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1. 发明申请

WO2007034253A1 AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIGANDS 审中-公开
标题翻译：氨基酸 - 酰胺衍生物作为CCR3受体配体
公开(公告)号：WO2007034253A1
公开(公告)日：2007-03-29
申请号：PCT/HU2006/000079
申请日：2006-09-19
申请人： SANOFI-AVENTIS , SÁNTA, Mihályné , PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , SZABÓ, Tibor , SUSÁN, Edit , KOVÁCS, Marianna
发明人： PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , SZABÓ, Tibor , SUSÁN, Edit , KOVÁCS, Marianna
IPC分类号： C07C233/40 , A61K31/165 , A61P37/00
CPC分类号： C07C233/36 , C07D263/58 , C07D277/68 , C07D277/82
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I), within them favourably to antagonists and to the salts, solvates and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and their salts, solvates and isomers and to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers and to the new intermediates of the general formula (XX) and (XXI).
摘要翻译：本发明涉及通式（I）的CCR3受体配体，其中有利于拮抗剂及其盐，溶剂化物和异构体，含有它们的药物组合物，涉及使用通式（ I）及其盐，溶剂合物和异构体以及通式（I）化合物及其盐，溶剂合物和异构体以及通式（XX）和（XXI）的新中间体的制备。

2. 发明申请

WO2007034254A3 AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIGANDS 审中-公开
公开(公告)号：WO2007034254A3
公开(公告)日：2007-03-29
申请号：PCT/HU2006/000080
申请日：2006-09-21
申请人： SANOFI-AVENTIS , SÁNTA, Mihályné , PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNE SZEREDI, Judit , SZABÓ, Tibor , SUSÁN, Edit , KOVÁCS, Marianna
发明人： PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNE SZEREDI, Judit , SZABÓ, Tibor , SUSÁN, Edit , KOVÁCS, Marianna
IPC分类号： C07C233/35 , C07C323/63 , A61K31/4965
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I), within them favourably to antagonists and to the salts, solvates and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and their salts, solvates and isomers and to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers.

3. 发明申请

WO2007034252A1 AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIQUIDS 审中-公开
标题翻译：氨基酸 - 酰胺衍生物作为CCR3受体液体
公开(公告)号：WO2007034252A1
公开(公告)日：2007-03-29
申请号：PCT/HU2006/000078
申请日：2006-09-19
申请人： SANOFI-AVENTIS , SÁNTA, Mihályné , PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , FERENCZY, György , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , WALCZ, Erzsébet , SUSÁN, Edit
发明人： PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , FERENCZY, György , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , WALCZ, Erzsébet , SUSÁN, Edit
IPC分类号： C07C233/35 , A61K31/4965
CPC分类号： C07C233/40 , C07D209/50 , C07D217/24 , C07D235/16 , C07D237/14 , C07D241/44 , C07D263/56 , C07D277/64 , C07D471/04 , C07D513/04
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I), within them favourably to antagonists and to the salts, solvates and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and their salts, solvates and isomers and to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers and to the new intermediates of the general formula (IIa).
摘要翻译：本发明涉及通式（I）的CCR3受体配体，其中有利于拮抗剂及其盐，溶剂化物和异构体，含有它们的药物组合物，涉及使用通式（ I）及其盐，溶剂化物和异构体以及通式（I）化合物及其盐，溶剂合物和异构体以及通式（IIa）的新中间体的制备。

4. 发明申请

WO2007034251A1 AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIGANDS 审中-公开
标题翻译：氨基酸 - 酰胺衍生物作为CCR3受体配体
公开(公告)号：WO2007034251A1
公开(公告)日：2007-03-29
申请号：PCT/HU2006/000077
申请日：2006-09-19
申请人： SANOFI-AVENTIS , SÁNTA, Mihályné , PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , FERENCZY, György , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , SZABÓ, Tibor , WALCZ, Erszébet
发明人： PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , FERENCZY, György , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , SZABÓ, Tibor , WALCZ, Erszébet
IPC分类号： C07C323/63 , C07C233/35 , A61K31/4965
CPC分类号： C07C323/60 , C07D209/30 , C07D233/84 , C07D235/28 , C07D239/34 , C07D239/38 , C07D241/44 , C07D257/04 , C07D263/58 , C07D271/113 , C07D277/16 , C07D277/70 , C07D401/04 , C07D405/04 , C07D413/04 , C07D471/04 , C07D513/04
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I), within them favourably to antagonists and to the salts, solvates and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers and to the new intermediates of the general formula (III).
摘要翻译：本发明涉及通式（I）的CCR3受体配体，其中有利于拮抗剂及其盐，溶剂化物和异构体，含有它们的药物组合物，涉及使用通式（ I）及其盐，溶剂合物和异构体制备通式（I）化合物及其盐，溶剂合物和异构体以及通式（III）的新中间体。

