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1. 发明申请

WO2006050385A2 CARDIAC MOTION CHARACTERIZATION BY STRAIN MEASUREMENT 审中-公开
标题翻译：通过应变测量的心脏运动特征
公开(公告)号：WO2006050385A2
公开(公告)日：2006-05-11
申请号：PCT/US2005039535
申请日：2005-10-31
申请人： PROTEUS BIOMEDICAL INC , JENSON MARC , THOMPSON TODD , COLLIOU OLIVIER , SAVAGE GEORGE M , ZDEBLICK MARK , FRANK JEREMY , ARNS LAWRENCE , WHITE ROBERT
发明人： JENSON MARC , THOMPSON TODD , COLLIOU OLIVIER , SAVAGE GEORGE M , ZDEBLICK MARK , FRANK JEREMY , ARNS LAWRENCE , WHITE ROBERT
IPC分类号： H01L21/44 , H01L21/48
CPC分类号： A61N1/056 , A61B5/1107 , A61B5/6851 , A61B5/6857 , A61B5/6858 , A61B5/686 , A61B2562/0266 , A61N1/08 , A61N1/3627
摘要： Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译：提供了用于评估心脏组织位置例如心脏壁的运动的方法。在本方法中，采用从与感兴趣的组织位置稳定相关联的应变仪获得的信号的定时来评估心脏组织位置的运动。还提供了用于实践主题方法的系统，装置和相关组合物。主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

2. 发明申请

WO2006042039A3 CONTINUOUS FIELD TOMOGRAPHY 审中-公开
标题翻译：连续现场测量
公开(公告)号：WO2006042039A3
公开(公告)日：2007-07-05
申请号：PCT/US2005036035
申请日：2005-10-06
申请人： PROTEUS BIOMEDICAL INC , SAVAGE GEORGE M , ZDEBLICK MARK , COSTELLO BENEDICT , THOMPSON TODD , COLLIOU OLIVIER , ROBERTSON TIMOTHY
发明人： SAVAGE GEORGE M , ZDEBLICK MARK , COSTELLO BENEDICT , THOMPSON TODD , COLLIOU OLIVIER , ROBERTSON TIMOTHY
IPC分类号： A61B8/02
CPC分类号： A61B5/1107 , A61B5/0031 , A61B5/686 , A61B8/12 , A61B8/488 , A61B8/56 , A61B2562/046 , A61N1/3627 , A61N1/365
摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via continuous field tomography are provided. In the subject methods, a continuous field (e.g., an electrical, mechanical, electro-mechanical, or other field) sensing element is stably associated with the tissue location. A property of the applied continuous field is detected with the sensing element to evaluate movement of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译：提供了通过连续场断层摄影评估诸如心脏位置（例如心脏壁）的组织运动的方法。在主题方法中，连续场（例如，电，机械，机电或其他场）感测元件与组织位置稳定地相关联。使用感测元件检测所施加的连续场的属性，以评估组织位置的运动。还提供了用于实践主题方法的系统，装置和相关组合物。主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

3. 发明申请

WO2006069322A2 IMPLANTABLE ADDRESSABLE SEGMENTED ELECTRODES 审中-公开
标题翻译：可植入地线的电极
公开(公告)号：WO2006069322A2
公开(公告)日：2006-06-29
申请号：PCT/US2005046811
申请日：2005-12-22
申请人： PROTEUS BIOMEDICAL INC , JENSEN MARC , COSTELLO BENEDICT J , THOMPSON TODD , ZDEBLICK MARK , FRANK JEREMY , LEI DINO , ADDIS BRUCE , COLLIOU OLIVIER
发明人： JENSEN MARC , COSTELLO BENEDICT J , THOMPSON TODD , ZDEBLICK MARK , FRANK JEREMY , LEI DINO , ADDIS BRUCE , COLLIOU OLIVIER
CPC分类号： A61N1/05 , A61N1/375
摘要： Implantable addressable segmented electrode devices, as well as methods for making and using the same, are provided. The subject devices include segmented electrode structures made up of an integrated circuit electrically coupled to two or more electrodes, where each electrode can be individually activated. Also provided are implantable devices and systems, as well as kits containing such devices and systems or components thereof, which include the segmented electrode structures.
摘要翻译：提供了可植入可寻址的分段电极装置，以及制造和使用它们的方法。主题装置包括由电耦合到两个或更多个电极的集成电路组成的分段电极结构，其中每个电极可以被单独激活。还提供了可植入装置和系统，以及包含这种装置和系统或其组件的试剂盒，其包括分段的电极结构。

