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1. 发明申请

WO2005046745A3 METHOD AND DEVICE FOR CONTROLLED DELIVERY OF ACTIVE SUBSTANCE 审中-公开
标题翻译：用于控制输送活性物质的方法和装置
公开(公告)号：WO2005046745A3
公开(公告)日：2005-07-28
申请号：PCT/US2004036489
申请日：2004-11-03
申请人： SCIMED LIFE SYSTEMS INC , STENZEL ERIC B
发明人： STENZEL ERIC B
IPC分类号： A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/61 , A61L2300/62
摘要： The invention relates to a method and device for coating a device with time release drugs by providing a plurality of micro coated pellets having different release rates on the surface of the medical device structure, e.g., a stent. Organizing the micro pellets with different release rates on the structure can result in the structure having a plurality of release regions with varying release profiles.
摘要翻译：本发明涉及一种通过在医疗装置结构例如支架的表面上提供具有不同释放速率的多个微涂层丸剂来涂覆具有时间释放药物的装置的方法和装置。在结构上以不同的释放速率组织微丸可导致结构具有多个具有变化释放曲线的释放区。

2. 发明申请

WO2004096097A2 CUTTING STENT AND BALLOON 审中-公开
标题翻译：切割棒和气球
公开(公告)号：WO2004096097A2
公开(公告)日：2004-11-11
申请号：PCT/US2004005570
申请日：2004-02-25
申请人： SCIMED LIFE SYSTEMS INC
发明人： SHAW WILLIAM J , STENZEL ERIC B , WANG LIXIAO
IPC分类号： A61B17/00 , A61B17/12 , A61B17/22 , A61M25/10 , A61F2/06
CPC分类号： A61B17/320725 , A61B17/22 , A61B2017/00831 , A61B2017/22051 , A61F2/958 , A61F2250/0028 , A61L29/126 , A61M25/10
摘要： A stent or sheath having one or more cutting blades may be constructed for implantation in the body. A balloon having one or more cutting blades may be used with a stent or a sheath.
摘要翻译：具有一个或多个切割刀片的支架或护套可构造成用于植入体内。具有一个或多个切割刀片的气囊可以与支架或护套一起使用。

3. 发明申请

WO2006047490A3 METHOD FOR COATING A MEDICAL DEVICE USING A SOLVENT TO REFLOW THE COATING 审中-公开
标题翻译：使用溶剂来涂覆涂层的医疗装置的方法
公开(公告)号：WO2006047490A3
公开(公告)日：2006-12-14
申请号：PCT/US2005038323
申请日：2005-10-25
申请人： BOSTON SCIENT SCIMED INC , STENZEL ERIC B
发明人： STENZEL ERIC B
IPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2420/02
摘要： A method is provided for coating at least a portion of at least one medical device. The method includes arranging a polymer on the portion of the medical device, arranging a bioactive agent on the portion of the medical device, and spraying, subsequent to the arranging of the polymer and the arranging of the bioactive agent, a solvent on the portion of the medical device. The method may further include selecting a composition of the solvent to achieve a desired agent release response profile for the medical device. A medical appliance is provided having a coating applied by a method that includes arranging a polymer on the portion of the medical device, arranging a bioactive agent on the portion of the medical device, and subsequently spraying a solvent on the portion of the medical device. A method is provided for achieving a desired agent release response profile for a medical device by reflowing the coating with a solvent.
摘要翻译：提供了一种用于涂覆至少一个医疗装置的至少一部分的方法。该方法包括将聚合物布置在医疗装置的该部分上，将生物活性剂设置在医疗装置的该部分上，并且在聚合物的排列和生物活性剂的排列之后喷洒溶剂医疗器械。该方法可以进一步包括选择溶剂的组合物以实现医疗装置的期望的药剂释放反应曲线。提供了一种医疗器具，其具有通过包括在医疗装置的部分上布置聚合物的方法施加的涂层，在医疗装置的该部分上布置生物活性剂，随后在医疗装置的该部分上喷涂溶剂。提供了一种用于通过用溶剂回流涂层来实现医疗装置的期望的药剂释放反应曲线的方法。

