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1. 发明申请

WO2010033740A3 SHREDDER FOR MECHANICAL DISRUPTION BY GENTLE CONTROLLED COMPRESSIVE ROTATION 审中-公开
标题翻译：由温德勒控制的压缩旋转引起的机械破坏的SHREDDER
公开(公告)号：WO2010033740A3
公开(公告)日：2010-05-06
申请号：PCT/US2009057370
申请日：2009-09-17
申请人： PRESSURE BIOSCIENCES INC , TING EDMUND Y , LAZAREV ALEXANDER , GROSS VERA , DUSSAULT CHARLES , LI CHUNQIN , LAWRENCE NATHAN , SCHUMACHER RICHARD T
发明人： TING EDMUND Y , LAZAREV ALEXANDER , GROSS VERA , DUSSAULT CHARLES , LI CHUNQIN , LAWRENCE NATHAN , SCHUMACHER RICHARD T
IPC分类号： G01N1/28
CPC分类号： G01N1/286 , C12M35/04 , G01N2001/2866
摘要： The systems and techniques of the present invention can also synergistically utilize mechanical disruption processes with the use of high hydrostatic pressure extraction, such as pressure cycling extraction techniques to achieve high yield of difficult to extract sample constituents without generating high shear stress or high temperatures.
摘要翻译：本发明的系统和技术还可协同利用机械破碎过程，使用高流体静力学压力提取（例如压力循环提取技术）以实现难以提取样品成分的高产率而不产生高剪切应力或高温。

2. 发明申请

WO2002102422A1 METHOD AND APPARTUS FOR HIGH PRESSURE TREATMENT OF SUBSTANCES UNDER CONTROLLED TEMPERATURE CONDITIONS 审中-公开
标题翻译：用于控制温度条件下物质高压处理的方法和装置
公开(公告)号：WO2002102422A1
公开(公告)日：2002-12-27
申请号：PCT/US2002/020183
申请日：2002-06-17
申请人： FLOW INTERNATIONAL CORPORATION , TING, Edmund, Y. , LONNEBORG, Nils-Gunnar , TRAFF, Anders
发明人： TING, Edmund, Y. , LONNEBORG, Nils-Gunnar , TRAFF, Anders
IPC分类号： A61L2/02
CPC分类号： A23L3/0155 , A61L2/0011 , A61L2/02 , A61L2/26
摘要： A product carrier (10) for use in ultrahigh pressure processing substances is substantially fluidically closed, and is insulated, to prevent heat transfer from the product being treated to the cooler wall of the pressure vessel. The insulating material (18) has compression heating properties, such that as the product is pressurized, the temperature of the insulation increases as does the temperature of the product and pressure media, thereby helping to prevent heat transfer from the product to the surrounding media and pressure vessel wall.
摘要翻译：用于超高压处理物质的产品载体（10）基本上是流体封闭的，并且是绝缘的，以防止被处理产品从压力容器的较冷壁传热。绝缘材料（18）具有压缩加热性能，使得当产品被加压时，绝缘体的温度随着产品和压力介质的温度而增加，从而有助于防止从产品到周围介质的热传递，压力容器壁。

3. 发明申请

WO9914498A3 TEMPERATURE CONTROL SYSTEM IN A HIGH PRESSURE PUMP FOR FAILURE DETECTION OF VALVES AND PLUNGER SEAL 审中-公开
标题翻译：用于故障检测阀和密封件的高压泵中的温度控制系统
公开(公告)号：WO9914498A3
公开(公告)日：1999-06-03
申请号：PCT/US9819401
申请日：1998-09-16
申请人： FLOW INT CORP , TING EDMUND Y , RAGHAVAN CHIDAMBARAM , TREMOULET OLIVER L JR
发明人： TING EDMUND Y , RAGHAVAN CHIDAMBARAM , TREMOULET OLIVER L JR
IPC分类号： F04B49/06 , F04B51/00
CPC分类号： F04B51/00 , F04B49/065 , F04B2201/0801
摘要： A method and apparatus for diagnosing components in high-pressure pumps to indicate when a component of the pump head is malfunctioning and to identify the malfunctioning component. In one embodiment, a high-pressure pump head incorporating a diagnostic system in accordance with the invention has a pressurization chamber and a pressurizing member at least partially received in the pressurization chamber. The pressurizing member moves within the pressurization chamber along an intake action to draw fluid into the pressurization chamber and along a pressurizing action to compress fluid in the pressurization chamber. An inlet fluid control assembly is coupled to the pressurization chamber to allow fluid to enter the pressurization chamber during the intake action, and a pressurized fluid control assembly is coupled between the pressurization chamber and an outlet chamber to selectively allow pressurized fluid into the outlet chamber during the pressurizing action. The pump head may also include a diagnostic system to indicate the operational status of each of the inlet fluid control assembly, the pressurized fluid control assembly and other components of the pump head upstream from the inlet fluid control assembly with respect to a fluid flow through the pump head during the pressurizing action.
摘要翻译：一种用于诊断高压泵中的部件的方法和装置，以指示泵头的部件何时发生故障并识别故障部件。在一个实施例中，结合根据本发明的诊断系统的高压泵头具有至少部分地容纳在加压室中的加压室和加压构件。加压构件沿着进气动作在加压室内移动，以将流体引入加压室，并沿加压动作压缩加压室中的流体。入口流体控制组件联接到加压室以允许流体在进气动作期间进入加压室，并且加压流体控制组件联接在加压室和出口室之间，以选择性地允许加压流体进入出口室加压动作。泵头还可以包括诊断系统，用于指示进口流体控制组件，加压流体控制组件和泵头的其他部件在入口流体控制组件上游相对于流过流体流体的流体流动的操作状态泵头在加压动作期间。

