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1. 发明申请

WO03076883B1 COMPACT APPARATUS FOR NONINVASIVE MEASUREMENT OF GLUCOSE THROUGH NEAR-INFRARED SPECTROSCOPY 审中-公开
标题翻译：通过近红外光谱法非葡萄糖测量的紧凑装置
公开(公告)号：WO03076883B1
公开(公告)日：2004-10-14
申请号：PCT/US0307065
申请日：2003-03-07
申请人： SENSYS MEDICAL INC , ACOSTA GEORGE , HENDERSON JAMES R , ABUL-HAJ ALAN N , RUCHTI TIMOTHY L , MONFRE STEPHEN L , BLANK THOMAS B , HAZEN KEVIN H , GRUBISIC DRAGAN
发明人： ACOSTA GEORGE , HENDERSON JAMES R , ABUL-HAJ ALAN N , RUCHTI TIMOTHY L , MONFRE STEPHEN L , BLANK THOMAS B , HAZEN KEVIN H , GRUBISIC DRAGAN
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , G01N21/49
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus (10, 14, 16) is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter preferably gluocse, in the sampled tissue. The preferred analyzer is a near-IR based glucose analyzer
摘要翻译：本发明涉及通过紧凑型分析仪监测生物参数。优选的装置（10,14,16）是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并且收集用于确定采样组织中的生物学参数，优选地粘性的光谱测量。优选的分析仪是基于近红外的葡萄糖分析仪

2. 发明申请

WO03076883A8 COMPACT APPARATUS FOR NONINVASIVE MEASUREMENT OF GLUCOSE THROUGH NEAR-INFRARED SPECTROSCOPY 审中-公开
标题翻译：通过近红外光谱法非葡萄糖测量的紧凑装置
公开(公告)号：WO03076883A8
公开(公告)日：2005-01-13
申请号：PCT/US0307065
申请日：2003-03-07
申请人： SENSYS MEDICAL INC , ACOSTA GEORGE , HENDERSON JAMES R , ABUL-HAJ ALAN N , RUCHTI TIMOTHY L , MONFRE STEPHEN L , BLANK THOMAS B , HAZEN KEVIN H , GRUBISIC DRAGAN
发明人： ACOSTA GEORGE , HENDERSON JAMES R , ABUL-HAJ ALAN N , RUCHTI TIMOTHY L , MONFRE STEPHEN L , BLANK THOMAS B , HAZEN KEVIN H , GRUBISIC DRAGAN
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , G01N21/49
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus (10, 14, 16) is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter preferably gluocse, in the sampled tissue. The preferred analyzer is a near-IR based glucose analyzer
摘要翻译：本发明涉及通过紧凑型分析仪监测生物参数。优选的装置（10,14,16）是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并且收集用于确定采样组织中的生物学参数，优选地粘性的光谱测量。优选的分析仪是基于近红外的葡萄糖分析仪

3. 发明申请

WO2006047273A3 METHOD AND APPARATUS FOR NONINVASIVE GLUCOSE CONCENTRATION ESTIMATION THROUGH NEAR-INFRARED SPECTROSCOPY 审中-公开
标题翻译：通过近红外光谱法测定非葡萄糖浓度估算方法和装置
公开(公告)号：WO2006047273A3
公开(公告)日：2007-02-22
申请号：PCT/US2005037860
申请日：2005-10-20
申请人： SENSYS MEDICAL INC , ACOSTA GEORGE M , ABUL-HAJ N ALAN , RUCHTI TIMOTHY L , MONFRE STEPHEN L , BLANK THOMAS B , HAZEN KEVIN H
发明人： ACOSTA GEORGE M , ABUL-HAJ N ALAN , RUCHTI TIMOTHY L , MONFRE STEPHEN L , BLANK THOMAS B , HAZEN KEVIN H
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2560/0223 , A61B2560/0233
摘要： A near-infrared spectrometer-based analyzer attaches continuously or semicontinuously to a human subject and is used to collect spectral measurements of a tissue sample. The spectral readings are used to estimate a biological parameter in the sampled tissue noninvasively, such as glucose concentration. The preferred apparatus is a near-infrared analyzer that includes a base module and a sample module connected together with a communication bundle. The base module contains the bulk of the analyzer, such as a spectrograph and a central processing unit with an algorithm used for converting the optical signal into a glucose concentration. The sample module is typically in a smaller module that interfaces to a tissue sample. The sample module is preferably handheld and provides minimal sampling distortion due to heat or pressure.
摘要翻译：基于近红外光谱仪的分析仪连续地或半连续地连接到人类受试者并用于收集组织样本的光谱测量。光谱读数用于非侵入性地估计采样组织中的生物学参数，如葡萄糖浓度。优选的装置是近红外分析器，其包括与通信束连接在一起的基本模块和样本模块。基本模块包含分析仪的大部分，例如光谱仪和具有用于将光信号转换为葡萄糖浓度的算法的中央处理单元。样品模块通常在与组织样品接口的较小模块中。样品模块优选是手持式的，并且由于热或压力而提供最小的采样失真。

