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1. 发明申请

WO2012033923A2 MAINTAINING HIGH PACE RATE CHARGE BALANCE 审中-公开
标题翻译：维持高价格收费平衡
公开(公告)号：WO2012033923A2
公开(公告)日：2012-03-15
申请号：PCT/US2011050842
申请日：2011-09-08
申请人： PROTEUS BIOMEDICAL INC , LEICHNER ROBERT , BERKMAN JEFFREY , ZDEBLICK MARK
发明人： LEICHNER ROBERT , BERKMAN JEFFREY , ZDEBLICK MARK
IPC分类号： A61N1/36 , A61N1/08 , A61N1/362
CPC分类号： A61N1/36125 , A61N1/37
摘要： Disclosed are a charge balance apparatus and a method for balancing at least one pacing electrode electrically coupled to the charge balance circuit. The charge balance apparatus receives a pace waveform from a pulse generator and provides a balanced flow of charge to the at least one pacing electrode. A charge monitor circuit is electrically coupled to the at least one pacing electrode and measures a flow of charge through the at least one pacing electrode in a first direction. A logic circuit interrupts a flow of charge in a second direction when a measured flow of charge in the second direction is substantially equal to a measured flow of charge in the first direction.
摘要翻译：公开了一种电荷平衡装置和用于平衡电耦合到电荷平衡电路的至少一个起搏电极的方法。电荷平衡装置从脉冲发生器接收步速波形，并向至少一个起搏电极提供平衡的电荷流。电荷监测电路电耦合到所述至少一个起搏电极并且测量沿着第一方向通过所述至少一个起搏电极的电荷流。当测量的第二方向的电荷基本上等于测量的第一方向的电荷时，逻辑电路在第二方向上中断电荷流。

2. 发明申请

WO2007075974A2 IMPLANTABLE INTEGRATED CIRCUIT 审中-公开
标题翻译：可嵌入式集成电路
公开(公告)号：WO2007075974A2
公开(公告)日：2007-07-05
申请号：PCT/US2006048944
申请日：2006-12-22
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , LEICHNER ROBERT , ARIA BEHARD , JANI NILAY , LI HAIFENG , THOMPSON TODD , ARNE LAWRENCE , ROBERTSON TIMOTHY , BI YAFEI , GELFANDBEIN VLADIMIER
发明人： ZDEBLICK MARK , LEICHNER ROBERT , ARIA BEHARD , JANI NILAY , LI HAIFENG , THOMPSON TODD , ARNE LAWRENCE , ROBERTSON TIMOTHY , BI YAFEI , GELFANDBEIN VLADIMIER
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61B5/0422 , A61N1/025 , A61N1/362 , A61N1/3686 , A61N1/372 , A61N1/37205 , A61N1/37276 , A61N1/37288 , A61N1/3756
摘要： Embodiments of the present invention enable robust, reliable control functionality for effectors present on intraluminal, e.g., vascular leads, as well as other types of implantable devices. Embodiments of the invention enable the required functionality for accurate long term control of effectors units, even ones present on multiplex carrier configurations, while provide for low power consumption. Aspects of the invention include implantable integrated circuits that have power extraction; energy storage; communication; and device configuration functional blocks, where these functional blocks are all present in a single integrated circuit on an intraluminal-sized support. Also provided by the invention are effector assemblies that include the integrated circuits, as well as implantable medical devices, e.g., pulse generators that include the same, as well as systems and kits thereof and methods of using the same, e.g., in pacing applications, including cardiac resynchronization therapy (CRT) applications.
摘要翻译：本发明的实施例对存在于管腔内（例如血管引线）以及其它类型的可植入装置的效果器提供了鲁棒，可靠的控制功能。本发明的实施例能够实现对效果器单元的准确的长期控制所需的功能，即使存在于多路载波配置上的单元也能提供低功耗。本发明的方面包括具有功率提取的可植入集成电路; 储能; 通讯; 以及器件配置功能块，其中这些功能块都存在于腔内尺寸支持体上的单个集成电路中。本发明还提供了包括集成电路的效应器组件以及可植入的医疗装置，例如包括其的脉冲发生器，以及其系统和套件，以及使用该装置的方法，例如在起搏应用中，包括心脏再同步治疗（CRT）应用。

