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1. 发明申请

WO2010033740A2 SHREDDER FOR MECHANICAL DISRUPTION BY GENTLE CONTROLLED COMPRESSIVE ROTATION 审中-公开
标题翻译：用于机械控制压缩旋转的机械式破坏机
公开(公告)号：WO2010033740A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057370
申请日：2009-09-17
申请人： PRESSURE BIOSCIENCES INC. , TING, Edmund, Y. , LAZAREV, Alexander , GROSS, Vera , DUSSAULT, Charles , LI, Chunqin , LAWRENCE, Nathan , SCHUMACHER, Richard, T.
发明人： TING, Edmund, Y. , LAZAREV, Alexander , GROSS, Vera , DUSSAULT, Charles , LI, Chunqin , LAWRENCE, Nathan , SCHUMACHER, Richard, T.
IPC分类号： G01N1/28
CPC分类号： G01N1/286 , C12M35/04 , G01N2001/2866
摘要： The systems and techniques of the present invention can also synergistically utilize mechanical disruption processes with the use of high hydrostatic pressure extraction, such as pressure cycling extraction techniques to achieve high yield of difficult to extract sample constituents without generating high shear stress or high temperatures.
摘要翻译：本发明的系统和技术还可以协同地利用机械破碎过程，使用高静态压力提取，例如压力循环提取技术，以实现高产率的难以提取样品组分而不产生高剪切应力或高温。

2. 发明申请

WO2008092102A2 PRESSURE CYCLING SYSTEMS AND RELATED METHOD 审中-公开
标题翻译：压力循环系统及相关方法
公开(公告)号：WO2008092102A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/052089
申请日：2008-01-25
申请人： PRESSURE BIOSCIENCES INC. , TING, Edmund, Y.
发明人： TING, Edmund, Y.
CPC分类号： B01J3/00 , B01J3/03 , B01J2219/00065 , B01J2219/00162 , B01J2219/002 , B01J2219/00213 , B01J2219/00231
摘要： A pressure cycling system includes a reaction chamber configured to receive a sample and a charge pump in fluid communication with the reaction chamber. The charge pump is operable to convey a fluid from a fluid source toward the reaction chamber. The system also includes a check valve disposed between the charge pump and the reaction chamber. The check valve is operable to inhibit the flow of fluid from the reaction chamber toward the charge pump. A pressure intensifier is in fluid communication with the reaction chamber. The pressure intensifier is pneumatically operable to adjust a pressure in the reaction chamber. A controller is configured to control operation of the charge pump and the pressure intensifier. The controller is configured to pressurize the reaction chamber to a first pressure through operation of the charge pump. The controller is also configured to fluctuate the pressure in the reaction chamber between a second pressure and a third pressure through operation of the pressure intensifier.
摘要翻译：压力循环系统包括配置成接收样本的反应室和与反应室流体连通的电荷泵。电荷泵可操作以将流体从流体源传送到反应室。该系统还包括设置在电荷泵和反应室之间的止回阀。止回阀可操作以阻止流体从反应室流向电荷泵。增压器与反应室流体连通。增压器可气动地操作以调节反应室中的压力。控制器被配置为控制电荷泵和增压器的操作。控制器构造成通过操作电荷泵将反应室加压至第一压力。该控制器还被配置为通过所述增压器的操作，以在波动第二压力和第三压力之间的反应室中的压力。

