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1. 发明申请

WO2020092153A1 BINDING COMPETITORS FOR USE IN MACROPHILIN-BINDING PHARMACEUTICAL ASSAYS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2020092153A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/058058
申请日：2019-10-25
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： WEI, Tie , TENG, Zhu , DRINAN, Martin , LI, Jie
IPC分类号： A61K38/12 , C07D405/02 , G01N33/566
摘要： Compositions comprising binding competitors that can be used in assays for macrophilin-binding pharmaceuticals in samples are disclosed, as well as kits containing same and methods of use thereof.

2. 发明申请

WO2015200178A1 ASSAYS FOR VITAMIN D EPIMERS 审中-公开
标题翻译： VITAMIN D EPIMERS的测定
公开(公告)号：WO2015200178A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/036900
申请日：2015-06-22
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： WEI, Tie Quan , TENG, Zhu , MAREEVA, Tatiana , LI, Jie , DRINAN, Martin A. , BAHAR, Izak , SHARMA, Manoj
IPC分类号： C07K16/44
CPC分类号： G01N33/82 , A61K39/385 , C07C401/00 , C07K16/44 , G01N21/76 , G01N33/532
摘要： Methods include determining an amount of an epimeric vitamin D analyte in a sample suspected of containing the epimeric vitamin D analyte. A combination is provided in an assay medium that includes the sample and a vitamin D epimer antibody that is specific for the epimeric vitamin D analyte. The assay medium is incubated under conditions for binding of the vitamin D epimer antibody to the epimeric vitamin D analyte to form an epimeric vitamin D antibody-bound complex. The amount of the epimeric vitamin D antibody-bound complex is determined and related to the amount of epimeric vitamin D analyte in the sample.
摘要翻译：方法包括确定怀疑含有差向异构维生素D分析物的样品中差向异构维生素D分析物的量。在包含样品和对于差向异构维生素D分析物特异的维生素D差向异构体抗体的测定培养基中提供了组合。将测定培养基在维生素D差向异构体抗体与差向异构维生素D分析物的结合条件下孵育以形成差向异构维生素D抗体结合复合物。测定差向异构维生素D抗体结合复合物的量，并与样品中差向异构维生素D分析物的量相关。

3. 发明申请

WO2011049968A1 STABILIZATION OF SIGNAL GENERATION IN PARTICLES USED IN ASSAYS 审中-公开
标题翻译：用于测定的颗粒中信号产生的稳定性
公开(公告)号：WO2011049968A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/053229
申请日：2010-10-19
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC. , CRAIG, Alan, R. , TENG, Zhu , SCHELP, Carsten , SNYDER, Jason , MORAN, Christine
发明人： CRAIG, Alan, R. , TENG, Zhu , SCHELP, Carsten , SNYDER, Jason , MORAN, Christine
IPC分类号： C09K11/06
CPC分类号： G01N21/76 , G01N21/6428 , G01N33/54393 , Y10S435/968 , Y10T436/10 , Y10T436/2525
摘要： Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with a solid support such as, for example, a particle. The support comprises a chemiluminescent composition that comprises a metal chelate. The present inventors observed that, when such support such as, e.g., particles, were employed in assays for the determination of an analyte, stability of signal output by the chemiluminescent composition associated with the particle was unacceptably reduced as compared to particles comprising other chemiluminescent compositions. In accordance with embodiments of the present invention, the stability of signal output from such particles is enhanced by including in a medium comprising the particles a sufficient amount of one or more stabilizing agents, which may be a chelating agent and/or a metal chelate such as, for example, the metal chelate that is associated with the particle.
摘要翻译：公开了用于进行测定的方法和试剂。本发明方法和试剂的实施方案涉及固体支持物，例如颗粒。载体包含包含金属螯合物的化学发光组合物。本发明人观察到，当将这种载体例如颗粒用于测定分析物时，与颗粒相关的化学发光组合物输出的信号的稳定性与包含其它化学发光组合物的颗粒相比是不可接受的降低。根据本发明的实施方案，通过在包含颗粒的介质中包含足量的一种或多种稳定剂（其可以是螯合剂和/或金属螯合物）来增加来自这些颗粒的信号输出的稳定性，例如例如，与颗粒相关的金属螯合物。

