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1. 发明申请

WO2008009005A2 APPARATUS AND METHOD FOR ADJUSTABLE FRACTIONAL OPTICAL DERMATOLOGICAL TREATMENT 审中-公开
标题翻译：用于可调节部分光学皮肤治疗的装置和方法
公开(公告)号：WO2008009005A2
公开(公告)日：2008-01-17
申请号：PCT/US2007073543
申请日：2007-07-13
申请人： RELIANT TECHNOLOGIES INC , CHAN KIN F , FRANGINEAS GEORGE , DEWEY DAVID , DEBENEDICTIS LEONARD C
发明人： CHAN KIN F , FRANGINEAS GEORGE , DEWEY DAVID , DEBENEDICTIS LEONARD C
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B18/20 , A61B2018/00452 , A61B2018/00636 , A61B2018/20351
摘要： A fractional treatment system can be configured with a laser wavelength that is selected such that absorption of the laser wavelength within the tissue increases as the tissue is heated by the laser (e.g., 1390-1425 nm). Desirably, the laser wavelength is primarily absorbed within a treated region of skin by water and has a thermally adjusted absorption coefficient within the range of about 8 cm"1 to about 30 cm 1. An adjustable mechanism can be used to adjust the beam shape, beam numerical aperture, beam focus depth, and/or beam size to affect the treatment depth and or the character of the resulting lesions. The system may be desiged to be switchable between a treatment mode that is semi-ablative and a treatment mode that is not semi-ablative. Adjustment of these parameters can improve the efficiency and efficacy of treatment. Illustrative examples of adjustable mechanisms include a set of spacers of different lengths, a rotatable turret with lens elements of different focal distances, an optical zoom lens, and a mechanical adjustment apparatus for adjusting the spacing between two optical lens elements.
摘要翻译：分数处理系统可以配置为选择激光波长，使得组织内的激光波长的吸收随着组织被激光加热（例如1390-1425nm）而增加。理想地，激光波长主要被水吸收在皮肤的处理区域内，并且具有在约8cm -1至约30cm -1范围内的热调节吸收系数。可调节机构可用于调节光束形状，光束数值孔径，光束聚焦深度和/或光束尺寸，以影响治疗深度或所得损伤的特征，该系统可以被设计为可在半烧蚀的治疗模式和治疗模式之间切换，这些参数的调整可以提高治疗的效率和效果，可调机构的说明性实例包括一组不同长度的间隔物，具有不同焦距的透镜元件的可旋转转台，光学变焦透镜和用于调节两个光学透镜元件之间的间距的机械调节装置。

2. 发明申请

WO2008008499A2 APPARATUS AND METHOD FOR ADJUSTABLE FRACTIONAL OPTICAL DERMATOLOGICAL TREATMENT 审中-公开
标题翻译：用于可调节分级光学皮肤病治疗的装置和方法
公开(公告)号：WO2008008499A2
公开(公告)日：2008-01-17
申请号：PCT/US2007016013
申请日：2007-07-13
申请人： RELIANT TECHNOLOGIES INC , CHAN KIN F , FRANGINEAS GEORGE , DEWEY DAVID , DEBENEDICTIS LEONARD C
发明人： CHAN KIN F , FRANGINEAS GEORGE , DEWEY DAVID , DEBENEDICTIS LEONARD C
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B18/20 , A61B2018/00452 , A61B2018/00636 , A61B2018/20351
摘要： In a fractional treatment system, an adjustable mechanism can be used to adjust the beam shape, beam numerical aperture, beam focus depth, and/or beam size to affect the treatment depth and or the character of the resulting lesions. Adjustment of these parameters can improve the efficiency and efficacy of treatment. Illustrative examples of adjustable mechanisms include a set of spacers of different lengths, a rotatable turret with lens elements of different focal distances, an optical zoom lens, and a mechanical adjustment apparatus for adjusting the spacing between two optical lens elements. In one aspect, the fractional treatment is configured with a laser wavelength that is selected such that absorption of the laser wavelength within the tissue decreases as the tissue is heated by the laser (e.g., 1480- 1640 nm). Desirably, the laser wavelength is primarily absorbed within a treated region of skin by water and has a thermally adjusted absorption coefficient within the range of about 7 cm -1 to about 26 cm -1 .
摘要翻译：在分数治疗系统中，可以使用可调整机构来调整光束形状，光束数值孔径，光束聚焦深度和/或光束大小，以影响治疗深度和/或所得损伤的特征。调整这些参数可以提高治疗的效率和疗效。可调节机构的说明性示例包括一组不同长度的间隔物，具有不同焦距的透镜元件的可旋转转台，光学变焦镜头以及用于调节两个光学透镜元件之间的间距的机械调节装置。在一个方面中，分级治疗被配置有激光波长，该激光波长被选择为使得当组织被激光加热时（例如，1480-1640nm），组织内激光波长的吸收降低。理想的是，激光波长主要通过水在皮肤的处理区域内被吸收，并且具有在约7cm -1至约26cm -1 -1的范围内的热调节吸收系数， SUP>。