4. 发明申请

WO2012024523A2 FLOW-THROUGH HIGH HYDROSTATIC PRESSURE MICROFLUIDIC SAMPLE PREPARATION DEVICE AND RELATED METHODS THEREFOR 审中-公开
标题翻译：流动性高静电压力微流体样品制备装置及其相关方法
公开(公告)号：WO2012024523A2
公开(公告)日：2012-02-23
申请号：PCT/US2011048302
申请日：2011-08-18
申请人： TING EDMUND Y , LAZAREV ALEXANDER
发明人： TING EDMUND Y , LAZAREV ALEXANDER
IPC分类号： B01L3/02
CPC分类号： G01N1/286 , G01N35/1095 , Y10T436/25
摘要： Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.
摘要翻译：本文描述的样品制备装置包括样品输送源，将样品从样品源转移到压力容器内的可变形通道中的在线装置，并且从通道进入下游分析部件，设置在压力范围内的可变形通道容器，可变形通道具有流体连接到高压阀的入口端和出口端，以及测量可变形通道内的流体压力的装置，可流体连接到压力容器的受控加压流体的外部源和控制器系统其通过控制外部压力容器流体监测和控制样品流体压力。

5. 发明申请

WO2007038166A2 THERMAL SENSOR CONNECTOR FOR PRESSURE VESSEL 审中-公开
标题翻译：用于压力容器的热传感器连接器
公开(公告)号：WO2007038166A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/036740
申请日：2006-09-21
申请人： AVURE TECHNOLOGIES INCORPORATED , TREMOULET, Olivier, L., Jr. , MONSERUD, David, O. , TING, Edmund, Y.
发明人： TREMOULET, Olivier, L., Jr. , MONSERUD, David, O. , TING, Edmund, Y.
IPC分类号： A23L3/015 , A61L2/00 , A61L2/02 , A61L2/04 , A61L2/26 , B01J3/00 , B01J3/03
CPC分类号： F17C13/02 , A23L3/0155 , A61L2/0011 , A61L2/02 , A61L2/26 , A61L2202/14 , F17C2201/0104 , F17C2205/0311 , F17C2209/224 , F17C2209/234 , F17C2250/032 , F17C2250/038 , F17C2250/0439 , F17C2250/0491 , F17C2260/024 , H01R13/5202
摘要： A connector for a pressure vessel includes a connector assembly having a first plurality of contacts, and a receiver assembly configured to be positioned within a receiver aperture formed in a closure of the pressure vessel and having a second plurality of contacts. The receiver assembly is configured to receive the connector assembly and place each of the first plurality of contacts in electrical contact with a corresponding one of the second plurality of contacts. A seal is provided between the connector assembly and the wall of the pressure vessel, for substantially sealing the receiver aperture from pressure within the vessel. The connector assembly is configured to be coupled to a product carrier, and sensors positioned in the vessel are coupled via the connector assembly to a data acquisition unit. When the closure is lowered onto the vessel, the receiver assembly contacts the connector assembly coupled to the carrier, closing the electrical contacts connecting the sensors to the acquisition unit.
摘要翻译：用于压力容器的连接器包括具有第一多个触点的连接器组件和被配置为定位在形成在压力容器的封闭件中并具有第二多个触点的接收器孔内的接收器组件。接收器组件被配置为接收连接器组件，并且将第一多个触点中的每一个与第二多个触点中的对应的一个触点电接触。在连接器组件和压力容器的壁之间设置密封件，用于将接收器孔径基本上密封在容器内的压力上。连接器组件被配置为联接到产品载体，并且位于容器中的传感器经由连接器组件耦合到数据采集单元。当封闭件下降到容器上时，接收器组件接触耦合到载体的连接器组件，将连接传感器的电触头闭合到采集单元。

