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1. 发明申请

WO2006108689A2 PROCESS FOR PREPARING BICYCLIC COMPOUNDS 审中-公开
标题翻译：制备双相化合物的方法
公开(公告)号：WO2006108689A2
公开(公告)日：2006-10-19
申请号：PCT/EP2006/003480
申请日：2006-04-06
申请人： SB PHARMCO PUERTO RICO INC , NEUROCRINE BIOSCIENCES INC , ANDREOTTI, Daniele , BACCHI, Sergio , DELPOGETTO, Monica , GUELFI, Simone , PERBONI, Alcide , RIBECAI, Arianna , SPADA, Simone , STABILE, Paolo , TAMPIERI, Marsia
发明人： ANDREOTTI, Daniele , BACCHI, Sergio , DELPOGETTO, Monica , GUELFI, Simone , PERBONI, Alcide , RIBECAI, Arianna , SPADA, Simone , STABILE, Paolo , TAMPIERI, Marsia
IPC分类号： C07D471/04 , A61K31/437 , A61P1/00 , A61P25/00
CPC分类号： C07D471/04 , C07D207/22
摘要： The present invention relates to a novel process for preparing compounds of formula (IA), which are potent and specific antagonists of corticotropin-releasing factor (CRF) receptors, from intermediate compounds of formula (I), by a coupling reaction catalysed by copper (I) (Ia)wherein R is aryl or heteroaryl, each of which may be substituted by 1 to 4 groups selected from: halogen, C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkoxy, C(O)R 5 , nitro, -NR 6 R 7 , cyano, and a group R 8 ; R 1 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkyl, halo C1-C6 alkoxy, halogen, NR 6 R 7 or cyano; R 5 is a C1-C4 alkyl, -OR 6 or -NR 6 R 7 ; R 6 is hydrogen or C1-C6 alkyl; R 7 is hydrogen or C1-C6 alkyl; R 8 is a 5-6 membered heterocycle, which may be saturated or may contain one to three double bonds, and which may be substituted by 1 or more R 11 groups; R 9 is a C1-C6 alkyl that may be substituted by one or more groups selected from: C3-C7 cycloalkyl, C1-C6 alkoxy, haloC1-C6 alkoxy, hydroxy, haloC1-C6 alkyl; R11 is C3-C7 cycloalkyl, C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, or C(O)NR 6 R 7 ; X is halogen; and R'' corresponds to R; R'' 1 corresponds to R 1 ; R 2 is hydrogen, C3-C7 cycloalkyl, or a group R 9 ; R 3 is C3-C7 cycloalkyl, or a group R 9 ; or R 2 and R 3 together with N form a 5-14 membered heterocycle, which may be substituted by 1 to 3 R 10 groups; R'' 4 is hydrogen; R'' 5 corresponds to R 5 ; R'' 6 corresponds to R 6 ; R'' 7 corresponds to R 7 ; R'' 8 corresponds to R 8 ; R'' 9 corresponds to R 9 ; R 10 is a group R 8 , C3-C7 cycloalkyl, C1-C6 alkyl, C1-C6 alkoxy, halo C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, C(O)NR 6 R 7 , phenyl which may be substituted by 1 to 4 R 11 groups; R'' 11 corresponds to R 11 .
摘要翻译：本发明涉及由式（I）的中间体化合物通过铜催化的偶联反应制备式（IA）化合物的新方法，其为促肾上腺皮质激素释放因子（CRF）受体的有效和特异性拮抗剂 I）（Ia）其中R是芳基或杂芳基，其各自可以被1至4个选自以下的基团取代：卤素，C 1 -C 6烷基，C 1 -C 6烷氧基，卤代C 1 -C 6烷基，C 2 -C 6烯基，C 2 -C 6炔基，卤代C 1 -C 6烷氧基，C（O）R 5，硝基，-NR 6 R 7，氰基和基团R 8; R 1是氢，C 1 -C 6烷基，C 2 -C 6烯基，C 2 -C 6炔基，卤代C 1 -C 6烷基，卤代C 1 -C 6烷氧基，卤素，NR 6 R 7或氰基; R 5是C 1 -C 4烷基，-OR 6或-NR 6 R 7; R 6是氢或C 1 -C 6烷基; R 7是氢或C 1 -C 6烷基; R 8是5-6元杂环，其可以是饱和的或可以含有一至三个双键，并且其可以被1个或更多个R 11个基团取代; R 9是可以被一个或多个选自以下的基团取代的C 1 -C 6烷基：C 3 -C 7环烷基，C 1 -C 6烷氧基，卤代C 1 -C 6烷氧基，羟基，卤代C 1 -C 6烷基; R 11是C 3 -C 7环烷基，C 1 -C 6烷基，C 1 -C 6烷氧基，卤代C 1 -C 6烷基，C 2 -C 6烯基，C 2 -C 6炔基，卤代C 1 -C 6烷氧基，羟基，卤素，硝基，氰基或C（ O）NR _{6 - [R _{7 ; X是卤素; 并且R“对应于R; R“1 对应于R 1; R 2是氢，C 3 -C 7环烷基或基团R 9; R 3是C 3 -C 7环烷基或基团R 9; 或R 2和R 3与N一起形成5-14元杂环，其可以被1至3个R 10个基团取代; R“4是氢; R“5”对应于R 5; R“6”对应于R 6; R“7对应于R 7; R“8对应于R 8; R“9对应于R 9; R 10是基团R 8，C 3 -C 7环烷基，C 1 -C 6烷基，C 1 -C 6烷氧基，卤代C 1 -C 6烷基，C 2 -C 6链烯基， C 6炔基，卤代C 1 -C 6烷氧基，羟基，卤素，硝基，氰基，C（O）NR 6 R 7，可被1至4个R 11个组; R“”11“对应于R 11。}}

