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1. 发明申请

WO2006055683A2 OCCLUSAL STENT AND METHODS FOR ITS USE 审中-公开
标题翻译： OCCLUSAL STENT及其使用方法
公开(公告)号：WO2006055683A2
公开(公告)日：2006-05-26
申请号：PCT/US2005041627
申请日：2005-11-16
申请人： PULMONX , SOLTESZ PETER P , WONDKA ANTHONY , LEE JEFFREY , KOTMEL ROBERT
发明人： SOLTESZ PETER P , WONDKA ANTHONY , LEE JEFFREY , KOTMEL ROBERT
IPC分类号： A61M31/00
CPC分类号： A61B17/12104 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B17/1219 , A61B2017/00862 , A61B2017/00867
摘要： Improved methods, systems and devices for occluding body passageways, particularly lung passageways. Such occlusion is achieved with occlusal stents which are particularly suited for use in performing Endobronchial Volume Reduction (EVR) in patients suffering from chronic obstructive pulmonary disease or other conditions where isolation of a lung segment or reduction of lung volume is desired. The present invention is likewise suitable for the treatment of bronchopleural fistula and potentially for other pulmonary diseases, such as hemoptysis and pneumothorax. The occlusal stents are delivered with the use of any suitable delivery system, particularly minimally invasive with instruments introduced through the mouth (endotracheally). A target lung tissue segment is isolated from other regions of the lung by deploying an occlusal stent into a target area of a lung passageway. A variety of different occlusal stent designs are provided to improve the performance and reliability of the delivered occlusal stent.
摘要翻译：改进的阻塞体通道的方法，系统和装置，特别是肺通道。使用特别适用于在患有慢性阻塞性肺疾病或其它需要肺部分离或肺容积减少的其他病症的患者中进行支气管扩张减少（EVR）的咬合支架实现这种阻塞。本发明同样适用于治疗支气管胸膜瘘并且可能用于其它肺部疾病，例如咯血和气胸。咬合支架使用任何合适的输送系统递送，特别是通过口腔（气管内）引入的器械具有最小侵入性。通过将咬合支架部署到肺通道的目标区域中，从肺的其他区域分离出目标肺组织段。提供了各种不同的咬合支架设计，以改善输送的咬合支架的性能和可靠性。

2. 发明申请

WO2006055692A2 PULMONARY OCCLUSAL STENT DELIVERY CATHETER, LOADING SYSTEM AND METHODS OF USE 审中-公开
标题翻译：脉冲式输卵管输送管，装载系统及使用方法
公开(公告)号：WO2006055692A2
公开(公告)日：2006-05-26
申请号：PCT/US2005041642
申请日：2005-11-16
申请人： PULMONX , WONDKA ANTHONY , SOLTESZ PETER P , KOTMEL ROBERT , MATOV NADIA , CROWDER THOMAS
发明人： WONDKA ANTHONY , SOLTESZ PETER P , KOTMEL ROBERT , MATOV NADIA , CROWDER THOMAS
IPC分类号： A61M16/00
CPC分类号： A61B17/12104 , A61B1/012 , A61B1/2676 , A61B17/12022 , A61B17/12172 , A61B2017/00867 , A61B2017/12054 , A61B2017/12086 , A61B2017/22069
摘要： Methods, systems and devices are provided for performing lung volume reduction in patients suffering from chronic obstructive pulmonary disease or other conditions where isolation of a lung segment or reduction of lung volume is desired. The methods are minimally invasive with instruments being introduced through the mouth (endotracheally) and rely on isolating the target lung tissue segment from other regions of the lung and occluding various lung passageways with the use of occlusal stents. The occlusal stents are delivered with the use of an occlusal stent delivery system which is loaded with the occlusal stent with the use of an occlusal stent loading system.
摘要翻译：提供了方法，系统和装置，用于在患有慢性阻塞性肺病或其它需要肺部分离或减少肺容积的其他病症的患者中进行肺容积减少。这些方法是微创的，仪器通过口腔（气管内）引入，并依赖于使用咬合支架将目标肺组织区段与肺其他区域隔离并阻塞各种肺通道。使用咬合支架输送系统递送咬合支架，该系统使用咬合支架装载系统装载咬合支架。

