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1. 发明申请

WO2005122880A2 PREPARATION KIT FOR NONINVASIVE GLUCOSE CONCENTRATION DETERMINATION 审中-公开
标题翻译：非挥发性葡萄糖浓度测定的制备工具
公开(公告)号：WO2005122880A2
公开(公告)日：2005-12-29
申请号：PCT/US2005019347
申请日：2005-06-02
申请人： SENSYS MEDICAL INC , MONFRE STEPHEN L , HAZEN KEVIN H
发明人： MONFRE STEPHEN L , HAZEN KEVIN H
IPC分类号： A61B5/00 , B01L99/00
CPC分类号： A61B5/14532 , A61B90/80 , A61B2562/24 , A61B2562/242 , A61B2562/245
摘要： The invention involves a kit for use in conjunction with a near-infrared, noninvasive glucose concentration analyzer. The preferred kit contains a set of elements used in preparation of a sample site and/or for use in a sampling process. The invention comprises a kit that includes any of a guide, a plug, an adhesive, an alignment tool, a cleaner, contact fluid, and a package for use in combination with a noninvasive glucose concentration analyzer.
摘要翻译：本发明涉及一种用于与近红外，无创葡萄糖浓度分析仪结合使用的试剂盒。优选的试剂盒包含用于制备样品位点和/或用于取样过程中的一组元素。本发明包括一种试剂盒，其包括用于与非侵入性葡萄糖浓度分析仪组合使用的引导剂，塞子，粘合剂，对准工具，清洁剂，接触流体和包装中的任何一种。

2. 发明申请

WO2005027152A3 MAGNETO-MECHANICAL APPARATUS 审中-公开
标题翻译：磁力机械装置
公开(公告)号：WO2005027152A3
公开(公告)日：2005-09-29
申请号：PCT/US2004028509
申请日：2004-08-31
申请人： SENSYS MEDICAL INC
发明人： KINCAID STEPHEN , ACOSTA GEORGE M , ABUL-HAJ ROXANNE , HAZEN KEVIN H
IPC分类号： A61B5/00 , F04B9/02 , F04B17/00 , G01N21/35 , G01N21/49 , H01F20060101 , H01F7/02 , H01F7/20 , H01H9/00 , H01H36/00
CPC分类号： F04B9/02 , A61B5/14532 , F04B17/00 , G01N21/49 , H01H3/34 , H01H36/0073
摘要： A magnetic field based mechanical apparatus is disclosed. The apparatus is based on coupled attracting or opposing magnets in conjunction with the insertion or removal of a magnetic field modifier. In the preferred embodiment, two repelling magnets (11, 12) are drawn together with the insertion of a magnetic field modifier (13). The field modifier may be another magnet having an opposing pole. Removal of the field modifier returns the forces to their original states. This oscillating motion may be driven with a low energy and/or small power supply. The resulting motion of the opposing magnets can drive mechanical system such as a linear, gear, ratchet, or reciprocating drive.
摘要翻译：公开了一种基于磁场的机械装置。该设备基于耦合吸引或反向磁体以及插入或移除磁场调节器。在优选实施例中，两个排斥磁体（11,12）随着磁场调节器（13）的插入一起被拉动。场调节器可以是具有相反极点的另一个磁体。删除字段修饰符会将力恢复到其原始状态。这种摆动运动可以用低能量和/或小功率电源来驱动。所产生的相对磁体的运动可以驱动机械系统，例如线性，齿轮，棘轮或往复驱动。

3. 发明申请

WO2004104644B1 METHOD OF SAMPLE CONTROL AND CALIBRATION ADJUSTMENT FOR USE WITH A NONINVASIVE ANALYZER 审中-公开
标题翻译：使用无损分析仪的样品控制和校准调整方法
公开(公告)号：WO2004104644B1
公开(公告)日：2005-05-19
申请号：PCT/US2004016064
申请日：2004-05-20
申请人： SENSYS MEDICAL INC
发明人： RUCHTI TIMOTHY L , HAZEN KEVIN H , BLANK THOMAS B
IPC分类号： A61B5/00 , G02B20060101
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/1455 , A61B5/1495 , G01N21/359
摘要： A method and apparatus for easing the use of an optically based noninvasive analyzer is presented. More particularly, a simplified algorithm is used that removes the daily requirement of collecting and using a noninvasive spectrum to update a calibration model. In another embodiment, a guide is used to substantially reduce variation in sample probe placement in relation to a skin tissue sampling site, resulting in the ability to maintain calibration performance with the use of a reference anaiyte concentration, with or without the use of a reference spectrum collected nearby in time.
摘要翻译：提出了一种用于缓解光学非侵入式分析仪的使用的方法和装置。更具体地，使用简化的算法，其消除收集和使用非侵入光谱以更新校准模型的每日需求。在另一个实施例中，引导件用于相对于皮肤组织采样部位大大减少样品探针放置的变化，导致在使用或不使用参考文献的情况下使用参考文献浓度来维持校准性能的能力频谱在时间附近收集。

