专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2003074500A3 N-AMINOACETYL-PYRROLIDINE-2-CARBONITRILES AND THEIR USE AS DDP-IV INHIBITORS 审中-公开
公开(公告)号：WO2003074500A3
公开(公告)日：2003-09-12
申请号：PCT/HU2003/000017
申请日：2003-03-04
申请人： SANOFI-SYNTHELABO , ARÁNYI, Péter , BALÁZS, László , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , BOVY, Philippe , KÁNAI, Károly , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , NAGY, Lajos, T. , URBÁN-SZABÓ, Katalin , VARGA, Márton
发明人： ARÁNYI, Péter , BALÁZS, László , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , BOVY, Philippe , KÁNAI, Károly , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , NAGY, Lajos, T. , URBÁN-SZABÓ, Katalin , VARGA, Márton
IPC分类号： C07D451/04
摘要： The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.

2. 发明申请

WO2003074500A2 NEW COMPOUNDS 审中-公开
标题翻译：新化合物
公开(公告)号：WO2003074500A2
公开(公告)日：2003-09-12
申请号：PCT/HU2003/000017
申请日：2003-03-04
申请人： SANOFI-SYNTHELABO , ARÁNYI, Péter , BALÁZS, László , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , BOVY, Philippe , KÁNAI, Károly , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , NAGY, Lajos, T. , URBÁN-SZABÓ, Katalin , VARGA, Márton
发明人： ARÁNYI, Péter , BALÁZS, László , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , BOVY, Philippe , KÁNAI, Károly , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , NAGY, Lajos, T. , URBÁN-SZABÓ, Katalin , VARGA, Márton
IPC分类号： C07D261/00
CPC分类号： C07D451/04 , C07D207/16 , C07D211/58 , C07D401/04 , C07D401/14 , C07D405/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/14
摘要： The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.
摘要翻译：本发明涉及含有氟原子的新的具有通式（I）的DPP-IV酶抑制剂。

3. 发明申请

WO2003106456A3 AZABICYCLO-OCTANE AND NONANE DERIVATIVES WITH DDP-IV INHIBITING ACTIVITY 审中-公开
公开(公告)号：WO2003106456A3
公开(公告)日：2003-12-24
申请号：PCT/HU2003/000041
申请日：2003-06-11
申请人： SANOFI-SYNTHELABO , ARÁNYI, Péter , BALÁZS, László , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , T. NAGY, Lajos , URBÁN-SZABÓ, Katalin , VARGA, Márton
发明人： ARÁNYI, Péter , BALÁZS, László , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , T. NAGY, Lajos , URBÁN-SZABÓ, Katalin , VARGA, Márton
IPC分类号： C07D451/04
摘要： The present invention relates to the novel compounds of the general formula (I) possessing DPP-IV inhibitory activity. These compounds contain tropane (B) building blocks.

4. 发明申请

WO2005021536A3 ADAMANTANE AND AZABICYCLO-OCTANE AND NONANE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS DPP-IV INHIBITORS 审中-公开
公开(公告)号：WO2005021536A3
公开(公告)日：2005-03-10
申请号：PCT/HU2004/000088
申请日：2004-08-27
申请人： SANOFI-AVENTIS , ARÁNYI, Péter , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , BOVY, Philippe , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , URBÁN-SZABÓ, Katalin , VARGA, Márton
发明人： ARÁNYI, Péter , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , BOVY, Philippe , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , URBÁN-SZABÓ, Katalin , VARGA, Márton
IPC分类号： C07D403/12
摘要： The invention relates to new compounds of the general formula (I), which are strong DPP-IV enzyme inhibitors.

5. 发明申请

WO2007034254A3 AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIGANDS 审中-公开
公开(公告)号：WO2007034254A3
公开(公告)日：2007-03-29
申请号：PCT/HU2006/000080
申请日：2006-09-21
申请人： SANOFI-AVENTIS , SÁNTA, Mihályné , PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNE SZEREDI, Judit , SZABÓ, Tibor , SUSÁN, Edit , KOVÁCS, Marianna
发明人： PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNE SZEREDI, Judit , SZABÓ, Tibor , SUSÁN, Edit , KOVÁCS, Marianna
IPC分类号： C07C233/35 , C07C323/63 , A61K31/4965
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I), within them favourably to antagonists and to the salts, solvates and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and their salts, solvates and isomers and to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers.