6. 发明申请

WO2002103254A1 METHOD AND APPARATUS FOR CHANGING THE TEMPERATURE OF A PRESSURIZED FLUID 审中-公开
标题翻译：用于改变加压流体温度的方法和装置
公开(公告)号：WO2002103254A1
公开(公告)日：2002-12-27
申请号：PCT/US2002/020182
申请日：2002-06-17
申请人： FLOW INTERNATIONAL CORPORATION , RAGHAVAN, Chidambaram , TING, Edmund, Y. , SCHUMAN, Bruce, M. , HASHISH, Mohamed, A.
发明人： RAGHAVAN, Chidambaram , TING, Edmund, Y. , SCHUMAN, Bruce, M. , HASHISH, Mohamed, A.
IPC分类号： F24H1/12
CPC分类号： F28F7/02 , F24H1/105 , F24H1/121
摘要： An assembly for changing the temperature of ultrahigh-pressure fluid as it flows through ultrahigh-pressure tubing includes several thermally conductive blocks. Each block has a first bore through which the ultrahigh-pressure tubing passes, and a second bore containing a source of heating or cooling. Alternatively, resistance heating is used to increase the temperature of the ultrahigh-pressure fluid, by coupling electrodes to the outer surface of the tubing. The ultrahigh-pressure fluid is heated or cooled after it is pressurized, and is then discharged from the ultrahigh-pressure tubing at a selected temperature for use. For example, the ultrahigh-pressure fluid at a selected temperature may be discharged through a nozzle to form an ultrahigh-pressure fluid jet to cut or clean any desired surface or object, or it may be discharged to a pressure vessel to pressure treat a substance.
摘要翻译：超高压流体通过超高压管道的温度改变的组件包括几个导热块。每个块具有超高压管通过的第一孔，以及包含加热或冷却源的第二孔。或者，电阻加热用于通过将电极连接到管的外表面来增加超高压流体的温度。超高压流体在加压之后被加热或冷却，然后在所选择的温度下从超高压管排出以供使用。例如，选定温度下的超高压流体可以通过喷嘴排出以形成超高压流体射流，以切割或清洁任何所需的表面或物体，或者可将其排出到压力容器中以对物质进行加压处理。

7. 发明申请

WO2008092102A9 PRESSURE CYCLING SYSTEMS AND RELATED METHOD 审中-公开
标题翻译：压力循环系统及相关方法
公开(公告)号：WO2008092102A9
公开(公告)日：2010-11-18
申请号：PCT/US2008052089
申请日：2008-01-25
申请人： PRESSURE BIOSCIENCES INC , TING EDMUND Y
发明人： TING EDMUND Y
IPC分类号： B01J3/00 , B01J3/03 , C12M1/00
CPC分类号： B01J3/00 , B01J3/03 , B01J2219/00065 , B01J2219/00162 , B01J2219/002 , B01J2219/00213 , B01J2219/00231
摘要： A pressure cycling system includes a reaction chamber configured to receive a sample and a charge pump in fluid communication with the reaction chamber. The charge pump is operable to convey a fluid from a fluid source toward the reaction chamber. The system also includes a check valve disposed between the charge pump and the reaction chamber. The check valve is operable to inhibit the flow of fluid from the reaction chamber toward the charge pump. A pressure intensifier is in fluid communication with the reaction chamber. The pressure intensifier is pneumatically operable to adjust a pressure in the reaction chamber. A controller is configured to control operation of the charge pump and the pressure intensifier. The controller is configured to pressurize the reaction chamber to a first pressure through operation of the charge pump. The controller is also configured to fluctuate the pressure in the reaction chamber between a second pressure and a third pressure through operation of the pressure intensifier.
摘要翻译：压力循环系统包括配置成接收样品的反应室和与反应室流体连通的电荷泵。电荷泵可操作以将流体从流体源传送到反应室。该系统还包括设置在电荷泵和反应室之间的止回阀。止回阀可操作以阻止流体从反应室朝向电荷泵的流动。增压器与反应室流体连通。增压器可气动地操作以调节反应室中的压力。控制器被配置为控制电荷泵和增压器的操作。控制器被配置为通过操作电荷泵将反应室加压至第一压力。控制器还被配置为通过操作压力增加器来在第二压力和第三压力之间波动反应室中的压力。

