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    • 1. 发明申请
    • COMPOSITIONS RELATING TO VITAMIN D
    • 与维生素D有关的组合物
    • WO2015200180A1
    • 2015-12-30
    • PCT/US2015/036904
    • 2015-06-22
    • SIEMENS HEALTHCARE DIAGNOSTICS INC.
    • TENG, ZhuLIAO, QimuSHARMA, ManojDRINAN, Martin, A.WEI, Tie, Quan
    • A61K31/59
    • C07C401/00C07C2601/14C07C2602/24G01N33/82
    • This invention relates to compositions, methods and kits for determining the presence and/or amount of vitamin D analytes, including vitamin D isomers, and metabolites thereof in a sample suspected of containing the same. Compounds include compounds of the Formula I, namely, (R 1 ) p -(L) q -Z wherein R 1 , L, p and q are as defined herein. These compounds are capable of binding specifically to corresponding antibodies. Compounds and antibodies in accordance with the principles described herein can have therapeutic activity. These compounds may be administered in therapeutically effective amount, which is an amount to provide treatment of a particular disease state associated with vitamin D. Administration of the examples of compounds in accordance with the principles described herein can be by means of any of the accepted modes of administration for agents that serve similar utilities.
    • 本发明涉及用于确定怀疑含有该维生素D分析物的维生素D分析物(包括维生素D异构体)及其代谢物的存在和/或量的组合物,方法和试剂盒。 化合物包括式I的化合物,即(R1)对 - (L)q -Z其中R1,L,p和q如本文所定义。 这些化合物能够特异性结合相应的抗体。 根据本文所述原理的化合物和抗体可具有治疗活性。 这些化合物可以以治疗有效量施用,其量是提供与维生素D相关的特定疾病状态的治疗量。根据本文所述原理施用化合物的实例可以通过任何接受的方式 为类似用途的代理商提供管理。