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1. 发明申请

WO2017048974A8 INHALABLE NICOTINE FORMULATIONS, AND METHODS OF MAKING AND USING THEREOF 审中-公开
公开(公告)号：WO2017048974A8
公开(公告)日：2017-03-23
申请号：PCT/US2016/051963
申请日：2016-09-15
申请人： SANSA CORPORATION (BARBADOS) INC.
发明人： STENZLER, Alex , ZAMEL, Noe , SLUTSKY, Arthur , ELLIS, Steven
IPC分类号： A24B15/40 , A24B15/10 , A24B15/28 , A24B15/32 , A24F47/00
摘要： The present invention provides dry powder formulations comprising nicotine, methods of using the same, and methods for making the same. The dry powder formulations may further comprise excipients, therapeutic agents, and flavor components The dry powder formulations may be manufactured by dry processes and wet processes.

2. 发明申请

WO2017048970A1 SYSTEM AND METHOD FOR CONTROLLING THE HARSHNESS OF NICOTINE-BASED DRY POWDER FORMULATIONS 审中-公开
标题翻译：用于控制基于尼古丁的干粉配方的收敛性的系统和方法
公开(公告)号：WO2017048970A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/051959
申请日：2016-09-15
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , ZAMEL, Noe , SLUTSKY, Arthur , ELLIS, Steven
IPC分类号： A61K9/72 , A61K31/465 , A61M15/06
CPC分类号： A24F47/002 , A61K9/0075 , A61K31/465
摘要： A method of controlling or electing the harshness of inhaled nicotine powder formulations is described. The method includes the steps of identifying a concentration of nicotine for a subject to inhale to achieve a desired level of harshness per inhalation, identifying the total dose of nicotine to be inhaled by the subject, and providing the subject with an amount of a formulation comprising nicotine particles having the identified concentration of nicotine, such that the total amount of nicotine particles in the formulation equals the total dose of nicotine.
摘要翻译：描述了控制或选择吸入尼古丁粉末制剂的粗糙度的方法。该方法包括以下步骤：鉴定吸入物体的尼古丁浓度以达到每次吸入所需的苛刻程度，识别受试者吸入的尼古丁的总剂量，以及向患者提供一定量的制剂，其包含具有确定的尼古丁浓度的尼古丁颗粒，使得制剂中的尼古丁颗粒的总量等于尼古丁的总剂量。

3. 发明申请

WO2016168274A1 DRY POWDER INHALER AND METHOD OF USE 审中-公开
标题翻译：干粉吸入剂及其使用方法
公开(公告)号：WO2016168274A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027252
申请日：2016-04-13
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , HAN, Steve , SLUTSKY, Arthur , ELLIS, Steven , ZAMEL, Noe , ALSTON, William
IPC分类号： A61M15/06 , A24F47/00
CPC分类号： A61M15/0036 , A61M15/0021 , A61M15/003 , A61M15/0038 , A61M15/06 , A61M2202/064
摘要： A device for accessing dry powder within a sealed chamber is described. The device includes a hollow housing having a proximal end opening, a primary distal end opening and a secondary distal end opening, at least one wing structure extending from the outer surface of the housing that is positioned distally from the primary distal opening. Also described is a dry powder inhaler having a housing, a penetrating component for accessing dry powder within a sealed chamber, and a mouthpiece, where the mouthpiece is connected to the proximal end opening of the penetrating component, and wherein the at least a portion of the distal end of the penetrating component is positioned within the inhaler housing.
摘要翻译：描述了用于在密封室内进入干粉的装置。该装置包括具有近端开口，初级远端开口和次级远端开口的中空壳体，从壳体的外表面延伸的至少一个翼结构，其从主远端开口向远侧定位。还描述了一种干粉吸入器，其具有壳体，用于在密封室内进入干粉的穿透部件和接口，其中接口件连接到穿透部件的近端开口，并且其中至少一部分穿透部件的远端位于吸入器壳体内。

