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1. 发明申请

WO2016118768A2 ANIMAL INTRANASAL ADMINISTRATION DEVICE, SYSTEMS, AND ASSOCIATED METHODS 审中-公开
标题翻译：动物行政管理装置，系统及相关方法
公开(公告)号：WO2016118768A2
公开(公告)日：2016-07-28
申请号：PCT/US2016/014351
申请日：2016-01-21
申请人： BOVICOR PHARMATECH INC. , MILLER, Christopher C. , REGEV-SHOSHANI, Gilly , STENZLER, Alex , HAN, Steve
发明人： MILLER, Christopher C. , REGEV-SHOSHANI, Gilly , STENZLER, Alex , HAN, Steve
IPC分类号： A61D7/04 , A61K9/00
CPC分类号： A61D7/04 , A61K9/0043 , A61K9/08 , A61K33/00
摘要： An animal intranasal administration device, and associated systems and methods, are disclosed. The animal intranasal administration device can include a nasal passage nozzle for each nostril configured to receive fluid from a fluid source. The animal intranasal administration device can also include a biasing mechanism to bias the nozzles toward a septum such that the device is secured in place about the septum during administration of the fluid into nasal passages.
摘要翻译：公开了一种动物鼻内给药装置及其相关系统和方法。动物鼻内给药装置可以包括用于每个鼻孔的鼻通道喷嘴，其构造成从流体源接收流体。动物鼻内给药装置还可以包括偏压机构以将喷嘴偏向隔膜，使得在将流体施用到鼻通道期间将该装置固定在隔膜周围的适当位置。

2. 发明申请

WO2015138042A2 NITRIC OXIDE TREATMENT OF BOVINE RESPIRATORY DISEASE COMPLEX AND OTHER RESPIRATORY CONDITIONS 审中-公开
标题翻译：一氧化氮治疗牛呼吸道疾病复合症及其他呼吸道疾病
公开(公告)号：WO2015138042A2
公开(公告)日：2015-09-17
申请号：PCT/US2014/072868
申请日：2014-12-30
申请人： BOVICOR PHARMATECH INC. , STENZLER, Alex , MILLER, Christopher C. , REGEV-SHOSHANI, Gilly
发明人： STENZLER, Alex , MILLER, Christopher C. , REGEV-SHOSHANI, Gilly
IPC分类号： A61K33/00
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/0078 , A61K47/12
摘要： Methods, devices, and systems for treating a respiratory condition using gNO delivered from a nitric oxide releasing solution (NORS) are disclosed and described. In one embodiment, the respiratory condition may be bovine respiratory disease complex (BRDc).
摘要翻译：公开并描述了使用从一氧化氮释放溶液（NORS）递送的gNO治疗呼吸病症的方法，装置和系统。在一个实施方案中，呼吸病症可以是牛呼吸道疾病综合征（BRDc）。

3. 发明申请

WO2015058127A1 PREPARATION AND DELIVERY OF SUSTAINED NITRIC OXIDE RELEASING SOLUTIONS 审中-公开
标题翻译：可持续发展的氮氧化物释放解决方案的准备和交付
公开(公告)号：WO2015058127A1
公开(公告)日：2015-04-23
申请号：PCT/US2014/061208
申请日：2014-10-17
申请人： BOVICOR PHARMATECH INC. , STENZLER, Alex , HAN, Steve , MILLER, Christopher C. , REGEV-SHOSHANI, Gilly
发明人： STENZLER, Alex , HAN, Steve , MILLER, Christopher C. , REGEV-SHOSHANI, Gilly
IPC分类号： A61M27/00
CPC分类号： A61K33/00 , A61K9/0078 , A61K9/7015 , A61K33/08 , A61L15/46 , A61L2300/114 , A61L2300/404 , A61M11/007 , A61M11/02 , A61M15/009 , A61M35/00 , A61M35/003 , A61M2202/0275 , A61M2205/07 , A61M2205/50 , A61M2205/82
摘要： The present invention relates to a system and method of treating a subject with nitric oxide gas and/or nitric oxide releasing solutions. The present invention also relates to compositions and devices useful for treating a subject with nitric oxide gas and/or nitric oxide releasing solutions.
摘要翻译：本发明涉及用一氧化氮气体和/或一氧化氮释放溶液治疗受试者的系统和方法。本发明还涉及用于用一氧化氮气体和/或一氧化氮释放溶液治疗受试者的组合物和装置。

