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1. 发明申请

WO2013159065A1 EXPANDABLE OCCLUSION DEVICES AND METHODS OF USE 审中-公开
标题翻译：可扩展的消息设备及其使用方法
公开(公告)号：WO2013159065A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/037484
申请日：2013-04-19
申请人： LUBOCK, Paul , COX, Brian, J. , ROSENBLUTH, Robert , QUICK, Richard
发明人： LUBOCK, Paul , COX, Brian, J. , ROSENBLUTH, Robert , QUICK, Richard
IPC分类号： A61B17/12 , A61M29/00 , A61F2/02 , A61B17/03
CPC分类号： A61B17/12172 , A61B17/0057 , A61B17/12031 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B17/12177 , A61B2017/00243 , A61B2017/00526 , A61B2017/00579 , A61B2017/00592 , A61B2017/00601 , A61B2017/00606 , A61B2017/0061 , A61B2017/00623 , A61B2017/00628 , A61B2017/00632 , A61B2017/00867 , A61B2017/00986 , A61B2017/1205 , A61B2017/12095 , A61B2090/3908 , A61B2090/3966 , D04C1/06 , D10B2509/08
摘要： An occlusion device and method for occluding an undesirable vascular structure, such as a septal defect or left atrial appendage. The occlusion device includes a lattice structure that expands from a contracted catheter-deliverable state to an expanded state that occludes the vascular structure. The lattice structure has one or more braided layers, with structural braided layers that provide structural support to the device, and occlusive layers that provide a lattice braiding or pore sizes that promote further occlusion by a biological process, such as tissue ingrowth that further occludes the affected vascular structure.
摘要翻译：一种用于闭塞不期望的血管结构（例如间隔缺损或左心耳）的闭塞装置和方法。闭塞装置包括从收缩的导管可输送状态扩展到封闭血管结构的扩张状态的晶格结构。晶格结构具有一个或多个编织层，其中结构编织层为器件提供结构支撑，以及封闭层，其提供了通过生物过程促进进一步闭塞的网格编织或孔径，例如组织向内生长，其进一步闭塞影响血管结构。

2. 发明申请

WO2013028579A1 EXPANDABLE OCCLUSION DEVICE AND METHODS 审中-公开
标题翻译：可扩展的设备和方法
公开(公告)号：WO2013028579A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/051502
申请日：2012-08-17
申请人： COX, Brian, J. , LUBOCK, Paul , QUICK, Richard , ROSENBLUTH, Robert
发明人： COX, Brian, J. , LUBOCK, Paul , QUICK, Richard , ROSENBLUTH, Robert
IPC分类号： A61B17/12 , A61M25/088 , A61M29/02 , A61F2/82
CPC分类号： A61B17/0057 , A61B17/12113 , A61B17/12122 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/00632 , A61B2017/00853 , A61B2017/00871
摘要： An occlusion device and method for occluding an undesirable passage through tissue, such as a septal defect, that provides an expandable cylinder or other structure that occludes the passage internally or by covering one or more openings to the passage. The occlusion device includes a wire lattice or mesh that expands from a contracted catheter-deliverable state to an expanded state that occludes the passage. The lattice or mesh has one or more layers, with layers that provide structural support to the device, and layers that provide a lattice braiding or pore sizes that promote further occlusion by a biological process, such as tissue ingrowth that further occludes the affected passage.
摘要翻译：一种闭塞装置和方法，用于阻塞通过诸如间隔缺损的组织的不期望的通道，其提供可在内部封闭通道或通过覆盖一个或多个开口到通道的可扩张的气缸或其他结构。闭塞装置包括从收缩的导管可输送状态扩展到闭塞通道的扩张状态的丝网或网状物。格子或网格具有一个或多个层，其中提供对该装置的结构支撑的层，以及提供格子编织或孔径的层，其通过生物过程促进进一步闭塞，例如进一步封闭受影响的通道的组织向内生长。