4. 发明申请

WO2016118328A1 NICOTINE-DIKETOPIPERAZINE MICROPARTICLE FORMULATIONS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：非甾体类酮胆碱微生物制剂及其制备方法
公开(公告)号：WO2016118328A1
公开(公告)日：2016-07-28
申请号：PCT/US2016/012437
申请日：2016-01-07
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： ZAMEL, Noe , SLUTSKY, Arthur , ELLIS, Steven
IPC分类号： A61K31/465
CPC分类号： A24B15/16 , A24F47/002 , A61K9/0075 , A61K9/1694 , A61K9/5084 , A61K31/465 , A61K31/495 , A61K45/06 , A61K2300/00
摘要： This invention relates to nicotine microparticles formulations made with the help of a diketopiperazine compound, in particular fumaryl diketopiperazine (FDKP). The invention relates to the various types of microparticles that can be made, in particular nicotine-coated and nicotine-loaded microparticles. The invention further relates to the various methods that can be used in making the microparticles. One particular method involves making FDKP microparticles which are further surface- coated with nicotine. Another particular method involves mixing nicotine with FDKP 2 " and/or FDKP and then forming microparticles which contain nicotine throughout their volume. The invention also relates to the use of this microparticles in tobacco related therapies, such as tobacco replacement or tobacco withdrawal.
摘要翻译：本发明涉及借助二酮哌嗪化合物，特别是富马酰二酮哌嗪（FDKP）制备的尼古丁微粒制剂。本发明涉及可以制成的各种类型的微粒，特别是尼古丁涂覆和负载尼古丁的微粒。本发明还涉及可用于制造微粒的各种方法。一个特别的方法是制备进一步用尼古丁表面涂覆的FDKP微粒。另一个具体方法是将尼古丁与FDKP2“和/或FDKP混合，然后在整个体积内形成含有尼古丁的微粒。本发明还涉及这种微粒在烟草相关疗法中的用途，例如烟草替代或烟草提取。

5. 发明申请

WO2017048972A1 NICOTINE FORMULATIONS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：尼古丁制剂及其制备方法和使用方法
公开(公告)号：WO2017048972A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/051961
申请日：2016-09-15
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , ZAMEL, Noe , SLUTSKY, Arthur , ELLIS, Steven
IPC分类号： A61K31/465 , A61K9/00 , A61K9/72 , A61K31/00
CPC分类号： A61K31/465 , A24F47/002 , A61K9/0075 , A61K45/06 , A61K2300/00
摘要： A method of reducing nicotine cravings is described. The method includes inhalation of a dry powder formulation containing a dose of nicotine by a subject seeking nicotine cravings reduction. The formulation includes amounts and concentrations of nicotine that are significantly lower than cigarettes or nicotine replacement therapies.
摘要翻译：描述了一种减少尼古丁渴望的方法。该方法包括通过寻求尼古丁渴望减少的受试者吸入含有一定剂量的尼古丁的干粉制剂。配方包括尼古丁的量和浓度明显低于香烟或尼古丁替代疗法。

6. 发明申请

WO2016168276A1 FLAVORING ELEMENT FOR AN INHALATION DEVICE 审中-公开
标题翻译：用于吸入装置的浮雕元件
公开(公告)号：WO2016168276A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027255
申请日：2016-04-13
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , HAN, Steve , SLUTSKY, Arthur , ELLIS, Steven , ZAMEL, Noe , NYAMBURA, Bildad
IPC分类号： A61M15/06 , A61M15/00 , A24F47/00
CPC分类号： A61M15/0003 , A24F47/002 , A61M15/0036 , A61M15/0041 , A61M15/06 , A61M2202/064 , A61M2206/18
摘要： A device for adding a flavor and/or cough suppressant component to an inhaler is described. The device includes a housing having an interior chamber, wherein the housing includes at least one air inlet and at least one air outlet connected to the interior chamber, thereby forming an airflow pathway through the interior chamber, and at least one flavoring and/or cough suppressant component positioned within the interior chamber, wherein the housing is attachable to an exterior surface of an inhaler having at least one air inlet, such that the at least one air outlet of the device aligns with the at least one air inlet of the inhaler to form an airflow path through the device and into the inhaler.
摘要翻译：描述了用于向吸入器中加入风味剂和/或止咳剂组分的装置。该装置包括具有内部室的壳体，其中壳体包括至少一个空气入口和连接到内部室的至少一个空气出口，从而形成通过内部室的气流通路，以及至少一种调味和/或咳嗽位于所述内部室内的所述抑制剂组分，其中所述壳体可附接到具有至少一个空气入口的吸入器的外表面，使得所述装置的所述至少一个空气出口与所述吸入器的所述至少一个空气入口对准，形成通过装置并进入吸入器的气流路径。