4. 发明申请

WO2006017700A3 ANALYTE FILTER METHOD AND APPARATUS 审中-公开
标题翻译：分析滤波方法和装置
公开(公告)号：WO2006017700A3
公开(公告)日：2007-06-07
申请号：PCT/US2005027818
申请日：2005-08-05
申请人： SENSYS MEDICAL INC , RUCHTI TIMOTHY L , LORENZ ALEXANDER D , HAZEN KEVIN H
发明人： RUCHTI TIMOTHY L , LORENZ ALEXANDER D , HAZEN KEVIN H
IPC分类号： G01J3/28 , A61B5/00 , G01J3/42 , G01J3/427 , G01N33/48
CPC分类号： G01N21/274 , G01J3/28 , G01J3/433 , G01N21/359 , G01N2201/129 , G01N2201/1293
摘要： The invention comprises a method and apparatus for enhancing the analysis of noninvasive spectra, resulting in improved analytical performance. More particularly, the invention comprises a method and apparatus for processing noninvasive spectra with an analyte filter that preferably rejects variation likely to be detrimental to the measurement system, while passing signal that probabilistically is unique to the target analyte. Subsequently, the analyte filtered data are used to estimate an analyte property, such as a glucose concentration, in the presence of noise, interferences, state changes, and/or across analyzers.
摘要翻译：本发明包括用于增强非侵入光谱分析的方法和装置，从而提高分析性能。更具体地，本发明包括用分析物过滤器处理非侵入光谱的方法和装置，其优选地拒绝可能对测量系统有害的变化，同时传递概率地对目标分析物是唯一的信号。随后，分析物过滤的数据用于在存在噪声，干扰，状态变化和/或跨分析仪的情况下估计分析物质（例如葡萄糖浓度）。

5. 发明申请

WO2005104806A3 NONINVASIVE ANALYZER SAMPLE PROBE INTERFACE METHOD AND APPARATUS 审中-公开
标题翻译：非分析分析仪样品探针接口方法和装置
公开(公告)号：WO2005104806A3
公开(公告)日：2006-07-06
申请号：PCT/US2005015164
申请日：2005-04-28
申请人： SENSYS MEDICAL INC
发明人： BLANK THOMAS B , ACOSTA GEORGE M , RUCHTI TIMOTHY L , MATTU MUTUA , LORENZ ALEXANDER D , HAZEN KEVIN H , HENDERSON JAMES R
IPC分类号： A61B5/00 , G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1495 , A61B5/4869 , A61B2560/0223 , A61B2560/0233 , A61B2562/0242 , G01N21/359
摘要： A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.
摘要翻译：提供了一种用于无创取样的方法和装置。更具体地，该方法和装置涉及光学样本探针界面相对于组织样本位点的运动的控制。使用动态探针接口来收集目标样品的光谱，根据x轴，y轴和z轴中的至少一个来控制样品探针相对于组织样品的定位和/或样品的控制组织位移以最小化由采样过程导致的频谱变化并增加分析物质的估计精度和准确度。

6. 发明申请

WO2005067633A2 METHOD AND APPARATUS FOR PRESENTATION OF NONINVASIVE GLUCOSE CONCENTRATION INFORMATION 审中-公开
标题翻译：用于介绍非葡萄糖浓度信息的方法和装置
公开(公告)号：WO2005067633A2
公开(公告)日：2005-07-28
申请号：PCT/US2005000420
申请日：2005-01-06
申请人： SENSYS MEDICAL INC
发明人： HOCKERSMITH LINDA , HAZEN KEVIN H , RUCHTI TIMOTHY L
IPC分类号： A61B5/00 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/7415 , A61B5/743 , A61B5/7475 , A61B5/749 , A61B2560/0456 , G16H15/00
摘要： The invention relates generally to the extraction and/or presentation of glucose concentrations estimated as a function of time into a format that facilitates conveyance of the underlying information. More particularly, glucose concentration histories are presented in terms of risk of behavior, in a video format, and/or in an audio format. The reduction of data into video format, selected by time period, cluster, or glucose concentration response, into an animated or video presentation allows diagnosis and treatment information to be more readily determined and used. Alternatively, glucose concentrations are output through a voice synthesizer or an earcon. These information presentations are useful for both the medical professional and the end user. The information presentation is preferably used with a noninvasive, implantable, semi-continuous, and/or continuous analyte analyzer, such as a glucose comcentration analyzer.
摘要翻译：本发明一般涉及将作为时间的函数估计的葡萄糖浓度的提取和/或表现提升为促进底层信息传递的格式。更具体地，葡萄糖浓度历史以行为风险，视频格式和/或音频格式呈现。将通过时间段，群集或葡萄糖浓度响应选择的视频格式的数据减少为动画或视频呈现允许更容易地确定和使用诊断和治疗信息。或者，葡萄糖浓度通过语音合成器或耳塞输出。这些信息介绍对于医疗专业人员和最终用户都是有用的。信息呈现优选与非侵入性，可植入，半连续和/或连续的分析物分析仪一起使用，例如葡萄糖浓度分析仪。

