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1. 发明申请

WO2018017358A1 DRY POWDER INHALER 审中-公开
标题翻译：干粉吸入器
公开(公告)号：WO2018017358A1
公开(公告)日：2018-01-25
申请号：PCT/US2017/041445
申请日：2017-07-11
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , TIBBATTS, James , COCKER, Robin, Craig , KING, Ben, Alexander , DAVIDSON, Christopher, Iain , MUTTI, Paul , HAN, Steve
IPC分类号： A61M15/00 , A61M16/00 , A61M16/10
摘要： The present invention provides in part dry powder inhaler (DPI) devices for dispensing dry powder and methods for using the same. The DPI devices feature exchangeable cartridges having drum mechanisms that prepare metered doses of dry powder, and are able to direct air in a turbulent manner sufficient to entrain and deagglomerate a dose of dry powder for delivery into a user's lungs. The DPI devices feature a reservoir of dry powder advanced by a plunger, as well as a gauge that advances with the plunger to indicate the amount of dry powder remaining in the reservoir.
摘要翻译：本发明部分提供用于分配干粉的干粉吸入器（DPI）装置及其使用方法。 DPI装置具有可更换的药筒，其具有可准备计量剂量的干粉的滚筒机构，并且能够以湍流的方式引导空气，以足以将一定剂量的干粉输送和散开以便输送到使用者的肺中。 DPI装置具有一个由柱塞推进的干粉储存器，以及与柱塞一起前进的量表，以指示储存器中残留的干粉量。

2. 发明申请

WO2017048972A1 NICOTINE FORMULATIONS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：尼古丁制剂及其制备方法和使用方法
公开(公告)号：WO2017048972A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/051961
申请日：2016-09-15
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , ZAMEL, Noe , SLUTSKY, Arthur , ELLIS, Steven
IPC分类号： A61K31/465 , A61K9/00 , A61K9/72 , A61K31/00
CPC分类号： A61K31/465 , A24F47/002 , A61K9/0075 , A61K45/06 , A61K2300/00
摘要： A method of reducing nicotine cravings is described. The method includes inhalation of a dry powder formulation containing a dose of nicotine by a subject seeking nicotine cravings reduction. The formulation includes amounts and concentrations of nicotine that are significantly lower than cigarettes or nicotine replacement therapies.
摘要翻译：描述了一种减少尼古丁渴望的方法。该方法包括通过寻求尼古丁渴望减少的受试者吸入含有一定剂量的尼古丁的干粉制剂。配方包括尼古丁的量和浓度明显低于香烟或尼古丁替代疗法。

3. 发明申请

WO2016168276A1 FLAVORING ELEMENT FOR AN INHALATION DEVICE 审中-公开
标题翻译：用于吸入装置的浮雕元件
公开(公告)号：WO2016168276A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027255
申请日：2016-04-13
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , HAN, Steve , SLUTSKY, Arthur , ELLIS, Steven , ZAMEL, Noe , NYAMBURA, Bildad
IPC分类号： A61M15/06 , A61M15/00 , A24F47/00
CPC分类号： A61M15/0003 , A24F47/002 , A61M15/0036 , A61M15/0041 , A61M15/06 , A61M2202/064 , A61M2206/18
摘要： A device for adding a flavor and/or cough suppressant component to an inhaler is described. The device includes a housing having an interior chamber, wherein the housing includes at least one air inlet and at least one air outlet connected to the interior chamber, thereby forming an airflow pathway through the interior chamber, and at least one flavoring and/or cough suppressant component positioned within the interior chamber, wherein the housing is attachable to an exterior surface of an inhaler having at least one air inlet, such that the at least one air outlet of the device aligns with the at least one air inlet of the inhaler to form an airflow path through the device and into the inhaler.
摘要翻译：描述了用于向吸入器中加入风味剂和/或止咳剂组分的装置。该装置包括具有内部室的壳体，其中壳体包括至少一个空气入口和连接到内部室的至少一个空气出口，从而形成通过内部室的气流通路，以及至少一种调味和/或咳嗽位于所述内部室内的所述抑制剂组分，其中所述壳体可附接到具有至少一个空气入口的吸入器的外表面，使得所述装置的所述至少一个空气出口与所述吸入器的所述至少一个空气入口对准，形成通过装置并进入吸入器的气流路径。

