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1. 发明申请

WO2007034254A2 AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIGANDS 审中-公开
标题翻译：氨基酸 - 酰胺衍生物作为CCR3受体配体
公开(公告)号：WO2007034254A2
公开(公告)日：2007-03-29
申请号：PCT/HU2006000080
申请日：2006-09-21
申请人： SANOFI AVENTIS , SANTA MIHALYNE , PAPPNE BEHR AGNES , KAPUI ZOLTAN , ARANYI PETER , BATORI SANDOR , BARTANE BODOR VERONIKA , VARGA MARTON , MIKUS ENDRE , URBAN-SZABO KATALIN , VARGANE SZEREDI JUDIT , SZABO TIBOR , SUSAN EDIT , KOVACS MARIANNA
发明人： PAPPNE BEHR AGNES , KAPUI ZOLTAN , ARANYI PETER , BATORI SANDOR , BARTANE BODOR VERONIKA , VARGA MARTON , MIKUS ENDRE , URBAN-SZABO KATALIN , VARGANE SZEREDI JUDIT , SZABO TIBOR , SUSAN EDIT , KOVACS MARIANNA , T NAGY LAJOS
IPC分类号： C07C233/35 , A61K31/4965 , C07C233/40 , C07C233/78 , C07C323/63 , C07D235/28 , C07D263/58
CPC分类号： C07C233/78 , C07C233/40 , C07D235/28 , C07D263/58
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I), within them favourably to antagonists and to the salts, solvates and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and their salts, solvates and isomers and to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers.
摘要翻译：本发明涉及通式（I）的CCR3受体配体，其有利于拮抗剂及其盐，溶剂化物和异构体，含有它们的药物组合物，涉及使用通式（ I）及其盐，溶剂合物和异构体以及通式（I）化合物及其盐，溶剂合物和异构体的制备。

2. 发明申请

WO2006010095A2 OXIME DERIVATIVE SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS 审中-公开
标题翻译： OXIME衍生物取代的羟乙胺天冬氨酸蛋白酶抑制剂
公开(公告)号：WO2006010095A2
公开(公告)日：2006-01-26
申请号：PCT/US2005/024469
申请日：2005-07-11
申请人： ELAN PHARMACEUTICALS INC. , JOHN, Varghese , MAILLARD, Michel , JAGODZINSKA, Barbara , AQUINO, Jose , PROBST, Gary , TUNG, Jay, S.
发明人： JOHN, Varghese , MAILLARD, Michel , JAGODZINSKA, Barbara , AQUINO, Jose , PROBST, Gary , TUNG, Jay, S.
IPC分类号： C07C233/40 , C07C235/34 , C07D209/20 , C07D213/40 , C07D215/42 , C07D311/68 , C07D335/06 , C07D409/12 , C07D413/12 , C07D405/12 , C07D403/12 , C07D207/32 , C07D233/54
CPC分类号： C07D285/08 , C07C233/36 , C07C237/20 , C07C251/44 , C07C251/54 , C07C251/84 , C07C255/42 , C07C255/58 , C07C2601/04 , C07C2601/14 , C07D213/40 , C07D231/12 , C07D231/56 , C07D233/64 , C07D257/04 , C07D261/20 , C07D271/10 , C07D335/06 , C07D405/10
摘要： The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a colletion of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译：本发明涉及治疗与淀粉样变性有关的疾病，病症和病症的新型化合物和方法。淀粉样变性是指收集与A-β蛋白异常沉积相关的疾病，病症和病症。

3. 发明申请

WO01019809A1 TRYPTASE INHIBITORS 审中-公开
标题翻译： TRYPTASE抑制剂
公开(公告)号：WO01019809A1
公开(公告)日：2001-03-22
申请号：PCT/EP2000/008899
申请日：2000-09-12
IPC分类号： C07D295/20 , A61K31/16 , A61K31/165 , A61K31/27 , A61K31/341 , A61K31/381 , A61K31/495 , A61K31/496 , A61P11/00 , C07C233/36 , C07C233/40 , C07C235/10 , C07C237/20 , C07C271/20 , C07D295/205 , C07D295/215 , C07D307/42 , C07D307/54 , C07D333/16 , C07D333/24
CPC分类号： C07D295/205 , C07D295/215
摘要： Compounds of formula (I), in which M, B1, B2, B3, B4, B5, B6, A1, A2, A3, A4, A5, A6, K1 and K2 have the meanings as indicated in the description are novel effective tryptase inhibitors.
摘要翻译：其中M，B1，B2，B3，B4，B5，B6，A1，A2，A3，A4，A5，A6，K1和K2具有如说明书中所示的含义的式（I）化合物是新型有效的类胰蛋白酶抑制剂。