7. 发明申请

WO2016168271A1 DUAL RESISTANCE DRY POWDER INHALER 审中-公开
标题翻译：双电阻干粉
公开(公告)号：WO2016168271A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027248
申请日：2016-04-13
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , HAN, Steve , SLUTSKY, Arthur , ELLIS, Steven , ZAMEL, Noe , ALSTON, William
IPC分类号： A61M15/06 , A24F47/00 , A61M15/00
CPC分类号： A61M15/0015 , A61M15/0021 , A61M15/0028 , A61M15/0086 , A61M15/06 , A61M2202/064
摘要： Described is a dry powder inhaler for inhalation of a dry powder composition. The inhaler includes an external housing that defines an internal passage. The inhaler also includes a mouthpiece, a compartment for holding a dry powder capsule or powder reservoir, and a powder fluidization and deagglomeration apparatus for directing airflow to the dry powder to generate airborne powder particles within the internal passage. When a user inhales through the mouthpiece, a first airflow pattern is generated that has a first airflow resistance, during which the fluidization and deagglomeration apparatus generates airborne dry powder particles within the internal passage. Upon reaching a threshold negative pressure value within the internal passage of the inhaler, a second airflow pattern is generated having a second airflow resistance that is lower than the first airflow resistance, which pulls the airborne dry powder into the user's lungs during the inhalation. Embodiments of elastomeric valves are also described.
摘要翻译：描述了一种用于吸入干粉组合物的干粉吸入器。吸入器包括限定内部通道的外部壳体。吸入器还包括一个接口管，用于容纳干燥粉末胶囊或粉末储存器的隔室，以及用于将气流引导到干粉末以在内部通道内产生空气中的粉末颗粒的粉末流化和解聚装置。当用户通过接口管吸入时，产生具有第一气流阻力的第一气流模式，在此期间流化和解聚装置在内部通道内产生空气传播的干粉颗粒。当达到吸入器的内部通道内的阈值负压值时，产生具有比第一气流阻力小的第二气流阻力的第二气流模式，其在吸入期间将空气干燥的粉末吸入使用者的肺部。还描述了弹性阀的实施例。

8. 发明申请

WO2016168266A1 DRY POWDER INHALERS WITH PARTIAL DOSAGE DELIVERY 审中-公开
标题翻译：干粉输送器，部分剂量输送
公开(公告)号：WO2016168266A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027240
申请日：2016-04-13
申请人： SANSA CORPORATION (BARBADOS) INC. , STENZLER, Alex
发明人： STENZLER, Alex , HAN, Steve , SLUTSKY, Arthur , ELLIS, Steven , ZAMEL, Noe , ALSTON, William
IPC分类号： A61M15/00
CPC分类号： A61M15/0013 , A61M15/0021 , A61M15/0061 , A61M15/0066 , A61M2202/064
摘要： A dry powder inhaler dispenses a partial dosage of a powder from a dry powder chamber during a single user inhalation. In certain embodiments, the dry powder chamber is a dry powder capsule that spins in a chamber with a protrusion for limiting the spin of the capsule. In certain embodiments, a capsule slides in a proximal and distal direction for dispensing partial dosages of powder medicament. Air inlets in communication whit the external environment can be included in the inhaler housing for generating a smooth inhalation experience for the user and facilitating operation of partial dosage mechanisms. In other embodiments, a hinged member, sliding member, rotating member, spring tensioned member, pressure actuated valve, dry powder chamber with patterned holes or combinations of these are used as a mechanism for dispensing a partial dosage of powder medicament during a single inhalation.
摘要翻译：干粉吸入器在单次用户吸入期间从干燥粉末室中分配一定量的粉末。在某些实施方案中，干燥粉末室是在具有用于限制胶囊旋转的突起的腔室中旋转的干粉末胶囊。在某些实施方案中，胶囊在近端和远端方向上滑动以分配部分剂量的粉末药物。在外部环境通风的空气入口可以被包括在吸入器壳体中，以便为使用者产生平滑的吸入体验，并且便于部分剂量机制的操作。在其它实施例中，使用铰接构件，滑动构件，旋转构件，弹簧张紧构件，压力致动阀，具有图案孔或其组合的干粉室作为在单次吸入期间分配部分剂量的粉末药物的机构。

9. 发明申请

WO2015173648A2 NICOTINE FORMULATIONS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译： NICOTINE制剂及其制备方法
公开(公告)号：WO2015173648A2
公开(公告)日：2015-11-19
申请号：PCT/IB2015/001327
申请日：2015-04-08
申请人： SANSA CORPORATION (BARBADOS) INC.
发明人： SLUTSKY, Arthur , ZAMEL, Noe
IPC分类号： A61K9/12 , A61K31/4439
CPC分类号： A61K9/0075 , A24F47/002 , A61K9/145 , A61K9/1623 , A61K31/045 , A61K31/465 , A61K45/06 , Y10T428/2982
摘要： A dry powder nicotine formulation suitable for inhalation is described. The formulation includes nicotine particles, wherein the nicotine particles are substantially in the range of about 1-10 micron in size, preferably 2-5 micron in size. The formulation may also include a cough suppressant component having particles in the 5-100 micron size range. The formulation may also include a cough suppressant component having particles in the 10-200 micron size range. The formulation may also include a flavor component having particles in the 10-1000 micron size range.
摘要翻译：描述了适用于吸入的干粉尼古丁制剂。制剂包括尼古丁颗粒，其中尼古丁颗粒的尺寸基本上在约1-10微米的范围内，优选2-5微米。制剂还可以包括具有5-100微米尺寸范围的颗粒的止咳剂组分。制剂还可以包括具有10-200微米尺寸范围内的颗粒的止咳剂组分。制剂还可以包括具有10-1000微米尺寸范围的颗粒的风味成分。

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