3. 发明申请

WO2009131749A3 INTEGRATED CIRCUIT IMPLEMENTATION AND FAULT CONTROL SYSTEM, DEVICE, AND METHOD 审中-公开
标题翻译：集成电路实现和故障控制系统，设备和方法
公开(公告)号：WO2009131749A3
公开(公告)日：2010-01-07
申请号：PCT/US2009035586
申请日：2009-02-27
申请人： PROTEUS BIOMEDICAL INC , BI YAFEI , LI HAIFENG , ZDEBLICK MARK , THOMPSON TODD , LEICHNER ROBERT
发明人： BI YAFEI , LI HAIFENG , ZDEBLICK MARK , THOMPSON TODD , LEICHNER ROBERT
IPC分类号： A61N1/372 , A61N1/36 , A61N1/365 , A61N1/375 , A61N1/378
CPC分类号： A61N1/05 , A61N1/025 , A61N1/37 , A61N1/378
摘要： Apparatus and methods enable robust, reliable control for implantable medical devices, including cardiac pacemakers, defibrillators and cardiac resynchronization devices. Integrated circuits in the devices have minimized interfaces, can derive power from the interface signals, and have high voltage and latch-up protection. A device lead has a power generation circuit and a switching circuit using cascaded PMOS transistors for operating with a stable voltage despite fluctuations in the supplied voltage. The lead has control electronics that provide a very low impedance between an electrode and a lead conductor during most of the duration of a pacing pulse, but during a brief initial portion of the pacing pulse, provide a very high impedance to permit charging up a power supply that is local to the control electronics. A method of stabilizing the external impedance and a system for fault detection and fault recovery for an implantable device are also provided.
摘要翻译：装置和方法能够对可植入医疗装置（包括心脏起搏器，除颤器和心脏再同步装置）进行可靠的，可靠的控制。器件中的集成电路具有最小化的接口，可以从接口信号中获取功率，并具有高电压和闭锁保护。器件引线具有发电电路和使用级联PMOS晶体管的开关电路，用于尽管工作电压的波动，以稳定的电压工作。引线具有控制电子学，其在起搏脉冲的大部分持续时间期间在电极和引线导体之间提供非常低的阻抗，但是在起搏脉冲的短暂初始部分期间，提供非常高的阻抗以允许充电电力供应是本地控制电子产品。还提供了稳定外部阻抗的方法和用于可植入装置的故障检测和故障恢复的系统。

4. 发明申请

WO2010080843A3 INGESTION-RELATED BIOFEEDBACK AND PERSONALIZED MEDICAL THERAPY METHOD AND SYSTEM 审中-公开
标题翻译：与摄入有关的生物反馈和个人化医疗治疗方法和系统
公开(公告)号：WO2010080843A3
公开(公告)日：2010-10-21
申请号：PCT/US2010020269
申请日：2010-01-06
申请人： PROTEUS BIOMEDICAL INC , JENSEN MARC , LEICHNER ROBERT , BEAULIEU PATRICK , AU-YEUNG KIT YEE , ARNE LAWRENCE , ZDEBLICK MARK , THOMPSON ANDREW , SAVAGE GEORGE , ROBERTSON TIMOTHY , BEHZADI YASHAR
发明人： JENSEN MARC , LEICHNER ROBERT , BEAULIEU PATRICK , AU-YEUNG KIT YEE , ARNE LAWRENCE , ZDEBLICK MARK , THOMPSON ANDREW , SAVAGE GEORGE , ROBERTSON TIMOTHY , BEHZADI YASHAR
IPC分类号： A61B1/00 , A61B5/02 , A61B5/0482 , H04B13/00
CPC分类号： A61B5/073 , A61B5/0002 , A61B5/021 , A61B5/024 , A61B5/1112 , A61B5/486 , A61B5/6833 , G06F19/3456 , G06F19/3481 , G16H10/60 , H04B13/005
摘要： Methods, devices and systems for acquiring information useful to support a patient in implementing and adhering to a medically prescribed therapy plan are provided. The therapy may incorporate biofeedback methods and/or personalized therapy aspects. A method includes steps of receiving, by a receiving device, biometric information associated with an ingestible event marker; analyzing, by a computing device having a microprocessor configured to perform a biometric information analysis, the biometric information; and determining a therapeutic recommendation at least partly on the basis of the analysis and/or integrating biofeedback techniques into patient therapy or activity. A system includes a biometric information module to receive biometric information associated with an ingestible event marker; an analysis module to analyze the biometric information; and a determination module to optionally determine and communicate a therapeutic recommendation at least partly on the basis of the analysis.
摘要翻译：提供了用于获取有用的信息的方法，设备和系统，以支持患者实施和遵守医学上规定的治疗计划。该疗法可以包含生物反馈方法和/或个性化治疗方面。一种方法包括以下步骤：由接收设备接收与可摄入事件标记相关联的生物测量信息; 通过具有被配置为执行生物计量信息分析的微处理器的计算设备分析所述生物计量信息; 以及至少部分基于分析和/或将生物反馈技术整合到患者治疗或活动中来确定治疗推荐。一种系统包括：生物统计信息模块，用于接收与可摄入事件标记相关联的生物统计信息; 分析模块，用于分析生物信息; 以及确定模块，用于至少部分地基于所述分析来可选地确定和传达治疗建议。

