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1. 发明申请

WO2008063638A2 MRI DETECTABLE OBTURATOR 审中-公开
标题翻译： MRI检测器
公开(公告)号：WO2008063638A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/024255
申请日：2007-11-20
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L. , BROADAWAY, Ethan , LOUW, Frank, R.
发明人： LUBOCK, Paul , JONES, Michael, L. , BROADAWAY, Ethan , LOUW, Frank, R.
IPC分类号： A61B19/00
CPC分类号： A61B17/32 , A61B17/3417 , A61B17/3431 , A61B17/3468 , A61B17/3496 , A61B17/3498 , A61B90/39 , A61B2017/00477 , A61B2017/00911 , A61B2090/062 , A61B2090/3908 , A61B2090/3954 , A61B2090/3987
摘要： An obturator with an elongated shaft, a proximal end, a substantially closed distal end and a MRI detectable distal shaft portion, which does not interfere with magnetic resonance imaging of tissue proximate thereto. Preferably, the distal shaft portion has an effective MRI detectable mass so as to provide a clear, T1-weighted image within an outline of the distal shaft portion upon magnetic resonance imaging.
摘要翻译：具有细长轴，近端，基本上封闭的远端和MRI可检测远端轴部分的闭孔器，其不干扰邻近于其的组织的磁共振成像。优选地，远侧轴部分具有有效的MRI检测质量，以便在磁共振成像时在远侧轴部分的轮廓内提供清晰的T1加权图像。

2. 发明申请

WO2007061655A2 TISSUE IRRADIATION WITH SHIELDING 审中-公开
标题翻译：组织辐射与屏蔽
公开(公告)号：WO2007061655A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/043891
申请日：2006-11-13
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael
发明人： LUBOCK, Paul , JONES, Michael
IPC分类号： A61N5/10 , A61M36/04
CPC分类号： A61N5/1015 , A61B2017/3419 , A61N2005/1005
摘要： Devices and methods are disclosed for treatment to tissue surrounding a body cavity or other intracorporeal site, such as after removal of tissue, e.g. cancer. Such a device includes a treatment location on a distal portion of the device with one or more radiation shielding components that partially encircle a radiation source at the treatment location to control emitted radiation from the radiation source. The device minimizes radiation damage to healthy tissue surrounding the body cavity or other site while irradiating tissue not shielded by the radiation shielding components. A device embodying features of the invention can include a sealing member at a location on a shaft of the device proximal to a treatment location to seal the passageway leading to the body cavity.
摘要翻译：公开了用于治疗围绕体腔或其他体内部位的组织的装置和方法，例如在去除组织后，例如，癌症。这种装置包括在装置的远端部分上的处理位置，其中一个或多个辐射屏蔽部件在处理位置部分地环绕辐射源以控制来自辐射源的辐射。该装置最小化对体腔或其他部位周围的健康组织的辐射损伤，同时辐射未被辐射屏蔽部件屏蔽的组织。体现本发明特征的装置可包括密封构件，该密封构件位于靠近处理位置的装置的轴上的位置处，以密封通向体腔的通道。

3. 发明申请

WO2009105177A1 POLYSACCHARIDE MARKERS 审中-公开
标题翻译：多糖标记
公开(公告)号：WO2009105177A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/000945
申请日：2009-02-13
申请人： SENORX, INC. , JONES, Michael, L. , LUBOCK, Paul
发明人： JONES, Michael, L. , LUBOCK, Paul
IPC分类号： A61B19/00
CPC分类号： A61B19/54 , A61B90/39 , A61B2017/00004 , A61B2017/00831 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3962 , A61B2090/3987 , A61K9/0024
摘要： The marker member delivery system described has a plurality of marker members disposed within a delivery tube or cannula which contain a suitable polysaccharide such as starch (e.g. corn starch or potato starch) and a binder such as methylcellulose. These marker members are preferably press-formed from powders. The system has preferably has at least one other marker member formed of bioabsorbable material with a radiopaque element attached to or incorporated therein. The marker with a radiopaque marker element is preferably disposed within the delivery tube between two marker members formed of polysaccharide and is preferably formed of a bioabsorbable material other than a polysaccharide.
摘要翻译：所述的标记物传送系统具有多个标记物，其设置在输送管或套管内，其包含合适的多糖如淀粉（例如玉米淀粉或马铃薯淀粉）和粘合剂如甲基纤维素。这些标记物优选由粉末压制成型。该系统优选地具有由生物可吸收材料形成的至少一个其它标记构件，其中附着或结合在其中的不透射线元件。具有不透射线标记元件的标记物优选设置在由多糖形成的两个标记物之间的输送管内，并且优选由除多糖之外的生物可吸收材料形成。