5. 发明申请

WO2008149168A8 TRIAZOLO [1, 5-A] QUINOLINES AS ADENOSINE A3 RECEPTOR LIGANDS 审中-公开
公开(公告)号：WO2008149168A8
公开(公告)日：2008-12-11
申请号：PCT/HU2008/000063
申请日：2008-06-02
申请人： SANOFI-AVENTIS , SUSÁN, Edit , BOÉR, Kinga , KAPUI, Zoltán , TÍMÁRI, Géza , BÁTORI, Sándor , SZLÁVIK, Zoltán , MIKUS, Endre , VARGÁNÉ SZEREDI, Judit , FINET, Michel , URBÁN SZABÓ, Katalin , SZABÓ, Tibor
发明人： SUSÁN, Edit , BOÉR, Kinga , KAPUI, Zoltán , TÍMÁRI, Géza , BÁTORI, Sándor , SZLÁVIK, Zoltán , MIKUS, Endre , VARGÁNÉ SZEREDI, Judit , FINET, Michel , URBÁN SZABÓ, Katalin , SZABÓ, Tibor
IPC分类号： C07D215/58 , C07D471/04 , C07F7/22 , A61K31/4745 , A61P11/06 , A61P29/00
摘要： The present invention relates to the adenosine A3 receptor ligands of the general formula (I), within them favourably to the antagonists, to their salts, solvates, N -oxides and isomers, to the pharmaceutical compositions containing the compounds of the general formula (I), their salts, solvates, N -oxides and isomers, to the use of the compounds of the general formula (I), their salts, solvates, N -oxides and isomers, to the preparation of the compounds of the general formula (I), their salts, solvates, N -oxides and isomers, as well as to the new intermediates of the general formula (II), (VI), (XI), (XII) and (XV), and to the preparation thereof.

6. 发明申请

WO2010013078A2 PYRROLIDINYL-ALKYL-AMIDE DERIVATIVES THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION AS CCR3 RECEPTOR LIGANDS 审中-公开
标题翻译：吡咯烷基 - 烷基 - 酰胺衍生物的制备及其作为CCR3受体配体的治疗应用
公开(公告)号：WO2010013078A2
公开(公告)日：2010-02-04
申请号：PCT/HU2009/000067
申请日：2009-07-29
申请人： SANOFI-AVENTIS , PAPPNÉ BEHR, Ágnes , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , SZLÁVIK, Zsolt , BATA, Imre , URBÁN SZABÓ, Katalin , KAPUI, Zoltán , MIKUS, Endre
发明人： PAPPNÉ BEHR, Ágnes , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , SZLÁVIK, Zsolt , BATA, Imre , URBÁN SZABÓ, Katalin , KAPUI, Zoltán , MIKUS, Endre
IPC分类号： C07D417/12 , C07D513/04 , A61K31/428 , A61K31/429 , A61K31/4353 , A61P11/06 , A61P11/02 , A61P17/00 , A61P1/04
CPC分类号： C07D513/04 , C07D417/12
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I) or (IA) -within them favourably to the antagonists-, and to the salts and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and (IA), and their salts and isomers and to the preparation of the compounds of the general formula (I) and (IA), and their salts and isomers.
摘要翻译：本发明涉及通式（I）或（IA）的CCR3受体配体 - 其在拮抗剂 - 及其盐和异构体中有利地包含含有它们涉及通式（I）和（IA）化合物及其盐和异构体的用途以及通式（I）和（IA）化合物及其盐和异构体的制备。

7. 发明申请

WO2005021536A3 ADAMANTANE AND AZABICYCLO-OCTANE AND NONANE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS DPP-IV INHIBITORS 审中-公开
公开(公告)号：WO2005021536A3
公开(公告)日：2005-03-10
申请号：PCT/HU2004/000088
申请日：2004-08-27
申请人： SANOFI-AVENTIS , ARÁNYI, Péter , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , BOVY, Philippe , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , URBÁN-SZABÓ, Katalin , VARGA, Márton
发明人： ARÁNYI, Péter , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , BOVY, Philippe , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , URBÁN-SZABÓ, Katalin , VARGA, Márton
IPC分类号： C07D403/12
摘要： The invention relates to new compounds of the general formula (I), which are strong DPP-IV enzyme inhibitors.