3. 发明申请

WO2006055692A9 PULMONARY OCCLUSAL STENT DELIVERY CATHETER, LOADING SYSTEM AND METHODS OF USE 审中-公开
标题翻译： PULMONARY OCCLUSAL STENT DELIVERY导尿管，加载系统和使用方法
公开(公告)号：WO2006055692A9
公开(公告)日：2006-08-24
申请号：PCT/US2005041642
申请日：2005-11-16
申请人： PULMONX , WONDKA ANTHONY , SOLTESZ PETER P , KOTMEL ROBERT , MATOV NADIA , CROWDER THOMAS
发明人： WONDKA ANTHONY , SOLTESZ PETER P , KOTMEL ROBERT , MATOV NADIA , CROWDER THOMAS
IPC分类号： A61M16/00
CPC分类号： A61B17/12104 , A61B1/012 , A61B1/2676 , A61B17/12022 , A61B17/12172 , A61B2017/00867 , A61B2017/12054 , A61B2017/12086 , A61B2017/22069
摘要： Methods, systems and devices are provided for performing lung volume reduction in patients suffering from chronic obstructive pulmonary disease or other conditions where isolation of a lung segment or reduction of lung volume is desired. The methods are minimally invasive with instruments being introduced through the mouth (endotracheally) and rely on isolating the target lung tissue segment from other regions of the lung and occluding various lung passageways with the use of occlusal stents. The occlusal stents are delivered with the use of an occlusal stent delivery system which is loaded with the occlusal stent with the use of an occlusal stent loading system.
摘要翻译：提供了用于在患有慢性阻塞性肺病或需要分离肺节段或减少肺容量的其他病症的患者中执行肺容量减小的方法，系统和设备。这些方法微创，通过口腔引入器械（气管内），依靠从肺部其他区域分离目标肺组织区段，并通过使用咬合支架阻塞各种肺通道。使用咬合支架输送系统输送咬合支架，所述咬合支架输送系统使用咬合支架装载系统装载咬合支架。

4. 发明申请

WO2006078451A3 MINIMALLY INVASIVE DETERMINATION OF COLLATERAL VENTILATION IN LUNGS 审中-公开
标题翻译：最小限度地确定肺内通气通气
公开(公告)号：WO2006078451A3
公开(公告)日：2007-10-18
申请号：PCT/US2006000221
申请日：2006-01-04
申请人： PULMONX , ALJURI NIKOLAI , WONDKA ANTHONY , SURJAN GEORGE , DAVIS KIRK , SOLTESZ PETER P , PERKINS RODNEY C
发明人： ALJURI NIKOLAI , WONDKA ANTHONY , SURJAN GEORGE , DAVIS KIRK , SOLTESZ PETER P , PERKINS RODNEY C
IPC分类号： A61F2/958 , A61B5/08
CPC分类号： A61B5/0935 , A61B5/087
摘要： Minimally invasive methods, systems and devices are provided for qualitatively and quantitatively assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding bronchus of the target compartment. The feeding bronchus is occluded by the catheter and a variety of measurements are taken with the use of the catheter in a manner which is of low risk to the patient. Examples of such measurements include but are not limited to flow rate, volume and pressure. These measurements are used to determine the presence of collateral ventilation and to quantify such collateral ventilation.
摘要翻译：提供了微创方法，系统和装置，用于定性和定量评估肺中的旁路通气。特别地，通过将导管穿过气管支气管树推进到目标隔室的进食支气管来评估患者的肺内的目标隔室的侧支通气。供血支气管被导管阻塞，并且以对患者的风险低的方式使用导管进行各种测量。这种测量的实例包括但不限于流量，体积和压力。这些测量用于确定侧支通气的存在并量化此类旁路通气。