3. 发明申请

WO2007027962A3 METHOD AND APPARATUS FOR MONITORING AND CONTROLLING THERMALLY INDUCED TISSUE TREATMENT 审中-公开
标题翻译：监测和控制热诱导组织治疗的方法和设备
公开(公告)号：WO2007027962A3
公开(公告)日：2007-07-12
申请号：PCT/US2006034132
申请日：2006-08-29
申请人： RELIANT TECHNOLOGIES INC , DEBENEDICTIS LEONARD C , FRANGINEAS GEORGE , CHAN KIN F , STUART B WAYNE III , SINK ROBERT KEHL , BLACK JOHN , MYERS THOMAS R , HANTASH BASIL
发明人： DEBENEDICTIS LEONARD C , FRANGINEAS GEORGE , CHAN KIN F , STUART B WAYNE III , SINK ROBERT KEHL , BLACK JOHN , MYERS THOMAS R , HANTASH BASIL
IPC分类号： A61B8/08
CPC分类号： A61B18/203 , A61B18/14 , A61B34/20 , A61B2017/00022 , A61B2017/00106 , A61B2018/00452 , A61B2018/00476 , A61B2034/2048 , A61B2034/2051 , A61B2034/2055 , A61B2034/2059 , A61B2034/2063 , A61B2034/2065 , A61B2090/373 , A61B2090/378 , A61B2090/395 , A61B2090/3958 , A61N5/062
摘要： A method and apparatus for thermal treatment of tissue by irradiating the skin with electromagnetic energy is disclosed. Sources of electromagnetic energy include radio frequency (RF) generators, lasers, and flashlamps. The apparatus includes either a positional sensor or a dosage evaluation sensor, or both types of sensors. These sensors provide feedback to a controller. The controller may control the electromagnetic source parameters, the electromagnetic source activation, and/or the sensor measurement parameters. An additional scanning delivery unit may be operably coupled to the controller or to the sensors to provide a controlled distribution of electromagnetic energy to the target region of the skin. The use of positional measurement sensors and dosage evaluation sensors permits the controller to automatically determine the proper electromagnetic source parameters including, for example, pulse timing and pulse frequency.
摘要翻译：公开了通过用电磁能照射皮肤来热处理组织的方法和装置。电磁能源包括射频（RF）发生器，激光器和闪光灯。该装置包括位置传感器或剂量评估传感器，或两种类型的传感器。这些传感器向控制器提供反馈。控制器可以控制电磁源参数，电磁源激活和/或传感器测量参数。额外的扫描传送单元可以可操作地耦合到控制器或传感器，以提供对皮肤的目标区域的受控分布的电磁能量。位置测量传感器和剂量评估传感器的使用允许控制器自动确定合适的电磁源参数，包括例如脉冲定时和脉冲频率。