3. 发明申请

WO2008088949A1 SENSING SYSTEMS AND METHODS FOR GASTRIC RESTRICTION DEVICES 审中-公开
标题翻译：传感系统和方法用于气体限制装置
公开(公告)号：WO2008088949A1
公开(公告)日：2008-07-24
申请号：PCT/US2008/050283
申请日：2008-01-04
申请人： ELLIPSE TECHNOLOGIES, INC. , POOL, Scott , CHANG, Arvin , WALKER, Blair , MCCOY, Jay, R. , MOADDEB, Shahram , QUICK, Richard, L. , DAVTYAN, David, G.
发明人： POOL, Scott , CHANG, Arvin , WALKER, Blair , MCCOY, Jay, R. , MOADDEB, Shahram , QUICK, Richard, L. , DAVTYAN, David, G.
IPC分类号： A61F5/00 , A61B5/103
CPC分类号： A61B5/05 , A61B5/03 , A61B5/411 , A61B17/1355 , A61B2017/00057 , A61B2017/00084 , A61B2090/063 , A61F5/0003 , A61F5/0053
摘要： Apparatus for quantifying the amount or rate of magnetically susceptible fluid within a gastric lumen are described. In one aspect, a magnetic sensor (150) located external to the patient is configured to detect a quantity of fluid disposed within the gastric lumen. The quantity of fluid may include fluid that is contained upstream with respect to a restriction formed in the gastric lumen (e.g., by a gastric restriction device). The quantity of fluid disposed within the gastric lumen is determined by the magnetic sensor. This quantity may be evaluated over time to then calculate a real time flow rate which can then be displayed to the physician. The devices allow a physician to dynamically view real time development of fluid flow within a restricted gastric lumen and may be used in conjunction with adjustments to the gastric restriction device to achieve target flow rates.
摘要翻译：描述了用于量化胃内腔内的易受感染的液体的量或速率的装置。在一个方面，位于患者外部的磁传感器（150）被配置为检测设置在胃管内的流体的量。流体的量可以包括相对于在胃腔中形成的限制（例如通过胃限制装置）上游的流体。设置在胃腔内的流体量由磁传感器确定。可以随时间评估该量，然后计算实时流速，然后可以将其显示给医师。这些装置允许医师动态地观察限制性胃腔内的流体流动的实时发展，并且可以与胃限制装置的调节结合使用以实现目标流速。

4. 发明申请

WO2008063636A3 MRI IMAGEABLE ASSEMBLY 审中-公开
公开(公告)号：WO2008063636A3
公开(公告)日：2008-05-29
申请号：PCT/US2007/024249
申请日：2007-11-20
申请人： SENORX, INC. , LUBOCK, Paul , QUICK, Richard, L. , BROADAWAY, Ethan
发明人： LUBOCK, Paul , QUICK, Richard, L. , BROADAWAY, Ethan
IPC分类号： A61B17/34 , A61B19/00
摘要： A marker delivery device is described which has an obturator (12) with an elongated shaft (16), an inner lumen (18), a proximal end, and a substantially sealed distal end (22). One or more tissue markers are deployed within the inner lumen of the elongated shaft of the obturator. Preferably, the tissue marker (s) is disposed within an inner lumen of a marker delivery tube (14) which is disposed within the inner lumen of the elongated shaft of the obturator. The marker delivery tube has an opening (42) for discharging the tissue markers into a body (e.g. biopsy) cavity. The distal tip of the marker • delivery tube is configured to penetrate the substantially sealed distal end of the obturator so that tissue markers can be delivered while the obturator is in place within the body. Preferably, the obturator includes a detectable element capable of producing a relatively significant image signature during MRI.

