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1. 发明申请

WO2010080843A3 INGESTION-RELATED BIOFEEDBACK AND PERSONALIZED MEDICAL THERAPY METHOD AND SYSTEM 审中-公开
标题翻译：与摄入有关的生物反馈和个人化医疗治疗方法和系统
公开(公告)号：WO2010080843A3
公开(公告)日：2010-10-21
申请号：PCT/US2010020269
申请日：2010-01-06
申请人： PROTEUS BIOMEDICAL INC , JENSEN MARC , LEICHNER ROBERT , BEAULIEU PATRICK , AU-YEUNG KIT YEE , ARNE LAWRENCE , ZDEBLICK MARK , THOMPSON ANDREW , SAVAGE GEORGE , ROBERTSON TIMOTHY , BEHZADI YASHAR
发明人： JENSEN MARC , LEICHNER ROBERT , BEAULIEU PATRICK , AU-YEUNG KIT YEE , ARNE LAWRENCE , ZDEBLICK MARK , THOMPSON ANDREW , SAVAGE GEORGE , ROBERTSON TIMOTHY , BEHZADI YASHAR
IPC分类号： A61B1/00 , A61B5/02 , A61B5/0482 , H04B13/00
CPC分类号： A61B5/073 , A61B5/0002 , A61B5/021 , A61B5/024 , A61B5/1112 , A61B5/486 , A61B5/6833 , G06F19/3456 , G06F19/3481 , G16H10/60 , H04B13/005
摘要： Methods, devices and systems for acquiring information useful to support a patient in implementing and adhering to a medically prescribed therapy plan are provided. The therapy may incorporate biofeedback methods and/or personalized therapy aspects. A method includes steps of receiving, by a receiving device, biometric information associated with an ingestible event marker; analyzing, by a computing device having a microprocessor configured to perform a biometric information analysis, the biometric information; and determining a therapeutic recommendation at least partly on the basis of the analysis and/or integrating biofeedback techniques into patient therapy or activity. A system includes a biometric information module to receive biometric information associated with an ingestible event marker; an analysis module to analyze the biometric information; and a determination module to optionally determine and communicate a therapeutic recommendation at least partly on the basis of the analysis.
摘要翻译：提供了用于获取有用的信息的方法，设备和系统，以支持患者实施和遵守医学上规定的治疗计划。该疗法可以包含生物反馈方法和/或个性化治疗方面。一种方法包括以下步骤：由接收设备接收与可摄入事件标记相关联的生物测量信息; 通过具有被配置为执行生物计量信息分析的微处理器的计算设备分析所述生物计量信息; 以及至少部分基于分析和/或将生物反馈技术整合到患者治疗或活动中来确定治疗推荐。一种系统包括：生物统计信息模块，用于接收与可摄入事件标记相关联的生物统计信息; 分析模块，用于分析生物信息; 以及确定模块，用于至少部分地基于所述分析来可选地确定和传达治疗建议。

2. 发明申请

WO2010005877A3 INGESTIBLE EVENT MARKER DATA FRAMEWORK 审中-公开
标题翻译：不可思议的事件标记数据框架
公开(公告)号：WO2010005877A3
公开(公告)日：2010-03-11
申请号：PCT/US2009049618
申请日：2009-07-02
申请人： PROTEUS BIOMEDICAL INC , O'REILLY DAVID , KARPLUS ERIKA , THOMPSON ANDREW , SAVAGE GEORGE , ZDEBLICK MARK , ROBERTSON TIMOTHY , ARNE LAWRENCE , BEHZADI YASHAR , MOON GREGORY , BEAULIEU PATRICK
发明人： O'REILLY DAVID , KARPLUS ERIKA , THOMPSON ANDREW , SAVAGE GEORGE , ZDEBLICK MARK , ROBERTSON TIMOTHY , ARNE LAWRENCE , BEHZADI YASHAR , MOON GREGORY , BEAULIEU PATRICK
IPC分类号： A61B5/06 , G05F1/00 , H04B13/00
CPC分类号： A61B5/07 , A61B5/0022 , A61B5/021 , G06F19/3418 , G06F19/3456
摘要： The ingestible event marker data framework provides a uniform, comprehensive framework to enable various functions and utilities related to ingestible event marker data (IEM data). The functions and utilities include data and / or information having an aspect of data derived from, collected by, aggregated by, or otherwise associated with, an ingestion event.
摘要翻译：可摄入事件标记数据框架提供统一的全面框架，以实现与可摄取事件标记数据（IEM数据）相关的各种功能和实用程序。功能和实用程序包括具有从摄取事件导出，收集，聚合或以其他方式与之相关的数据的方面的数据和/或信息。