7. 发明申请

WO2004081524B1 MEASUREMENT SITE DEPENDENT DATA PREPROCESSING METHOD FOR ROBUST CALIBRATION AND PREDICTION 审中-公开
标题翻译：测量站点依赖数据预处理方法进行稳健校准和预测
公开(公告)号：WO2004081524B1
公开(公告)日：2005-07-07
申请号：PCT/US2004007002
申请日：2004-03-05
申请人： SENSYS MEDICAL INC
发明人： LORENZ ALEXANDER D , RUCHTI TIMOTHY L , BLANK THOMAS B , HAZEN KEVIN H
IPC分类号： A61B5/00 , G01J3/28 , G01N20060101 , G01N21/35 , G01N21/49
CPC分类号： G01N21/359 , A61B5/0075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , G01N21/49
摘要： A solution for reducing interference in noninvasive spectroscopic measurements of tissue and blood analytes is provided. The noninvasive measurement of blood chemistry involves collecting a tissue measurement (301), preprocessing the measurement for enhancing the analytical signal and attenuating noises (302) applying a basis set to the preprocessed tissue measurement (304) to transform the preprocessed tissue measurement (303), performing an outlier detection (305), making a bias correction term (306), applying a multivariate calibration model to the transformed tissue measurement (307), and determining the measurement of the analyte digitally or/and graphically (308). By applying a basis set representing various tissue components to a collected sample measurement, measurement interferences resulting from the heterogeneity of tissue, sampling site differences, patient-to-patient variation, physiological variation, and instrumental differences are reduced. Consequently, the transformed sample measurements are more suitable for developing calibrations that are robust with respect to sample-to-sample variation, variation through time, and instrument related differences.
摘要翻译：提供了一种减少组织和血液分析物非侵入性光谱测量干扰的解决方案。血液化学的无创测量涉及收集组织测量（301），预处理用于增强分析信号的测量值，并将对基础组施加的噪声（302）应用于预处理组织测量（304）以变换预处理的组织测量（303）执行异常值检测（305），制作偏差校正项（306），将多变量校准模型应用于转化的组织测量（307），以及以数字或/或图形方式确定分析物的测量（308）。通过将代表各种组织成分的基础组合应用于收集的样本测量，减少了由组织异质性，采样位置差异，患者变异，生理变化和器械差异导致的测量干扰。因此，转化的样品测量更适合于开发相对于样品到样品变化，随时间变化和仪器相关差异而稳定的校准。

8. 发明申请

WO2004081524A2 MEASUREMENT SITE DEPENDENT DATA PREPROCESSING METHOD FOR ROBUST CALIBRATION AND PREDICTION 审中-公开
标题翻译：测量站点依赖数据预处理方法进行稳健校准和预测
公开(公告)号：WO2004081524A2
公开(公告)日：2004-09-23
申请号：PCT/US2004007002
申请日：2004-03-05
申请人： SENSYS MEDICAL INC
发明人： LORENZ ALEXANDER D , RUCHTI TIMOTHY L , BLANK THOMAS B , HAZEN KEVIN H
IPC分类号： A61B5/00 , G01J3/28 , G01N20060101 , G01N21/35 , G01N21/49 , G01N
CPC分类号： G01N21/359 , A61B5/0075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , G01N21/49
摘要： A solution for reducing interference in noninvasive spectroscopic measurements of tissue and blood analytes is provided. By applying a basis set representing various tissue components to a collected sample measurement, measurement interferences resulting from the heterogeneity of tissue, sampling site differences, patient-to-patient variation, physiological variation, and instrumental differences are reduced. Consequently, the transformed sample measurements are more suitable for developing calibrations that are robust with respect to sample-to-sample variation, variation through time, and instrument related differences. In the calibration phase, data associated with a particular tissue sample site is corrected using a selected subset of data within the same data set. This method reduces the complexity of the data and reduces the intra-subject, inter-subject, and inter-instrument variations by removing interference specific to the respective data subset. In the measurement phase, the basis set correction is applied using a minimal number of initial samples collected from the sample site(s) where future samples will be collected.
摘要翻译：提供了一种减少组织和血液分析物非侵入性光谱测量干扰的解决方案。通过将代表各种组织成分的基础组合应用于收集的样本测量，减少了由组织异质性，采样位置差异，患者变异，生理变化和器械差异导致的测量干扰。因此，转化的样品测量更适合于开发相对于样品到样品变化，随时间变化和仪器相关差异而稳定的校准。在校准阶段，使用相同数据集中的所选择的数据子集来校正与特定组织样本位点相关联的数据。该方法通过去除对各个数据子集的特定的干扰来降低数据的复杂度并减少受试者内，对象间和仪器间变化。在测量阶段，使用从样本站点采集的最少数量的初始样本应用基准集校正，将收集未来样品。

