专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1992004332A1 IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：咪唑衍生物，其制备和药物组合物
公开(公告)号：WO1992004332A1
公开(公告)日：1992-03-19
申请号：PCT/GB1991001544
申请日：1991-09-10
申请人： SMITH KLINE & FRENCH LABORATORIES LIMITED , HICKEY, Deirdre, Mary, Bernadette , COOPER, David, Gwynn , JAXA-CHAMIEC, Albert, Andrzej
发明人： SMITH KLINE & FRENCH LABORATORIES LIMITED
IPC分类号： C07D233/70
CPC分类号： C07D403/12 , C07D233/70 , C07D233/84 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07F9/6506
摘要： Substituted 4,5-diaryl-2-alkoxyimidazoles of structure (I), in which each group Ar is the same or different and is optionally substituted phenyl or optionally substituted heteroaryl; R is hydrogen, alkyl, optionally substituted phenyl or optionally substituted heteroaryl; Y is oxygen or sulphur; n is 4 to 12; and X is 5-tetrazolyl, SO3H, P(O)(OR)2, P(O)(OH)2, or P(O)(R)(OR) in which R is hydrogen or alkyl, or a pharmaceutically acceptable salt thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, inter alia, in the treatment of cardiovascular disorders.
摘要翻译：结构（I）的取代的4,5-二芳基-2-烷氧基咪唑，其中每个基团Ar相同或不同，并且是任选取代的苯基或任选取代的杂芳基; R 1是氢，烷基，任选取代的苯基或任选取代的杂芳基; Y是氧或硫; n为4〜12; 和X是其中R是氢或烷基的5-四唑基，SO 3 H，P（O）（OR）2，P（O）（OH）2或P（O）（R）（OR）其盐，其制备方法，含有它们的药物组合物及其在治疗中的用途，尤其用于治疗心血管疾病。

2. 发明申请

WO2008092874A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译： GLYT1运输商抑制剂及其在治疗神经病学和神经病学疾病中的应用
公开(公告)号：WO2008092874A1
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051079
申请日：2008-01-30
申请人： GLAXO GROUP LIMITED , UNIVERSITY OF NOTTINGHAM , AHMAD, Nadia, Mamoona , ANDREOTTI, Daniele , JAXA-CHAMIEC, Albert, Andrzej , LAI, Justine, Yeun Quai
发明人： AHMAD, Nadia, Mamoona , ANDREOTTI, Daniele , JAXA-CHAMIEC, Albert, Andrzej , LAI, Justine, Yeun Quai
IPC分类号： C07D235/02 , A61K31/4166 , A61P25/00 , A61P25/18 , A61P25/28
CPC分类号： C07D235/02
摘要： Compounds of Formula (I) or a salt thereof are provided: wherein R 6 , R 7 , R 8 , R 9 , X, Ar, n, and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.
摘要翻译：提供式（I）化合物或其盐：其中R 6，R 7，R 8，R 9， / SUP>，X，Ar，n和m如说明书中所定义。还公开了化合物作为药物的用途，以及用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物的制备。本发明还公开了包含该化合物的药物组合物和组合。