2. 发明申请

WO2012098400A1 PIPERAZINE DERIVATIVES AS CAV2.2 CALCIUM CHANNEL BLOCKERS 审中-公开
标题翻译：作为CAV2.2钙通道阻断剂的哌嗪衍生物
公开(公告)号：WO2012098400A1
公开(公告)日：2012-07-26
申请号：PCT/GB2012/050111
申请日：2012-01-19
申请人： CONVERGENCE PHARMACEUTICALS LIMITED , NORTON, David , ANDREOTTI, Daniele , WARD, Simon E , PROFETA, Roberto , SPADA, Simone , PRICE, Helen Susanne
发明人： NORTON, David , ANDREOTTI, Daniele , WARD, Simon E , PROFETA, Roberto , SPADA, Simone , PRICE, Helen Susanne
IPC分类号： C07D487/14 , A61K31/4985 , A61P3/14
CPC分类号： C07D471/14 , C07D487/14
摘要： The invention relates to novel piperazine compounds; to processes for their preparation; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Ca v 2.2 calcium channels is beneficial, i.e. in particular to treat pain.
摘要翻译：本发明涉及新型哌嗪化合物; 进行准备; 含有该化合物的药物组合物; 以及在治疗中使用化合物治疗阻断Cav2.2钙通道的疾病是有益的，即特别是治疗疼痛。

3. 发明申请

WO2006087169A1 COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE 审中-公开
标题翻译：可能的谷氨酸受体的化合物及其在医药中的应用
公开(公告)号：WO2006087169A1
公开(公告)日：2006-08-24
申请号：PCT/EP2006/001342
申请日：2006-02-13
申请人： GLAXO GROUP LIMITED , ANDREOTTI, Daniele , ARISTA, Luca , CARDULLO, Francesca , SPADA, Simone , THEWLIS, Kevin, Michael , WARD, Simon, Edward
发明人： ANDREOTTI, Daniele , ARISTA, Luca , CARDULLO, Francesca , SPADA, Simone , THEWLIS, Kevin, Michael , WARD, Simon, Edward
IPC分类号： C07D213/61 , C07D213/42 , C07D317/58 , C07D333/20 , C07D213/65 , C07D277/64 , A61K31/4418 , A61K31/36 , A61K31/381 , A61K31/426 , A61P25/18
CPC分类号： C07D277/64 , C07D213/42 , C07D213/61 , C07D213/65 , C07D317/58 , C07D333/20
摘要： This invention relates to potentiation of the glutamate receptor by novel compounds of formula (I): The invention also relates to the use of the derivatives in treating diseases and conditions mediated by potentiation of the glutamate receptor, compositions containing the derivatives and processes for their preparation.
摘要翻译：本发明涉及通过式（I）的新化合物增强谷氨酸受体：本发明还涉及该衍生物在治疗由谷氨酸受体增强介导的疾病和病症中的用途，含有衍生物的组合物及其制备方法。