5. 发明申请

WO2009151791A3 METHODS AND DEVICES FOR SENSING RESPIRATION AND CONTROLLING VENTILATOR FUNCTIONS 审中-公开
标题翻译：用于感应呼吸和控制通气功能的方法和装置
公开(公告)号：WO2009151791A3
公开(公告)日：2010-02-18
申请号：PCT/US2009041027
申请日：2009-04-17
申请人： BREATHE TECHNOLOGIES INC , WONDKA ANTHONY , BRYAN ROBERT F , MCCALL MARK , TRAN CUONG Q
发明人： WONDKA ANTHONY , BRYAN ROBERT F , MCCALL MARK , TRAN CUONG Q
IPC分类号： A61M16/10 , A62B7/00 , F16K31/02
CPC分类号： A61M16/00 , A61B5/03 , A61B5/085 , A61B5/087 , A61M16/0051 , A61M16/026 , A61M16/0427 , A61M16/0465 , A61M16/0475 , A61M16/0858 , A61M16/1055 , A61M16/106 , A61M2016/0015 , A61M2016/0413 , A61M2205/17
摘要： Improved methods and devices are described for sensing the respiration pattern of a patient and controlling ventilator functions, particularly for use in an open ventilation system. A ventilation and breath sensing apparatus may include a ventilation gas delivery circuit and a ventilation tube coupled to the ventilation gas delivery circuit. A plurality of pressure sensing elements may be separated by a distance and may produce independent signals. The signals may be used to detect pressure differentials between the plurality of pressure sensing elements. Sensing ports may be located in an airway, and connected to transducers that are valved to optimize sensitivity and overpressure protection. Airway pressure and flow can both be obtained and used to optimize ventilator synchronization and therapy.
摘要翻译：描述了改进的方法和装置，用于感测患者的呼吸模式并控制通气机功能，特别是用于开放式通风系统。通气和呼吸感测装置可以包括通气气体输送回路和连接到通气气体输送回路的通气管。多个压力感测元件可以分开一段距离并且可以产生独立的信号。信号可用于检测多个压力感测元件之间的压力差。感测端口可以位于气道中，并且连接到阀的换能器以优化灵敏度和超压保护。可以获得气道压力和流量，并用于优化呼吸机同步和治疗。

6. 发明申请

WO2009042973A1 METHODS AND DEVICES FOR TREATING SLEEP APNEA 审中-公开
标题翻译：治疗睡眠APNEA的方法和设备
公开(公告)号：WO2009042973A1
公开(公告)日：2009-04-02
申请号：PCT/US2008078031
申请日：2008-09-26
申请人： BREATHE TECHNOLOGIES INC , WONDKA ANTHONY , KAPUST GREGORY
发明人： WONDKA ANTHONY , KAPUST GREGORY
IPC分类号： A61M16/00
CPC分类号： A61M16/0096 , A61M16/0051 , A61M16/024 , A61M16/0465 , A61M16/0486 , A61M16/0666 , A61M16/0858 , A61M16/10 , A61M16/101 , A61M2016/0021 , A61M2016/0027 , A61M2016/0036 , A61M2016/0413 , A61M2202/0208 , A61M2202/03 , A61M2205/17 , A61M2205/332 , A61M2205/3569 , A61M2205/3592 , A61M2230/10 , A61M2230/205 , A61M2230/432 , A61M2230/60 , A61M2202/0007
摘要： A ventilation apparatus for treating sleep apnea is provided. A ventilator controlled by a control system may deliver ventilation gas through a ventilation gas delivery circuit to a ventilation catheter and a distal tip on the ventilation catheter. One or more sensors may detect a breathing cycle and the control system may operate the ventilator in synchrony with the breathing cycle. The distal tip may deliver the ventilation gas superiorly from the transtracheal ventilation catheter towards an upper airway, inferiorly from the transtracheal ventilation catheter towards a lung, or a combination of both. The ventilation catheter may be a transtracheal catheter, a trans-oral catheter or a trans-nasal catheter.
摘要翻译：提供一种治疗睡眠呼吸暂停的通气装置。由控制系统控制的通气机可以将通气气体通过通气气体输送回路输送到通气导管和通气导管上的远端。一个或多个传感器可以检测呼吸循环，并且控制系统可以与呼吸循环同步地操作呼吸机。远侧末端可以将通气气体从经气管通气导管向上传递到上呼吸道，在下呼吸道通气导管朝向肺部，或两者的组合。通气导管可以是经气管导管，经口导管或经鼻导管。