5. 发明申请

WO2010075115A3 BODY-ASSOCIATED RECEIVER AND METHOD 审中-公开
标题翻译：身体关联接收机和方法
公开(公告)号：WO2010075115A3
公开(公告)日：2010-09-23
申请号：PCT/US2009068128
申请日：2009-12-15
申请人： PROTEUS BIOMEDICAL INC , ROBERTSON TIMOTHY , OMIDVAR FATANEH , BEHZADI YASHAR , ARNE LAWRENCE , ROWBERRY KENNETH , HUTCHISON JAMES , LEICHNER ROBERT , SAVAGE GEORGE , THOMPSON ANDREW , ZDEBLICK MARK , KREIDLER MARC , HAFEZI HOOMAN , DUCK ROBERT
发明人： ROBERTSON TIMOTHY , OMIDVAR FATANEH , BEHZADI YASHAR , ARNE LAWRENCE , ROWBERRY KENNETH , HUTCHISON JAMES , LEICHNER ROBERT , SAVAGE GEORGE , THOMPSON ANDREW , ZDEBLICK MARK , KREIDLER MARC , HAFEZI HOOMAN , DUCK ROBERT
IPC分类号： A61B5/05 , A61B5/048 , H04B13/00
CPC分类号： A61M5/1723 , A61B5/0006 , A61B5/0028 , A61B5/02055 , A61B5/0404 , A61B5/04085 , A61B5/0428 , A61B5/053 , A61B5/11 , A61B5/1112 , A61B5/145 , A61B5/14532 , A61B5/4094 , A61B2560/0209 , A61B2560/0412 , A61B2560/0468 , A61B2562/0219 , A61M5/1452 , A61M5/172 , G06F19/34 , G06F19/3418 , H04B13/005
摘要： Receivers, which may be external or implantable, are provided. Aspects of receivers of the invention include the presence of one or more of: a high power-low power module; an intermediary module; a power supply module configured to activate and deactivate one or more power supplies to a high power processing block; a serial peripheral interface bus connecting master and slave blocks; and a multi-purpose connector. Receivers of the invention may be configured to receive a conductively transmitted signal. Also provided are systems that include the receivers, as well as methods of using the same. Additionally systems and methods are disclosed for using a receiver for coordinating with dosage delivery systems.
摘要翻译：提供接收器，可能是外置的或可植入的。本发明的接收器的方面包括以下中的一个或多个的存在：高功率低功率模块; 中介模块; 电源模块，被配置为激活和去激活到高功率处理块的一个或多个电源; 一个连接主和从块的串行外设接口总线; 和一个多用途连接器。本发明的接收器可以被配置为接收传导传输的信号。还提供了包括接收器的系统以及使用它们的方法。另外公开了使用接收器与剂量递送系统协调的系统和方法。

6. 发明申请

WO2009140291A3 CONTINUOUS FIELD TOMOGRAPHY SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：连续的田间计量系统及其使用方法
公开(公告)号：WO2009140291A3
公开(公告)日：2010-02-25
申请号：PCT/US2009043653
申请日：2009-05-12
申请人： PROTEUS BIOMEDICAL INC , ARNE LAWRENCE , BANOS ORLANDO , BEHZADI YASHAR , COLLIOU OLIVIER , COSTELLO BENEDICT , LEICHNER ROBERT , MOON GREGORY , ROBERTSON TIMOTHY , SAVAGE GEORGE , THOMPSON TODD , ZDEBLICK MARK
发明人： ARNE LAWRENCE , BANOS ORLANDO , BEHZADI YASHAR , COLLIOU OLIVIER , COSTELLO BENEDICT , LEICHNER ROBERT , MOON GREGORY , ROBERTSON TIMOTHY , SAVAGE GEORGE , THOMPSON TODD , ZDEBLICK MARK
IPC分类号： A61B5/0402 , A61B5/0408
CPC分类号： A61B5/046 , A61B5/0006 , A61B5/0031 , A61B5/0422 , A61B5/0536 , A61B5/0538 , A61B5/4519 , A61B5/743 , A61B5/7435 , A61B6/503 , A61B8/0883
摘要： Continuous field tomography systems are provided. Aspects of systems include a data aggregating module configured to receive both continuous field tomography data and non-continuous field physiological data and produce an aggregated data product from these disparate types of data. Also provided are methods of using systems of the invention in a variety of different applications, including diagnostic and therapeutic applications. The systems and methods of the invention find use in a variety of different applications, such as cardiac related applications.
摘要翻译：提供连续场断层摄影系统。系统的方面包括数据聚合模块，其配置为接收连续场断层摄影数据和非连续场生理数据，并从这些不同类型的数据产生聚合数据产物。还提供了在各种不同应用中使用本发明的系统的方法，包括诊断和治疗应用。本发明的系统和方法可用于各种不同的应用，例如心脏相关应用。