3. 发明申请

WO2010075115A3 BODY-ASSOCIATED RECEIVER AND METHOD 审中-公开
标题翻译：身体关联接收机和方法
公开(公告)号：WO2010075115A3
公开(公告)日：2010-09-23
申请号：PCT/US2009068128
申请日：2009-12-15
申请人： PROTEUS BIOMEDICAL INC , ROBERTSON TIMOTHY , OMIDVAR FATANEH , BEHZADI YASHAR , ARNE LAWRENCE , ROWBERRY KENNETH , HUTCHISON JAMES , LEICHNER ROBERT , SAVAGE GEORGE , THOMPSON ANDREW , ZDEBLICK MARK , KREIDLER MARC , HAFEZI HOOMAN , DUCK ROBERT
发明人： ROBERTSON TIMOTHY , OMIDVAR FATANEH , BEHZADI YASHAR , ARNE LAWRENCE , ROWBERRY KENNETH , HUTCHISON JAMES , LEICHNER ROBERT , SAVAGE GEORGE , THOMPSON ANDREW , ZDEBLICK MARK , KREIDLER MARC , HAFEZI HOOMAN , DUCK ROBERT
IPC分类号： A61B5/05 , A61B5/048 , H04B13/00
CPC分类号： A61M5/1723 , A61B5/0006 , A61B5/0028 , A61B5/02055 , A61B5/0404 , A61B5/04085 , A61B5/0428 , A61B5/053 , A61B5/11 , A61B5/1112 , A61B5/145 , A61B5/14532 , A61B5/4094 , A61B2560/0209 , A61B2560/0412 , A61B2560/0468 , A61B2562/0219 , A61M5/1452 , A61M5/172 , G06F19/34 , G06F19/3418 , H04B13/005
摘要： Receivers, which may be external or implantable, are provided. Aspects of receivers of the invention include the presence of one or more of: a high power-low power module; an intermediary module; a power supply module configured to activate and deactivate one or more power supplies to a high power processing block; a serial peripheral interface bus connecting master and slave blocks; and a multi-purpose connector. Receivers of the invention may be configured to receive a conductively transmitted signal. Also provided are systems that include the receivers, as well as methods of using the same. Additionally systems and methods are disclosed for using a receiver for coordinating with dosage delivery systems.
摘要翻译：提供接收器，可能是外置的或可植入的。本发明的接收器的方面包括以下中的一个或多个的存在：高功率低功率模块; 中介模块; 电源模块，被配置为激活和去激活到高功率处理块的一个或多个电源; 一个连接主和从块的串行外设接口总线; 和一个多用途连接器。本发明的接收器可以被配置为接收传导传输的信号。还提供了包括接收器的系统以及使用它们的方法。另外公开了使用接收器与剂量递送系统协调的系统和方法。