7. 发明申请

WO2008019102A3 METHODS AND DEVICES FOR MINIMALLY INVASIVE RESPIRATORY SUPPORT 审中-公开
标题翻译：最小侵入呼吸支持的方法和设备
公开(公告)号：WO2008019102A3
公开(公告)日：2008-07-03
申请号：PCT/US2007017400
申请日：2007-08-03
申请人： BREATHE TECHNOLOGIES INC , FREITAG LUTZ , WONDKA ANTHONY , KAPUST GREGORY , BRYAN ROBERT , KHENANSHO MICHAEL , GERBER ANTHONY
发明人： FREITAG LUTZ , WONDKA ANTHONY , KAPUST GREGORY , BRYAN ROBERT , KHENANSHO MICHAEL , GERBER ANTHONY
IPC分类号： A61M16/10
CPC分类号： A61M16/16 , A61M16/101 , A61M16/107 , A61M2202/0208 , A61M2202/03 , A61M2202/0007
摘要： Modes, methods, systems and devices are described for providing assisted ventilation to a patient, including wearable ventilation systems with integral gas supplies, special gas supply features, ventilation catheters and access devices, and breath sensing techniques.
摘要翻译：描述了为患者提供辅助通气的模式，方法，系统和装置，包括具有集成气体供应的可穿戴通气系统，特殊气体供应特征，通气导管和进入装置以及呼吸感测技术。

8. 发明申请

WO03022221A9 METHOD AND APPARATUS FOR ENDOBRONCHIAL DIAGNOSIS 审中-公开
标题翻译：用于胃肠道内诊断的方法和设备
公开(公告)号：WO03022221A9
公开(公告)日：2003-09-18
申请号：PCT/US0228863
申请日：2002-09-10
申请人： PULMONX
发明人： KOTMEL ROBERT , SOLTESZ PETER , WONDKA ANTHONY , PERKINS RODNEY
IPC分类号： A61B5/055 , A61B5/08 , A61B5/083 , A61B5/087 , A61B8/08 , A61M16/04 , A61B5/00
CPC分类号： A61B5/6853 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/082 , A61B5/083 , A61B5/085 , A61B5/087 , A61B5/7278 , A61B5/742 , A61B6/481 , A61B6/485 , A61B8/12 , A61B2562/0247 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M16/0459 , A61M16/0486 , A61M25/0026 , A61M25/10 , A61M2016/0413 , A61M2025/1052
摘要： The present invention provides systems, methods, devices and kits for assessing the level of pulmonary disease in individual lung compartments. A lung compartment comprises a subportion of a lung, such as a lobe, a segment or a subsegment, for example. By measuring individual lung compartments, the level of disease of the pulmonary system may be more precisely defined by determining values of disease parameters reflective of individual subportions or compartments of a lung. Likewise, compartments may be separately imaged to provide further measurement information. Once individual compartments are characterized, they may be compared and ranked based on a number of variables reflecting, for example, level of disease or need for treatment. Such comparison may be aided by simultaneous display of such variables or images on a visual display. Further, the same tests may be performed on the lung as a whole or on both lungs and to determine the affect of the diseased lung compartments on the overall lung performance. In addition, the diseased lung compartments may be temporarily isolated and the measurement tests performed to determine the affect of the isolation on overall lung performance. As a result, the most beneficial treatment options may be selected.
摘要翻译：本发明提供了用于评估个体肺部隔室中肺部疾病水平的系统，方法，装置和试剂盒。例如，肺隔室包括肺的子部分，例如肺叶，区段或子区段。通过测量个体肺部隔室，可以通过确定反映个体子部分或肺部隔室的疾病参数的值来更精确地定义肺部系统的疾病水平。同样，隔室可以分开成像以提供进一步的测量信息。一旦对各个区室进行了表征，就可以根据反映例如疾病水平或需要治疗的许多变量对其进行比较和排列。这种比较可以通过在视觉显示器上同时显示这些变量或图像来辅助。此外，可以对肺整体或在两个肺上进行相同的测试，并确定患病肺部隔室对整体肺性能的影响。此外，病变肺室可能会暂时隔离，并进行测量测试以确定隔离对整体肺部表现的影响。因此，可以选择最有利的治疗方案。