3. 发明申请

WO2003089409A1 COMPOUNDS HAVING AFFINITY AT 5HT2C RECEPTOR AND USE THEREOF IN THERAPY 审中-公开
标题翻译：在5HT2C受体中具有亲和力的化合物及其治疗用途
公开(公告)号：WO2003089409A1
公开(公告)日：2003-10-30
申请号：PCT/EP2003/004180
申请日：2003-04-17
申请人： GLAXO GROUP LIMITED , DAMIANI, Federica , HAMPRECHT, Dieter , JAXA-CHAMIEC, Albert, Andrzej , MICHELI, Fabrizio , PASQUARELLO, Alessandra , TEDESCO, Giovanna
发明人： DAMIANI, Federica , HAMPRECHT, Dieter , JAXA-CHAMIEC, Albert, Andrzej , MICHELI, Fabrizio , PASQUARELLO, Alessandra , TEDESCO, Giovanna
IPC分类号： C07D207/26
CPC分类号： C07D207/26 , C07D207/273 , C07D207/38 , C07D211/76 , C07D211/88 , C07D401/12
摘要： Compounds of formula (I) or a pharmaceutically acceptable salt thereof are disclosed: wherein R 1 is hydrogen, hydroxy, fluoro, chloro, C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyloxy, C 1-6 alkoxy or haloC 1-6 alkoxy; m is 0 when ======= is a double bond and m is 1 when ======= is a single bond; R 2 is hydrogen, halogen, cyano, nitro, C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyloxy, haloC 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkoxy, C 1-6 alkylthio, amino, mono- or di-C 1-6 alkylamino or an N-linked 4 to 7 membered heterocyclic group; X is -(CH 2 -CH 2 )-, -(CH=CH)-, -(CH 2 ) 3 -, -C(CH 3 ) 2 -, -(CH=CH-CH 2 )-, -(CH 2 -CH=CH)- or a group -(CHR 5 )- wherein R 5 is hydrogen, halogen, hydroxy, cyano, nitro, C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyloxy, haloC 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkoxy or C 1-6 alkylthio; R 3 is halogen, cyano, C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyloxy, C 1-6 alkoxy, C 1-6 alkylthio, hydroxy, amino, mono- or di-C 1-6 alkylamino, an N-linked 4 to 7 membered heterocyclic group, nitro, haloC 1-6 alkyl, haloC 1-6 alkoxy, aryl, arylC 1-6 alkyl, arylC 1-6 alkyloxy, arylC 1-6 alkylthio or COOR 6 , CONR 7 R 8 or COR 9 wherein R 6 , R 7 , R 8 and R 9 are independently hydrogen or C 1-6 alkyl; p is 0, 1 or 2 or 3; R 4 is hydrogen, halogen, hydroxy, cyano, nitro, C 1-6 alkyl, C 1-6 alkanoyl, C 3-7 cycloalkyl, C 3-7 cycloalkyloxy, haloC 1-6 alkyl, C 1-6 alkoxy, haloC 1-6 alkoxy, C 1-6 alkylthio, amino, mono- or di-C 1-6 alkylamino or an N-linked 4 to 7 membered heterocyclic group; Y is oxygen, sulfur, -CH 2 - or NR 10 wherein R 10 is hydrogen or C 1-6 alkyl; D is a single bond, -CH 2 -, -(CH 2 ) 2 - or -CH=CH-; and Z is an optionally substituted C-linked 4 to 7 membered heterocyclic group containing at least one nitrogen, an optionally substituted N-linked 4 to 7 membered heterocyclic group, or Z is -NR 11 R 12 where R 11 and R 12 are independently hydrogen or C 1-6 alkyl. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression and anxiety, are also disclosed.
摘要翻译：公开了式（I）化合物或其药学上可接受的盐：其中R 1是氢，羟基，氟，氯，C 1-6烷基，C 3-7环烷基，C 3-7环烷氧基，C 1-6烷氧基或卤代C 1-6烷氧基; 当<=======>是双键时，m为0，当<=======>为单键时，m为1; R2是氢，卤素，氰基，硝基，C1-6烷基，C3-7环烷基，C3-7环烷氧基，卤代C 1-6烷基，C 1-6烷氧基，卤代C 1-6烷氧基，C 1-6烷硫基，氨基，单或二C 1-6烷基氨基或 N-连接的4至7元杂环基; X是 - （CH 2 -CH 2） - ， - （CH = CH） - ， - （CH 2）3 - ， - C（CH 3）2 - ， - （CH = CH-CH 2） - ， - （CH 2 -CH = CH ） - 或基 - （CHR 5） - ，其中R 5是氢，卤素，羟基，氰基，硝基，C 1-6烷基，C 3-7环烷基，C 3-7环烷氧基，卤代C 1-6烷基，C 1-6烷氧基，卤代C 1-6烷氧基或C 1-6烷硫基 ; R 3是卤素，氰基，C 1-6烷基，C 3-7环烷基，C 3-7环烷氧基，C 1-6烷氧基，C 1-6烷硫基，羟基，氨基，单 - 或二-C 1-6烷基氨基，N-连接的4-7元杂环基，硝基，卤代C 1-6烷基，卤代C 1-6烷氧基，芳基，芳基C 1-6烷基，芳基C 1-6烷氧基，芳基C 1-6烷硫基或COOR 6，CONR 7 R 8或COR 9，其中R 6，R 7，R 8和R 9独立地为氢或C 1-6烷基; p为0,1或2或3; R4是氢，卤素，羟基，氰基，硝基，C1-6烷基，C1-6烷酰基，C3-7环烷基，C3-7环烷氧基，卤代C 1-6烷基，C 1-6烷氧基，卤代C 1-6烷氧基，C 1-6烷硫基，氨基，单或二 C 1-6烷基氨基或N-连接的4至7元杂环基; Y是氧，硫，-CH 2 - 或NR 10，其中R 10是氢或C 1-6烷基; D是单键，-CH 2 - ， - （CH 2）2 - 或-CH = CH-; Z为含有至少一个氮原子，任意取代的N-连接的4-7元杂环基的任意取代的C连接的4至7元杂环基，或Z为-NR 11 R 12，其中R 11和R 12独立地为氢或C 1-6烷基。还公开了其治疗方法及其在治疗中的用途，特别是CNS疾病如抑郁和焦虑。