4. 发明申请

WO2008058014A2 METHOD AND APPARATUS FOR NONINVASIVE PROPE/SKIN TISSUE CONTACT SENSING 审中-公开
标题翻译：非活性丙烯/皮肤组织接触传感的方法和装置
公开(公告)号：WO2008058014A2
公开(公告)日：2008-05-15
申请号：PCT/US2007083497
申请日：2007-11-02
申请人： SENSYS MEDICAL INC , RUCHTI TIMOTHY L , WELCH JAMES M , SLAWINSKI CHRISTOPHER , BLANK THOMAS B , MONFRE STEPHEN L
发明人： RUCHTI TIMOTHY L , WELCH JAMES M , SLAWINSKI CHRISTOPHER , BLANK THOMAS B , MONFRE STEPHEN L
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0531 , A61B5/14532 , A61B5/1459 , A61B5/6843 , A61B2562/146 , G01J3/0218 , G01J3/027 , G01J3/0278 , G01N21/359
摘要： The invention relates to a method and apparatus for performing noninvasive analyte property determination. More particularly, the invention relates to determining proximity and/or contact of an optical sample probe with skin tissue.
摘要翻译：本发明涉及一种执行非侵入性分析物质确定的方法和装置。更具体地，本发明涉及确定光学样本探针与皮肤组织的接近和/或接触。

5. 发明申请

WO02065090A2 NONINVASIVE MEASUREMENT OF GLUCOSE THROUGH THE OPTICAL PROPERTIES OF TISSUE 审中-公开
标题翻译：通过组织的光学性质对葡萄糖进行非导线测量
公开(公告)号：WO02065090A2
公开(公告)日：2002-08-22
申请号：PCT/US0202288
申请日：2002-01-25
申请人： INSTRUMENTATION METRICS INC , RUCHTI TIMOTHY L , THENNADIL SURESH N , BLANK THOMAS B , LORENZ ALEX , MONFRE STEPHEN L
发明人： RUCHTI TIMOTHY L , THENNADIL SURESH N , BLANK THOMAS B , LORENZ ALEX , MONFRE STEPHEN L
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , G01N21/31 , G01N21/33 , G01N21/35 , G01N21/65 , G01N
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1495 , A61B2560/0223 , G01N21/31 , G01N21/33 , G01N21/359 , G01N2021/3595
摘要： Methods and apparatus for non-invasive determination of blood analytes, such as glucose, through NIR spectroscopy utilize optical properties of tissue as reflected in key spectroscopic features to improve measurement accuracy and precision. Physiological conditions such as changes in water distribution among tissue compartments lead to complex alterations in the measured absorbance spectrum of skin and reflect a modification in the effective pathlength of light, leading to a biased noninvasive glucose measurement. Changes (106) in the optical properties of tissue are detected by identifying key features responsive to physiological variations. Conditions (107) not conducive to non-invasive measurement of glucose are detected. Non-invasive glucose measurements that are biased by physiological changes in tissue are compensated (103). In an alternate embodiment, glucose is measured indirectly based on natural physiological response of tissue to glucose concentration. A spectroscopic device capable of such measurements is provided.
摘要翻译：通过近红外光谱对血液分析物（如葡萄糖）进行非侵入性测定的方法和装置利用关键光谱特征所反映的组织光学性质来提高测量精度和精度。生理条件如组织间隔水分配变化导致测量的皮肤吸收光谱的复杂变化，并反映了有效光线长度的变化，导致偏向的非侵入性葡萄糖测量。通过识别响应于生理变化的关键特征来检测组织光学性质的变化（106）。检测到不利于葡萄糖无创测量的条件（107）。通过组织中的生理变化偏置的非侵入性葡萄糖测量被补偿（103）。在替代实施方案中，基于组织对葡萄糖浓度的天然生理反应间接测量葡萄糖。提供能够进行这种测量的光谱装置。