4. 发明申请

WO2006105474A2 AUTOMATED OPTIMIZATION OF MULTI-ELECTRODE PACING FOR CARDIAC RESYNCHRONIZATION 审中-公开
标题翻译：用于心脏再生的多电极电泳自动优化
公开(公告)号：WO2006105474A2
公开(公告)日：2006-10-05
申请号：PCT/US2006012246
申请日：2006-03-31
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , SAVAGE GEORGE , OMIDVAR FATANEH , COLLIOU OLIVIER , ARNE LAWRENCE , COSTELLO BEN , THOMPSON TODD
发明人： ZDEBLICK MARK , SAVAGE GEORGE , OMIDVAR FATANEH , COLLIOU OLIVIER , ARNE LAWRENCE , COSTELLO BEN , THOMPSON TODD
IPC分类号： A61N1/06
CPC分类号： A61N1/3627 , A61N1/08 , A61N1/36185 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/3686 , A61N1/37247
摘要： One embodiment of the present invention provides a system for automatically optimizing CRT procedures using a multi-electrode pacing lead. During operation, the system performs a first set of iterations to select one or more satellites on one or more pacing leads inserted in a patient. A pacing lead includes a plurality of pacing satellites, and a pacing satellite includes a plurality of electrodes that can be individually addressed and used for transmitting or detecting electric signals. The system then performs a second set of iterations to select one or more electrodes on the selected satellites. The system further performs a third set of iterations to select one or more timing configurations for pacing signals transmitted through one or more of the selected electrodes.
摘要翻译：本发明的一个实施例提供一种用于使用多电极起搏引线自动优化CRT程序的系统。在操作期间，系统执行第一组迭代以在插入患者体内的一个或多个起搏引线上选择一个或多个卫星。起搏引线包括多个起搏卫星，并且起搏卫星包括多个电极，其可单独寻址并用于发送或检测电信号。然后，系统执行第二组迭代以选择所选卫星上的一个或多个电极。系统进一步执行第三组迭代以选择一个或多个定时配置，用于通过一个或多个所选择的电极发射的起搏信号。

5. 发明申请

WO2007005641A3 DEPLOYABLE EPICARDIAL ELECTRODE AND SENSOR ARRAY 审中-公开
标题翻译：可展开的心电电极和传感器阵列
公开(公告)号：WO2007005641A3
公开(公告)日：2007-10-04
申请号：PCT/US2006025648
申请日：2006-06-30
申请人： PROTEUS BIOMEDICAL INC , JENSEN MARC , COLLIOU OLIVIER , COSTELLO BENEDICT , ZDEBLICK MARK , THOMPSON TODD , SAVAGE GEORGE , THOMPSON ANDREW
发明人： JENSEN MARC , COLLIOU OLIVIER , COSTELLO BENEDICT , ZDEBLICK MARK , THOMPSON TODD , SAVAGE GEORGE , THOMPSON ANDREW
IPC分类号： A61N1/05
CPC分类号： A61N1/0587
摘要： Minimally invasive deployable epicardial array devices are provided. The devices include deployable platform comprising two or more effectors, such as sensors and actuators, where the devices are configured to be deployed at an epicardial location via a minimally invasive, e.g., sub-xiphoid approach. In embodiments of the present invention, at least one area of the electrode patch is an electrical control area that comprises a series of effectors, e.g., sensors and/or electrodes. Other embodiments provide localized physical constraint and dynamic mechanical stimulation of the heart to effectuate physical and biological responses. Still other embodiments provide both of these functions. Also provided are methods of using the devices, as well as systems and kits that include the devices.
摘要翻译：提供了微创可展开心外膜阵列装置。这些装置包括可展开的平台，其包括两个或更多个效应器，例如传感器和致动器，其中所述装置被配置为经由微创，例如，剑突下方法被部署在心外膜位置。在本发明的实施例中，电极贴片的至少一个区域是包括一系列效应器（例如传感器和/或电极）的电控制区域。其他实施例提供心脏的局部物理约束和动态机械刺激以实现物理和生物反应。还有其他实施例提供这两种功能。还提供了使用这些设备的方法，以及包括这些设备的系统和套件。