4. 发明申请

WO1992004331A1 SUBSTITUTED 2 IMIDAZOLONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：取代2个咪唑啉酮衍生物，其制备和药物组合物
公开(公告)号：WO1992004331A1
公开(公告)日：1992-03-19
申请号：PCT/GB1991001543
申请日：1991-09-10
申请人： SMITH KLINE & FRENCH LABORATORIES LIMITED , HICKEY, Deirdre, Mary, Bernadette , COOPER, David, Gwynn , JAXA-CHAMIEC, Albert, Andrzej
发明人： SMITH KLINE & FRENCH LABORATORIES LIMITED
IPC分类号： C07D233/70
CPC分类号： C07D403/06 , C07D233/70 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07F9/6506
摘要： Substituted 4,5-diaryl-2-imidazolones of structure (I), in which each group Ar is the same or different and is optionally substituted phenyl or optionally substituted heteroaryl; R is hydrogen, alkyl, optionally substituted phenyl or optionally substituted heteroaryl; n is 4 to 12; and X is 5-tetrazolyl, SO3H, P(O)(OR)2, P(O)(OH)2 or P(O)(R)(OR) in which R is hydrogen acceptable salt thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, inter alia, in the treatment of cardiovascular disorders.
摘要翻译：结构（I）的取代的4,5-二芳基-2-咪唑啉酮，其中每个基团Ar相同或不同，并且是任选取代的苯基或任选取代的杂芳基; R 1是氢，烷基，任选取代的苯基或任选取代的杂芳基; n为4〜12; 和X是其中R是其氢可接受的盐的5-四唑基，SO 3 H，P（O）（OR）2，P（O）（OH）2或P（O）（R）（OR），含有它们的药物组合物及其在治疗中的用途，特别是治疗心血管疾病。