6. 发明申请

WO2005122880A2 PREPARATION KIT FOR NONINVASIVE GLUCOSE CONCENTRATION DETERMINATION 审中-公开
标题翻译：非挥发性葡萄糖浓度测定的制备工具
公开(公告)号：WO2005122880A2
公开(公告)日：2005-12-29
申请号：PCT/US2005019347
申请日：2005-06-02
申请人： SENSYS MEDICAL INC , MONFRE STEPHEN L , HAZEN KEVIN H
发明人： MONFRE STEPHEN L , HAZEN KEVIN H
IPC分类号： A61B5/00 , B01L99/00
CPC分类号： A61B5/14532 , A61B90/80 , A61B2562/24 , A61B2562/242 , A61B2562/245
摘要： The invention involves a kit for use in conjunction with a near-infrared, noninvasive glucose concentration analyzer. The preferred kit contains a set of elements used in preparation of a sample site and/or for use in a sampling process. The invention comprises a kit that includes any of a guide, a plug, an adhesive, an alignment tool, a cleaner, contact fluid, and a package for use in combination with a noninvasive glucose concentration analyzer.
摘要翻译：本发明涉及一种用于与近红外，无创葡萄糖浓度分析仪结合使用的试剂盒。优选的试剂盒包含用于制备样品位点和/或用于取样过程中的一组元素。本发明包括一种试剂盒，其包括用于与非侵入性葡萄糖浓度分析仪组合使用的引导剂，塞子，粘合剂，对准工具，清洁剂，接触流体和包装中的任何一种。

7. 发明申请

WO2005122880B1 PREPARATION KIT FOR NONINVASIVE GLUCOSE CONCENTRATION DETERMINATION 审中-公开
标题翻译：制备无血清葡萄糖浓度测定试剂盒
公开(公告)号：WO2005122880B1
公开(公告)日：2007-04-12
申请号：PCT/US2005019347
申请日：2005-06-02
申请人： SENSYS MEDICAL INC , MONFRE STEPHEN L , HAZEN KEVIN H
发明人： MONFRE STEPHEN L , HAZEN KEVIN H
IPC分类号： A61B5/00 , B01L99/00
CPC分类号： A61B5/14532 , A61B90/80 , A61B2562/24 , A61B2562/242 , A61B2562/245
摘要： The invention involves a kit for use in conjunction with a near-infrared, noninvasive glucose concentration analyzer. The preferred kit contains a set of elements used in preparation of a sample site and/or for use in a sampling process. The invention comprises a kit that includes any of a guide, a plug, an adhesive, an alignment tool, a cleaner, contact fluid, and a package for use in combination with a noninvasive glucose concentration analyzer.
摘要翻译：本发明涉及与近红外非侵入式葡萄糖浓度分析仪结合使用的试剂盒。优选的试剂盒包含用于制备样品地点和/或用于取样过程的一组元素。本发明包括套件，其包括与无创葡萄糖浓度分析仪组合使用的引导件，塞子，粘合剂，对准工具，清洁器，接触流体和包装中的任一种。