4. 发明申请

WO2009140291A3 CONTINUOUS FIELD TOMOGRAPHY SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：连续的田间计量系统及其使用方法
公开(公告)号：WO2009140291A3
公开(公告)日：2010-02-25
申请号：PCT/US2009043653
申请日：2009-05-12
申请人： PROTEUS BIOMEDICAL INC , ARNE LAWRENCE , BANOS ORLANDO , BEHZADI YASHAR , COLLIOU OLIVIER , COSTELLO BENEDICT , LEICHNER ROBERT , MOON GREGORY , ROBERTSON TIMOTHY , SAVAGE GEORGE , THOMPSON TODD , ZDEBLICK MARK
发明人： ARNE LAWRENCE , BANOS ORLANDO , BEHZADI YASHAR , COLLIOU OLIVIER , COSTELLO BENEDICT , LEICHNER ROBERT , MOON GREGORY , ROBERTSON TIMOTHY , SAVAGE GEORGE , THOMPSON TODD , ZDEBLICK MARK
IPC分类号： A61B5/0402 , A61B5/0408
CPC分类号： A61B5/046 , A61B5/0006 , A61B5/0031 , A61B5/0422 , A61B5/0536 , A61B5/0538 , A61B5/4519 , A61B5/743 , A61B5/7435 , A61B6/503 , A61B8/0883
摘要： Continuous field tomography systems are provided. Aspects of systems include a data aggregating module configured to receive both continuous field tomography data and non-continuous field physiological data and produce an aggregated data product from these disparate types of data. Also provided are methods of using systems of the invention in a variety of different applications, including diagnostic and therapeutic applications. The systems and methods of the invention find use in a variety of different applications, such as cardiac related applications.
摘要翻译：提供连续场断层摄影系统。系统的方面包括数据聚合模块，其配置为接收连续场断层摄影数据和非连续场生理数据，并从这些不同类型的数据产生聚合数据产物。还提供了在各种不同应用中使用本发明的系统的方法，包括诊断和治疗应用。本发明的系统和方法可用于各种不同的应用，例如心脏相关应用。

5. 发明申请

WO2013009779A3 COMMUNICATION SYSTEM USING AN IMPLANTABLE DEVICE 审中-公开
标题翻译：使用可移植设备的通信系统
公开(公告)号：WO2013009779A3
公开(公告)日：2013-04-18
申请号：PCT/US2012046116
申请日：2012-07-10
申请人： PROTEUS BIOMEDICAL INC , THOMPSON TODD , ZDEBLICK MARK J , BEHZADI YASHAR , COSTELLO BENEDICT , ROBERTSON TIMOTHY , HAFEZI HOOMAN , SAVAGE GEORGE
发明人： THOMPSON TODD , ZDEBLICK MARK J , BEHZADI YASHAR , COSTELLO BENEDICT , ROBERTSON TIMOTHY , HAFEZI HOOMAN , SAVAGE GEORGE
IPC分类号： A61B5/00 , A61B1/273 , A61B5/05 , H04B7/24
CPC分类号： A61B5/076 , A61B5/0028 , A61B5/073 , A61B5/14539 , A61B5/4839 , A61B2560/0214 , A61J3/007 , A61N1/37288 , G06F19/3418 , H01Q1/273
摘要： The system of the present invention includes an implantable device that can detect high and low frequency current signature. The implantable device can communicate with a communication device that includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, the communication device is activated.
摘要翻译：本发明的系统包括可以检测高频和低频电流签名的可植入装置。可植入装置可以与包括导电元件，电子部件和不同材料形式的部分电源的通信装置通信。当与导电流体接触时，通信装置被激活。

6. 发明申请

WO2008095183A3 INGESTIBLE EVENT MARKER SYSTEMS 审中-公开
标题翻译：令人难以置信的事件标记系统
公开(公告)号：WO2008095183A3
公开(公告)日：2008-12-18
申请号：PCT/US2008052845
申请日：2008-02-01
申请人： PROTEUS BIOMEDICAL INC , ROBERTSON TIMOTHY , SAVAGE GEORGE , ZDEBLICK MARK , BEHZADI YASHAR , COSTELLO BENEDICT , FRANK JEREMY , HAFEZI HOOMAN , HANIFF TARIQ , O'REILLY DAVID
发明人： ROBERTSON TIMOTHY , SAVAGE GEORGE , ZDEBLICK MARK , BEHZADI YASHAR , COSTELLO BENEDICT , FRANK JEREMY , HAFEZI HOOMAN , HANIFF TARIQ , O'REILLY DAVID
IPC分类号： A61B1/05
CPC分类号： A61B5/073 , A61B5/0028 , A61B5/0031 , A61B5/0073 , A61B5/0205 , A61B5/14507 , A61B5/6846 , A61B5/6861 , A61B5/6873 , A61B2560/0214 , A61J3/007 , G01N27/3277 , H01M6/005 , H01Q1/273 , H04B5/0068 , Y10S128/903
摘要： Ingestible event marker systems that include an ingestible event marker (i.e., an IEM) and a personal signal receiver are provided. Embodiments of the IEM include an identifier, which may or may not be present in a physiologically acceptable carrier. The identifier is characterized by being activated upon contact with a target internal physiological site of a body, such as digestive tract internal target site. The personal signal receiver is configured to be associated with a physiological location, e.g., inside of or on the body, and to receive a signal the IEM. During use, the IEM broadcasts a signal which is received by the personal signal receiver.
摘要翻译：提供了包括可摄取事件标记（即，IEM）和个人信号接收器的可摄入事件标记系统。 IEM的实施例包括可能存在或可能不存在于生理上可接受的载体中的标识符。该标识符的特征在于在与身体的目标内部生理部位（例如消化道内部目标部位）接触时被激活。个人信号接收器被配置为与例如身体内部或身体上的生理位置相关联，并且接收IEM的信号。在使用期间，IEM广播由个人信号接收器接收的信号。