4. 发明申请

WO2011141863A2 GASEOUS NITRIC OXIDE-SEQUESTERING PRODUCTS AND PROCESSES OF PREPARING SAME 审中-公开
标题翻译：气体氮氧化物测序产品及其制备方法
公开(公告)号：WO2011141863A2
公开(公告)日：2011-11-17
申请号：PCT/IB2011/052032
申请日：2011-05-09
申请人： ENOX BIOPHARMA, INC. , AV-GAY, Yossef , MILLER, Christopher C. , BOHBOT, Deborah , REGEV-SHOSHANI, Gilly
发明人： AV-GAY, Yossef , MILLER, Christopher C. , BOHBOT, Deborah , REGEV-SHOSHANI, Gilly
IPC分类号： A61L15/46
CPC分类号： B65D25/00 , A61L15/22 , A61L15/46 , A61L27/14 , A61L27/54 , A61L28/0007 , A61L28/0038 , A61L29/04 , A61L29/16 , A61L31/04 , A61L31/16 , A61L2300/114 , B65B5/00
摘要： A process of preparing articles having gaseous NO sequestered therein is disclosed, as well as articles prepared thereby. Also disclosed are articles having gaseous NO sequestered therewithin and having reduced amount of oxygen-containing and/or nitrogen-containing reactive species. Also disclosed are processes of preparing packaged articles having a non-gas permeable package that comprises gaseous NO therein and packaged articles made therefrom. Also disclosed are charging devices which can be utilized in the above-described processes. The articles prepared by the above-described processes are preferably medical devices such as indwelling catheters, intubation devices and tampons. Tampons having sequestered therein gaseous NO, uses thereof and processes of preparing same are also disclosed.
摘要翻译：公开了一种制备具有气态NO螯合的制品的方法，以及由此制备的制品。还公开了具有在其中螯合的气态NO并具有减少量的含氧和/或含氮反应性物质的制品。还公开了制备具有包含气态NO的非气体可渗透包装的包装制品的包装制品和由其制成的包装制品的方法。还公开了可以在上述处理中使用的充电装置。通过上述方法制备的制品优选为诸如留置导管，插管装置和棉塞的医疗装置。卫生棉条在其中存储有气态NO，其用途及其制备方法也被公开。

5. 发明申请

WO2006071957A1 DEVICE AND METHOD FOR TREATMENT OF WOUNDS WITH NITRIC OXIDE 审中-公开
标题翻译：用氮氧化物处理绕组的装置和方法
公开(公告)号：WO2006071957A1
公开(公告)日：2006-07-06
申请号：PCT/US2005/047319
申请日：2005-12-23
申请人： SENSORMEDICS CORPORATION , PULMONOX TECHNOLOGIES CORPORATION , STENZLER, Alex , MILLER, Christopher C.
发明人： STENZLER, Alex , MILLER, Christopher C.
IPC分类号： A61M37/00
CPC分类号： A61M35/00 , A61B90/40 , A61H33/14 , A61K33/00 , A61L2/0094 , A61L15/18 , A61L15/44 , A61L2300/114 , A61L2300/602 , A61M1/0031 , A61M1/0088 , A61M13/003 , A61M13/006 , A61M2202/0275 , A61M2205/3334 , A61K2300/00
摘要： Topical exposure of nitric oxide gas to wounds may promote healing of the wound and prepare the wound bed for further treatment and recovery. Nitric oxide gas may be used, to reduce the microbial infection, manage exudate secretion, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide may be provided to induce collagen expression aiding in the closure of the wound.
摘要翻译：一氧化氮气体局部暴露于伤口可以促进伤口愈合，并制备伤口床进一步治疗和恢复。可以使用一氧化氮气体，减少微生物感染，控制渗出物分泌，上调内源性胶原酶的表达以局部清创伤口，并调节胶原蛋白的形成。此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。在高浓度一氧化氮的第一次治疗期后，可以提供较低浓度的一氧化氮的第二治疗期以诱导有助于关闭伤口的胶原表达。