4. 发明申请

WO00055112A1 ANTI-VIRAL COMPOUNDS 审中-公开
标题翻译：反虚构化合物
公开(公告)号：WO00055112A1
公开(公告)日：2000-09-21
申请号：PCT/GB1999/003741
申请日：1999-11-10
IPC分类号： A61K31/14 , A61K31/216 , A61P31/12 , C07C219/10 , A61K31/215 , C07C225/06 , C07C233/40 , C07C327/44
CPC分类号： A61K31/216 , A61K31/14
摘要： The use of a compound of general formula (I), wherein Ar is a phenyl group or substituted aromatic group; R1 is an alkyl or alkenyl group; X is C, O, N or S; R2 is an alkyl or alkenyl group; Y is a primary, secondary or tertiary amino group or an ammonium ion thereof; and "n" and "m" are each an integer between 0 and 20, in the preparation of a medicament for the treatment of viral complaints. A preferred compound is in the form of an ammonium salt.
摘要翻译：使用通式（I）的化合物，其中Ar是苯基或取代的芳基; R1是烷基或烯基; X是C，O，N或S; R2是烷基或烯基; Y是伯，仲或叔氨基或其铵离子; 和“n”和“m”分别为0〜20的整数，用于制备用于治疗病毒性投诉的药物。优选的化合物是铵盐的形式。

5. 发明申请

WO99057564A1 METHOD FOR IMMOBILISING AND/OR CRYSTALLISING BIOLOGICAL MACROMOLECULES ON CARBON NANOTUBES AND USES 审中-公开
标题翻译：用于碳纳米管和用途的生物分析和/或结晶的方法
公开(公告)号：WO99057564A1
公开(公告)日：1999-11-11
申请号：PCT/FR1999/001086
申请日：1999-05-07
IPC分类号： C07C233/40 , C07C235/20 , C07D495/04 , C07F1/00 , C07F1/08 , C07F15/04 , C07K17/04 , C12N11/06 , C12N11/14 , C12N15/09 , C30B7/00 , G01N33/543 , G01N33/547 , G01N33/551
CPC分类号： C07D495/04 , B82Y30/00 , C07C233/40 , C07C235/20 , C07C2603/24 , C07C2603/54 , C07F1/005 , C07F15/045 , C30B7/00 , C30B29/58 , G01N33/54353 , G01N33/54373 , G01N33/551 , Y10S977/729 , Y10S977/742 , Y10S977/746 , Y10S977/747 , Y10S977/793 , Y10S977/842 , Y10S977/848 , Y10S977/894 , Y10S977/896 , Y10S977/898 , Y10S977/92
摘要： The invention concerns a method for immobilising and/or crystallising macromolecules, chemical reagents used in said method, resulting products and uses of said products in the field of materials and structural biology, in particular as biosensors or as biomaterials. Said method essentially consists in incubating, without stirring, for at least 15 minutes, a biological macromolecule in solution with carbon nanotubes closed at their ends, in suitable temperature and pH conditions.
摘要翻译：本发明涉及用于固定和/或结晶大分子的方法，在所述方法中使用的化学试剂，所得产品和所述产品在材料和结构生物学领域的用途，特别是作为生物传感器或作为生物材料。所述方法基本上在于在合适的温度和pH条件下，在不搅拌的情况下将碳纳米管封闭的溶液中的生物大分子孵育至少15分钟。

