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1. 发明申请

WO2007145926A3 BIOPSY SYSTEM WITH INTEGRATED ULTRASONIC IMAGING 审中-公开
公开(公告)号：WO2007145926A3
公开(公告)日：2007-12-21
申请号：PCT/US2007/013208
申请日：2007-06-05
申请人： SENORX, INC. , MALCHOW, Lloyd, H. , LUBOCK, Paul , DAW, Derek
发明人： MALCHOW, Lloyd, H. , LUBOCK, Paul , DAW, Derek
IPC分类号： A61B8/00 , A61B10/02 , A61B19/00 , A61B17/00
摘要： A biopsy system is disclosed that has a tissue removal system, an imaging system, an image display system and a common input console for these systems. The tissue removal system can have a mechanical tissue cutting blade or an electrosurgical cutting element and the tissue removal system is capable of handling both tissue cutting configurations. The imaging system is preferably an ultrasound imaging system and the image display system has a video screen for displaying diagnostic ultrasound images from an ultrasound probe. The common input console preferably has a touch screen display and a keyboard to facilitate operation of the tissue removal system, the ultrasound imaging system and the image display system from the same console.

2. 发明申请

WO2006049911A1 FIBROUS MARKER FORMED OF SYNTHETIC POLYMER STRANDS 审中-公开
标题翻译：混合标记形成合成聚合物结构
公开(公告)号：WO2006049911A1
公开(公告)日：2006-05-11
申请号：PCT/US2005/038027
申请日：2005-10-21
申请人： SENORX, INC. , JONES, Michael, L. , LUBOCK, Paul , MALCHOW, Lloyd, H.
发明人： JONES, Michael, L. , LUBOCK, Paul , MALCHOW, Lloyd, H.
IPC分类号： A61B19/00 , A61B17/00 , A61N5/10 , A61M37/00
CPC分类号： A61M37/0069 , A61B17/0057 , A61B90/39 , A61B2017/00831 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987
摘要： The invention is directed to an intracorporeal fibrous marker formed of a fibrous pad or mat with strands of synthetic polymeric material such as polyglycolic acid and delivery devices and methods of using such devices. The fibrous pad or mat has a bulk density of at least 10, preferably about 30 to about 100 mg/cc and typically about 40 mg/cc. The fibrous marker has an effective in vivo lifespan of at least three weeks.
摘要翻译：本发明涉及由具有合成聚合物材料如聚乙醇酸和递送装置的纤维垫或垫的纤维垫或垫形成的体内纤维标记物和使用这种装置的方法。纤维垫或垫的堆积密度为至少10，优选约30至约100mg / cc，通常为约40mg / cc。纤维标记物具有至少三周的有效的体内寿命。

3. 发明申请

WO2006058302A1 GRAPHICAL USER INTERFACE FOR TISSUE BIOPSY SYSTEM 审中-公开
标题翻译：用于组织生物系统的图形用户界面
公开(公告)号：WO2006058302A1
公开(公告)日：2006-06-01
申请号：PCT/US2005/042966
申请日：2005-11-28
申请人： SENORX, INC. , DAW, Derek , LOUW, Frank , LUBOCK, Paul , QUICK, Richard, L. , SHABAZ, Martin
发明人： DAW, Derek , LOUW, Frank , LUBOCK, Paul , QUICK, Richard, L. , SHABAZ, Martin
IPC分类号： A61B10/00
CPC分类号： A61B5/061 , A61B5/742 , A61B10/0266 , A61B10/0275 , A61B90/10 , A61B90/37 , A61B2034/254
摘要： A graphical user interface is disclosed for a tissue biopsy system having a tissue cutting member adapted for cutting one or more tissue specimens from tissue at a target site within a patient. The graphical user interface includes a first GUI area representing a first region of the target site from which the tissue cutting member has separated one or more tissue specimens. The graphical user interface further includes a second GUI area, visually distinguishable from the first GUI area, representing a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site.
摘要翻译：公开了一种用于组织活检系统的图形用户界面，该组织活检系统具有适于从患者内的目标部位的组织切割一个或多个组织标本的组织切割构件。图形用户界面包括代表目标站点的第一区域的第一GUI区域，组织切割构件从该第一区域分离出一个或多个组织标本。图形用户界面还包括第二GUI区域，其可视地与第一GUI区域区分开，代表第二区域，组织切割构件可从该第二区域将一个或多个附加的组织标本与目标部位的组织分开。