6. 发明申请

WO2018017722A1 ANIMAL INTRANASAL ADMINISTRATION DEVICE, SYSTEMS, AND ASSOCIATED METHODS 审中-公开
标题翻译：动物内部给药装置，系统和相关方法
公开(公告)号：WO2018017722A1
公开(公告)日：2018-01-25
申请号：PCT/US2017/042874
申请日：2017-07-19
申请人： ELI LILLY AND COMPANY , BOVICOR PHARMATECH INC.
发明人： MARR, Amy L. , HILL, Jeffrey K. , STRANGE, Casey J. , MILLER, Christopher C. , OWENS, Jane G. , WALN, Randall L. , REGEV-SHOSHANI, Gilly , STENZLER, Alex , HAN, Steve
IPC分类号： A61M16/06
摘要： A veterinary subject intranasal administration device, and associated systems and methods, are disclosed. The veterinary subject intranasal administration device can include a first support member portion including a septum interface portion sized for insertion into a nasal passage of the veterinary subject; an actuation mechanism connected to the first support member portion; and a fluid conduit having a distal end opposite a supported end, the distal end sized for insertion into the nasal passage of the veterinary subject, the fluid conduit being flexible and configured to receive fluid from a fluid source and discharge the fluid through the distal end into the nasal passage, the distal end of the fluid conduit being unsupported and movable relative to the septum interface portion.
摘要翻译：公开了一种兽医对象鼻内施用装置及相关系统和方法。兽医对象鼻内施用装置可以包括：第一支撑构件部分，其包括尺寸适于插入兽医患者的鼻腔通道中的隔膜界面部分; 连接到所述第一支撑构件部分的致动机构; 以及流体导管，所述流体导管具有与支撑端相对的远端，所述远端的尺寸设计成用于插入到所述兽医患者的鼻通道中，所述流体导管是柔性的并且被配置为接收来自流体源的流体并且通过所述远端进入鼻通道，流体导管的远端不被支撑并且可相对于隔膜界面部分移动。

7. 发明申请

WO2009124379A1 BIOFILM-INHIBITING CATHETERS AND TUBINGS 审中-公开
标题翻译：生物膜抑制导管和管
公开(公告)号：WO2009124379A1
公开(公告)日：2009-10-15
申请号：PCT/CA2009/000407
申请日：2009-03-25
申请人： ENOX BIOPHARMA, INC. , AV-GAY, Yossef , MAHLER, Livia , MILLER, Christopher C.
发明人： AV-GAY, Yossef , MAHLER, Livia , MILLER, Christopher C.
IPC分类号： A61M1/00 , A61L29/04 , A61L29/16 , A61L31/04 , A61L31/16 , A61M16/04 , A61M25/00 , A61M27/00 , A61B19/02
CPC分类号： A61L29/16 , A61L2300/114 , A61L2300/404 , A61M16/04 , A61M16/0465 , A61M2025/0056
摘要： Antimicrobial and biofilm-inhibiting nitric oxide-releasing medical appliances for installation into a patient, and processes for producing the medical appliances. The medical appliances are configured for conveying materials into and out of the patient's body and may comprise tubings or pouching systems. The medical appliances comprise a gas-permeable cured resin material selected from the group consisting of curable silicones, polyvinyl acetates, thermoplastic elastomers, acrylonitrile-butadiene-styrene copolymer rubber, polyurethanes and selected combinations thereof, wherein the gas-permeable cured resin material comprises a matrix suitable for releasably sequestering therein permeating gases. A plurality of nitric-oxide gas-releasing moieties is sequestered within and through the gas-permeable resin material. Nitric oxide is released from at least a portion of said plurality of nitric oxide gas-releasing moieties upon contact of the medical appliance with a moisture source. Exemplary medical appliances include endotracheal tubes, crichotracheotomy tubes, urinary catheters, wound drainage tubes, central intravenous catheters, peripheral intravenous catheters, and poucing systems.
摘要翻译：用于安装到患者体内的抗菌和生物膜抑制一氧化氮释放医疗器具，以及用于生产医疗器具的方法。医疗器具被配置为将材料输送进入和离开患者身体，并且可以包括管道或包囊系统。所述医疗器具包括选自可固化的硅酮，聚乙酸乙烯酯，热塑性弹性体，丙烯腈 - 丁二烯 - 苯乙烯共聚物橡胶，聚氨酯及其选择的组合的透气性固化树脂材料，其中透气性固化树脂材料包括基质适于在其中可释放地封闭渗透气体。多个一氧化氮气体释放部分被隔离在透气性树脂材料内并通过透气性树脂材料。当医疗器具与湿气源接触时，一氧化氮从所述多个一氧化氮气体释放部分的至少一部分释放。示例性医疗器具包括气管内导管，气管切开术管，导尿管，伤口引流管，中央静脉导管，外周静脉导管和灌注系统。

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