6. 发明申请

WO2010057046A2 MULTIPLEXED MULTI-ELECTRODE NEUROSTIMULATION DEVICES 审中-公开
标题翻译：多重复合多电极神经调节装置
公开(公告)号：WO2010057046A2
公开(公告)日：2010-05-20
申请号：PCT/US2009064468
申请日：2009-11-13
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , THOMPSON TODD , JENSEN MARC , COLLIOU OLIVIER , STRAND ANGELA
发明人： ZDEBLICK MARK , THOMPSON TODD , JENSEN MARC , COLLIOU OLIVIER , STRAND ANGELA
IPC分类号： A61N1/36 , A61N1/02 , A61N1/05
CPC分类号： A61N1/375 , A61N1/025 , A61N1/0551 , A61N1/0553 , A61N1/36017 , A61N1/36185
摘要： Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.
摘要翻译：提供植入式刺激装置。器件的各个方面包括配置用于神经刺激的多路复用多电极部件。多路复用的多电极部件包括电耦合到公共导体的两个或更多个可单独寻址的卫星电极结构。卫星结构包括可操作地耦合到一个或多个电极的密封集成电路控制器。还提供了包括本发明的设备的系统以及在各种不同的应用中使用该系统和设备的方法。

7. 发明申请

WO2009140291A3 CONTINUOUS FIELD TOMOGRAPHY SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：连续的田间计量系统及其使用方法
公开(公告)号：WO2009140291A3
公开(公告)日：2010-02-25
申请号：PCT/US2009043653
申请日：2009-05-12
申请人： PROTEUS BIOMEDICAL INC , ARNE LAWRENCE , BANOS ORLANDO , BEHZADI YASHAR , COLLIOU OLIVIER , COSTELLO BENEDICT , LEICHNER ROBERT , MOON GREGORY , ROBERTSON TIMOTHY , SAVAGE GEORGE , THOMPSON TODD , ZDEBLICK MARK
发明人： ARNE LAWRENCE , BANOS ORLANDO , BEHZADI YASHAR , COLLIOU OLIVIER , COSTELLO BENEDICT , LEICHNER ROBERT , MOON GREGORY , ROBERTSON TIMOTHY , SAVAGE GEORGE , THOMPSON TODD , ZDEBLICK MARK
IPC分类号： A61B5/0402 , A61B5/0408
CPC分类号： A61B5/046 , A61B5/0006 , A61B5/0031 , A61B5/0422 , A61B5/0536 , A61B5/0538 , A61B5/4519 , A61B5/743 , A61B5/7435 , A61B6/503 , A61B8/0883
摘要： Continuous field tomography systems are provided. Aspects of systems include a data aggregating module configured to receive both continuous field tomography data and non-continuous field physiological data and produce an aggregated data product from these disparate types of data. Also provided are methods of using systems of the invention in a variety of different applications, including diagnostic and therapeutic applications. The systems and methods of the invention find use in a variety of different applications, such as cardiac related applications.
摘要翻译：提供连续场断层摄影系统。系统的方面包括数据聚合模块，其配置为接收连续场断层摄影数据和非连续场生理数据，并从这些不同类型的数据产生聚合数据产物。还提供了在各种不同应用中使用本发明的系统的方法，包括诊断和治疗应用。本发明的系统和方法可用于各种不同的应用，例如心脏相关应用。

8. 发明申请

WO2007120884A3 VOID-FREE IMPLANTABLE HERMETICALLY SEALED STRUCTURES 审中-公开
标题翻译：无密封可塑性密封结构
公开(公告)号：WO2007120884A3
公开(公告)日：2008-03-27
申请号：PCT/US2007009270
申请日：2007-04-12
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK J , COSTELLO BENEDICT , FRANK JEREMY , JENSEN MARC , THOMPSON TODD , ISLAM MOHAMMED Z
发明人： ZDEBLICK MARK J , COSTELLO BENEDICT , FRANK JEREMY , JENSEN MARC , THOMPSON TODD , ISLAM MOHAMMED Z
IPC分类号： H01G4/005
CPC分类号： A61N1/05 , H01L21/561 , H01L23/3107 , H01L24/63 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01024 , H01L2924/01033 , H01L2924/01044 , H01L2924/01045 , H01L2924/01047 , H01L2924/01049 , H01L2924/01074 , H01L2924/01076 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/10253 , H01L2924/12042 , H01L2924/14 , H01L2924/1461 , H01L2924/15787 , Y10T29/49117 , H01L2924/00
摘要： An implantable integrated circuit structure comprising a conformal thin-film sealing layer for hermetically sealing circuitry layers is provided. Also disclosed are electrode structures, leads that include the same, implantable pulse generators that include the leads, as well as systems and kits having components thereof, other implantable devices utilizing the structures, and methods of making and using the subject structures.
摘要翻译：提供了一种包括用于密封电路层的保形薄膜密封层的可植入集成电路结构。还公开了电极结构，包括相同的引线，包括引线的可植入脉冲发生器，以及具有其部件的系统和套件，利用该结构的其它可植入装置，以及制造和使用受试结构的方法。