5. 发明申请

WO2011048390A3 GADD45BETA TARGETING AGENTS 审中-公开
标题翻译： GADD45BETA目标代理
公开(公告)号：WO2011048390A3
公开(公告)日：2011-11-03
申请号：PCT/GB2010001970
申请日：2010-10-22
申请人： IMP INNOVATIONS LTD , FRANZOSO GUIDO , JAXA-CHAMIEC ALBERT ANDRZEJ , LOW CAROLINE MINLI RACHEL , MONTI SIMONA MARIA , RUVO MENOTTI , TORNATORE LAURA , TRALAU-STEWART CATHERINE JANE
发明人： FRANZOSO GUIDO , JAXA-CHAMIEC ALBERT ANDRZEJ , LOW CAROLINE MINLI RACHEL , MONTI SIMONA MARIA , RUVO MENOTTI , TORNATORE LAURA , TRALAU-STEWART CATHERINE JANE
IPC分类号： C07K5/06 , C07K5/08 , C07K5/10
CPC分类号： C07K5/08 , A61K38/00 , C07K5/06078 , C07K5/06104 , C07K5/06113 , C07K5/0812 , C07K5/1016
摘要： Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use in treatment of cancer, inflammatory diseases, and other disorders.
摘要翻译：基于四肽，三肽和二肽的化合物和相应的肽酶。用于治疗癌症，炎性疾病和其他疾病的相关方法和药物组合物。

6. 发明申请

WO2011048390A2 GADD45BETA TARGETING AGENTS 审中-公开
标题翻译： GADD45BETA靶向剂
公开(公告)号：WO2011048390A2
公开(公告)日：2011-04-28
申请号：PCT/GB2010/001970
申请日：2010-10-22
申请人： IMPERIAL INNOVATIONS LIMITED , FRANZOSO, Guido , JAXA-CHAMIEC, Albert Andrzej , LOW, Caroline Minli Rachel , MONTI, Simona Maria , RUVO, Menotti , TORNATORE, Laura , TRALAU-STEWART, Catherine Jane
发明人： FRANZOSO, Guido , JAXA-CHAMIEC, Albert Andrzej , LOW, Caroline Minli Rachel , MONTI, Simona Maria , RUVO, Menotti , TORNATORE, Laura , TRALAU-STEWART, Catherine Jane
IPC分类号： C07K5/06 , C07K5/08 , C07K5/10
CPC分类号： C07K5/08 , A61K38/00 , C07K5/06078 , C07K5/06104 , C07K5/06113 , C07K5/0812 , C07K5/1016
摘要： Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use in treatment of cancer, inflammatory diseases, and other disorders.
摘要翻译：基于四肽，三肽和二肽的化合物以及相应的肽模体。用于治疗癌症，炎性疾病和其他疾病的相关方法和药物组合物。

7. 发明申请

WO2008092873A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译： GLYT1运输商抑制剂及其在治疗神经病学和神经病学疾病中的应用
公开(公告)号：WO2008092873A1
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051078
申请日：2008-01-30
申请人： GLAXO GROUP LIMITED , UNIVERSITY OF NOTTINGHAM , AHMAD, Nadia, Mamoona , JAXA-CHAMIEC, Albert, Andrzej , LAI, Justine, Yeun Quai , PORTER, Roderick, Alan
发明人： AHMAD, Nadia, Mamoona , JAXA-CHAMIEC, Albert, Andrzej , LAI, Justine, Yeun Quai , PORTER, Roderick, Alan
IPC分类号： C07D209/54 , A61K31/403 , A61P25/00 , A61P25/18 , A61P25/28
CPC分类号： C07D209/54
摘要： Compounds of formula (I) or a salt thereof are provided:(I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 21 and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.
摘要翻译：提供式（I）化合物或其盐：（I）其中R 1，R 2，R 3，R SUP R 4，R 5，R 6，R 7，R 8，R SUP， > 21＆gt;和m如说明书中所定义。还公开了化合物作为药物的用途，以及用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物的制备。本发明还公开了包含该化合物的药物组合物和组合。