4. 发明申请

WO2008063638A2 MRI DETECTABLE OBTURATOR 审中-公开
标题翻译： MRI检测器
公开(公告)号：WO2008063638A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/024255
申请日：2007-11-20
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L. , BROADAWAY, Ethan , LOUW, Frank, R.
发明人： LUBOCK, Paul , JONES, Michael, L. , BROADAWAY, Ethan , LOUW, Frank, R.
IPC分类号： A61B19/00
CPC分类号： A61B17/32 , A61B17/3417 , A61B17/3431 , A61B17/3468 , A61B17/3496 , A61B17/3498 , A61B90/39 , A61B2017/00477 , A61B2017/00911 , A61B2090/062 , A61B2090/3908 , A61B2090/3954 , A61B2090/3987
摘要： An obturator with an elongated shaft, a proximal end, a substantially closed distal end and a MRI detectable distal shaft portion, which does not interfere with magnetic resonance imaging of tissue proximate thereto. Preferably, the distal shaft portion has an effective MRI detectable mass so as to provide a clear, T1-weighted image within an outline of the distal shaft portion upon magnetic resonance imaging.
摘要翻译：具有细长轴，近端，基本上封闭的远端和MRI可检测远端轴部分的闭孔器，其不干扰邻近于其的组织的磁共振成像。优选地，远侧轴部分具有有效的MRI检测质量，以便在磁共振成像时在远侧轴部分的轮廓内提供清晰的T1加权图像。

5. 发明申请

WO2007019445A1 BIOPSY DEVICE WITH FLUID DELIVERY TO TISSUE SPECIMENS 审中-公开
标题翻译：具有流体输送到组织样本的生物装置
公开(公告)号：WO2007019445A1
公开(公告)日：2007-02-15
申请号：PCT/US2006/030722
申请日：2006-08-04
申请人： SENORX, INC. , QUICK, Richard, L. , SHABAZ, Martin, V. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason, H.
发明人： QUICK, Richard, L. , SHABAZ, Martin, V. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason, H.
IPC分类号： A61B10/02 , A61B17/32 , A61B17/00
CPC分类号： A61B17/32002 , A61B10/0275 , A61B10/0283 , A61B2010/0208 , A61B2010/0225 , A61B2017/00473
摘要： The invention is directed to a system and method for separating and collecting one or more tissue specimens from a target site within a patient and flushing the specimen to remove blood, debris and the like before the specimen is removed from the biopsy device. The flow of flushing fluid to the tissue collector is preferably controlled to coincide with delivery of one or more specimens to the collecting tray or basket of the device or after the receipt of the specimen within the tissue collector to ensure that the fluid (16) is applied to a fresh specimen. The tissue tray or basket within the tissue collector (14) has an open or foraminous portion to facilitate removal of fluid, such as the applied fluid and blood, and other debris from the tissue specimens on the tray. Vacuum (22) is provided within the tissue collector, preferably under the tray to remove fluid and debris from the collector interior.
摘要翻译：本发明涉及一种用于从患者内的目标部位分离和收集一个或多个组织样本的系统和方法，并且在从活检装置移除样本之前冲洗样本以除去血液，碎屑等。冲洗流体到组织收集器的流动优选地被控制以与一个或多个样本递送到装置的收集盘或篮子之间或在组织收集器中收到样本之后确保流体（16）是应用于新鲜的标本。组织收集器（14）内的纸巾托盘或篮子具有开放或有孔的部分，以有助于从托盘上的组织标本中去除流体，例如施加的流体和血液以及其它碎屑。真空（22）设置在组织收集器内，优选在托盘下面，以从收集器内部去除流体和碎屑。

6. 发明申请

WO2007061655A2 TISSUE IRRADIATION WITH SHIELDING 审中-公开
标题翻译：组织辐射与屏蔽
公开(公告)号：WO2007061655A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/043891
申请日：2006-11-13
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael
发明人： LUBOCK, Paul , JONES, Michael
IPC分类号： A61N5/10 , A61M36/04
CPC分类号： A61N5/1015 , A61B2017/3419 , A61N2005/1005
摘要： Devices and methods are disclosed for treatment to tissue surrounding a body cavity or other intracorporeal site, such as after removal of tissue, e.g. cancer. Such a device includes a treatment location on a distal portion of the device with one or more radiation shielding components that partially encircle a radiation source at the treatment location to control emitted radiation from the radiation source. The device minimizes radiation damage to healthy tissue surrounding the body cavity or other site while irradiating tissue not shielded by the radiation shielding components. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location to seal the passageway leading to the body cavity.
摘要翻译：公开了用于治疗围绕体腔或其他体内部位的组织的装置和方法，例如在去除组织后，例如，癌症。这种装置包括在装置的远端部分上的处理位置，其中一个或多个辐射屏蔽部件在处理位置部分地环绕辐射源以控制来自辐射源的辐射。该装置最小化对体腔或其他部位周围的健康组织的辐射损伤，同时辐射未被辐射屏蔽部件屏蔽的组织。体现本发明特征的装置可包括密封构件，该密封构件位于靠近处理位置的装置的轴上的位置处，以密封通向体腔的通道。