4. 发明申请

WO2003066589A1 PIPERIDYLCARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF TACHYKINIM-MEDIATED DISEASES 审中-公开
标题翻译：哌啶甲酰胺衍生物及其在治疗TACHYKINIM介导性疾病中的应用
公开(公告)号：WO2003066589A1
公开(公告)日：2003-08-14
申请号：PCT/GB2003/000499
申请日：2003-02-05
申请人： GLAXO GROUP LIMITED , ALVARO, Giuseppe , PAIO, Alfredo , PONTIROLI, Alessandro , SPADA, Simone , TRANQUILLINI, Maria, Elvira
发明人： ALVARO, Giuseppe , PAIO, Alfredo , PONTIROLI, Alessandro , SPADA, Simone , TRANQUILLINI, Maria, Elvira
IPC分类号： C07D211/58
CPC分类号： C07D401/04 , C07D211/58 , C07D405/12
摘要： The present invention relates to piperidine derivatives of formula (I) wherein R represents halogen or C 1-4 alkyl; R 1 represents hydrogen or C 1-4 alkyl; R 2 represents hydrogen , C 1-4 alkyl or R 2 together with R 3 represents C 3-7 cycloalkyl; R 3 represents hydrogen, C 1-4 alkyl, C 3-7 cycloalkyl or C 3-6 alkenyl; or R 1 and R 3 together with nitrogen and carbon atom to which they are attached respectively represent a 5 to 6 membered heterocyclic group; R 4 represents trifluoromethyl, C 1-4 alkyl, C 1-4 alkoxy, trifluoromethoxy or halogen; R is hydrogen and R is NR 7 R 8 or R 5 is NR 8 R 9 and R 6 is hydrogen; R 7 represents hydrogen or C 1-4 alkyl or R 7 and R 8 together with nitrogen to which they are attached are a saturated 5 to 7 membered heterocyclic group containing oxygen; R 8 represents hydrogen, phenyl, C 3-7 cycloalkyl, (CH2)pC(O)NR 10 R 11 , a saturated 5 to 7 membered heterocyclic group containing 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen and optionally substituted by C 1-4 alkyl, S(O) 2 C 1-4 alkyl or C(O) C 1-4 alkyl, a 5 membered heteroaryl group containing 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen and optionally substituted by C 1-4 alkyl S(O) 2 C 1-4 alkyl or C(O) C 1-4 alkyl or R 8 represents a 6 membered heteroaryl group containing 1 to 3 nitrogen atoms and optionally substituted by C 1-4 alkyl, S(O) 2 C 1-4 alkyl or C(O) C 1-4 alkyl; or R 8 is a C 1-6 alkyl group optionally substituted by one or two groups selected from fluorine, phenyl(optionally substituted by C 1-4 alkyl, C(O) C 1-4 alkyl or halogen), =O, C 3-7 cycloalkyl, hydroxy, amino, dimethylamino, aminocarbonyl, C 1-4 alkoxy or trifluoromethyl; R 9 is hydrogen, C 1-4 alkyl or R 9 and R 8 together with nitrogen to which they are attached are a 5 to 7 membered heterocyclic group optionally containing another heroatom selected from oxygen, sulphur and nitrogen and optionally substituted by one or two groups selected from C 1-4 alkyl, =O, S(O) 2 C 1-4 alkyl, C(O) C 3-7 cycloalkyl or C(O) C 1-4 alkyl; R 10 and R 11 are independently hydrogen or C 1-4 alkyl group; X represents a nitrogen atom and Y is CH or X represents CH and Y is nitrogen;m is zero or an integer from 1 to 3; n is an integer from 1 to 3; p is zero, 1 or 2; and pharmaceutically acceptable salts and solvates thereof; the process for their preparation and their use in the treatment of conditions mediated by tachykinins.
摘要翻译：本发明涉及式I的哌啶衍生物，其中R表示卤素或C 1-4烷基R 1表示氢或C 1-4烷基R 2表示氢，C 1-4烷基或R 2与R 3表示C 3-7环烷基R 3表示氢，C 1 -4-烷基，C 3-7环烷基或C 3-6烯基或R 1和R 3与它们所连接的氮原子和碳原子分别表示5至6元杂环基，R 4表示三氟甲基，C 1-4烷基，C 1-4烷氧基，三氟甲氧基或卤素R是氢，R是NR7R8或R5是NR8R9，R6是氢，R7代表氢或C1-4烷基或R7和R8与它们所连接的氮一起是含有氧的饱和5至7元杂环基 R 8表示氢，苯基，C 3-7环烷基，CH 2 pCONR 10 R 11，饱和5至7元杂环基，其含有1-3个选自氧，硫和氮的杂原子，且任选被C 1-4烷基，SO 2 C 1-4烷基或 CO C 1-4烷基，含有1至3个选自氧，硫和氮的杂原子并且任选被C 1-4烷基SO 2 C 1-4烷基或CO C 1-4烷基取代的5元杂芳基或R 8表示含有 1至3个氮原子，任选被C 1-4烷基，SO 2 C 1-4烷基或CO C 1-4烷基取代，或R 8是任选被一个或两个选自氟取代的C1-6烷基，被氟取代，被C1-4烷基取代烷基，CO C 1-4烷基或卤素，= O，C 3-7环烷基，羟基，氨基，二甲基氨基，氨基羰基，C 1-4烷氧基或三氟甲基R 9是氢，C 1-4烷基或R 9和R 8与它们任选地含有选自氧，硫和氮的另一个主原子，并且任选被一个或两个选自C 1-4烷基，O，SO 2 C 1-4烷基，CO C 3-7环烷基或基团的基团取代的5至7元杂环基， CO C 1-4烷基R 10和R 11独立地是氢或C 1-4烷基基团X表示氮原子，Y表示CH或X表示CH，Y表示氮