4. 发明申请

WO2016168271A1 DUAL RESISTANCE DRY POWDER INHALER 审中-公开
标题翻译：双电阻干粉
公开(公告)号：WO2016168271A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027248
申请日：2016-04-13
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , HAN, Steve , SLUTSKY, Arthur , ELLIS, Steven , ZAMEL, Noe , ALSTON, William
IPC分类号： A61M15/06 , A24F47/00 , A61M15/00
CPC分类号： A61M15/0015 , A61M15/0021 , A61M15/0028 , A61M15/0086 , A61M15/06 , A61M2202/064
摘要： Described is a dry powder inhaler for inhalation of a dry powder composition. The inhaler includes an external housing that defines an internal passage. The inhaler also includes a mouthpiece, a compartment for holding a dry powder capsule or powder reservoir, and a powder fluidization and deagglomeration apparatus for directing airflow to the dry powder to generate airborne powder particles within the internal passage. When a user inhales through the mouthpiece, a first airflow pattern is generated that has a first airflow resistance, during which the fluidization and deagglomeration apparatus generates airborne dry powder particles within the internal passage. Upon reaching a threshold negative pressure value within the internal passage of the inhaler, a second airflow pattern is generated having a second airflow resistance that is lower than the first airflow resistance, which pulls the airborne dry powder into the user's lungs during the inhalation. Embodiments of elastomeric valves are also described.
摘要翻译：描述了一种用于吸入干粉组合物的干粉吸入器。吸入器包括限定内部通道的外部壳体。吸入器还包括一个接口管，用于容纳干燥粉末胶囊或粉末储存器的隔室，以及用于将气流引导到干粉末以在内部通道内产生空气中的粉末颗粒的粉末流化和解聚装置。当用户通过接口管吸入时，产生具有第一气流阻力的第一气流模式，在此期间流化和解聚装置在内部通道内产生空气传播的干粉颗粒。当达到吸入器的内部通道内的阈值负压值时，产生具有比第一气流阻力小的第二气流阻力的第二气流模式，其在吸入期间将空气干燥的粉末吸入使用者的肺部。还描述了弹性阀的实施例。

5. 发明申请

WO2016168266A1 DRY POWDER INHALERS WITH PARTIAL DOSAGE DELIVERY 审中-公开
标题翻译：干粉输送器，部分剂量输送
公开(公告)号：WO2016168266A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027240
申请日：2016-04-13
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , HAN, Steve , SLUTSKY, Arthur , ELLIS, Steven , ZAMEL, Noe , ALSTON, William
IPC分类号： A61M15/00
CPC分类号： A61M15/0013 , A61M15/0021 , A61M15/0061 , A61M15/0066 , A61M2202/064
摘要： A dry powder inhaler dispenses a partial dosage of a powder from a dry powder chamber during a single user inhalation. In certain embodiments, the dry powder chamber is a dry powder capsule that spins in a chamber with a protrusion for limiting the spin of the capsule. In certain embodiments, a capsule slides in a proximal and distal direction for dispensing partial dosages of powder medicament. Air inlets in communication whit the external environment can be included in the inhaler housing for generating a smooth inhalation experience for the user and facilitating operation of partial dosage mechanisms. In other embodiments, a hinged member, sliding member, rotating member, spring tensioned member, pressure actuated valve, dry powder chamber with patterned holes or combinations of these are used as a mechanism for dispensing a partial dosage of powder medicament during a single inhalation.
摘要翻译：干粉吸入器在单次用户吸入期间从干燥粉末室中分配一定量的粉末。在某些实施方案中，干燥粉末室是在具有用于限制胶囊旋转的突起的腔室中旋转的干粉末胶囊。在某些实施方案中，胶囊在近端和远端方向上滑动以分配部分剂量的粉末药物。在外部环境通风的空气入口可以被包括在吸入器壳体中，以便为使用者产生平滑的吸入体验，并且便于部分剂量机制的操作。在其它实施例中，使用铰接构件，滑动构件，旋转构件，弹簧张紧构件，压力致动阀，具有图案孔或其组合的干粉室作为在单次吸入期间分配部分剂量的粉末药物的机构。

6. 发明申请

WO2017048970A1 SYSTEM AND METHOD FOR CONTROLLING THE HARSHNESS OF NICOTINE-BASED DRY POWDER FORMULATIONS 审中-公开
标题翻译：用于控制基于尼古丁的干粉配方的收敛性的系统和方法
公开(公告)号：WO2017048970A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/051959
申请日：2016-09-15
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , ZAMEL, Noe , SLUTSKY, Arthur , ELLIS, Steven
IPC分类号： A61K9/72 , A61K31/465 , A61M15/06
CPC分类号： A24F47/002 , A61K9/0075 , A61K31/465
摘要： A method of controlling or electing the harshness of inhaled nicotine powder formulations is described. The method includes the steps of identifying a concentration of nicotine for a subject to inhale to achieve a desired level of harshness per inhalation, identifying the total dose of nicotine to be inhaled by the subject, and providing the subject with an amount of a formulation comprising nicotine particles having the identified concentration of nicotine, such that the total amount of nicotine particles in the formulation equals the total dose of nicotine.
摘要翻译：描述了控制或选择吸入尼古丁粉末制剂的粗糙度的方法。该方法包括以下步骤：鉴定吸入物体的尼古丁浓度以达到每次吸入所需的苛刻程度，识别受试者吸入的尼古丁的总剂量，以及向患者提供一定量的制剂，其包含具有确定的尼古丁浓度的尼古丁颗粒，使得制剂中的尼古丁颗粒的总量等于尼古丁的总剂量。