3. 发明申请

WO2002102422A1 METHOD AND APPARTUS FOR HIGH PRESSURE TREATMENT OF SUBSTANCES UNDER CONTROLLED TEMPERATURE CONDITIONS 审中-公开
标题翻译：用于控制温度条件下物质高压处理的方法和装置
公开(公告)号：WO2002102422A1
公开(公告)日：2002-12-27
申请号：PCT/US2002/020183
申请日：2002-06-17
申请人： FLOW INTERNATIONAL CORPORATION , TING, Edmund, Y. , LONNEBORG, Nils-Gunnar , TRAFF, Anders
发明人： TING, Edmund, Y. , LONNEBORG, Nils-Gunnar , TRAFF, Anders
IPC分类号： A61L2/02
CPC分类号： A23L3/0155 , A61L2/0011 , A61L2/02 , A61L2/26
摘要： A product carrier (10) for use in ultrahigh pressure processing substances is substantially fluidically closed, and is insulated, to prevent heat transfer from the product being treated to the cooler wall of the pressure vessel. The insulating material (18) has compression heating properties, such that as the product is pressurized, the temperature of the insulation increases as does the temperature of the product and pressure media, thereby helping to prevent heat transfer from the product to the surrounding media and pressure vessel wall.
摘要翻译：用于超高压处理物质的产品载体（10）基本上是流体封闭的，并且是绝缘的，以防止被处理产品从压力容器的较冷壁传热。绝缘材料（18）具有压缩加热性能，使得当产品被加压时，绝缘体的温度随着产品和压力介质的温度而增加，从而有助于防止从产品到周围介质的热传递，压力容器壁。

4. 发明申请

WO2012058412A1 SYSTEM AND METHOD FOR MICROPLATE PRESSURIZATION 审中-公开
标题翻译：微波加压的系统和方法
公开(公告)号：WO2012058412A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/058062
申请日：2011-10-27
申请人： TING, Edmund, Y. , LAZAREV, Alexander
发明人： TING, Edmund, Y. , LAZAREV, Alexander
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , B01L3/50851 , B01L9/50 , B01L2200/021 , B01L2200/0631 , B01L2200/0678 , B01L2200/0689 , B01L2200/141 , B01L2300/042 , B01L2300/048 , B01L2300/123 , B01L2300/14 , B01L2400/0487 , G01N1/28
摘要： A pressurizable sample system includes a microplate having a planar plate surface and several sample wells. Each sample well has a flange positioned circumferentially around an outer surface of the sample well and against the planar plate surface. The sample system further includes a capping plate with a planar cap surface and several caps projecting from the planar cap surface. Each cap has a geometrical configuration in complementary correspondence with the configuration of the sample well.
摘要翻译：可加压的样品系统包括具有平板表面和几个样品孔的微孔板。每个样品阱具有围绕样品阱的外表面周围定位并且抵靠平板表面的凸缘。样品系统还包括具有平面盖表面的盖板和从平面盖表面突出的多个盖。每个盖具有与样品阱的构造互补对应的几何构型。

5. 发明申请

WO2007038166A2 THERMAL SENSOR CONNECTOR FOR PRESSURE VESSEL 审中-公开
标题翻译：用于压力容器的热传感器连接器
公开(公告)号：WO2007038166A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/036740
申请日：2006-09-21
申请人： AVURE TECHNOLOGIES INCORPORATED , TREMOULET, Olivier, L., Jr. , MONSERUD, David, O. , TING, Edmund, Y.
发明人： TREMOULET, Olivier, L., Jr. , MONSERUD, David, O. , TING, Edmund, Y.
IPC分类号： A23L3/015 , A61L2/00 , A61L2/02 , A61L2/04 , A61L2/26 , B01J3/00 , B01J3/03
CPC分类号： F17C13/02 , A23L3/0155 , A61L2/0011 , A61L2/02 , A61L2/26 , A61L2202/14 , F17C2201/0104 , F17C2205/0311 , F17C2209/224 , F17C2209/234 , F17C2250/032 , F17C2250/038 , F17C2250/0439 , F17C2250/0491 , F17C2260/024 , H01R13/5202
摘要： A connector for a pressure vessel includes a connector assembly having a first plurality of contacts, and a receiver assembly configured to be positioned within a receiver aperture formed in a closure of the pressure vessel and having a second plurality of contacts. The receiver assembly is configured to receive the connector assembly and place each of the first plurality of contacts in electrical contact with a corresponding one of the second plurality of contacts. A seal is provided between the connector assembly and the wall of the pressure vessel, for substantially sealing the receiver aperture from pressure within the vessel. The connector assembly is configured to be coupled to a product carrier, and sensors positioned in the vessel are coupled via the connector assembly to a data acquisition unit. When the closure is lowered onto the vessel, the receiver assembly contacts the connector assembly coupled to the carrier, closing the electrical contacts connecting the sensors to the acquisition unit.
摘要翻译：用于压力容器的连接器包括具有第一多个触点的连接器组件和被配置为定位在形成在压力容器的封闭件中并具有第二多个触点的接收器孔内的接收器组件。接收器组件被配置为接收连接器组件，并且将第一多个触点中的每一个与第二多个触点中的对应的一个触点电接触。在连接器组件和压力容器的壁之间设置密封件，用于将接收器孔径基本上密封在容器内的压力上。连接器组件被配置为联接到产品载体，并且位于容器中的传感器经由连接器组件耦合到数据采集单元。当封闭件下降到容器上时，接收器组件接触耦合到载体的连接器组件，将连接传感器的电触头闭合到采集单元。