7. 发明申请

WO2013009786A3 POLYPHARMACY CO-PACKAGED MEDICATION DOSING UNIT INCLUDING COMMUNICATION SYSTEM THEREFOR 审中-公开
标题翻译：多功能包装药物剂量单位包括通讯系统
公开(公告)号：WO2013009786A3
公开(公告)日：2013-04-11
申请号：PCT/US2012046124
申请日：2012-07-10
申请人： PROTEUS BIOMEDICAL INC , ROBERTSON TIMOTHY , MOON GREGORY , COSTELLO BENEDICT , ZDEBLICK MARK , HAFEZI HOOMAN
发明人： ROBERTSON TIMOTHY , MOON GREGORY , COSTELLO BENEDICT , ZDEBLICK MARK , HAFEZI HOOMAN
IPC分类号： A61J7/04 , A61J1/00 , B65D51/24 , G06Q50/22 , G08B21/02
CPC分类号： A61J3/007 , A61B5/0002 , A61B5/073 , A61B5/4839 , A61B2560/0412 , A61J7/0084 , A61J7/04 , A61J7/0418 , A61J7/0436 , A61J7/0481 , A61J2200/30 , A61J2205/60 , G06F19/3462 , H01Q1/273 , Y10T29/49826
摘要： A custom medication dosing unit is disclosed. The custom medication dosing unit includes a housing having a shell element provided with a bottom surface and a circumferential edge extending from the bottom surface and a portion defining an opening for accommodating a medication. A first closure element provided with a circumferential edge is placed on the circumferential edge of the shell element in an adhering and closing manner. A medication is disposed within the opening defined between the shell element and the first closure element. A circuit module is associated within the first closure element. A system includes the custom medication dosing unit operative to communicate with a local node. Also disclosed is a method of manufacturing the custom medication dosing unit.
摘要翻译：公开了一种定制的药物给药单元。定制药物给药单元包括壳体，壳体具有底部表面和从底部表面延伸的周向边缘以及限定用于容纳药物的开口的部分。具有圆周边缘的第一封闭元件以粘合和封闭方式放置在外壳元件的圆周边缘上。药物设置在限定在壳元件和第一闭合元件之间的开口内。电路模块连接在第一封闭元件内。系统包括用于与本地节点通信的定制药物给药单元。还公开了制造定制药物给药单元的方法。

8. 发明申请

WO2010105250A3 VOLUME SENSING 审中-公开
标题翻译：体积感知
公开(公告)号：WO2010105250A3
公开(公告)日：2011-01-13
申请号：PCT/US2010027261
申请日：2010-03-13
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK
发明人： ZDEBLICK MARK
IPC分类号： A61B5/0295
CPC分类号： A61B5/029 , A61B5/0535 , A61B5/0538 , A61B5/6846
摘要： Each sensor in one or more pairs of sensors is associated with a particular tissue, for example a first tissue location and a second tissue location respectively. Tissue at a particular tissue location may be solid, for example, muscle tissue, fat tissue, etc., or fluid, for example, blood, fluids associated with edema, etc. The area between the two tissue locations associated with a pair of sensors may comprise solid tissue, fluid tissue, an empty chamber, or combinations thereof. For each pair of sensors in the at least one pair of sensors, a first impedance measurement between the pair of sensors and associated with a first frequency is determined. For each pair of sensors in the at least one pair of sensors, a second impedance measurement between the pair of sensors and associated with a second frequency is determined. A comparison of a ratio of the first impedance measurement at a point in time to the second impedance measurement at a corresponding point in time may be made to determine a volume- related value associated with an area located between the first tissue location and the second tissue location.
摘要翻译：一对或多对传感器中的每个传感器分别与特定组织，例如第一组织位置和第二组织位置相关联。在特定组织位置处的组织可以是实心的，例如肌肉组织，脂肪组织等，或流体，例如血液，与水肿相关的流体等。与一对传感器相关联的两个组织位置之间的区域可以包括固体组织，流体组织，空腔或其组合。对于至少一对传感器中的每对传感器，确定该对传感器之间并与第一频率相关联的第一阻抗测量。对于至少一对传感器中的每对传感器，确定一对传感器之间并与第二频率相关联的第二阻抗测量。可以对在相应时间点的时间点上的第一阻抗测量值与第二阻抗测量值的比率进行比较，以确定与位于第一组织位置和第二组织之间的区域相关联的体积相关值位置。