5. 发明申请

WO2007080159A2 COMPOUNDS HAVING ACTIVITY AT THE GLYCINE TRANSPORTER GLYT1 AND USES THEREOF 审中-公开
标题翻译：在GLYCINE TRANSPORTER GLYT1中具有活性的化合物及其用途
公开(公告)号：WO2007080159A2
公开(公告)日：2007-07-19
申请号：PCT/EP2007/050157
申请日：2007-01-08
申请人： GLAXO GROUP LIMITED , BRANCH, Clive, Leslie , MARSHALL, Howard , MCCRITCHIE, Jackie , PORTER, Roderick, Alan , SPADA, Simone
发明人： BRANCH, Clive, Leslie , MARSHALL, Howard , MCCRITCHIE, Jackie , PORTER, Roderick, Alan , SPADA, Simone
CPC分类号： C07D333/38 , C07D213/70 , C07D261/18
摘要： The present invention relates to compounds of formula (I), salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. Formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are as defined in the description.
摘要翻译：本发明涉及式（I）化合物，其盐或溶剂化物，它们在制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物中的用途。本发明还包括制备这些化合物及其药物制剂的方法。式（I）其中R 1，R 2，R 3，R 4，R 4， 5，R 6和n如说明书中所定义。

6. 发明申请

WO2006067437A1 OXYGEN CONTAINING HETEROCYCLES AS GLYCINE TRANSPORTER INHIBITING COMPOUNDS 审中-公开
标题翻译：含氧化合物作为甘氨酸运输抑制剂的含氧化合物
公开(公告)号：WO2006067437A1
公开(公告)日：2006-06-29
申请号：PCT/GB2005/004969
申请日：2005-12-21
申请人： GLAXO GROUP LIMITED , BOZZOLI, Andrea , BRANCH, Clive, Leslie , MACRITCHIE, Jacqueline, Anne , MARSHALL, Howard, Robert , PORTER, Roderick, Alan , SPADA, Simone
发明人： BOZZOLI, Andrea , BRANCH, Clive, Leslie , MACRITCHIE, Jacqueline, Anne , MARSHALL, Howard, Robert , PORTER, Roderick, Alan , SPADA, Simone
IPC分类号： C07D307/84 , A61K31/343 , A61P25/00
CPC分类号： C07D307/84 , C07D317/48
摘要： The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. Formula (I) wherein R1 is a group selected from:
摘要翻译：本发明涉及式（I）化合物或其盐或溶剂合物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。本发明还包括制备这些化合物及其药物制剂的方法。式（I）其中R1是选自：