5. 发明申请

WO2006127729A1 TISSUE-CUTTING MEMBER FOR A BIOPSY DEVICE 审中-公开
标题翻译：用于生物装置的组织切割构件
公开(公告)号：WO2006127729A1
公开(公告)日：2006-11-30
申请号：PCT/US2006/019959
申请日：2006-05-23
申请人： SENORX, INC. , LUBOCK, Paul , LOUW, Frank, R. , QUICK, Richard, L.
发明人： LUBOCK, Paul , LOUW, Frank, R. , QUICK, Richard, L.
IPC分类号： A61B10/00 , A61B17/32 , A61B17/34
CPC分类号： A61B10/0275 , A61B10/0283 , A61B17/320016 , A61B17/3417
摘要： The invention is directed to tissue cutting members and biopsy devices with such tissue cutting member for separating a tissue specimen from a patient's body at a target site. The tissue cutting member is slidably disposed within an inner lumen of an elongated probe member of the biopsy device to cut a tissue specimen drawn into the interior of an outer cannula of the biopsy device through a tissue receiving aperture in the probe. The tissue cutting member has a tubular distal portion with a distal tip having an outer tissue cutting edge, an inner tissue receiving aperture, and a longitudinally oriented opening with a closed proximal end and open distal end which opens to the inner tissue receiving aperture to facilitate flaring of the distal tubular portion. The cutting member has at least one opening in a wall of the tubular portion to maintain a vacuum during use.
摘要翻译：本发明涉及具有这种组织切割构件的组织切割构件和活检装置，用于在目标部位处将组织标本与患者的身体分离。组织切割构件可滑动地设置在活检装置的细长探针构件的内腔中，以通过探针中的组织接收孔切割拉入活检装置的外套管内部的组织样本。组织切割构件具有管状远端部分，远侧末端具有外部组织切割边缘，内部组织接收孔和纵向定向的开口，其具有封闭的近端和敞开的远端，该远端通向内部组织接收孔，以便于远端管状部分的扩口。切割构件在管状部分的壁中具有至少一个开口，以在使用期间保持真空。

6. 发明申请

WO2012082791A2 APPARATUS AND METHODS FOR TREATING SLEEP APNEA 审中-公开
标题翻译：用于治疗睡眠呼吸暂停的设备和方法
公开(公告)号：WO2012082791A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/064726
申请日：2011-12-13
申请人： QUIESCENCE MEDICAL, INC. , PFLUEGER, D., Russell , THOMPSON, Christopher, Paul , BACICH, Steven, R. , QUICK, Richard, L. , YUREK, Matthew
发明人： PFLUEGER, D., Russell , THOMPSON, Christopher, Paul , BACICH, Steven, R. , QUICK, Richard, L. , YUREK, Matthew
IPC分类号： A61F5/56 , A61F2/20 , A61F2/04 , A61B1/267
CPC分类号： A61F5/566
摘要： Apparatus and methods are provided for treating sleep apnea, snoring, and the like using an implant within an oropharyngeal region adjacent an anterior longitudinal ligament. The implant may include a relatively narrow central region between first and second relatively wide outer regions. In one embodiment, one of the outer regions is compressible to allow the outer region to be directed through or behind the ligament such that the central region is disposed within or behind the ligament, the outer region being resiliently expandable after passing through or behind the ligament. In another embodiment, the implant may include one or more tines or other features that may be directed into adjacent tissue to secure the implant within the oropharyngeal region.
摘要翻译：提供了使用邻近前纵韧带的口咽区域内的植入物来治疗睡眠呼吸暂停，打鼾等的装置和方法。植入物可以包括在第一和第二相对较宽的外部区域之间的相对较窄的中心区域。在一个实施例中，外部区域中的一个是可压缩的，以允许外部区域被引导通过韧带或在韧带后面，使得中心区域被设置在韧带内或后面，外部区域在穿过韧带之后或者在韧带之后弹性地可扩展。在另一个实施例中，植入物可以包括一个或多个尖齿或其他特征，其可以被引导到相邻的组织中以将植入物固定在口咽区域内。