7. 发明申请

WO2010111403A2 PROBABLISTIC PHARMACOKINETIC AND PHARMACODYNAMIC MODELING 审中-公开
标题翻译： PROBABLISTIC药物动力学和药物动力学建模
公开(公告)号：WO2010111403A2
公开(公告)日：2010-09-30
申请号：PCT/US2010028518
申请日：2010-03-24
申请人： PROTEUS BIOMEDICAL INC , ROBERTSON TIMOTHY , BEHZADI YASHAR
发明人： ROBERTSON TIMOTHY , BEHZADI YASHAR
IPC分类号： G01N33/15 , A61K9/48 , G06F19/00
CPC分类号： A61M5/1723 , G06F19/3456
摘要： The subject matter disclosed herein provides a response to a dose of a substance and/or controls the administration of the dose. In one aspect, there is provided a system. The system may include a processor and at least one memory configured to provide a response determinator. The response determinator may receive therapeutic and wellness data. Moreover, the response determinator may determine a response based on the received therapeutic and wellness data. The response may represent a reaction to a substance integrated with an ingestible event marker. The determined response may be provided to, for example, a therapy controller. Related systems, methods, and articles of manufacture are also described.
摘要翻译：本文公开的主题提供对物质的剂量的响应和/或控制剂量的施用。一方面，提供了一种系统。该系统可以包括处理器和配置成提供响应确定器的至少一个存储器。响应确定器可以接收治疗和健康数据。此外，响应确定器可以基于接收到的治疗和健康数据来确定响应。该反应可能代表与可摄入事件标记物结合的物质的反应。所确定的响应可以被提供给例如治疗控制器。还描述了相关系统，方法和制品。

8. 发明申请

WO2011146767A3 TRACKING AND DELIVERY CONFIRMATION OF PHARMACEUTICAL PRODUCTS 审中-公开
标题翻译：跟踪和交付药物产品的确认
公开(公告)号：WO2011146767A3
公开(公告)日：2012-03-15
申请号：PCT/US2011037236
申请日：2011-05-19
申请人： PROTEUS BIOMEDICAL INC , THOMPSON TODD , ARNE LAWRENCE , OMIDVAR FATANEH , BEHZADI YASHAR , DUCK ROBERT , DICARLO LORENZO , MOON GREGORY
发明人： THOMPSON TODD , ARNE LAWRENCE , OMIDVAR FATANEH , BEHZADI YASHAR , DUCK ROBERT , DICARLO LORENZO , MOON GREGORY
IPC分类号： G06F19/00 , G06F15/16
CPC分类号： G06Q50/22 , A61M3/00 , G06F19/3462 , G06F19/3468 , G08C15/06 , H04N7/18
摘要： A system and method are disclosed that track a deliverable to a user. The system includes an identifier or tag secured to the deliverable, a computer system for interrogating the identifier, and a personal device in communication with the computer system, wherein the personal device is held by the user at the time the user is administered the deliverable to detect the unique identity associated with the identifier device and confirms delivery of the deliverable to the user. The method includes attaching an identifiable tag that produces a unique signature to the deliverable, interrogating the tag at about the time of delivery to the user, and confirming that the user has been administered the deliverable through detecting the identifiable tag.
摘要翻译：公开了一种跟踪可交付给用户的系统和方法。系统包括固定到可交付物的标识符或标签，用于询问标识符的计算机系统以及与计算机系统通信的个人设备，其中在用户被管理可交付物时，个人设备由用户持有检测与标识符设备相关联的唯一身份，并确认可交付物品的传送给用户。该方法包括将产生唯一签名的可识别标签附加到可交付物，在大约递送给用户的时间询问标签，并通过检测可识别标签来确认用户已经对可交付物进行了管理。