4. 发明申请

WO2007097956A2 TEMPORARY CATHETER FOR BIOPSY SITE TISSUE FIXATION 审中-公开
标题翻译：用于生物场地组织固定的临时导管
公开(公告)号：WO2007097956A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/003877
申请日：2007-02-14
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L.
发明人： LUBOCK, Paul , JONES, Michael, L.
IPC分类号： A61M25/10 , A61B17/00 , A61B17/22 , A61N5/10
CPC分类号： A61M29/02 , A61B10/0041 , A61B17/0218 , A61B90/02 , A61B2017/00557 , A61B2017/00796 , A61B2090/3908 , A61M25/10 , A61M29/00 , A61M2025/1095 , A61N5/1015
摘要： Devices and methods are provided for temporarily maintaining access to a body cavity in a targeted tissue region within a patient's body. One embodiment of the catheter device includes an elongated shaft having a proximal shaft section which is flexible enough to be folded or coiled into a configuration for deployment within the patient. An alternate embodiment includes a catheter device having one or more detachable proximal shaft sections and having at least one one-way valve to restrict fluid flow of inflation fluid to flow to the balloon. After deployment of the catheter device completely within the patient, the opening through which the catheter device is deployed is closed, e.g. by sutures, adhesives and the like to minimize infection at the site. Within a few days or weeks after the tissue has been evaluated for cancer, the temporary catheter device may be removed from the patient. If cancer or pre-cancer cells are found in the specimen removed from the cavity, then a radiation balloon catheter or other irradiation device can be inserted into the patient to irradiate tissue surrounding the biopsy cavity to ensure that cancer cells within the tissue surrounding the cavity are killed.
摘要翻译：提供了用于暂时维持对患者体内的目标组织区域中的体腔的访问的装置和方法。导管装置的一个实施例包括细长轴，其具有近侧轴部，该近端轴部足够柔性以折叠或卷绕成用于部署在患者体内的构造。替代实施例包括具有一个或多个可分离近侧轴部分并且具有至少一个单向阀以限制充气流体流入气囊的流体流动的导管装置。在将导管装置完全展开在患者体内之后，将导管装置展开的开口关闭，例如，通过缝线，粘合剂等来最小化现场的感染。在组织已经被评估癌症后的几天或几周内，临时导管装置可以从患者身上移除。如果在从腔中取出的样品中发现癌症或癌前细胞，则可以将放射气球导管或其它照射装置插入患者体内以照射活检腔周围的组织，以确保围绕腔的组织内的癌细胞被杀

5. 发明申请

WO2008019001A2 MARKER FORMED OF STARCH OR OTHER SUITABLE POLYSACCHARIDE 审中-公开
标题翻译：标记为淀粉或其他适用的多糖
公开(公告)号：WO2008019001A2
公开(公告)日：2008-02-14
申请号：PCT/US2007/016902
申请日：2007-07-27
申请人： SENORX, INC. , JONES, Michael , LUBOCK, Paul
发明人： JONES, Michael , LUBOCK, Paul
IPC分类号： A61B19/00
CPC分类号： A61B90/39 , A61B2017/00004 , A61B2017/00831 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3962 , A61B2090/3987
摘要： The marker member delivery system described has at least one marker member disposed within a delivery tube or cannula is formed at least in part of starch or a suitable polysaccharide. The marker member is preferably in the form of fibrous member.
摘要翻译：所描述的标记物传送系统具有设置在输送管内的至少一个标记物，或至少部分淀粉或合适的多糖形成插管。标记构件优选为纤维构件的形式。

