抗体。这些化合物能够特异性结合相应的抗体。抗体对维生素D的差向异构体是特异性的。根据本文描述的原理的抗体可以用于在维生素D分析物的非分解形式的测定中最小化或消除3-差向异构体交叉反应性。使用3-差向异构体维生素D与维生素D分析物的抗体的交叉反应性引起的总非分解维生素D分析物的过度估计可以基本上避免使用针对免疫原制备的抗体作为阻断剂式（I）其中Z是免疫原性载体。

5. 发明申请

WO2016100116A1 SANDWICH ASSAY DESIGN FOR SMALL MOLECULES 审中-公开
标题翻译： SANDWICH测定小分子设计
公开(公告)号：WO2016100116A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/065237
申请日：2015-12-11
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： ZHENG, Yi Feng , WEI, Tie Q. , SHARMA, Manoj
IPC分类号： G01N33/566 , C07K16/00 , C12P21/08
CPC分类号： C07K16/00 , C07D497/04 , C07K16/44 , C07K2317/10 , C07K2317/54 , G01N33/566 , G01N33/9493
摘要： Methods are disclosed of designing antibodies for a sandwich assay for a small molecule having a molecular weight of about 500 to about 2,000. The method comprises preparing a first antibody that binds to the small molecule, and preparing a second antibody that binds to the small molecule at a portion of the small molecule other than a portion to which the first antibody binds. The second antibody is prepared from an immunogen that comprises a predetermined portion of the small molecule. The antibodies may be employed in sandwich assays for the small molecule.
摘要翻译：公开了分子量为约500至约2,000的小分子的夹心测定设计抗体的方法。该方法包括制备与小分子结合的第一抗体，以及制备除了第一抗体结合部分之外的小分子的一部分结合小分子的第二抗体。第二抗体由包含小分子的预定部分的免疫原制备。抗体可用于小分子的夹心测定。

6. 发明申请

WO2015200180A1 COMPOSITIONS RELATING TO VITAMIN D 审中-公开
标题翻译：与维生素D有关的组合物
公开(公告)号：WO2015200180A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/036904
申请日：2015-06-22
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： TENG, Zhu , LIAO, Qimu , SHARMA, Manoj , DRINAN, Martin, A. , WEI, Tie, Quan
IPC分类号： A61K31/59
CPC分类号： C07C401/00 , C07C2601/14 , C07C2602/24 , G01N33/82
摘要： This invention relates to compositions, methods and kits for determining the presence and/or amount of vitamin D analytes, including vitamin D isomers, and metabolites thereof in a sample suspected of containing the same. Compounds include compounds of the Formula I, namely, (R 1 ) p -(L) q -Z wherein R 1 , L, p and q are as defined herein. These compounds are capable of binding specifically to corresponding antibodies. Compounds and antibodies in accordance with the principles described herein can have therapeutic activity. These compounds may be administered in therapeutically effective amount, which is an amount to provide treatment of a particular disease state associated with vitamin D. Administration of the examples of compounds in accordance with the principles described herein can be by means of any of the accepted modes of administration for agents that serve similar utilities.
摘要翻译：本发明涉及用于确定怀疑含有该维生素D分析物的维生素D分析物（包括维生素D异构体）及其代谢物的存在和/或量的组合物，方法和试剂盒。化合物包括式I的化合物，即（R1）对 - （L）q -Z其中R1，L，p和q如本文所定义。这些化合物能够特异性结合相应的抗体。根据本文所述原理的化合物和抗体可具有治疗活性。这些化合物可以以治疗有效量施用，其量是提供与维生素D相关的特定疾病状态的治疗量。根据本文所述原理施用化合物的实例可以通过任何接受的方式为类似用途的代理商提供管理。

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