4. 发明申请

WO2006031632A3 INTERCHANGEABLE TIPS FOR MEDICAL LASER TREATMENTS AND METHODS FOR USING SAME 审中-公开
标题翻译：用于医疗激光治疗的交叉提示及其使用方法
公开(公告)号：WO2006031632A3
公开(公告)日：2009-04-09
申请号：PCT/US2005032083
申请日：2005-09-09
申请人： RELIANT TECHNOLOGIES INC , DEBENEDICTIS LEONARD C , BLACK JOHN F , SINK ROBERT KEHL , CHAN KIN F , MYERS THOMAS R , FRANGINEAS GEORGE , STUART III B WAYNE , SOBIECH JEFF
发明人： DEBENEDICTIS LEONARD C , BLACK JOHN F , SINK ROBERT KEHL , CHAN KIN F , MYERS THOMAS R , FRANGINEAS GEORGE , STUART III B WAYNE , SOBIECH JEFF
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B90/98 , A61B2017/0046 , A61B2017/00482 , A61B2018/00452 , A61B2018/0047 , A61B2018/00988
摘要： A typical treatment system for use with tip embodiments includes an optical energy source, such as, for example, a laser. A set of tips may be interchangeably attached to the treatment system, for example to alter the system parameters and the treatment provided through the individual tips. Embodiments of the present invention include tips with a security chip and/or a memory. A security chip protects the treatment system from use with unauthorized tips, and the memory stores information about the tips and/or the treatment system to enhance the treatment.
摘要翻译：用于尖端实施例的典型处理系统包括光能源，例如激光。一组尖端可以可互换地附接到治疗系统，例如以改变系统参数和通过各个提示提供的治疗。本发明的实施例包括具有安全芯片和/或存储器的尖端。安全芯片保护治疗系统不被使用未经授权的技巧，并且存储器存储关于提示和/或治疗系统的信息以增强治疗。

5. 发明申请

WO2008052189A2 MICROPORE DELIVERY OF ACTIVE SUBSTANCES 审中-公开
标题翻译： MICROPORE交付活性物质
公开(公告)号：WO2008052189A2
公开(公告)日：2008-05-02
申请号：PCT/US2007082728
申请日：2007-10-26
申请人： RELIANT TECHNOLOGIES INC , CHAN KIN F , HANTASH BASIL M , BEDI VIKRAMADITYA P , FRANGINEAS GEORGE
发明人： CHAN KIN F , HANTASH BASIL M , BEDI VIKRAMADITYA P , FRANGINEAS GEORGE
IPC分类号： A61K31/375
CPC分类号： A61K31/375 , A61B18/203 , A61B2017/00765 , A61B2018/00452
摘要： A method and device for delivering active substances into and through the skin for treatment of the skin during and/or following fractional laser radiation treatment of the skin are described.
摘要翻译：描述了用于在皮肤的分数激光放射治疗期间和/或之后将活性物质输送到皮肤中并通过皮肤以治疗皮肤的方法和装置。

6. 发明申请

WO2008052198A3 METHODS OF INCREASING SKIN PERMEABILITY BY TREATMENT WITH ELECTROMAGNETIC RADIATION 审中-公开
标题翻译：用电磁辐射处理增加皮肤渗透性的方法
公开(公告)号：WO2008052198A3
公开(公告)日：2008-06-26
申请号：PCT/US2007082743
申请日：2007-10-26
申请人： RELIANT TECHNOLOGIES INC , CHAN KIN F , HANTASH BASIL M , BEDI VIKRAMADITYA P , FRANGINEAS GEORGE
发明人： CHAN KIN F , HANTASH BASIL M , BEDI VIKRAMADITYA P , FRANGINEAS GEORGE
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2017/00765 , A61B2018/00452 , A61B2018/0047
摘要： Methods of treating tissue with fractional laser radiation are disclosed. The fractional laser treatment methods reversibly increase skin permeability while maintaining a substantially intact stratum corneum and producing alterations within the epidermis and dermis. The alterations in the epidermis and dermis can include necrosis and/or coagulation. The alterations in the epidermis can include the creation of a plurality of pores in the stratum corneum and/or the creation of vacuoles in the layers of the epidermis below the stratum corneum. The fractional laser treatment methods disclosed herein can be used to provide treatments to the skin, to increase permeation of active substances into or through tissue, to deliver active substances locally or systemically, and to control the delivery of active substances.
摘要翻译：公开了用分数激光辐射治疗组织的方法。分次激光治疗方法可逆地增加皮肤渗透性，同时维持基本完整的角质层并在表皮和真皮内产生改变。表皮和真皮的改变可能包括坏死和/或凝血。表皮的改变可以包括在角质层中产生多个孔和/或在角质层下面的表皮层中产生液泡。本文公开的分数激光治疗方法可以用于向皮肤提供治疗，增加活性物质渗透进入组织或穿过组织，局部或全身递送活性物质以及控制活性物质的输送。