8. 发明申请

WO2008092878A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译： GLYT1运输商抑制剂及其在治疗神经病学和神经病学疾病中的应用
公开(公告)号：WO2008092878A1
公开(公告)日：2008-08-07
申请号：PCT/EP2008/051084
申请日：2008-01-30
申请人： GLAXO GROUP LIMITED , UNIVERSITY OF NOTTINGHAM , BRANCH, Clive, Leslie , AHMAD, Nadia, Mamoona , JAXA-CHAMIEC, Albert, Andrzej , LAI, Justine, Yeun Quai , NASH, David, John
发明人： AHMAD, Nadia, Mamoona , JAXA-CHAMIEC, Albert, Andrzej , LAI, Justine, Yeun Quai , NASH, David, John
IPC分类号： C07D235/02 , A61K31/4166 , A61P25/00 , A61P25/18 , A61P25/28
CPC分类号： C07D235/02
摘要： Compounds of Formula (I) or a salt thereof are provided: wherein R 6 , R 7 , R 8 , R 21 , X, Ar, and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.
摘要翻译：提供式（I）化合物或其盐：其中R 6，R 7，R 8，R 21， / SUP>，X，Ar和m如说明书中所定义。还公开了化合物作为药物的用途，以及用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物的制备。本发明还公开了包含该化合物的药物组合物和组合。

9. 发明申请

WO2006067423A1 GLYCINE TRANSPORT INHIBITORS 审中-公开
标题翻译：甘氨酸运输抑制剂
公开(公告)号：WO2006067423A1
公开(公告)日：2006-06-29
申请号：PCT/GB2005/004951
申请日：2005-12-21
申请人： GLAXO GROUP LIMITED , BRADLEY, Daniel, Marcus , BRANCH, Clive, Leslie , CHAN, Wai, Ngor , COULTON, Steven , GILPIN, Martin, Leonard , HARRIS, Andrew, Jonathan , JAXA-CHAMIEC, Albert, Andrzej , LAI, Justine, Yeun, Quai , MARSHALL, Howard, Robert , MACRITCHIE, Jacqueline, Anne , NASH, David, John , PORTER, Roderick, Alan , SPADA, Simone , THEWLIS, Kevin, Michael , WARD, Simon, Edward
发明人： BRADLEY, Daniel, Marcus , BRANCH, Clive, Leslie , CHAN, Wai, Ngor , COULTON, Steven , GILPIN, Martin, Leonard , HARRIS, Andrew, Jonathan , JAXA-CHAMIEC, Albert, Andrzej , LAI, Justine, Yeun, Quai , MARSHALL, Howard, Robert , MACRITCHIE, Jacqueline, Anne , NASH, David, John , PORTER, Roderick, Alan , SPADA, Simone , THEWLIS, Kevin, Michael , WARD, Simon, Edward
IPC分类号： C07C233/78 , A61K31/166 , C07C211/36
CPC分类号： C07C233/78 , C07C235/50 , C07C235/60 , C07C323/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/20 , C07D209/02 , C07D295/13 , C07D307/22
摘要： The present invention relates to compounds of formula (I), or to salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
摘要翻译：本发明涉及式（I）化合物或其盐或溶剂化物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。本发明还包括制备这些化合物及其药物制剂的方法。

10. 发明申请

WO2004026890A1 ACETYLENE COMPOUNDS 审中-公开
标题翻译：乙烯化合物
公开(公告)号：WO2004026890A1
公开(公告)日：2004-04-01
申请号：PCT/EP2003/010350
申请日：2003-09-16
申请人： GLAXO GROUP LIMITED , ELLIS, Frank , FULTON, Heather, Elizabeth , HALL, Adrian , JAXA-CHAMIEC, Albert, Andrzej , SWANSON, Stephen , VILE, Sadie
发明人： ELLIS, Frank , FULTON, Heather, Elizabeth , HALL, Adrian , JAXA-CHAMIEC, Albert, Andrzej , SWANSON, Stephen , VILE, Sadie
IPC分类号： C07H19/167
CPC分类号： C07H19/16 , C07H19/167
摘要： The present invention is concerned with certain adenosine derivatives having an acetylene group attached in the 5' position by a linker, which are adenosine A1 agonists, and to their use in therapy.
摘要翻译：本发明涉及具有乙炔基的腺苷衍生物，其通过连接体（其为腺苷A1激动剂）在5'位上连接，并且用于治疗。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式