8. 发明申请

WO2005009969A1 AMINOQUINOLINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS 审中-公开
标题翻译：氨基喹啉衍生物及其作为腺苷A3配体使用
公开(公告)号：WO2005009969A1
公开(公告)日：2005-02-03
申请号：PCT/HU2004/000080
申请日：2004-07-23
申请人： SANOFI-AVENTIS , ARÁNYI, Péter , BÁTORI, Sándor , TÍMARÍ, Géza , BOÉR, Kinga , KAPUI, Zoltán , MIKUS, Endre , URBÁN-SZABÓ, Katalin , GERBER, Katalin , VARGÁNÉ SZEREDI, Judit , FINET, Michel
发明人： ARÁNYI, Péter , BÁTORI, Sándor , TÍMARÍ, Géza , BOÉR, Kinga , KAPUI, Zoltán , MIKUS, Endre , URBÁN-SZABÓ, Katalin , GERBER, Katalin , VARGÁNÉ SZEREDI, Judit , FINET, Michel
IPC分类号： C07D215/54
CPC分类号： C07D405/12 , C07C229/50 , C07D215/48 , C07D405/14 , C07D409/12 , C07D409/14 , C07D491/04
摘要： Compounds of the general formula (I), and their salts, solvates, isomers (tautomers, desmotrops, optically active isomers) as well as the salts and solvates; are strong adenosine A 3 receptor ligands preferably antagonists.
摘要翻译：氨基喹啉衍生物（I）及其盐，溶剂合物，异构体（互变异构体，去亲质，旋光异构体）及其盐或溶剂化物是新的。式（I）的氨基喹啉衍生物及其盐，溶剂合物，异构体（互变异构体，去结构异构体，旋光异构体）及其盐或溶剂化物是新的。 R 1> H或1-4C烷基; R 2> H或1-4C烷基; R 3> H，1-4C烷基，3-6C环烷基，苯基，噻吩基或呋喃基（任选被1-4C烷基，1-4C烷氧基或卤素取代），含有1-3N的5-6元杂芳环，5元含有O，N或S（任选被1-4C烷基，1-4C烷氧基或卤素取代的）的杂芳环; R 4>，R 5> H，3-6C环烷基或1-4C烷基（任选地含有被1-2个1-4C烷基取代的氨基，OH，羧基或被1-4C烷基取代的烷基），苄基， SO 2 OH或1-4C酰基; NR 4> R 5>式（a）的基团; R 7> R 8> H，1-4C烷基或3-6C环烷基; R 6> H，1-4C烷基，苯基，苄基，噻吩基或呋喃基（任选被亚甲二氧基或1或多个1-4C烷基，1-4C烷氧基，羟基，三氟甲基，氰基或卤素取代）或5或6元杂芳环（含1-3 N，1 N和1 O或1 N和1 S，并任选被1个或多个1-4C烷基，1-4C烷氧基或卤素取代）; X：CH 2，NH，NR 9，S，O，磺基或磺氧基; R 9> 1-4C烷基或3-6C环烷基; Z：O，S，CHR 1> 0或NR 1>; H，1-4C烷基或3-6C环烷基; R 1> H，1-4C烷基，3-6C环烷基，SO 2 OH或1-4C酰基; n：0-2; m，o：1-3; 和p，r：0-1。条件是：（1）R 4>和R 5>是H，3-6C环烷基或1-4C烷基任选地含有氨基取代的1-2 1-4C烷基，OH，羧基或被1-4C取代的烷基烷基; （2）R 4>是H，1-4C烷基或苄基，R 5是H，-SO 2 OH或1-4C酰基; 或（3）NR 4> R 5>是（a）。 [图]独立申索也包括以下内容：（1）准备（一）; 和（2）式（II“），（III”），（IV“），（V”），（VI“），（VII”），（VIII“）和（XIII'）。活动： Nephrotropic; 呼吸根; CNS根; 抑制细胞生长; 眼科; 抗炎; 平喘; Vasotropic; 抗抑郁药; 抗心律不整; 抗帕金森氏病; 精神药物; 抗过敏; 皮肤; 抗关节炎; 免疫抑制; 胃肠道根; 同化; 高血压; 银屑病; 抗风湿; 神经保护; 抗糖尿病。作用机制：腺苷A3配体。（I）在HEK-293细胞中测试腺苷A3配体活性。（I）的抑制常数值为0.5-15nM。

9. 发明申请

WO2003106456A3 AZABICYCLO-OCTANE AND NONANE DERIVATIVES WITH DDP-IV INHIBITING ACTIVITY 审中-公开
公开(公告)号：WO2003106456A3
公开(公告)日：2003-12-24
申请号：PCT/HU2003/000041
申请日：2003-06-11
申请人： SANOFI-SYNTHELABO , ARÁNYI, Péter , BALÁZS, László , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , T. NAGY, Lajos , URBÁN-SZABÓ, Katalin , VARGA, Márton
发明人： ARÁNYI, Péter , BALÁZS, László , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , T. NAGY, Lajos , URBÁN-SZABÓ, Katalin , VARGA, Márton
IPC分类号： C07D451/04
摘要： The present invention relates to the novel compounds of the general formula (I) possessing DPP-IV inhibitory activity. These compounds contain tropane (B) building blocks.

10. 发明申请

WO2003074500A3 N-AMINOACETYL-PYRROLIDINE-2-CARBONITRILES AND THEIR USE AS DDP-IV INHIBITORS 审中-公开
公开(公告)号：WO2003074500A3
公开(公告)日：2003-09-12
申请号：PCT/HU2003/000017
申请日：2003-03-04
申请人： SANOFI-SYNTHELABO , ARÁNYI, Péter , BALÁZS, László , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , BOVY, Philippe , KÁNAI, Károly , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , NAGY, Lajos, T. , URBÁN-SZABÓ, Katalin , VARGA, Márton
发明人： ARÁNYI, Péter , BALÁZS, László , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , BOVY, Philippe , KÁNAI, Károly , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , NAGY, Lajos, T. , URBÁN-SZABÓ, Katalin , VARGA, Márton
IPC分类号： C07D451/04
摘要： The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.

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