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1. 发明申请

WO2009147165A1 NOVEL EP4 RECEPTOR AGONIST COMPOUNDS 审中-公开
标题翻译：新EP4受体激动剂化合物
公开(公告)号：WO2009147165A1
公开(公告)日：2009-12-10
申请号：PCT/EP2009/056789
申请日：2009-06-03
申请人： GLAXO GROUP LIMITED , GAIBA, Alessandra , HEALY, Mark, Patrick , PRICE, Helen, Susanne , STANWAY, Steven, James , SWARBRICK, Martin, Edward
发明人： GAIBA, Alessandra , HEALY, Mark, Patrick , PRICE, Helen, Susanne , STANWAY, Steven, James , SWARBRICK, Martin, Edward
IPC分类号： C07C235/64 , C07C237/40 , A61K31/192 , A61K31/196 , A61P19/08
CPC分类号： C07C235/64 , C07C237/40
摘要： A compound selected from the group consisting of: (3-chloro-4-{[(5-chloro-2-{[(2- chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; {3-chloro-4-[({5-chloro-2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (3-chloro-4-{[(5-chloro-2-{[(3- chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}-2- fluorophenyl)acetic acid; {3-chloro-4-[({2-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (3-chloro-4-{[(2-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({2-chloro-6-[(phenylmethyl)oxy]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(2-chloro-6-{[(3-chlorophenyl)methyl]oxy}phenyl)carbonyl]amino}phenyl)acetic acid; {4-[({5-chloro-2-[(phenylmethyl)amino]phenyl}carbonyl)amino]phenyl}acetic acid; (4-{[(5-chloro-2-{[(3-chlorophenyl)methyl]amino}phenyl)carbonyl]amino}phenyl)acetic acid; and (4-{[(5-chloro-2-{[(2-chlorophenyl)methyl]amino}phenyl)carbonyl]amino}phenyl)acetic acid, or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
摘要翻译：选自：（3-氯-4 - {[（5-氯-2 - {[（2-氯苯基）甲基]氧基}苯基）羰基]氨基}苯基）乙酸的化合物。 {4 - [（{5-氯-2 - [（苯基甲基）氧基]苯基}羰基）氨基]苯基}乙酸; {3-氯-4 - [（{5-氯-2 - [（苯基甲基）氧基]苯基}羰基）氨基]苯基}乙酸; （3-氯-4 - {[（5-氯-2 - {[（3-氯苯基）甲基]氧基}苯基）羰基]氨基}苯基）乙酸; {4 - [（{2 - [（苯基甲基）氧基]苯基}羰基）氨基]苯基}乙酸; （4 - {[（5-氯-2 - {[（3-氯苯基）甲基]氧基}苯基）羰基]氨基} -2-氟苯基）乙酸; {3-氯-4 - [（{2 - [（苯基甲基）氧基]苯基}羰基）氨基]苯基}乙酸; （3-氯-4 - {[（2 - {[（3-氯苯基）甲基]氧基}苯基）羰基]氨基}苯基）乙酸 {4 - [（{2-氯-6 - [（苯基甲基）氧基]苯基}羰基）氨基]苯基}乙酸; （4 - {[（2-氯-6 - {[（3-氯苯基）甲基]氧基}苯基）羰基]氨基}苯基）乙酸; {4 - [（{5-氯-2 - [（苯基甲基）氨基]苯基}羰基）氨基]苯基}乙酸; （4 - {[（5-氯-2 - {[（3-氯苯基）甲基]氨基}苯基）羰基]氨基}苯基）乙酸; 和（4 - {[（5-氯-2 - {[（2-氯苯基）甲基]氨基}苯基）羰基]氨基}苯基）乙酸或其药学上可接受的盐，包含这些化合物的药物组合物和药物中的这种化合物。

2. 发明申请

WO2009083526A1 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO2009083526A1
公开(公告)日：2009-07-09
申请号：PCT/EP2008/068150
申请日：2008-12-22
申请人： SMITHKLINE BEECHAM CORPORATION , BLANC, Jean-Baptiste, Emmanuel , ALLAN, Amanda, Claire , FIELDHOUSE, Charlotte , GIBLIN, Gerard, Martin, Paul , GIBSON, Mairi , HEALY, Mark, Patrick , JANDU, Karamjit, Singh , LAMBERT III, Millard, Hurst , PRICE, Helen Susanne , SHEARER, Barry, George
发明人： BLANC, Jean-Baptiste, Emmanuel , ALLAN, Amanda, Claire , FIELDHOUSE, Charlotte , GIBLIN, Gerard, Martin, Paul , GIBSON, Mairi , HEALY, Mark, Patrick , JANDU, Karamjit, Singh , LAMBERT III, Millard, Hurst , PRICE, Helen Susanne , SHEARER, Barry, George
IPC分类号： C07D235/06 , C07D235/08 , C07D235/10 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , A61K31/4184 , A61P3/10 , A61P25/28
CPC分类号： C07D235/10 , C07D235/06 , C07D235/08 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12
摘要： The invention relates to novel benzimidazole compounds of formula (I) wherein R 1 to R 1 are as defined in the specification, pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds that are agonists of peroxisome proliferators-activated receptorγ (PPARγ).
摘要翻译：本发明涉及式（I）的新型苯并咪唑化合物，其中R 1至R 1如本说明书中所定义，其药学上可接受的盐，含有它们的药物组合物及其在药物中的用途。特别地，本发明涉及作为过氧化物酶体增殖物激活受体的激动剂的化合物（PPAR？）。

