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1. 发明申请

WO2010017418A1 PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE 审中-公开
标题翻译： D-氨基酸氧化酶的融合杂环抑制剂的制备
公开(公告)号：WO2010017418A1
公开(公告)日：2010-02-11
申请号：PCT/US2009/053049
申请日：2009-08-06
申请人： SEPRACOR INC. , HEFFERNAN, Michele, L.R. , DENNIS, Richard , DORSEY, James, M. , FOGLESONG, Robert, J. , JONES, Michael, L. , OGBU, Cyprian, O. , SOUKRI, Mustapha , SPEAR, Kerry, L. , WILKINSON, H., Scott , ORSINI, Michael Anthony
发明人： HEFFERNAN, Michele, L.R. , DENNIS, Richard , DORSEY, James, M. , FOGLESONG, Robert, J. , JONES, Michael, L. , OGBU, Cyprian, O. , SOUKRI, Mustapha , SPEAR, Kerry, L. , WILKINSON, H., Scott , ORSINI, Michael Anthony
IPC分类号： C07D491/04 , A61K31/407 , A61P25/00
CPC分类号： C07D491/04
摘要： The invention relates to prodrugs of fused heterocyclic inhibitors of D-amino oxidase (DAAO) and methods of treating diseases and conditions, wherein modulation of D- amino acid oxidase activity, D-serine levels, D-serine oxidative products and NMDA receptor activity in the nervous system of a mammalian subject is effective.
摘要翻译：本发明涉及D-氨基氧化酶（DAAO）的稠合杂环抑制剂的前药和治疗疾病和病症的方法，其中调节D-氨基酸氧化酶活性，D-丝氨酸水平，D-丝氨酸氧化产物和NMDA受体活性哺乳动物受试者的神经系统是有效的。

2. 发明申请

WO2009105177A1 POLYSACCHARIDE MARKERS 审中-公开
标题翻译：多糖标记
公开(公告)号：WO2009105177A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/000945
申请日：2009-02-13
申请人： SENORX, INC. , JONES, Michael, L. , LUBOCK, Paul
发明人： JONES, Michael, L. , LUBOCK, Paul
IPC分类号： A61B19/00
CPC分类号： A61B19/54 , A61B90/39 , A61B2017/00004 , A61B2017/00831 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3962 , A61B2090/3987 , A61K9/0024
摘要： The marker member delivery system described has a plurality of marker members disposed within a delivery tube or cannula which contain a suitable polysaccharide such as starch (e.g. corn starch or potato starch) and a binder such as methylcellulose. These marker members are preferably press-formed from powders. The system has preferably has at least one other marker member formed of bioabsorbable material with a radiopaque element attached to or incorporated therein. The marker with a radiopaque marker element is preferably disposed within the delivery tube between two marker members formed of polysaccharide and is preferably formed of a bioabsorbable material other than a polysaccharide.
摘要翻译：所述的标记物传送系统具有多个标记物，其设置在输送管或套管内，其包含合适的多糖如淀粉（例如玉米淀粉或马铃薯淀粉）和粘合剂如甲基纤维素。这些标记物优选由粉末压制成型。该系统优选地具有由生物可吸收材料形成的至少一个其它标记构件，其中附着或结合在其中的不透射线元件。具有不透射线标记元件的标记物优选设置在由多糖形成的两个标记物之间的输送管内，并且优选由除多糖之外的生物可吸收材料形成。

3. 发明申请

WO2007097956A2 TEMPORARY CATHETER FOR BIOPSY SITE TISSUE FIXATION 审中-公开
标题翻译：用于生物场地组织固定的临时导管
公开(公告)号：WO2007097956A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/003877
申请日：2007-02-14
申请人： SENORX, INC. , LUBOCK, Paul , JONES, Michael, L.
发明人： LUBOCK, Paul , JONES, Michael, L.
IPC分类号： A61M25/10 , A61B17/00 , A61B17/22 , A61N5/10
CPC分类号： A61M29/02 , A61B10/0041 , A61B17/0218 , A61B90/02 , A61B2017/00557 , A61B2017/00796 , A61B2090/3908 , A61M25/10 , A61M29/00 , A61M2025/1095 , A61N5/1015
摘要： Devices and methods are provided for temporarily maintaining access to a body cavity in a targeted tissue region within a patient's body. One embodiment of the catheter device includes an elongated shaft having a proximal shaft section which is flexible enough to be folded or coiled into a configuration for deployment within the patient. An alternate embodiment includes a catheter device having one or more detachable proximal shaft sections and having at least one one-way valve to restrict fluid flow of inflation fluid to flow to the balloon. After deployment of the catheter device completely within the patient, the opening through which the catheter device is deployed is closed, e.g. by sutures, adhesives and the like to minimize infection at the site. Within a few days or weeks after the tissue has been evaluated for cancer, the temporary catheter device may be removed from the patient. If cancer or pre-cancer cells are found in the specimen removed from the cavity, then a radiation balloon catheter or other irradiation device can be inserted into the patient to irradiate tissue surrounding the biopsy cavity to ensure that cancer cells within the tissue surrounding the cavity are killed.
摘要翻译：提供了用于暂时维持对患者体内的目标组织区域中的体腔的访问的装置和方法。导管装置的一个实施例包括细长轴，其具有近侧轴部，该近端轴部足够柔性以折叠或卷绕成用于部署在患者体内的构造。替代实施例包括具有一个或多个可分离近侧轴部分并且具有至少一个单向阀以限制充气流体流入气囊的流体流动的导管装置。在将导管装置完全展开在患者体内之后，将导管装置展开的开口关闭，例如，通过缝线，粘合剂等来最小化现场的感染。在组织已经被评估癌症后的几天或几周内，临时导管装置可以从患者身上移除。如果在从腔中取出的样品中发现癌症或癌前细胞，则可以将放射气球导管或其它照射装置插入患者体内以照射活检腔周围的组织，以确保围绕腔的组织内的癌细胞被杀