8. 发明申请

WO03017048A2 A METHOD OF SCREENING FOR DISORDERS OF GLUCOSE METABOLISM 审中-公开
标题翻译：一种筛选葡萄糖代谢异常的方法
公开(公告)号：WO03017048A2
公开(公告)日：2003-02-27
申请号：PCT/US0225764
申请日：2002-08-13
申请人： SENSYS MEDICAL INC
发明人： MONFRE STEPHEN L , HOCKERSMITH LINDA , HETZEL DONALD , HAZEN KEVIN , CONE ANDREW
IPC分类号： A61B5/00 , G01N33/487 , G06F
CPC分类号： A61B5/7264 , A61B5/14532
摘要： A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose profile and classifies the profile into one of several predefined clusters, each cluster corresponding either to a normal condition or one of several abnormal conditions. The series of blood glucose values making up the glucose tolerance curve may be measured using any glucose analyzer including: invasive, minimally invasive and noninvasive types. The method is executed on a processing device programmed to perform the steps of the method. Depending on the outcome of the screening, a subject may be provided with additional information concerning their condition and/or counseled to consult further with their health care provider.
摘要翻译：筛选葡萄糖代谢紊乱如葡萄糖耐量异常和糖尿病的方法允许预防或早期检测和治疗糖尿病并发症如心血管疾病，视网膜病变和主要器官和系统的其他病症。数学算法评估受试者的葡萄糖谱的形状并将轮廓分类为几个预定义的簇之一，每个簇对应于正常条件或几个异常条件之一。构成葡萄糖耐量曲线的一系列血糖值可以使用任何葡萄糖分析仪来测量，包括：侵入性，微创和非侵入性类型。该方法在被编程为执行该方法的步骤的处理装置上执行。根据筛查结果，可能会向受试者提供有关其病情的信息和/或咨询，以便与其医护人员进一步协商。

9. 发明申请

WO2004051320A8 SPECTROSCOPIC SYSTEM AND METHOD USING A CERAMIC OPTICAL REFERENCE 审中-公开
标题翻译：采用陶瓷光学参考的光谱系统和方法
公开(公告)号：WO2004051320A8
公开(公告)日：2004-10-07
申请号：PCT/US0337969
申请日：2003-11-26
申请人： SENSYS MEDICAL INC
发明人： ACOSTA GEORGE M , HAZEN KEVIN H , ABUL-HAJ N ALAN , MONFRE STEPHEN L , BLANK THOMAS B
IPC分类号： G01N21/27 , G01N21/47 , G01N21/49 , G02B
CPC分类号： G01N21/278 , G01N21/4738 , G01N21/4785 , G01N21/49 , G01N2021/4735
摘要： A ceramic reference in conjunction with a spectrometer, a metallized ceramic material, and a method of utilizing a ceramic material as a reference in the ultraviolet, visible, near-infrared, or infrared spectral regions are presented. The preferred embodiments utilize a ceramic reference material to diffusely reflect incident source light toward a detector element for quantification in a reproducible fashion. Alternative embodiments metallize either the incident surface or back surface of to form a surface diffuse reflectance standard. Optional wavelength reference layers or protective layers may be added to the ceramic or to the metallized layer. The reference ceramic is used to provide a measure of optical signal of an analyzer as a function of the analyzers spatial, temporal, and environmental state.
摘要翻译：介绍了与光谱仪，金属化陶瓷材料以及利用陶瓷材料作为紫外，可见光，近红外或红外光谱区域参考的方法相结合的陶瓷参考。优选实施例利用陶瓷参考材料将入射光源漫射地反射到检测器元件以用于以可再现的方式定量。替代实施例将入射表面或后表面金属化以形成表面漫反射标准。可选的波长参考层或保护层可以添加到陶瓷或金属化层。参考陶瓷用于根据分析仪的空间，时间和环境状态提供分析仪光信号的测量值。

10. 发明申请

WO2006093816A2 NONINVASIVE TARGETING SYSTEM METHOD AND APPARATUS 审中-公开
公开(公告)号：WO2006093816A2
公开(公告)日：2006-09-08
申请号：PCT/US2006006496
申请日：2006-02-24
申请人： SENSYS MEDICAL INC
发明人： MONFRE STEPHEN L , BLANK THOMAS B , HAZEN KEVIN H , ABUL-HAJ ALAN , RUCHTI TIMOTHY L , HENDERSON JAMES RYAN , STIPPICK TIM , ABUL-HAJ ROXANNE
CPC分类号： A61B5/14532 , A61B5/061 , A61B5/1455 , A61B5/1495 , A61B5/489 , A61B5/7264 , A61B2562/0242 , A61B2562/146
摘要： The invention provides a targeting system used to direct a measuring system to a targeted sample site or volume. The targeting system increases analyte estimation performance by increasing precision and accuracy of sampling and/or by targeting an analyte rich tissue volume.

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