9. 发明申请

WO2009158601A2 CLINICAL APPLICATIONS FOR ELECTRICAL TOMOGRAPHY DERIVED METRICS 审中-公开
标题翻译：临床应用电子衍生标准
公开(公告)号：WO2009158601A2
公开(公告)日：2009-12-30
申请号：PCT/US2009048828
申请日：2009-06-26
申请人： PROTEUS BIOMEDICAL INC , BEHZADI YASHAR , ROBERTSON TIMOTHY , MOON GREGORY , COLLIOU OLIVIER
发明人： BEHZADI YASHAR , ROBERTSON TIMOTHY , MOON GREGORY , COLLIOU OLIVIER
IPC分类号： A61B8/13 , A61B8/02 , A61B8/06
CPC分类号： A61B5/05 , A61B5/415 , A61B5/7217
摘要： Clinical applications for electrical tomography derived metrics are disclosed. One aspect of the present invention pertains to a method for generating clinical data by processing one or more metrics obtained via an electrical tomography. The method comprises receiving one or more metrics of an electrode stably associated with a tissue site of a subject, where the metrics are based on an induced signal of the electrode generated in response to one or more continuous electrical fields applied to the subject during an electrical tomography process. In addition, the method comprises generating clinical data of the internal organ of the subject based on the metrics.
摘要翻译：公开了用于电断层摄影的临床应用。本发明的一个方面涉及通过处理通过电断层摄影获得的一个或多个度量来产生临床数据的方法。该方法包括接收与受试者的组织部位稳定相关联的电极的一个或多个度量，其中度量基于响应于在电气期间施加到对象的一个或多个连续电场而产生的电极的感应信号层析成像过程。此外，该方法包括基于度量产生对象的内部器官的临床数据。

10. 发明申请

WO2010065539A3 OPTIMIAL DRIVE FREQUENCY SELECTION IN ELECTRICAL TOMOGRAPHY 审中-公开
标题翻译：电子层析成像中的最佳驱动频率选择
公开(公告)号：WO2010065539A3
公开(公告)日：2010-10-21
申请号：PCT/US2009066251
申请日：2009-12-01
申请人： PROTEUS BIOMEDICAL INC , BEHZADI YASHAR , CRANDALL KENNETH C
发明人： BEHZADI YASHAR , CRANDALL KENNETH C
IPC分类号： A61B6/00
CPC分类号： A61B5/05 , A61B5/415 , A61B5/7257
摘要： Electrical tomography drive frequency selection systems and methods are disclosed. One aspect of the present invention pertains to a system for optimally selecting a drive frequency of an electrical tomography which comprises a sensor electrode stably associated with a tissue site within an internal organ of a subject for generating an induced signal based on a noise signal over a range of frequency bands, wherein an electrical field for the electrical tomography is turned off. In addition, the system comprises a noise processing module for isolating the induced signal for each frequency band over the range of frequency bands. Furthermore, the system comprises a frequency select module for selecting a drive frequency of the electrical field for the electrical tomography by comparing the induced signal for each frequency band over the range of frequency bands.
摘要翻译：公开了电断层摄影驱动频率选择系统和方法。本发明的一个方面涉及一种用于最佳地选择电断层摄影术的驱动频率的系统，其包括与对象的内部器官内的组织部位稳定关联的传感器电极，用于基于噪声信号产生感应信号，其中用于电断层摄影的电场被关闭。另外，该系统包括噪声处理模块，用于隔离频带范围内每个频带的感应信号。此外，该系统包括频率选择模块，用于通过比较频带范围内的每个频带的感应信号来选择用于电断层摄影的电场的驱动频率。

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