4. 发明申请

WO2005053546A3 OCCLUSION DEVICE FOR ASYMMETRICAL UTERINE ARTERY ANATOMY 审中-公开
标题翻译：非对称性子宫动脉解剖的装置
公开(公告)号：WO2005053546A3
公开(公告)日：2007-08-16
申请号：PCT/US2004038276
申请日：2004-11-16
申请人： VASCULAR CONTROL SYSTEMS INC , BURBANK FRED H , ALTIERI GREIG E , JONES MICHAEL L , OLSON ED
发明人： BURBANK FRED H , ALTIERI GREIG E , JONES MICHAEL L , OLSON ED
IPC分类号： A61B17/42 , A61B17/12 , A61B17/28
CPC分类号： A61B17/42 , A61B17/12 , A61B2017/2927 , A61B2017/2944 , A61B2017/4216 , A61B2017/4225
摘要： An occluding device is disclosed for occluding a female patient's uterine arteries which have unsymmetrical anatomy with respect to the patient's uterine cervix. The occluding device has a pair of pivotally connected occluding members, with at least one of the occluding member having a movable occluding element on a distal shaft section of the occluding member. The position and orientation of the occluding elements on the distal shaft sections may be adjusted by operative members on the proximal shaft sections of the occluding members to accommodate for asymmetrical uterine artery anatomy. The occluding elements have pressure applying surfaces with one or more blood flow sensors such as Doppler chips which help the physician to better identify the uterine artery and to monitor blood flow therein. A tenaculum-like guiding element configured to be secured within the patient's uterine cervix, may be provided to guide the occluding device to the patient's cervix.
摘要翻译：公开了一种闭塞装置，用于阻塞相对于患者的子宫颈具有不对称解剖结构的女性患者的子宫动脉。闭塞装置具有一对枢转连接的闭塞构件，其中至少一个阻塞构件在闭塞构件的远侧轴部上具有可移动的闭塞元件。闭合元件在远侧轴部分上的位置和取向可以通过闭塞构件的近侧轴部分上的操作构件来调整，以适应不对称的子宫动脉解剖。闭塞元件具有一个或多个血液流量传感器（例如多普勒碎片）的压力施加表面，其帮助医生更好地识别子宫动脉并监测其中的血液流动。被配置成固定在患者的子宫颈内的十字形引导元件可以设置成将闭塞装置引导到病人的子宫颈。

5. 发明申请

WO1997004656A1 NOVEL COMPOSITIONS FOR USE IN EMBOLIZING BLOOD VESSELS 审中-公开
标题翻译：用于灌注血液容器的新型组合物
公开(公告)号：WO1997004656A1
公开(公告)日：1997-02-13
申请号：PCT/US1996012435
申请日：1996-07-29
申请人： MICRO THERAPEUTICS, INC. , GREFF, Richard, J. , JONES, Michael, L. , EVANS, Scott
发明人： MICRO THERAPEUTICS, INC.
IPC分类号： A01N59/08
CPC分类号： A61L24/08 , A61K49/0404 , A61K49/0414 , A61L24/001 , A61L24/046 , A61L24/06 , A61L2430/36 , C08L29/04
摘要： Disclosed are compositions suitable for use in embolizing blood vessels which compositions comprise an ethylene vinyl alcohol copolymer, a biocompatible solvent and a water insoluble contrasting agent selected from the group consisting of tantalum, tantalum oxide and barium sulfate. Also disclosed are methods for embolizing a blood vessel using the compositions described herein.
摘要翻译：公开了适用于栓塞血管的组合物，其组合物包含乙烯乙烯醇共聚物，生物相容性溶剂和选自钽，氧化钽和硫酸钡的水不溶性对比剂。还公开了使用本文所述的组合物栓塞血管的方法。