7. 发明申请

WO2007044840A3 LASER-INDUCED TRANSEPIDERMAL ELIMINATION OF CONTENT BY FRACTIONAL PHOTOTHERMOLYSIS 审中-公开
标题翻译：激光诱导的通过分光光度法分析的内容物
公开(公告)号：WO2007044840A3
公开(公告)日：2007-09-07
申请号：PCT/US2006039829
申请日：2006-10-10
申请人： RELIANT TECHNOLOGIES INC , CHAN KIN F , HANTASH BASIL , HERRON G SCOTT , BEDI VIKRAMADITYA P
发明人： CHAN KIN F , HANTASH BASIL , HERRON G SCOTT , BEDI VIKRAMADITYA P
IPC分类号： A61N5/06
CPC分类号： A61B18/203 , A61B2018/00452
摘要： Subjects treated with nonablative fractional photothermolysis (FP) have an intact stratum corneum, but can have microscopic lesions and vacuole formation within the epidermis. The vacuoles thus formed can trap dermal material and extrude it through the epidermis. Thus, FP can be used for the treatment of recalcitrant melasma, solar elastosis, and tattoos.
摘要翻译：用非消融性分光光热解（FP）处理的受试者具有完整的角质层，但可以在表皮内具有微观损伤和液泡形成。这样形成的空泡可以捕获真皮材料并通过表皮挤出。因此，FP可用于治疗顽固性黑斑病，太阳能弹性病和纹身。

8. 发明申请

WO2008103922A2 METHOD AND DEVICE FOR TIGHTENING TISSUE USING ELECTROMAGNETIC RADIATION 审中-公开
标题翻译：使用电磁辐射加强组织的方法和装置
公开(公告)号：WO2008103922A2
公开(公告)日：2008-08-28
申请号：PCT/US2008054753
申请日：2008-02-22
申请人： RELIANT TECHNOLOGIES INC , HANTASH BASIL M , CHAN KIN F
发明人： HANTASH BASIL M , CHAN KIN F
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00452 , A61B2018/20351
摘要： Methods and devices for treatment of skin are disclosed. These methods and devices use electromagnetic radiation to create networks or patterns of treatment zones. The networks or patterns of treatment zones comprise at least four treatment zones, at least two of the treatment zones in the network or pattern are slanted at angles in the skin, and the treatment zones extend at least as deep as the dermal-epidermal junction of the skin. Producing intersecting treatment zones and/or overlapping treatment patterns can increase the effectiveness of the treatments. The devices comprise a hand piece operably coupled to a delivery element, wherein delivery of electromagnetic radiation through the device to a portion of skin produces a network or pattern of treatment zones. The use of these methods and devices results in tightening of the skin and/or improvement in the cosmetic appearance of wrinkles in the portion of skin treated.
摘要翻译：公开了治疗皮肤的方法和装置。这些方法和设备使用电磁辐射来创建治疗区域的网络或模式。处理区域的网络或图案包括至少四个处理区域，网络或图案中的至少两个处理区域以皮肤的角度倾斜，并且处理区域至少与真皮 - 表皮连接处皮。产生相交处理区和/或重叠处理模式可以提高处理的有效性。这些装置包括可操作地耦合到输送元件的手部件，其中将电磁辐射穿过该装置传送到皮肤的一部分产生处理区域的网络或图案。这些方法和装置的使用导致皮肤收紧和/或皱纹化妆品外观的改善。