7. 发明申请

WO2010091048A1 APPARATUS AND METHOD FOR ACCESSING A BODY SITE 审中-公开
标题翻译：用于接收身体场所的装置和方法
公开(公告)号：WO2010091048A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/022993
申请日：2010-02-03
申请人： SENORX, INC. , SHABAZ, Martin, V. , QUICK, Richard, L. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason
发明人： SHABAZ, Martin, V. , QUICK, Richard, L. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason
IPC分类号： A61B10/02
CPC分类号： A61B10/0275 , A61B10/0283 , A61B17/32002 , A61B17/32053 , A61B17/3417 , A61B2010/0208 , A61B2010/0225 , A61B2017/00473 , A61B2017/3405
摘要： A device to access a desired tissue site within a patient's body and separate a tissue specimen from the tissue site. The device includes a probe member having a tissue penetrating distal tip having a plurality of concaved surfaces which form curved cutting edges at the intersection of adjacent concave surfaces. The probe member has an inner lumen which when subjected to a vacuum, secures tissue for the specimen to the surface of a distal tubular section of the probe which may be off-set from a central longitudinal axis. A circular tissue-cutting blade is configured to move longitudinally to sever a tissue specimen from tissue secured to the surface of the distal tubular section by the application of a vacuum to the inner lumen of the probe.
摘要翻译：一种用于访问患者体内所需组织部位并从组织部位分离组织标本的装置。该装置包括具有组织穿透远侧末端的探针构件，该组织穿透远侧末端具有多个凹面，其在相邻凹面的交叉处形成弯曲的切割边缘。探针构件具有内腔，当经受真空时，将内窥镜的组织固定在探针的远侧管状部分的表面上，该表面可以从中心纵向轴线偏离。圆形组织切割刀片构造成纵向移动以通过向探针的内腔施加真空而将组织标本从组织固定到远端管状部分的表面。

8. 发明申请

WO2008063636A2 MRI IMAGEABLE ASSEMBLY 审中-公开
标题翻译： MRI成像组件
公开(公告)号：WO2008063636A2
公开(公告)日：2008-05-29
申请号：PCT/US2007024249
申请日：2007-11-20
申请人： SENORX INC , LUBOCK PAUL , QUICK RICHARD L , BROADAWAY ETHAN
发明人： LUBOCK PAUL , QUICK RICHARD L , BROADAWAY ETHAN
IPC分类号： A61B19/00
CPC分类号： A61B17/3468 , A61B5/055 , A61B17/3498 , A61B90/39 , A61B2017/00477 , A61B2090/062 , A61B2090/3908 , A61B2090/3954 , A61B2090/3987
摘要： A marker delivery device is described which has an obturator with an elongated shaft, an inner lumen, a proximal end, and a substantially sealed distal end. One or more tissue markers are deployed within the inner lumen of the elongated shaft of the obturator. Preferably, the tissue marker(s) is disposed within an inner lumen of a marker delivery tube which is disposed within the inner lumen of the elongated shaft of the obturator. The marker delivery tube has an opening for discharging the tissue markers into a body (e.g. biopsy) cavity. The distal tip of the marker delivery tube is configured to penetrate the substantially sealed distal end of the obturator so that tissue markers can be delivered while the obturator is in place within the body. Preferably, the obturator includes a detectable element capable of producing a relatively significant image signature during MRI.
摘要翻译：描述了一种标记输送装置，其具有带有细长轴，内腔，近端和基本上密封的远端的闭孔器。一个或多个组织标记部署在闭孔器的细长轴的内腔内。优选地，组织标记物设置在设置在闭孔器的细长轴的内腔内的标记物输送管的内腔内。标记物输送管具有用于将组织标记物排放到体内（例如活检）腔的开口。标记物输送管的远端构造成穿透填塞物的基本上密封的远端，使得组织标记物可以在囊腔在体内就位的同时被输送。优选地，闭孔器包括能够在MRI期间产生相对显着的图像特征的可检测元件。