9. 发明申请

WO03022221A3 METHOD AND APPARATUS FOR ENDOBRONCHIAL DIAGNOSIS 审中-公开
标题翻译：方法和装置用于内分泌诊断
公开(公告)号：WO03022221A3
公开(公告)日：2003-07-03
申请号：PCT/US0228863
申请日：2002-09-10
申请人： PULMONX
发明人： KOTMEL ROBERT , SOLTESZ PETER , WONDKA ANTHONY , PERKINS RODNEY
IPC分类号： A61B5/055 , A61B5/08 , A61B5/083 , A61B5/087 , A61B8/08 , A61M16/04 , A61B5/00
CPC分类号： A61B5/6853 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/082 , A61B5/083 , A61B5/085 , A61B5/087 , A61B5/7278 , A61B5/742 , A61B6/481 , A61B6/485 , A61B8/12 , A61B2562/0247 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M16/0459 , A61M16/0486 , A61M25/0026 , A61M25/10 , A61M2016/0413 , A61M2025/1052
摘要： The present invention provides systems, methods, devices and kits for assessing the level of pulmonary disease in individual lung compartments. A lung compartment comprises a subportion of a lung, such as a lobe, a segment or a subsegment, for example. By measuring individual lung compartments, the level of disease of the pulmonary system may be more precisely defined by determining values of disease parameters reflective of individual subportions or compartments of a lung. Likewise, compartments may be separately imaged to provide further measurement information. Once individual compartments are characterized, they may be compared and ranked based on a number of variables reflecting, for example, level of disease or need for treatment. Such comparison may be aided by simultaneous display of such variables or images on a visual display. Further, the same tests may be performed on the lung as a whole or on both lungs and to determine the affect of the diseased lung compartments on the overall lung performance. In addition, the diseased lung compartments may be temporarily isolated and the measurement tests performed to determine the affect of the isolation on overall lung performance. As a result, the most beneficial treatment options may be selected.
摘要翻译：本发明提供用于评估单个肺隔室中肺部疾病水平的系统，方法，装置和试剂盒。肺隔室包括例如肺的子部分，例如叶，片段或子段。通过测量单个肺隔室，可以通过确定反映个体子部分或肺室的疾病参数的值来更精确地定义肺系统的疾病水平。同样，隔室也可以单独成像以提供进一步的测量信息。一旦个体隔室被表征，可以基于反映例如疾病水平或治疗需要的多个变量来比较和排名。可以通过在视觉显示器上同时显示这样的变量或图像来辅助这种比较。此外，可以在肺部作为整体或在两个肺上进行相同的测试，并且确定患病肺隔室对整体肺功能的影响。此外，可以暂时隔离患病的肺隔室，并进行测量测试以确定隔离对整体肺功能的影响。因此，可以选择最有益的治疗方案。

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