7. 发明申请

WO2006067430A1 2-AMINO-1-PHENYLETHYLCARBOXAMIDE DERIVATIVES 审中-公开
标题翻译： 2-氨基-1-苯基乙酰胺衍生物
公开(公告)号：WO2006067430A1
公开(公告)日：2006-06-29
申请号：PCT/GB2005/004960
申请日：2005-12-21
申请人： GLAXO GROUP LIMITED , BOZZOLI, Andrea , BRANCH, Clive Leslie , MACRITCHIE, Jacqueline, Anne , MARSHALL, Howard, Robert , PORTER, Roderick, Alan , SPADA, Simone
发明人： BOZZOLI, Andrea , BRANCH, Clive Leslie , MACRITCHIE, Jacqueline, Anne , MARSHALL, Howard, Robert , PORTER, Roderick, Alan , SPADA, Simone
IPC分类号： C07D215/48 , C07C233/80 , A61K31/166 , A61K31/47 , C07D215/50 , A61P25/00
CPC分类号： C07C255/57 , C07C233/78 , C07C235/66 , C07C237/48 , C07C2601/08 , C07C2602/08 , C07D215/50 , C07D295/135 , C07D405/12
摘要： The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. Formula (I) wherein R 1 is a group selected from: Formulas (A), (B), (C)
摘要翻译：本发明涉及式（I）化合物或其盐或溶剂化物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。本发明还包括制备这些化合物及其药物制剂的方法。式（I）其中R 1是选自：式（A），（B），（C）

8. 发明申请

WO2006067423A1 GLYCINE TRANSPORT INHIBITORS 审中-公开
标题翻译：甘氨酸运输抑制剂
公开(公告)号：WO2006067423A1
公开(公告)日：2006-06-29
申请号：PCT/GB2005/004951
申请日：2005-12-21
申请人： GLAXO GROUP LIMITED , BRADLEY, Daniel, Marcus , BRANCH, Clive, Leslie , CHAN, Wai, Ngor , COULTON, Steven , GILPIN, Martin, Leonard , HARRIS, Andrew, Jonathan , JAXA-CHAMIEC, Albert, Andrzej , LAI, Justine, Yeun, Quai , MARSHALL, Howard, Robert , MACRITCHIE, Jacqueline, Anne , NASH, David, John , PORTER, Roderick, Alan , SPADA, Simone , THEWLIS, Kevin, Michael , WARD, Simon, Edward
发明人： BRADLEY, Daniel, Marcus , BRANCH, Clive, Leslie , CHAN, Wai, Ngor , COULTON, Steven , GILPIN, Martin, Leonard , HARRIS, Andrew, Jonathan , JAXA-CHAMIEC, Albert, Andrzej , LAI, Justine, Yeun, Quai , MARSHALL, Howard, Robert , MACRITCHIE, Jacqueline, Anne , NASH, David, John , PORTER, Roderick, Alan , SPADA, Simone , THEWLIS, Kevin, Michael , WARD, Simon, Edward
IPC分类号： C07C233/78 , A61K31/166 , C07C211/36
CPC分类号： C07C233/78 , C07C235/50 , C07C235/60 , C07C323/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/20 , C07D209/02 , C07D295/13 , C07D307/22
摘要： The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
摘要翻译：本发明涉及式（I）化合物或其盐或溶剂化物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。本发明还包括制备这些化合物及其药物制剂的方法。