6. 发明申请

WO2009058186A3 SOFT BODY CATHETER WITH LOW FRICTION LUMEN 审中-公开
公开(公告)号：WO2009058186A3
公开(公告)日：2009-05-07
申请号：PCT/US2008/011435
申请日：2008-10-03
申请人： SENORX, INC. , JONES, Michael, L. , LOUW, Frank, R.
发明人： JONES, Michael, L. , LOUW, Frank, R.
IPC分类号： A61L29/06 , A61L29/14
摘要： The disclosure is directed to radiation catheter devices, methods for controlled application of irradiation to tissue at a body site, such as a cavity formed after removal of tissue, e.g. cancer, using such radiation catheter devices, solutions for forming a more lubricious luminal surface and method for lining lumens of such devices to improve the frictional characteristics thereof. The catheter device includes a flexible elongated shaft which is formed of low durometer polymeric material, which can be readily folded or coiled for securing the shaft to or under the skin of the patient and a radiation lumen lined with high durometer polymeric material and finely divided particulate to improve the frictional characteristics. The elongated shaft has at least one inner lumen for receiving a radiation source which has a layer of high durometer polymeric material that provides lower surface friction to facilitate advancement of a radiation source therein.

7. 发明申请

WO2008005456A3 FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE 审中-公开
公开(公告)号：WO2008005456A3
公开(公告)日：2008-01-10
申请号：PCT/US2007/015396
申请日：2007-07-02
申请人： SEPRACOR INC. , DORSEY, James, M. , HOPKINS, Seth, C. , FOGLESONG, Robert, J. , HEFFERNAN, Michele, L.r. , JONES, Michael, L. , PERALES, Joseph, B. , FANG, Qun, Kevin , OGBU, Cyprian, O. , JONES, Steven, W. , SOUKRI, Mustapha , VARNEY, Mark, A. , SPEAR, Kerry, L.
发明人： DORSEY, James, M. , HOPKINS, Seth, C. , FOGLESONG, Robert, J. , HEFFERNAN, Michele, L.r. , JONES, Michael, L. , PERALES, Joseph, B. , FANG, Qun, Kevin , OGBU, Cyprian, O. , JONES, Steven, W. , SOUKRI, Mustapha , VARNEY, Mark, A. , SPEAR, Kerry, L.
IPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04 , A61K31/381 , A61K31/407 , A61K31/429 , A61K31/4162 , A61P25/00
摘要： This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. Also provided are methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure wherein Q is a member selected from O, S, CR 1 and N, X and Y are members independently selected from CR 2 , O, S, N and NR 3 .

8. 发明申请

WO2007097956A3 TEMPORARY CATHETER FOR BIOPSY SITE TISSUE FIXATION 审中-公开
标题翻译：活体组织固定用临时导尿管
公开(公告)号：WO2007097956A3
公开(公告)日：2007-10-11
申请号：PCT/US2007003877
申请日：2007-02-14
申请人： SENORX INC , LUBOCK PAUL , JONES MICHAEL L
发明人： LUBOCK PAUL , JONES MICHAEL L
IPC分类号： A61F2/958 , A61B17/00 , A61B17/22 , A61N5/10
CPC分类号： A61M29/02 , A61B10/0041 , A61B17/0218 , A61B90/02 , A61B2017/00557 , A61B2017/00796 , A61B2090/3908 , A61M25/10 , A61M29/00 , A61M2025/1095 , A61N5/1015
摘要： Devices and methods are provided for temporarily maintaining access to a body cavity in a targeted tissue region within a patient's body. One embodiment of the catheter device includes an elongated shaft having a proximal shaft section which is flexible enough to be folded or coiled into a configuration for deployment within the patient. An alternate embodiment includes a catheter device having one or more detachable proximal shaft sections and having at least one one-way valve to restrict fluid flow of inflation fluid to flow to the balloon. After deployment of the catheter device completely within the patient, the opening through which the catheter device is deployed is closed, e.g. by sutures, adhesives and the like to minimize infection at the site. Within a few days or weeks after the tissue has been evaluated for cancer, the temporary catheter device may be removed from the patient. If cancer or pre-cancer cells are found in the specimen removed from the cavity, then a radiation balloon catheter or other irradiation device can be inserted into the patient to irradiate tissue surrounding the biopsy cavity to ensure that cancer cells within the tissue surrounding the cavity are killed.
摘要翻译：提供了用于临时保持对患者体内目标组织区域中的体腔进入的设备和方法。导管装置的一个实施例包括具有近侧轴部分的细长轴，该近侧轴部分足够柔性以折叠或盘绕成用于在患者体内展开的构造。一个替代实施例包括导管装置，该导管装置具有一个或多个可拆卸的近侧轴部分并且具有至少一个单向阀以限制充胀流体的流体流动以流动到球囊。在将导管装置完全布置在患者体内之后，导管装置所穿过的开口关闭，例如，通过缝合线，粘合剂等来减少现场感染。在组织评估了癌症之后的几天或几周内，临时导管装置可以从患者身上移除。如果在从腔中取出的样本中发现癌症或癌前细胞，则可以将辐射球囊导管或其他照射装置插入患者中以照射活检腔周围的组织，以确保围绕腔的组织内的癌细胞遇难。

