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1. 发明申请

WO2012058412A1 SYSTEM AND METHOD FOR MICROPLATE PRESSURIZATION 审中-公开
标题翻译：微波加压的系统和方法
公开(公告)号：WO2012058412A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/058062
申请日：2011-10-27
申请人： TING, Edmund, Y. , LAZAREV, Alexander
发明人： TING, Edmund, Y. , LAZAREV, Alexander
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , B01L3/50851 , B01L9/50 , B01L2200/021 , B01L2200/0631 , B01L2200/0678 , B01L2200/0689 , B01L2200/141 , B01L2300/042 , B01L2300/048 , B01L2300/123 , B01L2300/14 , B01L2400/0487 , G01N1/28
摘要： A pressurizable sample system includes a microplate having a planar plate surface and several sample wells. Each sample well has a flange positioned circumferentially around an outer surface of the sample well and against the planar plate surface. The sample system further includes a capping plate with a planar cap surface and several caps projecting from the planar cap surface. Each cap has a geometrical configuration in complementary correspondence with the configuration of the sample well.
摘要翻译：可加压的样品系统包括具有平板表面和几个样品孔的微孔板。每个样品阱具有围绕样品阱的外表面周围定位并且抵靠平板表面的凸缘。样品系统还包括具有平面盖表面的盖板和从平面盖表面突出的多个盖。每个盖具有与样品阱的构造互补对应的几何构型。

2. 发明申请

WO2010033740A2 SHREDDER FOR MECHANICAL DISRUPTION BY GENTLE CONTROLLED COMPRESSIVE ROTATION 审中-公开
标题翻译：用于机械控制压缩旋转的机械式破坏机
公开(公告)号：WO2010033740A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057370
申请日：2009-09-17
申请人： PRESSURE BIOSCIENCES INC. , TING, Edmund, Y. , LAZAREV, Alexander , GROSS, Vera , DUSSAULT, Charles , LI, Chunqin , LAWRENCE, Nathan , SCHUMACHER, Richard, T.
发明人： TING, Edmund, Y. , LAZAREV, Alexander , GROSS, Vera , DUSSAULT, Charles , LI, Chunqin , LAWRENCE, Nathan , SCHUMACHER, Richard, T.
IPC分类号： G01N1/28
CPC分类号： G01N1/286 , C12M35/04 , G01N2001/2866
摘要： The systems and techniques of the present invention can also synergistically utilize mechanical disruption processes with the use of high hydrostatic pressure extraction, such as pressure cycling extraction techniques to achieve high yield of difficult to extract sample constituents without generating high shear stress or high temperatures.
摘要翻译：本发明的系统和技术还可以协同地利用机械破碎过程，使用高静态压力提取，例如压力循环提取技术，以实现高产率的难以提取样品组分而不产生高剪切应力或高温。

3. 发明申请

WO2008151136A1 PRESSURE-ENHANCED EXTRACTION AND PARTITIONING OF MOLECULES 审中-公开
标题翻译：压力提高和分子分离
公开(公告)号：WO2008151136A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/065541
申请日：2008-06-02
申请人： PRESSURE BIOSCIENCES INC. , LAZAREV, Alexander , GROSS, Vera
发明人： LAZAREV, Alexander , GROSS, Vera
IPC分类号： B01D21/01
CPC分类号： C07K1/145
摘要： Methods of extracting a component of interest from a plurality of components are described.
摘要翻译：描述了从多个部件中提取关注部件的方法。

4. 发明申请

WO2012024523A3 FLOW-THROUGH HIGH HYDROSTATIC PRESSURE MICROFLUIDIC SAMPLE PREPARATION DEVICE AND RELATED METHODS THEREFOR 审中-公开
公开(公告)号：WO2012024523A3
公开(公告)日：2012-02-23
申请号：PCT/US2011/048302
申请日：2011-08-18
申请人： PRESSURE BIOSCIENCES, INC. , LAZAREV, Alexander
发明人： PRESSURE BIOSCIENCES, INC. , LAZAREV, Alexander
IPC分类号： G01N1/10
摘要： Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.

5. 发明申请

WO2010129704A2 MICROTUBE AND RELATED METHODS THEREFOR 审中-公开
标题翻译： MICROTUBE及其相关方法
公开(公告)号：WO2010129704A2
公开(公告)日：2010-11-11
申请号：PCT/US2010/033770
申请日：2010-05-05
申请人： PRESSURE BIOSCIENCES INC. , TING, Edmund , LAZAREV, Alexander , SCHUMACHER, Richard , DUSSAULT, Charles , FRITZSCHE, Wayne
发明人： TING, Edmund , LAZAREV, Alexander , SCHUMACHER, Richard , DUSSAULT, Charles , FRITZSCHE, Wayne
IPC分类号： G01N1/28
CPC分类号： G01N1/286 , B01L3/505 , B01L3/5082 , B01L9/06 , B01L2300/14
摘要： Sample processing devices having collapsible, flexible bodies are disclosed. The flexible microtube sampling devices are utilizable in pressure mediated, pressure cycling procedures. Externally applied pressure on the flexible microtube sample processing devices allow buckling thereof and transfer of the applied pressure to the sample contained therein.
摘要翻译：公开了具有可折叠，柔性体的样品处理装置。柔性微管采样装置可用于压力介导的压力循环程序。柔性微管样品处理装置上的外部施加的压力允许其弯曲并将施加的压力转移到其中所含的样品。