6. 发明申请

WO2007034253A1 AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIGANDS 审中-公开
标题翻译：氨基酸 - 酰胺衍生物作为CCR3受体配体
公开(公告)号：WO2007034253A1
公开(公告)日：2007-03-29
申请号：PCT/HU2006/000079
申请日：2006-09-19
申请人： SANOFI-AVENTIS , SÁNTA, Mihályné , PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , SZABÓ, Tibor , SUSÁN, Edit , KOVÁCS, Marianna
发明人： PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , SZABÓ, Tibor , SUSÁN, Edit , KOVÁCS, Marianna
IPC分类号： C07C233/40 , A61K31/165 , A61P37/00
CPC分类号： C07C233/36 , C07D263/58 , C07D277/68 , C07D277/82
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I), within them favourably to antagonists and to the salts, solvates and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and their salts, solvates and isomers and to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers and to the new intermediates of the general formula (XX) and (XXI).
摘要翻译：本发明涉及通式（I）的CCR3受体配体，其中有利于拮抗剂及其盐，溶剂化物和异构体，含有它们的药物组合物，涉及使用通式（ I）及其盐，溶剂合物和异构体以及通式（I）化合物及其盐，溶剂合物和异构体以及通式（XX）和（XXI）的新中间体的制备。

7. 发明申请

WO2003053968A1 TRIAZOLO-QUINOLIN DERIVATIVES USEFUL AS ADENOSINE RECEPTOR LIGANDS 审中-公开
标题翻译：作为腺苷受体配体的TRIAZOLO-QUINOLIN衍生物有用
公开(公告)号：WO2003053968A1
公开(公告)日：2003-07-03
申请号：PCT/HU2002/000143
申请日：2002-12-17
申请人： SANOFI-SYNTHELABO , ARÁNYI, Péter , BALÁZS, László , BÁTORI, Sándor , BENCE, Judit , BOÉR, Kinga , HAJDÚ, Félix , KAPUI, Zoltán , MIKUS, Endre , SZABÓ, Tibor , T. NAGY, Lajos , TÍMÁRI, Géza , URBÁN-SZABÓ, Katalin , WALCZ, Erzsébet
发明人： ARÁNYI, Péter , BALÁZS, László , BÁTORI, Sándor , BENCE, Judit , BOÉR, Kinga , HAJDÚ, Félix , KAPUI, Zoltán , MIKUS, Endre , SZABÓ, Tibor , T. NAGY, Lajos , TÍMÁRI, Géza , URBÁN-SZABÓ, Katalin , WALCZ, Erzsébet
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D215/54 , C07D215/56
摘要： The present invention relates to adenosine A¿3? receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and theirs salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and to the preparation thereof.
摘要翻译：三唑并喹啉衍生物是新的。式（I）的三唑并喹啉衍生物，其盐，溶剂合物和旋光异构体及其盐或溶剂化物是新的。 R 1> R 2> H或直链或支链的1-4C烷基; R 3>直链或支链的1-4C烷基，苯基，噻吩基，呋喃基（任选被至少一个直链或支链的1-4C烷基，直链或支链的1-4C烷氧基或卤素取代），H，5-6元杂芳环含有一个氮原子和一个氧原子或一个氮原子和一个硫原子的1-3元原子或5元杂芳环（任选被至少一个直链或支链的1-4C烷基，直链或支链的1-4C烷氧基或卤素）; R 4>和R 5> H; R 4> + R 5> 1,3-丁二烯基（任选被亚甲二氧基或至少一个直链或支链的1-4C烷基，直链或支链的1-4C烷氧基，OH或卤素取代）; R 6> H，氰基，氨基羰基，1-4C烷氧基羰基或羧基; R 7>苯基，苄基，噻吩基，呋喃基（全部由亚甲二氧基或至少一个直链或支链的1-4C烷基，直链或支链的1-4C烷氧基，OH，三氟甲基，氰基或卤素取代），H，直链或支链 1-4C烷基或1-4C亚烷基（任选被苯基取代），氨基，一或二烷基氨基，含有1-3个N原子的5-6元杂芳族环或含有一个氮原子和一个氧原子的5元杂芳环，或一个氮原子和一个硫原子（任选被至少一个直链或支链的1-4C烷基，直链或支链的1-4C烷氧基或卤素取代）; X：-CH 2 - ， - NH - ， - NR 1 - ， - S，O，磺基或磺氧基; R 1> 2>直链或支链的1-4C烷基或3-6C环烷基; 还包括：（1）（I）的制备; 和（2）式（II）的新的中间体1,2-二氨基吡啶盐。活动： Nephrotropic; 抗过敏; 抗炎; 皮肤; 银屑病; 低血压; 眼科; 降血糖; 平喘; 免疫抑制; 抗风湿; 抑制细胞生长; Vasotropic; 抗心律不整。作用机制：腺苷A 3受体拮抗剂。使用HEK-293细胞测试化合物的腺苷A 3受体拮抗活性。描述测试细节，但没有给出具体化合物的结果。通常化合物（I）显示K i为3.5和0.78nM。