6. 发明申请

WO99033786A1 ANTI-INFLAMMATORY COMPOUNDS 审中-公开
标题翻译：抗炎化合物
公开(公告)号：WO99033786A1
公开(公告)日：1999-07-08
申请号：PCT/US1998/027712
申请日：1998-12-29
IPC分类号： C07D317/58 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/27 , A61K31/36 , A61K31/381 , A61K31/382 , A61K31/405 , A61K31/4402 , A61P17/00 , A61P29/00 , C07C233/05 , C07C233/11 , C07C233/12 , C07C233/13 , C07C233/16 , C07C233/30 , C07C233/40 , C07C233/51 , C07C271/44 , C07C311/13 , C07C311/16 , C07C317/44 , C07C323/62 , C07D209/18 , C07D209/42 , C07D213/56 , C07D213/81 , C07D333/24 , C07D333/38 , C07D333/40 , C07D333/60 , C07D333/70 , C07D335/12 , C07D409/12 , A61K31/38 , A61K31/395 , C07D333/36
CPC分类号： C07C311/13 , C07C233/05 , C07C233/11 , C07C233/13 , C07C271/44 , C07C311/16 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2603/18 , C07C2603/32 , C07D209/18 , C07D209/42 , C07D213/56 , C07D333/24 , C07D333/38 , C07D333/60 , C07D333/70
摘要： This invention relates to anti-inflammatory compounds, methods of making such compounds and methods of using such compounds having structure (I).
摘要翻译：本发明涉及抗炎化合物，制备此类化合物的方法和使用具有结构（I）的化合物的方法。

7. 发明申请

WO98050342A1 PROTEASE INHIBITORS 审中-公开
标题翻译： PROTEASE抑制剂
公开(公告)号：WO98050342A1
公开(公告)日：1998-11-12
申请号：PCT/US1998/008764
申请日：1998-04-30
IPC分类号： C07D295/14 , A61K31/166 , A61K31/18 , A61K31/27 , A61K31/421 , A61K31/4402 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/498 , A61K31/5375 , A61K31/5377 , A61P1/02 , A61P19/02 , A61P19/04 , A61P19/10 , A61P29/00 , A61P43/00 , C07C233/40 , C07C271/22 , C07C311/18 , C07C311/19 , C07D211/62 , C07D213/30 , C07D213/56 , C07D213/71 , C07D213/81 , C07D215/36 , C07D215/48 , C07D233/54 , C07D257/02 , C07D257/04 , C07D263/32 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07C233/00
CPC分类号： C07D213/30 , C07C233/40 , C07C271/22 , C07C311/18 , C07C2601/14 , C07D211/62 , C07D213/56 , C07D213/71 , C07D213/81 , C07D215/36 , C07D215/48 , C07D233/64 , C07D257/04 , C07D401/12
摘要： The present invention provides bis-aminomethylcarbonyl compounds that are inhibitors of cysteine and serine proteases. The compounds are particularly useful for treating diseases in which excess cysteine protease activity has been implicated, including osteoporosis, periodontitis and arthritis.
摘要翻译：本发明提供作为半胱氨酸和丝氨酸蛋白酶抑制剂的双氨基甲基羰基化合物。该化合物特别可用于治疗涉及过量半胱氨酸蛋白酶活性的疾病，包括骨质疏松症，牙周炎和关节炎。