6. 发明申请

WO2006049911A1 FIBROUS MARKER FORMED OF SYNTHETIC POLYMER STRANDS 审中-公开
标题翻译：混合标记形成合成聚合物结构
公开(公告)号：WO2006049911A1
公开(公告)日：2006-05-11
申请号：PCT/US2005/038027
申请日：2005-10-21
申请人： SENORX, INC. , JONES, Michael, L. , LUBOCK, Paul , MALCHOW, Lloyd, H.
发明人： JONES, Michael, L. , LUBOCK, Paul , MALCHOW, Lloyd, H.
IPC分类号： A61B19/00 , A61B17/00 , A61N5/10 , A61M37/00
CPC分类号： A61M37/0069 , A61B17/0057 , A61B90/39 , A61B2017/00831 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987
摘要： The invention is directed to an intracorporeal fibrous marker formed of a fibrous pad or mat with strands of synthetic polymeric material such as polyglycolic acid and delivery devices and methods of using such devices. The fibrous pad or mat has a bulk density of at least 10, preferably about 30 to about 100 mg/cc and typically about 40 mg/cc. The fibrous marker has an effective in vivo lifespan of at least three weeks.
摘要翻译：本发明涉及由具有合成聚合物材料如聚乙醇酸和递送装置的纤维垫或垫的纤维垫或垫形成的体内纤维标记物和使用这种装置的方法。纤维垫或垫的堆积密度为至少10，优选约30至约100mg / cc，通常为约40mg / cc。纤维标记物具有至少三周的有效的体内寿命。

7. 发明申请

WO2010039184A3 POROUS BIOABSORBABLE IMPLANT 审中-公开
公开(公告)号：WO2010039184A3
公开(公告)日：2010-04-08
申请号：PCT/US2009/005268
申请日：2009-09-22
申请人： SENORX, INC. , GOVIL, Amit , JONES, Michael, L. , LUBOCK, Paul
发明人： GOVIL, Amit , JONES, Michael, L. , LUBOCK, Paul
IPC分类号： A61L27/20 , A61L27/50 , A61L27/56 , A61L27/58
摘要： The bioabsorbable implant described has a porous body formed of bioabsorbable materials that have an in vivo life span of at least 2 weeks, preferably at least three weeks and not greater than 20 weeks, preferably no greater than ten weeks. The implant has a scaffolding structure which facilitates tissue in-growth and ultimately tissue replacement of the scaffolding structure. The implant has a radiopaque imaging agent at least at the exterior margins and an orientation plurality of radiopaque elements in the interior of implant. The implant preferably has three radiopaque elements within the interior that form a plane within the implant interior.

8. 发明申请

WO2009134314A1 ASSEMBLY WITH HEMOSTATIC AND RADIOGRAPHICALLY DETECTABLE PELLETS 审中-公开
标题翻译：装配有HEMOSTATIC和RADIOGRAPHICALLY DETECTABLE PELLETS
公开(公告)号：WO2009134314A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/002297
申请日：2009-04-14
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L.
发明人： LUBOCK, Paul , JONES, Michael, L.
IPC分类号： A61B19/00
CPC分类号： A61M37/0069 , A61B90/39 , A61B2017/00004 , A61B2017/00831 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3962 , A61B2090/3987
摘要： The remotely imageable pellet system (10) described has a plurality of pellets (18) disposed within a delivery tube or cannula (11) that are formed at least in part of a polysaccharide such as starch and at least one radiographically detectable bioabsorbable pellet (18) which preferably has a radiopaque element. The radiographically detectable bioabsorbable pellet has at least one and preferably two pellets proximal and distal thereto which are formed of polysaccharide.
摘要翻译：所描述的可远程成像的颗粒系统（10）具有设置在输送管或插管（11）内的多个颗粒（18），其形成为至少部分多糖如淀粉和至少一个可放射线检测的生物可吸收颗粒（18）），其优选地具有不透射线的元件。可放射线检测的生物可吸收颗粒具有由多糖形成的至少一个且优选两个近端和远端的颗粒。