6. 发明申请

WO2002103254A1 METHOD AND APPARATUS FOR CHANGING THE TEMPERATURE OF A PRESSURIZED FLUID 审中-公开
标题翻译：用于改变加压流体温度的方法和装置
公开(公告)号：WO2002103254A1
公开(公告)日：2002-12-27
申请号：PCT/US2002/020182
申请日：2002-06-17
申请人： FLOW INTERNATIONAL CORPORATION , RAGHAVAN, Chidambaram , TING, Edmund, Y. , SCHUMAN, Bruce, M. , HASHISH, Mohamed, A.
发明人： RAGHAVAN, Chidambaram , TING, Edmund, Y. , SCHUMAN, Bruce, M. , HASHISH, Mohamed, A.
IPC分类号： F24H1/12
CPC分类号： F28F7/02 , F24H1/105 , F24H1/121
摘要： An assembly for changing the temperature of ultrahigh-pressure fluid as it flows through ultrahigh-pressure tubing includes several thermally conductive blocks. Each block has a first bore through which the ultrahigh-pressure tubing passes, and a second bore containing a source of heating or cooling. Alternatively, resistance heating is used to increase the temperature of the ultrahigh-pressure fluid, by coupling electrodes to the outer surface of the tubing. The ultrahigh-pressure fluid is heated or cooled after it is pressurized, and is then discharged from the ultrahigh-pressure tubing at a selected temperature for use. For example, the ultrahigh-pressure fluid at a selected temperature may be discharged through a nozzle to form an ultrahigh-pressure fluid jet to cut or clean any desired surface or object, or it may be discharged to a pressure vessel to pressure treat a substance.
摘要翻译：超高压流体通过超高压管道的温度改变的组件包括几个导热块。每个块具有超高压管通过的第一孔，以及包含加热或冷却源的第二孔。或者，电阻加热用于通过将电极连接到管的外表面来增加超高压流体的温度。超高压流体在加压之后被加热或冷却，然后在所选择的温度下从超高压管排出以供使用。例如，选定温度下的超高压流体可以通过喷嘴排出以形成超高压流体射流，以切割或清洁任何所需的表面或物体，或者可将其排出到压力容器中以对物质进行加压处理。

7. 发明申请

WO2017044590A1 ULTRAHIGH PRESSURE COMPACT VALVE WITH THROTTLING CAPABILITY 审中-公开
标题翻译：超高压紧凑型阀具有屈曲能力
公开(公告)号：WO2017044590A1
公开(公告)日：2017-03-16
申请号：PCT/US2016/050717
申请日：2016-09-08
申请人： PRESSURE BIOSCIENCES, INC.
发明人： TING, Edmund, Y. , LAZAREV, Alexander , MA, Jun
IPC分类号： F16K3/24 , F16K1/12 , F16K1/38 , F16K31/62
CPC分类号： F16K1/12 , F16K1/14 , F16K1/38 , F16K3/24 , F16K31/62
摘要： A high pressure valve includes a lever and a variable force generator for facilitating control of opening and closing the valve at high pressures. The high pressure valve includes a housing having a chamber providing fluid communication between a first port and a second port, a pin movable within the chamber between an open position and a closed position. A first end of a lever is coupled to the pin and a second end of the lever is coupled to a variable force generator. The lever pivots about a pivot point. A controller coupled to the variable force generator is configured to adjust a force applied to the second end of the lever by the variable force generator to control the movement of the pin between the open position and the closed position.
摘要翻译：高压阀包括杠杆和可变力发生器，用于在高压下便于控制阀的打开和关闭。高压阀包括壳体，壳体具有在第一端口和第二端口之间提供流体连通的腔室，在腔室内在打开位置和关闭位置之间可移动的销。杠杆的第一端联接到销，并且杆的第二端联接到可变力发生器。杠杆围绕枢轴点枢转。耦合到可变力发生器的控制器被配置为通过可变力发生器来调节施加到杆的第二端的力，以控制销在打开位置和关闭位置之间的运动。