8. 发明申请

WO1993022279A1 DIAMINE DERIVATIVES HAVING SELECTIVE AFFINITY FOR SIGMA RECEPTORS 审中-公开
标题翻译：具有SIGMA受体选择性亲和力的DIAMINE衍生物
公开(公告)号：WO1993022279A1
公开(公告)日：1993-11-11
申请号：PCT/CH1993000106
申请日：1993-04-22
申请人： BATTELLE MEMORIAL INSTITUTE , ROCHER, Jean-Philippe
发明人： BATTELLE MEMORIAL INSTITUTE
IPC分类号： C07C233/40
CPC分类号： C07D207/325 , C07C211/27 , C07C233/36 , C07C233/37 , C07C233/40 , C07C2603/74 , C07D295/125
摘要： Diamine derivatives of formula (I), wherein n = 0-8; R1 is hydrogen or a C1-3 alkyl residue; each of R2, R3, R4, R5 and R6 is hydrogen, a C1-6 alkyl residue, branched C4-12 alkyl or alkenyl; R2 and R3 together may form a C3-8 ring optionally including a heteroatom and optionally partially or wholly unsatured; R5 and R6 taken together may form a C2-8 ring; X is a single bond, -CH2-, -C (=O)-, -S (O)-, or -S (O)2-; Y is an alkyl residue, cycloalkyl, cycloalkylalkyl, adamantyl, optionally substituted phenyl or an aromatic heterocyclic ring; Ar is an optionally substituted phenyl radical, naphtyl or an aromatic heterocyclic ring. Said derivatives are psychotropic agents particularly suitable for treating psychotic disorders, convulsion, dyskinesia, brain distress (ischaemia, hypoxia) and anxiety, and further have anti-inflammatory properties.
摘要翻译：式（I）的二胺衍生物，其中n = 0-8; R1是氢或C1-3烷基残基; R2，R3，R4，R5和R6各自为氢，C1-6烷基，支链C4-12烷基或烯基; R2和R3一起可以形成任选地包括杂原子并且任选地部分或全部不成熟的C 3-8环; R5和R6一起可以形成C2-8环; X是单键，-CH 2 - ， - C（= O） - ， - S（O） - 或-S（O）2 - Y是烷基残基，环烷基，环烷基烷基，金刚烷基，任选取代的苯基或芳族杂环; Ar是任选取代的苯基，萘基或芳族杂环。所述衍生物是特别适用于治疗精神病，惊厥，运动障碍，脑窘迫（缺血，缺氧）和焦虑的精神药物，并且还具有抗炎特性。

9. 发明申请

WO2011115687A3 ALKYLATED SP-B PEPTOID COMPOUNDS AND RELATED LUNG SURFACTANT COMPOSITIONS 审中-公开
标题翻译：碱性SP-B PEPTOID化合物和相关的肺表面活性剂组合物
公开(公告)号：WO2011115687A3
公开(公告)日：2012-02-16
申请号：PCT/US2011000511
申请日：2011-03-21
申请人： UNIV NORTHWESTERN , BARRON ANNELISE E , DOHM MICHELLE , SERVOSS SHANNON L
发明人： BARRON ANNELISE E , DOHM MICHELLE , SERVOSS SHANNON L
IPC分类号： C07C237/20 , A61K31/165 , A61P11/00 , C07C233/40 , C07C237/10
CPC分类号： A61K31/165 , C07C237/52 , C07K14/785
摘要： SP-B peptoid compounds, lung surfactant compositions and related surfactant replacement therapies. Such SP-B peptoids can mimic lung surfactant protein B, and can be used in conjunction with biomimetic SP-C compounds over a range of lung surfactant compositions.
摘要翻译： SP-B拟肽化合物，肺表面活性剂组合物和相关的表面活性剂替代疗法。这样的SP-B拟肽可以模拟肺表面活性蛋白B，并且可以在一系列肺表面活性剂组合物上与仿生SP-C化合物联合使用。

10. 发明申请

WO2007034253A1 AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIGANDS 审中-公开
标题翻译：氨基酸 - 酰胺衍生物作为CCR3受体配体
公开(公告)号：WO2007034253A1
公开(公告)日：2007-03-29
申请号：PCT/HU2006/000079
申请日：2006-09-19
申请人： SANOFI-AVENTIS , SÁNTA, Mihályné , PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , SZABÓ, Tibor , SUSÁN, Edit , KOVÁCS, Marianna
发明人： PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , SZABÓ, Tibor , SUSÁN, Edit , KOVÁCS, Marianna
IPC分类号： C07C233/40 , A61K31/165 , A61P37/00
CPC分类号： C07C233/36 , C07D263/58 , C07D277/68 , C07D277/82
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I), within them favourably to antagonists and to the salts, solvates and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and their salts, solvates and isomers and to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers and to the new intermediates of the general formula (XX) and (XXI).
摘要翻译：本发明涉及通式（I）的CCR3受体配体，其中有利于拮抗剂及其盐，溶剂化物和异构体，含有它们的药物组合物，涉及使用通式（ I）及其盐，溶剂合物和异构体以及通式（I）化合物及其盐，溶剂合物和异构体以及通式（XX）和（XXI）的新中间体的制备。

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