9. 发明申请

WO2005122880B1 PREPARATION KIT FOR NONINVASIVE GLUCOSE CONCENTRATION DETERMINATION 审中-公开
标题翻译：制备无血清葡萄糖浓度测定试剂盒
公开(公告)号：WO2005122880B1
公开(公告)日：2007-04-12
申请号：PCT/US2005019347
申请日：2005-06-02
申请人： SENSYS MEDICAL INC , MONFRE STEPHEN L , HAZEN KEVIN H
发明人： MONFRE STEPHEN L , HAZEN KEVIN H
IPC分类号： A61B5/00 , B01L99/00
CPC分类号： A61B5/14532 , A61B90/80 , A61B2562/24 , A61B2562/242 , A61B2562/245
摘要： The invention involves a kit for use in conjunction with a near-infrared, noninvasive glucose concentration analyzer. The preferred kit contains a set of elements used in preparation of a sample site and/or for use in a sampling process. The invention comprises a kit that includes any of a guide, a plug, an adhesive, an alignment tool, a cleaner, contact fluid, and a package for use in combination with a noninvasive glucose concentration analyzer.
摘要翻译：本发明涉及与近红外非侵入式葡萄糖浓度分析仪结合使用的试剂盒。优选的试剂盒包含用于制备样品地点和/或用于取样过程的一组元素。本发明包括套件，其包括与无创葡萄糖浓度分析仪组合使用的引导件，塞子，粘合剂，对准工具，清洁器，接触流体和包装中的任一种。

10. 发明申请

WO2005067633B1 METHOD AND APPARATUS FOR PRESENTATION OF NONINVASIVE GLUCOSE CONCENTRATION INFORMATION 审中-公开
标题翻译：用于介绍非葡萄糖浓度信息的方法和装置
公开(公告)号：WO2005067633B1
公开(公告)日：2006-07-06
申请号：PCT/US2005000420
申请日：2005-01-06
申请人： SENSYS MEDICAL INC
发明人： HOCKERSMITH LINDA , HAZEN KEVIN H , RUCHTI TIMOTHY L
IPC分类号： A61B5/00 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/7415 , A61B5/743 , A61B5/7475 , A61B5/749 , A61B2560/0456 , G16H15/00
摘要： The invention relates generally to the extraction and/or presentation of glucose concentrations estimated as a function of time into a format that facilitates conveyance of the underlying information. More particularly, glucose concentration histories are presented in terms of risk of behavior, in a video format, and/or in an audio format. The reduction of data into video format, selected by time period, cluster, or glucose concentration response, into an animated or video presentation allows diagnosis and treatment information to be more readily determined and used. Alternatively, glucose concentrations are output through a voice synthesizer or an earcon. These information presentations are useful for both the medical professional and the end user. The information presentation is preferably used with a noninvasive, implantable, semi-continuous, and/or continuous analyte analyzer, such as a glucose comcentration analyzer.
摘要翻译：本发明一般涉及将作为时间的函数估计的葡萄糖浓度的提取和/或表现提升为促进底层信息传递的格式。更具体地，葡萄糖浓度历史以行为风险，视频格式和/或音频格式呈现。将通过时间段，群集或葡萄糖浓度响应选择的视频格式的数据减少为动画或视频呈现允许更容易地确定和使用诊断和治疗信息。或者，葡萄糖浓度通过语音合成器或耳塞输出。这些信息介绍对于医疗专业人员和最终用户都是有用的。信息呈现优选与非侵入性，可植入，半连续和/或连续的分析物分析仪一起使用，例如葡萄糖浓度分析仪。

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