3. 发明申请

WO2009050227A1 PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION 审中-公开
标题翻译：抑制β-淀粉样肽生产的吡啶衍生物
公开(公告)号：WO2009050227A1
公开(公告)日：2009-04-23
申请号：PCT/EP2008/063950
申请日：2008-10-16
申请人： GLAXO GROUP LIMITED , EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , HALL, Adrian , JOHNSON, Matthew, Russell , LE, Joelle , MITCHELL, William, Leonard , MYATT, James , NORTON, David , PRICE, Helen, Susanne
发明人： EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , HALL, Adrian , JOHNSON, Matthew, Russell , LE, Joelle , MITCHELL, William, Leonard , MYATT, James , NORTON, David , PRICE, Helen, Susanne
IPC分类号： C07D403/10 , A61K31/501
CPC分类号： C07D403/10
摘要： The present invention relates to novel compounds that inhibit the production of β- amyloid peptide (1-42), processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.
摘要翻译：本发明涉及抑制β-淀粉样蛋白肽（1-42）的制备，其制备方法，含有它们的组合物及其用于治疗特征在于β-淀粉样蛋白升高或β- 淀粉样沉积物，特别是阿尔茨海默氏病。

4. 发明申请

WO2007088189A1 BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的苯并噻唑衍生物
公开(公告)号：WO2007088189A1
公开(公告)日：2007-08-09
申请号：PCT/EP2007/050991
申请日：2007-02-01
申请人： GLAXO GROUP LIMITED , HEALY, Mark, Patrick , GIBLIN, Gerard, Martin, Paul , PRICE, Helen, Susanne
发明人： HEALY, Mark, Patrick , GIBLIN, Gerard, Martin, Paul , PRICE, Helen, Susanne
IPC分类号： C07D209/64 , C07D209/66 , A61K31/4035 , A61P25/02
CPC分类号： C07D209/64 , C07D209/66
摘要： A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R 1 , R 2 , R 3 , X and Y are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
摘要翻译：其中R 1，R 2，R 3，X和Y分别是如说明书中所定义; 制备这种化合物的方法; 包含这些化合物的药物组合物; 并在药物中使用这些化合物。

5. 发明申请

WO2006114313A1 PYRAZOLE COMPOUNDS AS PROSTAGLANDIN RECEPTORS LIGANDS 审中-公开
标题翻译：作为PROSTAGLANDIN受体配体的吡咯化合物
公开(公告)号：WO2006114313A1
公开(公告)日：2006-11-02
申请号：PCT/EP2006/003919
申请日：2006-04-24
申请人： GLAXO GROUP LIMITED , CONWAY, Elizabeth, Ann , GIBLIN, Gerard, Martin, Paul , GIBSON, Mairi , HALL, Adrian , HAYHOW, Thomas, George, Christopher , HEALY, Mark, Patrick , HURST, David, Nigel , KILFORD, Ian, Reginald , MCKEOWN, Stephen, Carl , NAYLOR, Alan , PRICE, Helen Susanne , RAWLINGS, Derek Anthony
发明人： CONWAY, Elizabeth, Ann , GIBLIN, Gerard, Martin, Paul , GIBSON, Mairi , HALL, Adrian , HAYHOW, Thomas, George, Christopher , HEALY, Mark, Patrick , HURST, David, Nigel , KILFORD, Ian, Reginald , MCKEOWN, Stephen, Carl , NAYLOR, Alan , PRICE, Helen Susanne , RAWLINGS, Derek Anthony
IPC分类号： A61K31/4155 , C07D231/14 , C07D231/20 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/04 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12
CPC分类号： C07D231/40 , C07D231/14 , C07D231/20 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein Z, R 1 ,R 2a , R 2b , R 10 , R 11 and R x are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其药学上可接受的衍生物：其中Z，R 1，R 2a，R 2b，R 2b， 10，R 11和R x如本说明书中所定义，制备这些化合物的方法，包含这些化合物的药物组合物和使用药物中的这种化合物。