9. 发明申请

WO2008008089A2 ASYMMETRICAL IRRADIATION OF A BODY CAVITY 审中-公开
标题翻译：非对称辐照人体腔
公开(公告)号：WO2008008089A2
公开(公告)日：2008-01-17
申请号：PCT/US2006/044067
申请日：2006-11-13
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L. , LOUW, Frank, R.
发明人： LUBOCK, Paul , JONES, Michael, L. , LOUW, Frank, R.
IPC分类号： A61N5/10 , A61M36/04
CPC分类号： A61N5/1014 , A61N5/1002 , A61N5/1015 , A61N2005/1003 , A61N2005/1004 , A61N2005/1005 , A61N2005/1018 , A61N2005/1024
摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.
摘要翻译：本公开描述了用于在体腔或部位处的不对称辐射的装置和方法，例如在移除组织之后，活检或癌症。一个装置包括从纵轴偏离或偏离的腔，以增加由体腔周围的第一组织部分从辐射源接收的辐射强度，并减少或最小化由第二组织部分接收的辐射（例如健康组织）围绕着体腔。

10. 发明申请

WO2007019445A1 BIOPSY DEVICE WITH FLUID DELIVERY TO TISSUE SPECIMENS 审中-公开
标题翻译：具有流体输送到组织样本的生物装置
公开(公告)号：WO2007019445A1
公开(公告)日：2007-02-15
申请号：PCT/US2006/030722
申请日：2006-08-04
申请人： SENORX, INC. , QUICK, Richard, L. , SHABAZ, Martin, V. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason, H.
发明人： QUICK, Richard, L. , SHABAZ, Martin, V. , LOUW, Frank, R. , LUBOCK, Paul , SAFABASH, Jason, H.
IPC分类号： A61B10/02 , A61B17/32 , A61B17/00
CPC分类号： A61B17/32002 , A61B10/0275 , A61B10/0283 , A61B2010/0208 , A61B2010/0225 , A61B2017/00473
摘要： The invention is directed to a system and method for separating and collecting one or more tissue specimens from a target site within a patient and flushing the specimen to remove blood, debris and the like before the specimen is removed from the biopsy device. The flow of flushing fluid to the tissue collector is preferably controlled to coincide with delivery of one or more specimens to the collecting tray or basket of the device or after the receipt of the specimen within the tissue collector to ensure that the fluid (16) is applied to a fresh specimen. The tissue tray or basket within the tissue collector (14) has an open or foraminous portion to facilitate removal of fluid, such as the applied fluid and blood, and other debris from the tissue specimens on the tray. Vacuum (22) is provided within the tissue collector, preferably under the tray to remove fluid and debris from the collector interior.
摘要翻译：本发明涉及一种用于从患者内的目标部位分离和收集一个或多个组织样本的系统和方法，并且在从活检装置移除样本之前冲洗样本以除去血液，碎屑等。冲洗流体到组织收集器的流动优选地被控制以与一个或多个样本递送到装置的收集盘或篮子之间或在组织收集器中收到样本之后确保流体（16）是应用于新鲜的标本。组织收集器（14）内的纸巾托盘或篮子具有开放或有孔的部分，以有助于从托盘上的组织标本中去除流体，例如施加的流体和血液以及其它碎屑。真空（22）设置在组织收集器内，优选在托盘下面，以从收集器内部去除流体和碎屑。

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