9. 发明申请

WO2006049911A1 FIBROUS MARKER FORMED OF SYNTHETIC POLYMER STRANDS 审中-公开
标题翻译：混合标记形成合成聚合物结构
公开(公告)号：WO2006049911A1
公开(公告)日：2006-05-11
申请号：PCT/US2005/038027
申请日：2005-10-21
申请人： SENORX, INC. , JONES, Michael, L. , LUBOCK, Paul , MALCHOW, Lloyd, H.
发明人： JONES, Michael, L. , LUBOCK, Paul , MALCHOW, Lloyd, H.
IPC分类号： A61B19/00 , A61B17/00 , A61N5/10 , A61M37/00
CPC分类号： A61M37/0069 , A61B17/0057 , A61B90/39 , A61B2017/00831 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2090/3908 , A61B2090/3925 , A61B2090/3987
摘要： The invention is directed to an intracorporeal fibrous marker formed of a fibrous pad or mat with strands of synthetic polymeric material such as polyglycolic acid and delivery devices and methods of using such devices. The fibrous pad or mat has a bulk density of at least 10, preferably about 30 to about 100 mg/cc and typically about 40 mg/cc. The fibrous marker has an effective in vivo lifespan of at least three weeks.
摘要翻译：本发明涉及由具有合成聚合物材料如聚乙醇酸和递送装置的纤维垫或垫的纤维垫或垫形成的体内纤维标记物和使用这种装置的方法。纤维垫或垫的堆积密度为至少10，优选约30至约100mg / cc，通常为约40mg / cc。纤维标记物具有至少三周的有效的体内寿命。

10. 发明申请

WO2005053546A2 OCCLUSION DEVICE FOR ASYMMETRICAL UTERINE ARTERY ANATOMY 审中-公开
标题翻译：非对称性子宫动脉解剖的装置
公开(公告)号：WO2005053546A2
公开(公告)日：2005-06-16
申请号：PCT/US2004/038276
申请日：2004-11-16
申请人： VASCULAR CONTROL SYSTEMS, INC. , BURBANK, Fred, H. , ALTIERI, Greig, E. , JONES, Michael, L. , OLSON, Ed
发明人： BURBANK, Fred, H. , ALTIERI, Greig, E. , JONES, Michael, L. , OLSON, Ed
IPC分类号： A61B17/00
CPC分类号： A61B17/42 , A61B17/12 , A61B2017/2927 , A61B2017/2944 , A61B2017/4216 , A61B2017/4225
摘要： An occluding device is disclosed for occluding a female patient's uterine arteries which have unsymmetrical anatomy with respect to the patient's uterine cervix. The occluding device has a pair of pivotally connected occluding members, with at least one of the occluding member having a movable occluding element on a distal shaft section of the occluding member. The position and orientation of the occluding elements on the distal shaft sections may be adjusted by operative members on the proximal shaft sections of the occluding members to accommodate for asymmetrical uterine artery anatomy. The occluding elements have pressure applying surfaces with one or more blood flow sensors such as Doppler chips which help the physician to better identify the uterine artery and to monitor blood flow therein. A tenaculum-like guiding element configured to be secured within the patient's uterine cervix, may be provided to guide the occluding device to the patient's cervix.
摘要翻译：公开了一种闭塞装置，用于阻塞相对于患者的子宫颈具有不对称解剖结构的女性患者的子宫动脉。闭塞装置具有一对枢转连接的闭塞构件，其中至少一个阻塞构件在闭塞构件的远侧轴部上具有可移动的闭塞元件。封闭元件在远侧轴部分上的位置和取向可以通过闭塞构件的近侧轴部分上的操作构件来调节，以适应不对称的子宫动脉解剖。闭塞元件具有一个或多个血液流量传感器（例如多普勒碎片）的压力施加表面，其帮助医生更好地识别子宫动脉并监测其中的血液流动。构造成固定在患者子宫颈内的十字形引导元件可被设置成将闭塞装置引导到病人的子宫颈。

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