6. 发明申请

WO2012098400A1 PIPERAZINE DERIVATIVES AS CAV2.2 CALCIUM CHANNEL BLOCKERS 审中-公开
标题翻译：作为CAV2.2钙通道阻断剂的哌嗪衍生物
公开(公告)号：WO2012098400A1
公开(公告)日：2012-07-26
申请号：PCT/GB2012/050111
申请日：2012-01-19
申请人： CONVERGENCE PHARMACEUTICALS LIMITED , NORTON, David , ANDREOTTI, Daniele , WARD, Simon E , PROFETA, Roberto , SPADA, Simone , PRICE, Helen Susanne
发明人： NORTON, David , ANDREOTTI, Daniele , WARD, Simon E , PROFETA, Roberto , SPADA, Simone , PRICE, Helen Susanne
IPC分类号： C07D487/14 , A61K31/4985 , A61P3/14
CPC分类号： C07D471/14 , C07D487/14
摘要： The invention relates to novel piperazine compounds; to processes for their preparation; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Ca v 2.2 calcium channels is beneficial, i.e. in particular to treat pain.
摘要翻译：本发明涉及新型哌嗪化合物; 进行准备; 含有该化合物的药物组合物; 以及在治疗中使用化合物治疗阻断Cav2.2钙通道的疾病是有益的，即特别是治疗疼痛。

7. 发明申请

WO2008020055A1 NOVEL ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS 审中-公开
标题翻译：新的ISOINDOL衍生物作为EP4受体激动剂
公开(公告)号：WO2008020055A1
公开(公告)日：2008-02-21
申请号：PCT/EP2007/058514
申请日：2007-08-16
申请人： GLAXO GROUP LIMITED , GIBLIN, Gerard Martin Paul , HEALY, Mark Patrick , LIVERMORE, David George , PRICE, Helen Susanne , SWARBRICK, Martin Edward
发明人： GIBLIN, Gerard Martin Paul , HEALY, Mark Patrick , LIVERMORE, David George , PRICE, Helen Susanne , SWARBRICK, Martin Edward
IPC分类号： C07D209/46 , C07D209/48 , A61K31/4035 , A61P25/00
CPC分类号： C07D209/46 , C07D209/48
摘要： A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R 1 , R 2 , R 3 , R 4 and R 5 , X and Y are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中R 1，R 2，R 3，R 3， 4和R 5，X和Y如说明书中所定义; 制备这种化合物的方法; 包含这些化合物的药物组合物; 并在药物中使用这些化合物。

8. 发明申请

WO2008012347A1 BENZO [F] ISOINDOLES AS EP4 RECEPTOR AGONISTS 审中-公开
标题翻译： BENZO [F] ISOINDOLES作为EP4受体激动剂
公开(公告)号：WO2008012347A1
公开(公告)日：2008-01-31
申请号：PCT/EP2007/057716
申请日：2007-07-26
申请人： GLAXO GROUP LIMITED , GIBLIN, Gerard Martin Paul , HEALY, Mark Patrick , PRICE, Helen Susanne
发明人： GIBLIN, Gerard Martin Paul , HEALY, Mark Patrick , PRICE, Helen Susanne
IPC分类号： C07D209/64 , C07D209/66 , A61P21/00
CPC分类号： C07D209/64 , C07D209/66
摘要： The present invention relates to naphthalene derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.
摘要翻译：本发明涉及萘衍生物，其制备方法，含有它们的药物组合物及其在医药中的用途。

9. 发明申请

WO2008012344A1 NAPHTHALENE DERIVATIVES USED AS EP4 RECEPTOR AGONISTS 审中-公开
标题翻译：用作EP4受体激动剂的萘普生衍生物
公开(公告)号：WO2008012344A1
公开(公告)日：2008-01-31
申请号：PCT/EP2007/057711
申请日：2007-07-26
申请人： GLAXO GROUP LIMITED , GIBLIN, Gerard Martin Paul , HEALY, Mark Patrick , PRICE, Helen Susanne
发明人： GIBLIN, Gerard Martin Paul , HEALY, Mark Patrick , PRICE, Helen Susanne
IPC分类号： C07D209/64 , C07D209/66 , A61K31/4015 , A61P25/00
CPC分类号： C07D209/64 , C07D209/66
摘要： A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R 1 R 2 R 3 , X and Y are as defined in the specification; a process fo preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds as EP 4 receptor agonists.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中R 1，R 2，R 3，X和Y如上定义在规范中; 制备这种化合物的方法; 包含这些化合物的药物组合物; 以及使用这些化合物作为EP 4受体激动剂。

10. 发明申请

WO2008061955A1 BENZOISOINDOLE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR AGONISTS 审中-公开
标题翻译：苯并噻唑衍生物及其作为EP4受体激动剂的用途
公开(公告)号：WO2008061955A1
公开(公告)日：2008-05-29
申请号：PCT/EP2007/062497
申请日：2007-11-19
申请人： GLAXO GROUP LIMITED , GIBLIN, Gerard, Martin, Paul , HEALY, Mark, Patrick , PRICE, Helen, Susanne
发明人： GIBLIN, Gerard, Martin, Paul , HEALY, Mark, Patrick , PRICE, Helen, Susanne
IPC分类号： C07D209/64 , C07D209/66 , A61K31/403 , A61P25/00
CPC分类号： C07D209/64 , C07D209/66
摘要： The present invention relates to benzoisoindole phenylacetic acid derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine as EP4 receptor organists.
摘要翻译：本发明涉及苯并异吲哚苯乙酸衍生物，其制备方法，含有它们的药物组合物及其作为EP4受体器官的医药用途。

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