9. 发明申请

WO2008016551A1 MARKER DELIVERY SYSTEM WITH OBTURATOR 审中-公开
标题翻译：带有驱动器的标记输送系统
公开(公告)号：WO2008016551A1
公开(公告)日：2008-02-07
申请号：PCT/US2007/016918
申请日：2007-07-27
申请人： SENORX, INC. , LUBOCK, Paul , QUICK, Richard
发明人： LUBOCK, Paul , QUICK, Richard
IPC分类号： A61B17/34 , A61B17/00 , A61B19/00
CPC分类号： A61B17/3468 , A61B17/3498 , A61B90/39 , A61B90/40 , A61B2017/00796 , A61B2090/062 , A61B2090/3908 , A61B2090/3954 , A61B2090/3987
摘要： A marker delivery device is described which has an obturator with an elongated shaft, an inner lumen, a proximal end, and a substantially sealed distal end. One or more tissue markers are deployed within the inner lumen of the elongated shaft of the obturator. Preferably, the tissue marker(s) is disposed within an inner lumen of a marker delivery tube which is disposed within the inner lumen of the elongated shaft of the obturator. The marker delivery tube has an opening for discharging the tissue markers into a body (e.g. biopsy) cavity. The distal tip of the marker delivery tube is configured to penetrate the substantially sealed distal end of the obturator so that tissue markers can be delivered while the obturator is in place within the body. Preferably, the obturator includes a detectable element capable of producing a relatively significant image signature during MRI.
摘要翻译：描述了一种标记输送装置，其具有带有细长轴，内腔，近端和基本密封的远端的闭塞器。一个或多个组织标记部署在闭塞器的细长轴的内腔内。优选地，组织标记设置在标记输送管的内腔内，该标记物输送管设置在闭塞器的细长轴的内腔内。标记物输送管具有用于将组织标记物排放到体内（例如活检）腔的开口。标记物输送管的远侧末端构造成穿透闭塞器的基本上密封的远端，使得组织标记物可以在闭塞器在体内就位的同时被输送。优选地，闭孔器包括能够在MRI期间产生相对显着的图像特征的可检测元件。

10. 发明申请

WO2006017400A3 BIOPSY DEVICE WITH SELECTABLE TISSUE RECEIVING APERTURE ORIENTATION AND SITE ILLUMINATION 审中-公开
标题翻译：具有选择性组织的生物装置接收孔径方位和场地照明
公开(公告)号：WO2006017400A3
公开(公告)日：2006-05-18
申请号：PCT/US2005027071
申请日：2005-07-29
申请人： SENORX INC , SHABAZ MARTIN V , QUICK RICHARD L , LOUW FRANK R , LUBOCK PAUL , SAFABASH JASON H
发明人： SHABAZ MARTIN V , QUICK RICHARD L , LOUW FRANK R , LUBOCK PAUL , SAFABASH JASON H
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00 , A61B17/32 , A61B17/34
CPC分类号： A61B10/0275 , A61B10/0266 , A61B10/0283 , A61B17/32002 , A61B17/3417 , A61B90/30 , A61B2010/0208 , A61B2010/0225 , A61B2017/00473 , A61B2017/00486 , A61B2017/3405 , A61B2090/3908 , A61B2090/3987
摘要： The invention is directed to a system and device for separating and collecting a tissue specimen from a target site within a patient. The device includes a probe component (11) with an elongated tubular section (15), a penetrating distal tip (16) and a tissue receiving aperture (17) in the distal end of the tubular section proximal to the distal tip, and a tissue cutting member (20) which is slidably disposed within the probe member to cut a tissue specimen drawn into the interior of the device through the aperture by applying a vacuum to the inner lumen of the tissue cutting member. The device also has a driver component (12) to which the probe component is releasably secured. The driver has a drive member (22,23) for adjusting the orientation of the tubular section and thus the aperture therein and one or more drive members (30) for moving the tissue cutting member within the tubular section to sever a tissue specimen from tissue extending into the interior of the tubular section through the aperture. The motion imparted to the tissue cutter is at least longitudinal and preferably is also oscillation and/or rotational to effectively separate a tissue specimen from tissue extending through the aperture in the tubular section.
摘要翻译：本发明涉及一种用于从患者内的目标部位分离和收集组织标本的系统和装置。该装置包括具有细长管状部分（15）的探针部件（11），远侧末端的管状部分的远端中的穿透远侧末端（16）和组织接收孔（17），以及组织切割构件（20），其可滑动地设置在所述探针构件内，以通过对所述组织切割构件的内腔施加真空来切割通过所述孔被拉入所述装置的内部的组织样本。该装置还具有驱动器部件（12），探针部件可释放地固定到该部件上。驱动器具有用于调节管状部分的取向并因此调节其中的孔的驱动构件（22,23）和一个或多个驱动构件（30），用于移动管状区段内的组织切割构件以从组织切断组织样本通过孔延伸到管状部分的内部。赋予组织切割器的运动至少是纵向的，并且优选地也是振动和/或旋转以有效地将组织样本与延伸穿过管状部分中的孔的组织分离。

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