9. 发明申请

WO2006049992A3 APPARATUS AND METHOD TO TREAT HEART DISEASE USING LASERS TO FORM MICROCHANNELS 审中-公开
标题翻译：使用激光治疗心肌疾病形成微通道的装置和方法
公开(公告)号：WO2006049992A3
公开(公告)日：2006-11-16
申请号：PCT/US2005038589
申请日：2005-10-26
申请人： RELIANT TECHNOLOGIES INC , BOMMANNAN BOMMI D , CHAN KIN F
发明人： BOMMANNAN BOMMI D , CHAN KIN F
IPC分类号： A61B18/18 , A61N5/067
CPC分类号： A61B18/24 , A61B2017/00247 , A61B2018/00392 , A61B2018/2211
摘要： Methods and devices (200) for increasing revascularization in an ischemic heart (1) and for reducing muscle mass or volume in congestive heart failure patients are described. The method includes using laser energy to create microchannels (102, 104) in the target tissue (12). The microchannels (102, 104) are separated from each other to maintain tissue that is untreated or undamaged by laser energy. Such undamaged tissue augments angiogenesis. The method also includes delivery of bioactive agents that are angiogenic. The apparatus simultaneously creates a plurality of microchannels that are separated from each other and thereby promote angiogenesis, revascularization and/or muscle reduction.
摘要翻译：描述了在缺血性心脏（1）中增加血运重建和减少充血性心力衰竭患者的肌肉质量或体积的方法和装置（200）。该方法包括使用激光能量来在目标组织（12）中产生微通道（102,104）。微通道（102,104）彼此分离以维持未经处理或未被激光能量损伤的组织。这种未损伤的组织增加血管生成。该方法还包括递送血管生成的生物活性剂。该装置同时产生彼此分离的多个微通道，从而促进血管生成，血运重建和/或肌肉减少。

10. 发明申请

WO2011003013A2 CATHETER-BASED OFF-AXIS OPTICAL COHERENCE TOMOGRAPHY IMAGING SYSTEM 审中-公开
标题翻译：基于导管的离轴光学相干层析成像系统
公开(公告)号：WO2011003013A2
公开(公告)日：2011-01-06
申请号：PCT/US2010040811
申请日：2010-07-01
申请人： AVINGER INC , SPENCER MAEGAN K , WHITE CHRISTOPHER B , MCNALL CHARLES W , JACKSON DENNIS W , ZUNG MICHAEL , SPINELLI NICHOLAS J , NGO BENJAMIN , LUMABAS EVANGELINE , CHAN KIN F , BLACK JOHN F , ROSENTHAL MICHAEL H , SIMPSON JOHN B
发明人： SPENCER MAEGAN K , WHITE CHRISTOPHER B , MCNALL CHARLES W , JACKSON DENNIS W , ZUNG MICHAEL , SPINELLI NICHOLAS J , NGO BENJAMIN , LUMABAS EVANGELINE , CHAN KIN F , BLACK JOHN F , ROSENTHAL MICHAEL H , SIMPSON JOHN B
IPC分类号： A61B5/00 , G01B9/02 , G01N21/17
CPC分类号： A61B5/6852 , A61B5/0062 , A61B5/0066 , A61B5/0073 , A61B5/0084 , A61B5/02007 , A61B5/7257 , G01B9/0205 , G01B9/02057 , G01B9/02089 , G01B9/02091 , G01N2021/1787
摘要： Catheter-based Optical Coherence Tomography (OCT) systems utilizing an optical fiber that is positioned off-axis of the central longitudinal axis of the catheter have many advantage over catheter-based OCT systems, particularly those having centrally-positioned optical fibers or fibers that rotate independently of the elongate body of the catheter. An OCT system having an off-axis optical fiber for visualizing the inside of a body lumen may be rotated with the body of the elongate catheter, relative to a handle portion. The handle may include a fiber management pathway for the optical fiber that permits the off-axis optical fiber to rotate with the catheter body relative to the handle. The system may also include optical processing elements adapted to prepare and process the OCT image collected by the off-axis catheter systems described herein.
摘要翻译：利用位于导管中心纵轴的轴外的光纤的基于导管的光学相干断层扫描（OCT）系统与基于导管的OCT系统相比具有许多优点，特别是那些具有中心定位的光纤或光纤独立于导管的细长体。具有用于可视化体腔内部的离轴光纤的OCT系统可以与细长导管的本体相对于手柄部分一起旋转。手柄可以包括用于光纤的光纤管理路径，其允许离轴光纤与导管主体相对于手柄一起旋转。该系统还可以包括光学处理元件，其适于准备和处理由本文所述的离轴导管系统收集的OCT图像。

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