8. 发明申请

WO2007034251A1 AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIGANDS 审中-公开
标题翻译：氨基酸 - 酰胺衍生物作为CCR3受体配体
公开(公告)号：WO2007034251A1
公开(公告)日：2007-03-29
申请号：PCT/HU2006/000077
申请日：2006-09-19
申请人： SANOFI-AVENTIS , SÁNTA, Mihályné , PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , FERENCZY, György , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , SZABÓ, Tibor , WALCZ, Erszébet
发明人： PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , FERENCZY, György , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , SZABÓ, Tibor , WALCZ, Erszébet
IPC分类号： C07C323/63 , C07C233/35 , A61K31/4965
CPC分类号： C07C323/60 , C07D209/30 , C07D233/84 , C07D235/28 , C07D239/34 , C07D239/38 , C07D241/44 , C07D257/04 , C07D263/58 , C07D271/113 , C07D277/16 , C07D277/70 , C07D401/04 , C07D405/04 , C07D413/04 , C07D471/04 , C07D513/04
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I), within them favourably to antagonists and to the salts, solvates and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers and to the new intermediates of the general formula (III).
摘要翻译：本发明涉及通式（I）的CCR3受体配体，其中有利于拮抗剂及其盐，溶剂化物和异构体，含有它们的药物组合物，涉及使用通式（ I）及其盐，溶剂合物和异构体制备通式（I）化合物及其盐，溶剂合物和异构体以及通式（III）的新中间体。

9. 发明申请

WO2005060959A1 PYRAZOLE DERIVATIVES AND USE THEREOF AS OREXIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：吡唑衍生物及其作为OREXIN受体拮抗剂的用途
公开(公告)号：WO2005060959A1
公开(公告)日：2005-07-07
申请号：PCT/HU2004/000117
申请日：2004-12-15
申请人： SANOFI-AVENTIS , ALETRU, Michel , ARÁNYI, Péter , BALOGH, Mária , BÁTORI, Sándor , BENCE, Judit , BOVY, Philippe , KAPUI, Zoltán , MIKUS, Endre , NAMANE, Claudie , PHILIPPO, Christophe , SZABÓ, Tibor , TÖMÖSKÖZI, Zsuzsanna , URBÁN-SZABÓ, Katalin
发明人： ALETRU, Michel , ARÁNYI, Péter , BALOGH, Mária , BÁTORI, Sándor , BENCE, Judit , BOVY, Philippe , KAPUI, Zoltán , MIKUS, Endre , NAMANE, Claudie , PHILIPPO, Christophe , SZABÓ, Tibor , TÖMÖSKÖZI, Zsuzsanna , URBÁN-SZABÓ, Katalin
IPC分类号： A61K31/415
CPC分类号： C07D409/04 , C07D231/16 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.
摘要翻译：本发明涉及食欲素受体拮抗剂通式（I）化合物及其异构体，盐和溶剂合物，其含有它们的药物组合物及其治疗应用。

10. 发明申请

WO2008149168A8 TRIAZOLO [1, 5-A] QUINOLINES AS ADENOSINE A3 RECEPTOR LIGANDS 审中-公开
公开(公告)号：WO2008149168A8
公开(公告)日：2008-12-11
申请号：PCT/HU2008/000063
申请日：2008-06-02
申请人： SANOFI-AVENTIS , SUSÁN, Edit , BOÉR, Kinga , KAPUI, Zoltán , TÍMÁRI, Géza , BÁTORI, Sándor , SZLÁVIK, Zoltán , MIKUS, Endre , VARGÁNÉ SZEREDI, Judit , FINET, Michel , URBÁN SZABÓ, Katalin , SZABÓ, Tibor
发明人： SUSÁN, Edit , BOÉR, Kinga , KAPUI, Zoltán , TÍMÁRI, Géza , BÁTORI, Sándor , SZLÁVIK, Zoltán , MIKUS, Endre , VARGÁNÉ SZEREDI, Judit , FINET, Michel , URBÁN SZABÓ, Katalin , SZABÓ, Tibor
IPC分类号： C07D215/58 , C07D471/04 , C07F7/22 , A61K31/4745 , A61P11/06 , A61P29/00
摘要： The present invention relates to the adenosine A3 receptor ligands of the general formula (I), within them favourably to the antagonists, to their salts, solvates, N -oxides and isomers, to the pharmaceutical compositions containing the compounds of the general formula (I), their salts, solvates, N -oxides and isomers, to the use of the compounds of the general formula (I), their salts, solvates, N -oxides and isomers, to the preparation of the compounds of the general formula (I), their salts, solvates, N -oxides and isomers, as well as to the new intermediates of the general formula (II), (VI), (XI), (XII) and (XV), and to the preparation thereof.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式