7. 发明申请

WO2016168274A1 DRY POWDER INHALER AND METHOD OF USE 审中-公开
标题翻译：干粉吸入剂及其使用方法
公开(公告)号：WO2016168274A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027252
申请日：2016-04-13
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , HAN, Steve , SLUTSKY, Arthur , ELLIS, Steven , ZAMEL, Noe , ALSTON, William
IPC分类号： A61M15/06 , A24F47/00
CPC分类号： A61M15/0036 , A61M15/0021 , A61M15/003 , A61M15/0038 , A61M15/06 , A61M2202/064
摘要： A device for accessing dry powder within a sealed chamber is described. The device includes a hollow housing having a proximal end opening, a primary distal end opening and a secondary distal end opening, at least one wing structure extending from the outer surface of the housing that is positioned distally from the primary distal opening. Also described is a dry powder inhaler having a housing, a penetrating component for accessing dry powder within a sealed chamber, and a mouthpiece, where the mouthpiece is connected to the proximal end opening of the penetrating component, and wherein the at least a portion of the distal end of the penetrating component is positioned within the inhaler housing.
摘要翻译：描述了用于在密封室内进入干粉的装置。该装置包括具有近端开口，初级远端开口和次级远端开口的中空壳体，从壳体的外表面延伸的至少一个翼结构，其从主远端开口向远侧定位。还描述了一种干粉吸入器，其具有壳体，用于在密封室内进入干粉的穿透部件和接口，其中接口件连接到穿透部件的近端开口，并且其中至少一部分穿透部件的远端位于吸入器壳体内。

8. 发明申请

WO2017048974A8 INHALABLE NICOTINE FORMULATIONS, AND METHODS OF MAKING AND USING THEREOF 审中-公开
公开(公告)号：WO2017048974A8
公开(公告)日：2017-03-23
申请号：PCT/US2016/051963
申请日：2016-09-15
申请人： SANSA CORPORATION (BARBADOS) INC.
发明人： STENZLER, Alex , ZAMEL, Noe , SLUTSKY, Arthur , ELLIS, Steven
IPC分类号： A24B15/40 , A24B15/10 , A24B15/28 , A24B15/32 , A24F47/00
摘要： The present invention provides dry powder formulations comprising nicotine, methods of using the same, and methods for making the same. The dry powder formulations may further comprise excipients, therapeutic agents, and flavor components The dry powder formulations may be manufactured by dry processes and wet processes.

9. 发明申请

WO2015138042A2 NITRIC OXIDE TREATMENT OF BOVINE RESPIRATORY DISEASE COMPLEX AND OTHER RESPIRATORY CONDITIONS 审中-公开
标题翻译：一氧化氮治疗牛呼吸道疾病复合症及其他呼吸道疾病
公开(公告)号：WO2015138042A2
公开(公告)日：2015-09-17
申请号：PCT/US2014/072868
申请日：2014-12-30
申请人： BOVICOR PHARMATECH INC. , STENZLER, Alex , MILLER, Christopher C. , REGEV-SHOSHANI, Gilly
发明人： STENZLER, Alex , MILLER, Christopher C. , REGEV-SHOSHANI, Gilly
IPC分类号： A61K33/00
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/0078 , A61K47/12
摘要： Methods, devices, and systems for treating a respiratory condition using gNO delivered from a nitric oxide releasing solution (NORS) are disclosed and described. In one embodiment, the respiratory condition may be bovine respiratory disease complex (BRDc).
摘要翻译：公开并描述了使用从一氧化氮释放溶液（NORS）递送的gNO治疗呼吸病症的方法，装置和系统。在一个实施方案中，呼吸病症可以是牛呼吸道疾病综合征（BRDc）。

10. 发明申请

WO2010014818A1 METHODS OF TREATING AN INFECTION WITH NITRIC OXIDE 审中-公开
标题翻译：用氮氧化物治疗感染的方法
公开(公告)号：WO2010014818A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/052268
申请日：2009-07-30
申请人： NITRIC BIOTHERAPEUTICS, INC. , CARDINAL HEALTH 207, INC. , MCCANEY, Frank, J. , STENZLER, Alex , MILLER, Chris
发明人： MCCANEY, Frank, J. , STENZLER, Alex , MILLER, Chris
IPC分类号： A61K33/00
CPC分类号： A61K33/00 , A61K2300/00
摘要： The present invention provides methods of treating bacterial, viral, protozoan, parasitic, arthropod and fungal infections by applying gaseous nitric oxide to a patient having an infection. The present invention further provides improved methods of treating bacterial, viral, protozoan, parasitic and fungal infections by applying gaseous nitric oxide, in combination with oxygen, to a patient having an infection.
摘要翻译：本发明提供了通过向患有感染的患者施加气体一氧化氮来治疗细菌，病毒，原生动物，寄生虫，节肢动物和真菌感染的方法。本发明进一步提供了通过将氧气与氧气一起应用于具有感染的患者的细菌，病毒，原生动物，寄生虫和真菌感染的改进方法。

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