7. 发明申请

WO2010091048A1 APPARATUS AND METHOD FOR ACCESSING A BODY SITE 审中-公开
标题翻译：用于接收身体场所的装置和方法
公开(公告)号：WO2010091048A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/022993
申请日：2010-02-03
申请人： SENORX, INC. , SHABAZ, Martin, V. , QUICK, Richard, L. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason
发明人： SHABAZ, Martin, V. , QUICK, Richard, L. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason
IPC分类号： A61B10/02
CPC分类号： A61B10/0275 , A61B10/0283 , A61B17/32002 , A61B17/32053 , A61B17/3417 , A61B2010/0208 , A61B2010/0225 , A61B2017/00473 , A61B2017/3405
摘要： A device to access a desired tissue site within a patient's body and separate a tissue specimen from the tissue site. The device includes a probe member having a tissue penetrating distal tip having a plurality of concaved surfaces which form curved cutting edges at the intersection of adjacent concave surfaces. The probe member has an inner lumen which when subjected to a vacuum, secures tissue for the specimen to the surface of a distal tubular section of the probe which may be off-set from a central longitudinal axis. A circular tissue-cutting blade is configured to move longitudinally to sever a tissue specimen from tissue secured to the surface of the distal tubular section by the application of a vacuum to the inner lumen of the probe.
摘要翻译：一种用于访问患者体内所需组织部位并从组织部位分离组织标本的装置。该装置包括具有组织穿透远侧末端的探针构件，该组织穿透远侧末端具有多个凹面，其在相邻凹面的交叉处形成弯曲的切割边缘。探针构件具有内腔，当经受真空时，将内窥镜的组织固定在探针的远侧管状部分的表面上，该表面可以从中心纵向轴线偏离。圆形组织切割刀片构造成纵向移动以通过向探针的内腔施加真空而将组织标本从组织固定到远端管状部分的表面。

8. 发明申请

WO2009105177A1 POLYSACCHARIDE MARKERS 审中-公开
标题翻译：多糖标记
公开(公告)号：WO2009105177A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/000945
申请日：2009-02-13
申请人： SENORX, INC. , JONES, Michael, L. , LUBOCK, Paul
发明人： JONES, Michael, L. , LUBOCK, Paul
IPC分类号： A61B19/00
CPC分类号： A61B19/54 , A61B90/39 , A61B2017/00004 , A61B2017/00831 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3962 , A61B2090/3987 , A61K9/0024
摘要： The marker member delivery system described has a plurality of marker members disposed within a delivery tube or cannula which contain a suitable polysaccharide such as starch (e.g. corn starch or potato starch) and a binder such as methylcellulose. These marker members are preferably press-formed from powders. The system has preferably has at least one other marker member formed of bioabsorbable material with a radiopaque element attached to or incorporated therein. The marker with a radiopaque marker element is preferably disposed within the delivery tube between two marker members formed of polysaccharide and is preferably formed of a bioabsorbable material other than a polysaccharide.
摘要翻译：所述的标记物传送系统具有多个标记物，其设置在输送管或套管内，其包含合适的多糖如淀粉（例如玉米淀粉或马铃薯淀粉）和粘合剂如甲基纤维素。这些标记物优选由粉末压制成型。该系统优选地具有由生物可吸收材料形成的至少一个其它标记构件，其中附着或结合在其中的不透射线元件。具有不透射线标记元件的标记物优选设置在由多糖形成的两个标记物之间的输送管内，并且优选由除多糖之外的生物可吸收材料形成。