8. 发明申请

WO2010033740A2 SHREDDER FOR MECHANICAL DISRUPTION BY GENTLE CONTROLLED COMPRESSIVE ROTATION 审中-公开
标题翻译：用于机械控制压缩旋转的机械式破坏机
公开(公告)号：WO2010033740A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057370
申请日：2009-09-17
申请人： PRESSURE BIOSCIENCES INC. , TING, Edmund, Y. , LAZAREV, Alexander , GROSS, Vera , DUSSAULT, Charles , LI, Chunqin , LAWRENCE, Nathan , SCHUMACHER, Richard, T.
发明人： TING, Edmund, Y. , LAZAREV, Alexander , GROSS, Vera , DUSSAULT, Charles , LI, Chunqin , LAWRENCE, Nathan , SCHUMACHER, Richard, T.
IPC分类号： G01N1/28
CPC分类号： G01N1/286 , C12M35/04 , G01N2001/2866
摘要： The systems and techniques of the present invention can also synergistically utilize mechanical disruption processes with the use of high hydrostatic pressure extraction, such as pressure cycling extraction techniques to achieve high yield of difficult to extract sample constituents without generating high shear stress or high temperatures.
摘要翻译：本发明的系统和技术还可以协同地利用机械破碎过程，使用高静态压力提取，例如压力循环提取技术，以实现高产率的难以提取样品组分而不产生高剪切应力或高温。

9. 发明申请

WO2012058412A1 SYSTEM AND METHOD FOR MICROPLATE PRESSURIZATION 审中-公开
标题翻译：微波加压的系统和方法
公开(公告)号：WO2012058412A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/058062
申请日：2011-10-27
申请人： TING, Edmund, Y. , LAZAREV, Alexander
发明人： TING, Edmund, Y. , LAZAREV, Alexander
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , B01L3/50851 , B01L9/50 , B01L2200/021 , B01L2200/0631 , B01L2200/0678 , B01L2200/0689 , B01L2200/141 , B01L2300/042 , B01L2300/048 , B01L2300/123 , B01L2300/14 , B01L2400/0487 , G01N1/28
摘要： A pressurizable sample system includes a microplate having a planar plate surface and several sample wells. Each sample well has a flange positioned circumferentially around an outer surface of the sample well and against the planar plate surface. The sample system further includes a capping plate with a planar cap surface and several caps projecting from the planar cap surface. Each cap has a geometrical configuration in complementary correspondence with the configuration of the sample well.
摘要翻译：可加压的样品系统包括具有平板表面和几个样品孔的微孔板。每个样品阱具有围绕样品阱的外表面周围定位并且抵靠平板表面的凸缘。样品系统还包括具有平面盖表面的盖板和从平面盖表面突出的多个盖。每个盖具有与样品阱的构造互补对应的几何构型。

10. 发明申请

WO2008092102A3 PRESSURE CYCLING SYSTEMS AND RELATED METHOD 审中-公开
标题翻译：压力循环系统及相关方法
公开(公告)号：WO2008092102A3
公开(公告)日：2008-10-16
申请号：PCT/US2008052089
申请日：2008-01-25
申请人： PRESSURE BIOSCIENCES INC , TING EDMUND Y
发明人： TING EDMUND Y
IPC分类号： B01J3/00 , B01J3/03 , C12M1/00
CPC分类号： B01J3/00 , B01J3/03 , B01J2219/00065 , B01J2219/00162 , B01J2219/002 , B01J2219/00213 , B01J2219/00231
摘要： A pressure cycling system includes a reaction chamber configured to receive a sample and a charge pump in fluid communication with the reaction chamber. The charge pump is operable to convey a fluid from a fluid source toward the reaction chamber. The system also includes a check valve disposed between the charge pump and the reaction chamber. The check valve is operable to inhibit the flow of fluid from the reaction chamber toward the charge pump. A pressure intensifier is in fluid communication with the reaction chamber. The pressure intensifier is pneumatically operable to adjust a pressure in the reaction chamber. A controller is configured to control operation of the charge pump and the pressure intensifier. The controller is configured to pressurize the reaction chamber to a first pressure through operation of the charge pump. The controller is also configured to fluctuate the pressure in the reaction chamber between a second pressure and a third pressure through operation of the pressure intensifier.
摘要翻译：压力循环系统包括配置成接收样品的反应室和与反应室流体连通的电荷泵。电荷泵可操作以将流体从流体源传送到反应室。该系统还包括设置在电荷泵和反应室之间的止回阀。止回阀可操作以阻止流体从反应室朝向电荷泵的流动。增压器与反应室流体连通。增压器可气动地操作以调节反应室中的压力。控制器被配置为控制电荷泵和增压器的操作。控制器被配置为通过操作电荷泵将反应室加压至第一压力。控制器还被配置为通过操作压力增加器来在第二压力和第三压力之间波动反应室中的压力。

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