6. 发明申请

WO2013119922A1 OPTICAL FILM 审中-公开
标题翻译：光学胶片
公开(公告)号：WO2013119922A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/025305
申请日：2013-02-08
申请人： CRYSOPTIX KK , LAZAREV, Alexander
发明人： LAZAREV, Alexander
IPC分类号： C09K19/04
CPC分类号： G02B1/10 , C09K19/04 , C09K19/22 , G02B1/04 , G02B1/11 , G02F1/133634 , G02F2001/133635 , G02F2201/38 , G02F2201/50 , G02F2202/022 , G02F2202/28 , G02F2413/11 , G02F2413/12 , Y10T428/24364 , Y10T428/24521 , Y10T428/24942 , Y10T428/2848 , Y10T428/31507 , Y10T428/31623 , Y10T428/31721 , Y10T428/31725 , Y10T428/31736 , Y10T428/3175 , Y10T428/31757
摘要： The present invention relates generally to optical retardation films. The invention may be used as optical element in liquid crystal display (LCD) devices, particularly as phase- shifting component of LCDs of both reflection and transmission type, and in ant other field of science and technology where optical retardation films are applied such as architecture, automobile industry, decoration arts. The present invention provides an optical film comprising a substrate having front and rear surfaces, and at least one solid optical retardation layer on the front surface of the substrate. The solid optical retardation layer comprises organic rigid rod-like macromolecules based on 2,2'-disulfo-4,4'-benzidine terephthalamide-isophthalamide copolymer or its salt of the general structural formula I. The solid optical retardation layer is a negative C-type or Ac-type plate substantially transparent to electromagnetic radiation in the visible spectral range.
摘要翻译：本发明一般涉及光学延迟膜。本发明可以用作液晶显示器（LCD）器件中的光学元件，特别是作为反射和透射型LCD的相移元件以及其他应用光学延迟膜的其他科技领域的结构，汽车工业，装饰艺术。本发明提供了一种光学膜，其包括具有前表面和后表面的基底，以及在所述基底的前表面上的至少一个固体光学延迟层。固体光学延迟层包括基于2,2'-二磺基-4,4'-联苯胺对苯二酰胺 - 间苯二甲酰胺共聚物的有机刚性棒状大分子或其通式为结构式I的盐。固体光学延迟层为负C 型或Ac型板对可见光谱范围内的电磁辐射基本上是透明的。

7. 发明申请

WO2009137695A9 EXTRACTION OF BIOMOLECULAR COMPLEXES ASSISTED BY ALTERNATING HYDROSTATIC PRESSURE 审中-公开
公开(公告)号：WO2009137695A9
公开(公告)日：2009-11-12
申请号：PCT/US2009/043168
申请日：2009-05-07
申请人： PRESSURE BIOSCIENCES INC. , TAO, Feng , SCHUMACHER, Richard , LAWRENCE, Nathan , GROSS, Vera , SMEJKAL, Gary , LAZAREV, Alexander , HAN, Rui
发明人： TAO, Feng , SCHUMACHER, Richard , LAWRENCE, Nathan , GROSS, Vera , SMEJKAL, Gary , LAZAREV, Alexander , HAN, Rui
IPC分类号： C12M1/33 , G01N30/28
摘要： Extraction methods that allow a molecular complex (e.g., an organelle) to be extracted from a sample by employing pressure cycling are described.

8. 发明申请

WO2007140016A2 DEVICES, METHODS AND APPLICATIONS FOR EXTRACTION OF MOLECULES FROM POLYMERIC GEL ELECTROPHORETIC MEDIA 审中-公开
标题翻译：从聚合胶体电泳介质中提取分子的装置，方法和应用
公开(公告)号：WO2007140016A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/012729
申请日：2007-05-29
申请人： NORTHEASTERN UNIVERSITY , LAZAREV, Alexander , REJTAR, Thomas , KARGER, Barry, L.
发明人： LAZAREV, Alexander , REJTAR, Thomas , KARGER, Barry, L.
IPC分类号： B02C18/28
CPC分类号： B01L3/502 , B01L2200/06 , B01L2300/0832 , B01L2400/0409 , G01N1/34 , G01N35/0099
摘要： A device and method to provide a simplified wash process and controlled disintegration of a soft substance, such as a gel, are disclosed. In use, a block of, e.g., gel matrix is placed in the device and washed with a series of appropriate solutions to remove interfering contaminants. The washing liquid is removed through a deformable narrow opening in the bottom of the device, and, subsequently, the gel block is extruded through the deformable narrow opening, by a physical force, such as centrifugal force, a vacuum or positive pressure from a gas or liquid, etc., resulting in fragmentation of the gel block into a series of particles of similar size. The fragmentation of the gel results from shear forces exerted onto the gel block traveling through the deformable narrow opening in the device. The rate of such fragmentation and resulting fragment size can be controlled by extruding the gel block using a predefined level of force as well as by controlling the dimensions and shape of the narrow opening (s) in the device.
摘要翻译：公开了一种提供简化的洗涤过程并控制软物质如凝胶的分解的装置和方法。在使用中，将一块例如凝胶基质置于装置中并用一系列适当的溶液洗涤以除去干扰的污染物。洗涤液体通过设备底部的可变形的窄开口被去除，随后，凝胶块通过物理力，例如离心力，来自气体的真空或正压挤压通过可变形的窄开口或液体等，导致凝胶块破碎成一系列类似尺寸的颗粒。凝胶的断裂是由施加在凝胶块上的剪切力所引起的，该凝胶块穿过装置中的可变形的窄开口。可以通过使用预定水平的力挤压凝胶块以及通过控制装置中的窄开口的尺寸和形状来控制这种碎裂和所得碎片尺寸的速率。

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