9. 发明申请

WO2003066635A1 PIPERIDINE DERIVATIVES 审中-公开
标题翻译：哌啶衍生物
公开(公告)号：WO2003066635A1
公开(公告)日：2003-08-14
申请号：PCT/EP2003/001308
申请日：2003-02-10
申请人： GLAXO GROUP LIMITED , ALVARO, Giuseppe , DI FABIO, Romano , TRANQUILLINI, Maria, Elvira , SPADA, Simone
发明人： ALVARO, Giuseppe , DI FABIO, Romano , TRANQUILLINI, Maria, Elvira , SPADA, Simone
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/445
摘要： The present invention relates to piperidine derivatives of formula (I): R represents halogen or C 1-4 alkyl; R 1 represents C 1-4 alkyl; R 2 or R 3 independently represent hydrogen or C 1-4 alkyl; R 4 represents trifluoromethyl, C 1-4 alkyl, C 1-4 alkoxy, trifluoromethoxy or halogen; R 5 represents hydrogen , C 1-4 alkyl or C 3-7 cycloalkyl; R 6 is hydrogen and R 7 is a radical of formula (W): R 6 is a radical of formula (W) and R 7 is hydrogen; X represents CH 2 , NR 5 or O; Y represents Nitrogen and Z is CH or Y represents CH and Z is Nitrogen; A represents C(O) or S(O)q, provided that when Y is nitrogen and Z is CH, A is not S(O)q; m is zero or an integer from 1 to 3; n is an integer from 1 to 3; p and q are independently an integer from 1 to 2; and pharmaceutically acceptable salts and solvates thereof. The process for their preparation and their use in the treatment of condition mediated by tachykinins.
摘要翻译：本发明涉及式（I）的哌啶衍生物：R代表卤素或C 1-4烷基; R1表示C1-4烷基; R2或R3独立地表示氢或C1-4烷基; R 4表示三氟甲基，C 1-4烷基，C 1-4烷氧基，三氟甲氧基或卤素; R5代表氢，C1-4烷基或C3-7环烷基; R6是氢，R7是式（W）的基团：R6是式（W）的基团，R7是氢; X表示CH 2，NR 5或O; Y表示氮，Z表示CH或Y表示CH，Z表示氮; A表示C（O）或S（O）q，条件是当Y为氮且Z为CH时，A不为S（O）q; m为0或1〜3的整数; n为1〜3的整数， p和q独立地为1至2的整数; 及其药学上可接受的盐和溶剂化物。其制备方法及其用于治疗由速激肽介导的病症。

10. 发明申请

WO2006067417A1 GLYCINE TRANSPORT INHIBITORS 审中-公开
标题翻译：甘氨酸运输抑制剂
公开(公告)号：WO2006067417A1
公开(公告)日：2006-06-29
申请号：PCT/GB2005/004943
申请日：2005-12-21
申请人： GLAXO GROUP LIMITED , BRADLEY, Daniel, Marcus , BRANCH, Clive, Leslie , CHAN, Wai, Ngor , COULTON, Steven , GILPIN, Martin, Leonard , HARRIS, Andrew, Jonathan , LAI, Justine, Yeun, Quai , MARSHALL, Howard, Robert , MACRITCHIE, Jacqueline, Anne , NASH, David, John , PORTER, Roderick, Alan , SPADA, Simone , THEWLIS, Kevin, Michael , WARD, Simon, Edward
发明人： BRADLEY, Daniel, Marcus , BRANCH, Clive, Leslie , CHAN, Wai, Ngor , COULTON, Steven , GILPIN, Martin, Leonard , HARRIS, Andrew, Jonathan , LAI, Justine, Yeun, Quai , MARSHALL, Howard, Robert , MACRITCHIE, Jacqueline, Anne , NASH, David, John , PORTER, Roderick, Alan , SPADA, Simone , THEWLIS, Kevin, Michael , WARD, Simon, Edward
IPC分类号： C07C233/78 , A61K31/166 , C07C211/27
CPC分类号： C07C235/60 , C07C211/27 , C07C233/78 , C07C235/50 , C07C323/62
摘要： The present invention relates to compounds of Formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
摘要翻译：本发明涉及式（I）化合物或其盐或溶剂合物，它们在制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物中的用途。本发明还包括制备这些化合物及其药物制剂的方法。

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