4. 发明申请

WO2006020659A2 METHOD OF CRYOGENICALLY COATING A DEVICE 审中-公开
标题翻译：低温涂层装置的方法
公开(公告)号：WO2006020659A2
公开(公告)日：2006-02-23
申请号：PCT/US2005028305
申请日：2005-08-09
申请人： BOSTON SCIENT SCIMED INC , STENZEL ERIC B
发明人： STENZEL ERIC B
IPC分类号： B05D3/00 , A61L33/00 , B05D1/02 , C23C16/52
CPC分类号： C23C8/02 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D3/002 , B05D3/048 , C23C8/40 , C23C8/80
摘要： The present invention is directed to a method for coating a surface of a medical device with a coating composition. The method involves chilling the surface to be coated to below the freezing point of at least one solvent contained in the composition. This coating composition is applied to the chilled surface, and a portion of the coating composition is allowed to freeze onto the surface. The surface can then be heated (either by the application of heat from an external source, by allowing to heat by ambient air) to above the freezing point of the solvent in the coating composition to allow the solvent to thaw and be removed, thereby forming a smooth, uniform coating on the surface of the medical device.
摘要翻译：本发明涉及一种用涂料组合物涂覆医疗器械表面的方法。该方法包括将待涂覆的表面冷却至组合物中所含的至少一种溶剂的凝固点以下。将该涂料组合物施加到冷却的表面上，并使一部分涂料组合物冷冻到表面上。然后可以将表面加热（通过外部来源的加热，通过环境空气加热）到涂层组合物中溶剂的凝固点以上，以使溶剂解冻并除去，从而形成医疗装置表面上光滑均匀的涂层。

5. 发明申请

WO03092517A8 METHOD, TOOL, AND SYSTEM FOR DEPLOYING AN IMPLANT INTO THE BODY 审中-公开
标题翻译：将植入物投入身体的方法，工具和系统
公开(公告)号：WO03092517A8
公开(公告)日：2003-12-31
申请号：PCT/US0232238
申请日：2002-10-10
申请人： SCIMED LIFE SYSTEMS INC
发明人： STENZEL ERIC B
IPC分类号： A61B17/28 , A61B17/34 , A61B19/00
CPC分类号： A61B17/29 , A61B17/3417 , A61B17/3421 , A61B17/3439 , A61B17/3468 , A61B90/39 , A61B2017/2902 , A61B2017/3484 , A61B2017/3486
摘要： In one embodiment of the present invention a system for maneuvering an implant to a target site and deploying the implant at the target site is provided. This system includes an inner housing and an outer housing where the inner housing is slidable within the outer housing. The outer housing may have a working channel with a first end and a second end and a piercing jaw moveably coupled to the first end. The inner housing may have a working passage with a distal end and a proximal end, the distal end having a piercing jaw moveably coupled to it.
摘要翻译：在本发明的一个实施例中，提供了一种用于将植入物操纵到目标部位并将植入物部署在目标部位的系统。该系统包括内壳体和外壳体，其中内壳体可在外壳体内滑动。外部壳体可以具有工作通道，其具有第一端和第二端以及可移动地联接到第一端的穿孔钳。内壳体可以具有远端和近端的工作通道，远端具有可移动地联接到其上的穿刺钳口。

6. 发明申请

WO2007024308A3 MEDICAL DEVICE HAVING A LUBRICANT 审中-公开
标题翻译：具有润滑剂的医疗装置
公开(公告)号：WO2007024308A3
公开(公告)日：2007-06-21
申请号：PCT/US2006019800
申请日：2006-05-23
申请人： BOSTON SCIENT SCIMED INC , STENZEL ERIC B
发明人： STENZEL ERIC B
IPC分类号： A61F2/02
CPC分类号： A61L31/08 , A61L31/14 , A61L31/16 , A61L2300/00
摘要： A medical device includes a member (210) , a coating (220) , and a lubricant (230) . In one embodiment, the coating includes a therapeutic agent. In one embodiment, the coating is disposed on at least a portion of the body and the lubricant is disposed on at least a portion of the coating. In one embodiment, the lubricant is formulated to provide an effective degree of lubricity between the coating and at least one of a surface of a package configured to receive at least a portion of the medical device, another portion of the medical device, a coating of another medical device, and an uncoated portion of another medical device. In one embodiment, the lubricant is soluble in at least one of water and a bodily fluid of a mammal. In one embodiment, the coating is formulated to release from the member when the medical device is placed within a body of a patient.
摘要翻译：医疗装置包括构件（210），涂层（220）和润滑剂（230）。在一个实施方案中，涂层包括治疗剂。在一个实施例中，涂层设置在主体的至少一部分上，润滑剂设置在涂层的至少一部分上。在一个实施方案中，配制润滑剂以在涂层与包装的表面中的至少一个之间提供有效的润滑性，其被配置为容纳医疗装置的至少一部分，医疗装置的另一部分，另一医疗设备，以及另一医疗设备的未涂覆部分。在一个实施方案中，润滑剂可溶于哺乳动物的水和体液中的至少一种。在一个实施方案中，当医疗装置放置在患者体内时，涂层被配制成从构件释放。