4. 发明申请

WO2021118706A1 PHOTOCURABLE REAGENT(S) FOR FORMING CHLORIDE ION-SELECTIVE SENSOR(S) AND METHODS OF PRODUCTION AND USE THEREOF 审中-公开
公开(公告)号：WO2021118706A1
公开(公告)日：2021-06-17
申请号：PCT/US2020/058206
申请日：2020-10-30
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： CHA, Kyoung, Ha , TENG, Zhu , YANG, Si
IPC分类号： G01N27/333 , C08G59/04 , C08K5/17 , G01N27/414
摘要： Improved formulation(s), device(s), and method(s) for producing ion-selective electrodes (ISEs) that comprise at least one photo-curable, epoxy-based, ion-selective chloride membrane(s) compounds that can be pre-mixed together to form a singularly-dispensed mixture for the formation of an ion-exchange resin membrane(s) for incorporation and use in a chloride ISE.

5. 发明申请

WO2020028110A1 KITS, MICROFLUIDICS DEVICES, AND METHODS FOR PERFORMING BIOTIN ASSAYS 审中-公开
公开(公告)号：WO2020028110A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/043195
申请日：2019-07-24
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： WEI, Tie Q. , TENG, Zhu , LIU, Xiaodong , DRINAN, Martin
IPC分类号： G01N21/76 , G01N33/58 , F21K2/06 , B01L3/00
摘要： Kits containing a chemiluminescent detection system and microfluidics devices and methods for determining the concentration of biotin in a sample are disclosed. The kits, microfluidics devices, and methods utilize a sensitizer capable of generating singlet oxygen in its excited state and having avidin or an analog thereof directly or indirectly bound thereto, as well as a singlet oxygen-activatable chemiluminescent compound having biotin or an analog thereof directly or indirectly bound thereto.

6. 发明申请

WO2015200180A1 COMPOSITIONS RELATING TO VITAMIN D 审中-公开
标题翻译：与维生素D有关的组合物
公开(公告)号：WO2015200180A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/036904
申请日：2015-06-22
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： TENG, Zhu , LIAO, Qimu , SHARMA, Manoj , DRINAN, Martin, A. , WEI, Tie, Quan
IPC分类号： A61K31/59
CPC分类号： C07C401/00 , C07C2601/14 , C07C2602/24 , G01N33/82
摘要： This invention relates to compositions, methods and kits for determining the presence and/or amount of vitamin D analytes, including vitamin D isomers, and metabolites thereof in a sample suspected of containing the same. Compounds include compounds of the Formula I, namely, (R 1 ) p -(L) q -Z wherein R 1 , L, p and q are as defined herein. These compounds are capable of binding specifically to corresponding antibodies. Compounds and antibodies in accordance with the principles described herein can have therapeutic activity. These compounds may be administered in therapeutically effective amount, which is an amount to provide treatment of a particular disease state associated with vitamin D. Administration of the examples of compounds in accordance with the principles described herein can be by means of any of the accepted modes of administration for agents that serve similar utilities.
摘要翻译：本发明涉及用于确定怀疑含有该维生素D分析物的维生素D分析物（包括维生素D异构体）及其代谢物的存在和/或量的组合物，方法和试剂盒。化合物包括式I的化合物，即（R1）对 - （L）q -Z其中R1，L，p和q如本文所定义。这些化合物能够特异性结合相应的抗体。根据本文所述原理的化合物和抗体可具有治疗活性。这些化合物可以以治疗有效量施用，其量是提供与维生素D相关的特定疾病状态的治疗量。根据本文所述原理施用化合物的实例可以通过任何接受的方式为类似用途的代理商提供管理。

7. 发明申请

WO2015021108A1 COMPOSITIONS AND METHODS FOR DETECTING CORTISOL 审中-公开
标题翻译：检测CORTISOL的组合物和方法
公开(公告)号：WO2015021108A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/049875
申请日：2014-08-06
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： TENG, Zhu , SEIPLE, Lauren , DRINAN, Martin
IPC分类号： A61K51/00 , C07K16/00 , G01N33/53
CPC分类号： G01N33/743 , C07B2200/11 , C07J41/0016 , C07K16/44
摘要： Methods of detecting Cortisol in samples suspected of containing Cortisol are disclosed that utilize conjugates of 11-a-cortisol linked at he 3-position to an assay molecule. In addition, compounds are disclosed that have the formula: (structure) wherein L is a linking group nd X is as further defined herein.
摘要翻译：公开了在怀疑含有皮质醇的样品中检测皮质醇的方法，其使用在3位连接的11-α-皮质醇与测定分子的缀合物。此外，公开了具有下式的化合物：（结构式）其中L是连接基团，并且X如本文进一步定义。

8. 发明申请

WO2020068541A1 METHODS AND COMPOSITIONS FOR REMOVING BIOTIN INTERFERENCE FROM ASSAYS USING MOLECULAR TRAPS 审中-公开
公开(公告)号：WO2020068541A1
公开(公告)日：2020-04-02
申请号：PCT/US2019/051867
申请日：2019-09-19
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： WEI, Tie , TENG, Zhu , BAHAR, Izak
IPC分类号： G01N33/543
摘要： The present invention relates to methods and compositions to remove or reduce biotin interference from certain assays.