9. 发明申请

WO2010127164A2 IMPLANTABLE DEVICE, SYSTEM, AND METHOD FOR MEASURING PHYSIOLOGIC PARAMETERS 审中-公开
标题翻译：可植入装置，系统和测量生理参数的方法
公开(公告)号：WO2010127164A2
公开(公告)日：2010-11-04
申请号：PCT/US2010033040
申请日：2010-04-29
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK
发明人： ZDEBLICK MARK
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/08 , A61B5/0538 , A61B5/085 , A61B5/6855 , A61B5/6871 , A61B5/6874 , A61N1/36135 , A61N1/36521 , A61N1/368
摘要： An apparatus having at least one implantable lead, e.g., two leads, three leads, etc., is provided. In one example, the apparatus includes at least two satellites electrically coupled to a common implantable pulse generator by at least two conductors extending from the common implantable pulse generator to each of the at least two satellites. Each satellite, for example, is associated with a respective tissue site such as a cardiac wall.
摘要翻译：提供了具有至少一个可植入引线的装置，例如两个引线，三个引线等。在一个示例中，该装置包括至少两个卫星，该至少两个卫星通过从公共可植入脉冲发生器延伸到至少两个卫星中的每个卫星的至少两个导体电耦合到公共可植入脉冲发生器。每个卫星例如与相应的组织部位如心脏壁相关联。

10. 发明申请

WO2008095183A3 INGESTIBLE EVENT MARKER SYSTEMS 审中-公开
标题翻译：令人难以置信的事件标记系统
公开(公告)号：WO2008095183A3
公开(公告)日：2008-12-18
申请号：PCT/US2008052845
申请日：2008-02-01
申请人： PROTEUS BIOMEDICAL INC , ROBERTSON TIMOTHY , SAVAGE GEORGE , ZDEBLICK MARK , BEHZADI YASHAR , COSTELLO BENEDICT , FRANK JEREMY , HAFEZI HOOMAN , HANIFF TARIQ , O'REILLY DAVID
发明人： ROBERTSON TIMOTHY , SAVAGE GEORGE , ZDEBLICK MARK , BEHZADI YASHAR , COSTELLO BENEDICT , FRANK JEREMY , HAFEZI HOOMAN , HANIFF TARIQ , O'REILLY DAVID
IPC分类号： A61B1/05
CPC分类号： A61B5/073 , A61B5/0028 , A61B5/0031 , A61B5/0073 , A61B5/0205 , A61B5/14507 , A61B5/6846 , A61B5/6861 , A61B5/6873 , A61B2560/0214 , A61J3/007 , G01N27/3277 , H01M6/005 , H01Q1/273 , H04B5/0068 , Y10S128/903
摘要： Ingestible event marker systems that include an ingestible event marker (i.e., an IEM) and a personal signal receiver are provided. Embodiments of the IEM include an identifier, which may or may not be present in a physiologically acceptable carrier. The identifier is characterized by being activated upon contact with a target internal physiological site of a body, such as digestive tract internal target site. The personal signal receiver is configured to be associated with a physiological location, e.g., inside of or on the body, and to receive a signal the IEM. During use, the IEM broadcasts a signal which is received by the personal signal receiver.
摘要翻译：提供了包括可摄取事件标记（即，IEM）和个人信号接收器的可摄入事件标记系统。 IEM的实施例包括可能存在或可能不存在于生理上可接受的载体中的标识符。该标识符的特征在于在与身体的目标内部生理部位（例如消化道内部目标部位）接触时被激活。个人信号接收器被配置为与例如身体内部或身体上的生理位置相关联，并且接收IEM的信号。在使用期间，IEM广播由个人信号接收器接收的信号。

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