8. 发明申请

WO2013052696A1 HIGH PRESSURE SAMPLE CONTAINMENT SYSTEM FOR ELECTROMAGNETIC MEASUREMENTS 审中-公开
标题翻译：用于电磁测量的高压样品容纳系统
公开(公告)号：WO2013052696A1
公开(公告)日：2013-04-11
申请号：PCT/US2012/058792
申请日：2012-10-04
申请人： PRESSURE BIOSCIENCES, INC.
发明人： TING, Edmund, Y. , LAZAREV, Alexander
IPC分类号： G01V3/00
CPC分类号： G01R33/305 , G01N24/10 , G01R33/60
摘要： The present invention is related to systems and methods for chemical and biological analysis and, in particular, to systems, apparatus, and methods of sample conditioning and analysis.
摘要翻译：本发明涉及用于化学和生物分析的系统和方法，特别涉及样品调节和分析的系统，装置和方法。

9. 发明申请

WO2021067428A1 HIGH PRESSURE, WEAR RESISTANT VALVE FOR STOP FLOW AND/OR THROTTLING CONTROL 审中-公开
公开(公告)号：WO2021067428A1
公开(公告)日：2021-04-08
申请号：PCT/US2020/053534
申请日：2020-09-30
申请人： PRESSURE BIOSCIENCES, INC.
发明人： TING, Edmund, Y. , LAZAREV, Alexander
IPC分类号： B65D47/06 , A47G19/22 , A61B1/00
摘要： A valve includes a valve seat body received by a sleeve with an interference fit between the valve seat body and the sleeve. An upper end of the sleeve extends beyond an upper end of the valve seat body. A valve assembly including the valve is also provided.

10. 发明申请

WO2016160667A1 SYSTEM FOR HIGH PRESSURE, HIGH SHEAR PROCESSING OF FLUIDS 审中-公开
标题翻译：高压，流体高剪切加工系统
公开(公告)号：WO2016160667A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/024452
申请日：2016-03-28
申请人： PRESSURE BIOSCIENCES, INC.
发明人： TING, Edmund, Y.
IPC分类号： F04B9/115 , A23L3/015 , F04B9/10 , F04B9/103 , F04B9/107 , F04B15/00
CPC分类号： F04B49/225 , A23L3/0155 , F04B9/111 , F04B15/02 , F04B19/22 , F04B37/12 , F04B53/08 , F04B53/10
摘要： A method for high fluid shear processing of a fluid uses an isolator that has a first sub-chamber for containing a first fluid and a second sub-chamber for containing a second fluid defined by a separator positioned in the chamber and movable between a first end of the chamber and a second end of the chamber. The two sub-chambers are in pressure communication with each other but are not in fluid communication with each other. A first fluid is pumped at an ultrahigh pressure into the first-sub chamber, and the pressure in the first sub-chamber causes a second fluid to be processed to be discharged from the second sub-chamber into a processing valve. A system is also provided for performing the steps of this method.
摘要翻译：用于流体的高流体剪切处理的方法使用隔离器，其具有用于容纳第一流体的第一子室和用于容纳由位于室中的分离器限定的第二流体的第二子室，该第二流体可在第一端的腔室和腔室的第二端。两个子室彼此压力连通但不彼此流体连通。将第一流体以超高压泵送到第一副室中，并且第一子室中的压力使得第二流体被处理从第二子室排出到处理阀中。还提供了一种用于执行该方法的步骤的系统。

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