9. 发明申请

WO2015200186A1 BINDING PARTNERS SPECIFIC FOR VITAMIN D EPIMERS IN VITAMIN D ASSAYS 审中-公开
标题翻译：维生素D测定中VITAMIN D EPIMERS的具体合作伙伴
公开(公告)号：WO2015200186A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/036912
申请日：2015-06-22
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： WEI, Tie, Quan , LI, Jie , SHARMA, Manoj , TENG, Zhu
IPC分类号： C07K16/44
CPC分类号： G01N33/82 , A61K39/385 , C07C401/00 , C07K16/44 , G01N21/76 , G01N33/532
摘要： Methods include determining an amount of vitamin D analyte in a sample suspected of containing the vitamin D analyte. A combination is provided in an assay medium that includes the sample, a vitamin D epimer antibody that is specific for epimers of the vitamin D analyte wherein the vitamin D epimer antibody does not bind to any detectable degree to the vitamin D analyte, and a vitamin D antibody that is specific for the vitamin D analyte, and. The assay medium is incubated under conditions for binding of the vitamin D epimer antibody to the epimers of the vitamin D analyte and for binding of the vitamin D antibody to the vitamin D analyte to form a vitamin D antibody-bound complex. The amount of vitamin D antibody-bound complex is determined and related to the amount of vitamin D analyte in the sample.
摘要翻译：方法包括确定怀疑含有维生素D分析物的样品中的维生素D分析物的量。在包含样品的测定培养基中提供组合，所述样品是维生素D分析物的差向异构体的维生素D差向异构体抗体，其中维生素D差向异构体抗体不与维生素D分析物的任何可检测度结合， D抗体对维生素D分析物具有特异性，将测定培养基在维生素D差向异构体抗体与维生素D分析物的差向异构体结合的条件下孵育，并将维生素D抗体与维生素D分析物结合以形成维生素D抗体结合复合物。测定维生素D抗体结合复合物的量并与样品中维生素D分析物的量相关。

10. 发明申请

WO2015200182A1 BINDING PARTNERS SPECIFIC FOR VITAMIN D EPIMERS 审中-公开
标题翻译： VITAMIN D EPIMERS的具体合作伙伴
公开(公告)号：WO2015200182A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/036907
申请日：2015-06-22
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC.
发明人： SHARMA, Manoj , MAREEVA, Tatiana , SMIRNOV, Yuriy , BEDZYK, William D. , TENG, Zhu , WEI, Tie Quan
IPC分类号： C07K16/44
CPC分类号： C07K16/44 , B01D15/3809 , C07K16/26 , C07K2317/33 , G01N33/82
摘要： Antibodies are raised against compounds of Formula (I) where Z is an immunogenic carrier. These compounds are capable of binding specifically to corresponding antibodies. The antibodies are specific for epimers of vitamin D. Antibodies in accordance with the principles described herein may be employed to minimize or eliminate 3-epimer cross-reactivity in assays for non-epimeric forms of vitamin D analytes. Over-estimation of total non-epimeric vitamin D analyte caused by the cross-reactivity of 3-epimer vitamin D with an antibody for vitamin D analyte can be substantially avoided employing, as blocking agents, antibodies prepared against immunogens that are a compound of the Formula (I) wherein Z is an immunogenic carrier.
摘要翻译：针对其中Z是免疫原性载体的式（I）化合物产生抗体。这些化合物能够特异性结合相应的抗体。抗体对维生素D的差向异构体是特异性的。根据本文描述的原理的抗体可以用于在维生素D分析物的非分解形式的测定中最小化或消除3-差向异构体交叉反应性。使用3-差向异构体维生素D与维生素D分析物的抗体的交叉反应性引起的总非分解维生素D分析物的过度估计可以基本上避免使用针对免疫原制备的抗体作为阻断剂式（I）其中Z是免疫原性载体。

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