7. 发明申请

WO2006115920A3 TISSUE ABLATION SYSTEM WITH MULTI-POINT CONVERGENT RF BEAMS 审中-公开
标题翻译：具有多点融合射频束的组织消融系统
公开(公告)号：WO2006115920A3
公开(公告)日：2006-12-21
申请号：PCT/US2006014661
申请日：2006-04-18
申请人： BOSTON SCIENT SCIMED INC , STENZEL ERIC B
发明人： STENZEL ERIC B
IPC分类号： A61N5/02 , A61N1/40
CPC分类号： A61B18/18 , A61B18/1815 , A61N1/403 , A61N5/02
摘要： A system for treating tissue includes a first source (102a) for delivering a first beam (224a) of radiofrequency energy, and a second source (102b) for delivering a second beam (224b) of radiofreguency energy, wherein the first and second sources may be independently directed to converge on a targeted tissue region (226) to be treated. The system may comprise more than two sources, e.g. three or four sources, independently directed to converge on a target tissue region. The source comprises a microwave generator (202), a travelling wave tube (204), a beam expander optic (212), a collimating optic (214) and a focusing optic (222).
摘要翻译：一种用于治疗组织的系统包括用于传送射频能量的第一光束（224a）的第一光源（102a）和用于传送无线电频率能量的第二光束（224b）的第二光源（102b），其中所述第一和第二光源可以独立地指向会聚在待治疗的靶组织区域（226）上。该系统可以包括两个以上的源，例如。三个或四个源，独立地指向会聚在目标组织区域上。源包括微波发生器（202），行波管（204），扩束器光学器件（212），准直光学器件（214）和聚焦光学器件（222）。

8. 发明申请

WO2006052575A3 MEDICAL DEVICE FOR DELIVERING THERAPEUTIC AGENTS OVER DIFFERENT TIME PERIODS 审中-公开
标题翻译：用于在不同时期递送治疗药物的医疗装置
公开(公告)号：WO2006052575A3
公开(公告)日：2006-10-05
申请号：PCT/US2005039592
申请日：2005-11-01
申请人： BOSTON SCIENT SCIMED INC , STENZEL ERIC B
发明人： STENZEL ERIC B
IPC分类号： A61L31/12 , A61F2/82 , A61L29/12 , A61L29/16 , A61L31/16
CPC分类号： A61K31/337 , A61F2/82 , A61F2/91 , A61F2250/0035 , A61F2250/0067 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/61 , A61L2420/08
摘要： A medical device comprising a surface coated by at least two coating regions comprising a therapeutic agent is disclosed. These coating regions allow for the release of the therapeutic agent over different time periods.
摘要翻译：公开了包括由包含治疗剂的至少两个涂层区域涂覆的表面的医疗装置。这些涂覆区域允许在不同时间段内释放治疗剂。

9. 发明申请

WO02065949A3 LOCKING STENT 审中-公开
标题翻译：锁定杆
公开(公告)号：WO02065949A3
公开(公告)日：2002-11-28
申请号：PCT/US0203241
申请日：2002-02-06
申请人： SCIMED LIFE SYSTEMS INC
发明人： STENZEL ERIC B
IPC分类号： A61F2/00 , A61F2/06 , A61F2/90
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/30329 , A61F2002/91508 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2002/91566 , A61F2002/91591 , A61F2220/0025 , A61F2230/0013
摘要： A stent may be constructed to have at least one lockable cell which includes a first locking member and a second locking member. The first and second locking members are movable between a first position in which they are not locked together to a second position in which they are locked together and impart increased scaffolding strength to the stent.
摘要翻译：支架可被构造成具有至少一个可锁定单元，其包括第一锁定构件和第二锁定构件。第一和第二锁定构件可以在第一位置和第二位置之间移动，在第一位置中，第一和第二锁定构件未被锁定在第二位置，在第二位置中，它们被锁定在一起并且赋予支架增加的脚手架

10. 发明申请

WO2007067293A3 METHOD AND SYSTEM FOR COATING A MEDICAL DEVICE 审中-公开
标题翻译：用于涂敷医疗装置的方法和系统
公开(公告)号：WO2007067293A3
公开(公告)日：2008-05-29
申请号：PCT/US2006043421
申请日：2006-11-06
申请人： BOSTON SCIENT SCIMED INC , STENZEL ERIC B
发明人： STENZEL ERIC B
IPC分类号： B05B15/12 , A61L31/10 , B05D1/12
CPC分类号： B05B15/1225 , A61L27/34 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2420/02 , B05B15/0406 , B05D1/12 , B05D3/0218 , Y02P70/36
摘要： A method and device for coating a medical device including the step of heating the medical device and applying frozen ground up particles of coating material to the heated medical device such that the coating material flows on the surface of the medical device and forms a coating thereon.
摘要翻译：一种用于涂覆医疗装置的方法和装置，包括以下步骤：加热医疗装置并将加热的医疗装置的冷冻磨碎的颗粒施加到加热的医疗装置上，使得涂层材料在医疗装置的表面上流动并在其上形成涂层。

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