9. 发明申请

WO2008016551A1 MARKER DELIVERY SYSTEM WITH OBTURATOR 审中-公开
标题翻译：带有驱动器的标记输送系统
公开(公告)号：WO2008016551A1
公开(公告)日：2008-02-07
申请号：PCT/US2007/016918
申请日：2007-07-27
申请人： SENORX, INC. , LUBOCK, Paul , QUICK, Richard
发明人： LUBOCK, Paul , QUICK, Richard
IPC分类号： A61B17/34 , A61B17/00 , A61B19/00
CPC分类号： A61B17/3468 , A61B17/3498 , A61B90/39 , A61B90/40 , A61B2017/00796 , A61B2090/062 , A61B2090/3908 , A61B2090/3954 , A61B2090/3987
摘要： A marker delivery device is described which has an obturator with an elongated shaft, an inner lumen, a proximal end, and a substantially sealed distal end. One or more tissue markers are deployed within the inner lumen of the elongated shaft of the obturator. Preferably, the tissue marker(s) is disposed within an inner lumen of a marker delivery tube which is disposed within the inner lumen of the elongated shaft of the obturator. The marker delivery tube has an opening for discharging the tissue markers into a body (e.g. biopsy) cavity. The distal tip of the marker delivery tube is configured to penetrate the substantially sealed distal end of the obturator so that tissue markers can be delivered while the obturator is in place within the body. Preferably, the obturator includes a detectable element capable of producing a relatively significant image signature during MRI.
摘要翻译：描述了一种标记输送装置，其具有带有细长轴，内腔，近端和基本密封的远端的闭塞器。一个或多个组织标记部署在闭塞器的细长轴的内腔内。优选地，组织标记设置在标记输送管的内腔内，该标记物输送管设置在闭塞器的细长轴的内腔内。标记物输送管具有用于将组织标记物排放到体内（例如活检）腔的开口。标记物输送管的远侧末端构造成穿透闭塞器的基本上密封的远端，使得组织标记物可以在闭塞器在体内就位的同时被输送。优选地，闭孔器包括能够在MRI期间产生相对显着的图像特征的可检测元件。

10. 发明申请

WO2007097956A2 TEMPORARY CATHETER FOR BIOPSY SITE TISSUE FIXATION 审中-公开
标题翻译：用于生物场地组织固定的临时导管
公开(公告)号：WO2007097956A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/003877
申请日：2007-02-14
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L.
发明人： LUBOCK, Paul , JONES, Michael, L.
IPC分类号： A61M25/10 , A61B17/00 , A61B17/22 , A61N5/10
CPC分类号： A61M29/02 , A61B10/0041 , A61B17/0218 , A61B90/02 , A61B2017/00557 , A61B2017/00796 , A61B2090/3908 , A61M25/10 , A61M29/00 , A61M2025/1095 , A61N5/1015
摘要： Devices and methods are provided for temporarily maintaining access to a body cavity in a targeted tissue region within a patient's body. One embodiment of the catheter device includes an elongated shaft having a proximal shaft section which is flexible enough to be folded or coiled into a configuration for deployment within the patient. An alternate embodiment includes a catheter device having one or more detachable proximal shaft sections and having at least one one-way valve to restrict fluid flow of inflation fluid to flow to the balloon. After deployment of the catheter device completely within the patient, the opening through which the catheter device is deployed is closed, e.g. by sutures, adhesives and the like to minimize infection at the site. Within a few days or weeks after the tissue has been evaluated for cancer, the temporary catheter device may be removed from the patient. If cancer or pre-cancer cells are found in the specimen removed from the cavity, then a radiation balloon catheter or other irradiation device can be inserted into the patient to irradiate tissue surrounding the biopsy cavity to ensure that cancer cells within the tissue surrounding the cavity are killed.
摘要翻译：提供了用于暂时维持对患者体内的目标组织区域中的体腔的访问的装置和方法。导管装置的一个实施例包括细长轴，其具有近侧轴部，该近端轴部足够柔性以折叠或卷绕成用于部署在患者体内的构造。替代实施例包括具有一个或多个可分离近侧轴部分并且具有至少一个单向阀以限制充气流体流入气囊的流体流动的导管装置。在将导管装置完全展开在患者体内之后，将导管装置展开的开口关闭，例如，通过缝线，粘合剂等来最小化现场的感染。在组织已经被评估癌症后的几天或几周内，临时导管装置可以从患者身上移除。如果在从腔中取出的样品中发现癌症或癌前细胞，则可以将放射气球导管或其它照射装置插入患者体内以照射活检腔周围的组织，以确保围绕腔的组织内的癌细胞被杀

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