9. 发明申请

WO2012125425A3 WEARABLE PERSONAL BODY ASSOCIATED DEVICE WITH VARIOUS PHYSICAL CONFIGURATIONS 审中-公开
标题翻译：具有各种物理配置的可佩戴个人身体关联设备
公开(公告)号：WO2012125425A3
公开(公告)日：2012-12-06
申请号：PCT/US2012028343
申请日：2012-03-08
申请人： PROTEUS BIOMEDICAL INC , THOMPSON TODD , COLLIOU OLIVIER , DUCK ROBERT
发明人： THOMPSON TODD , COLLIOU OLIVIER , DUCK ROBERT
IPC分类号： A61B5/0402 , A61B5/0408 , A61B5/0488 , A61B5/0492 , H04B13/00
CPC分类号： A61B5/6833 , A61B5/0006 , A61B5/0022 , A61B5/0024 , A61B5/01 , A61B5/021 , A61B5/02405 , A61B5/0408 , A61B5/04087 , A61B5/042 , A61B5/0476 , A61B5/0488 , A61B5/0809 , A61B5/1116 , A61B5/1118 , A61B5/145 , A61B2560/0412 , A61B2562/0219 , H04B13/005
摘要： A body associated device comprises a housing, an adhesive layer configured to be applied to a body of a living subject, and at least one standoff located between the housing and the adhesive layer. An electronic module may be located within the housing of the body associated device. A personal communication system comprises a body associated device including an electronic module and further comprises a feedback portion coupled to the housing and to the electronic module. The feedback portion is configured to communicate information between the living subject and the body associated device. An external local node is operative to provide at least one of transmit communications to and receive communications from the body associated device.
摘要翻译：身体关联装置包括壳体，构造成应用于活体的身体的粘合剂层以及位于壳体和粘合剂层之间的至少一个支座。电子模块可以位于身体关联设备的外壳内。个人通信系统包括身体关联设备，该身体关联设备包括电子模块并且还包括耦合到外壳和电子模块的反馈部分。反馈部分被配置为在活体和身体关联设备之间传递信息。外部本地节点可操作来提供发送通信中的至少一个以及从身体关联设备接收通信。

10. 发明申请

WO2011014465A3 LEAD FOR USE IN RF FIELD 审中-公开
标题翻译：用于射频场领域
公开(公告)号：WO2011014465A3
公开(公告)日：2011-05-05
申请号：PCT/US2010043288
申请日：2010-07-27
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , THOMPSON TODD
发明人： ZDEBLICK MARK , THOMPSON TODD
IPC分类号： A61B5/055 , A61B5/0402 , A61B5/0408
CPC分类号： A61N1/05 , A61N1/086
摘要： A lead such as used for pacemaking or neural stimulation has a current block IC which blocks current when RF is detected. In this way problems of tissue heating are reduced or eliminated when the patient carrying such a lead is given an MRI. The lead may also detect localized temperature, to be reported to equipment external to the lead. This may permit more judicious use of the RF energy, for example during an MRI session. Localized and spurious tissue heating nearby to an electrode of a lead, due to RF energy from an MRI, is reduced or eliminated by detecting the RF field, deriving energy from the field, and actively driving a node that is coupled to such an electrode so as to minimize voltage excursions at the electrode. A state is maintained or set within electronics nearby to an electrode of a lead, so that a can which connects with the lead is able to learn whether an MRI event has occurred since the last time that the can had sent commands to the electronics to set particular internal states. For a lead that delivers pacing pulses, a pacing detector is provided in addition to an MRI detector, and the blocking action is carried out most of the time but is disabled briefly for each pacing pulse. During a time of presence of RF energy, a bucking circuit attempts, to the extent possible, to drive a node toward blood potential, the node capacitively coupled with electrodes of the lead.
摘要翻译：诸如用于起搏或神经刺激的导联具有电流阻断IC，其在检测到RF时阻断电流。以这种方式，当携带这样的导线的患者被给予MRI时，组织加热的问题被减少或消除。导联还可以检测局部温度，并将其报告给导联外部的设备。这可以允许更明智地使用RF能量，例如在MRI会话期间。通过检测RF场，从场获得能量并且主动驱动耦合到这样的电极的节点，减少或消除了由于来自MRI的RF能量而导致的导线电极附近的局部和虚假组织加热以最小化电极处的电压偏移。状态被维持或设置在导线的电极附近的电子器件中，使得与导线连接的罐能够获知自上次能够向电子设备发送命令以设定MRI事件是否已经发生特定的内部状态。对于提供起搏脉冲的导线，除MRI检测器外还提供起搏探测器，大部分时间进行阻断动作，但对每个起搏脉冲暂时禁用。在存在RF能量期间，补偿电路尽可能尝试将节点驱动至血压，该节点与引线的电极电容耦合。

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