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1. 发明申请

WO2009073401A3 SILICONE HYDROGELS FOR TISSUE ADHESIVES AND TISSUE DRESSING APPLICATIONS 审中-公开
公开(公告)号：WO2009073401A3
公开(公告)日：2009-10-15
申请号：PCT/US2008084306
申请日：2008-11-21
申请人： POLYMER TECHNOLOGY GROUP INC , MCCREA KEITH , WARD ROBERT S , TIAN YUAN
发明人： MCCREA KEITH , WARD ROBERT S , TIAN YUAN
IPC分类号： A61L26/00
CPC分类号： A61L15/60 , A61L15/225 , A61L15/26 , A61L26/0019 , A61L26/0076 , A61L26/008 , C08L83/04
摘要： A silicone hydrogel formulation may contains random and/or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethylacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS).

2. 发明申请

WO2007142683A3 SELF-ASSEMBLING MONOMERS AND OLIGOMERS AS SURFACE-MODIFYING ENDGROUPS FOR POLYMERS 审中-公开
标题翻译：自组装单体和低聚物作为表面修饰聚合物的终端
公开(公告)号：WO2007142683A3
公开(公告)日：2008-10-30
申请号：PCT/US2006046586
申请日：2006-12-07
申请人： POLYMER TECHNOLOGY GROUP INC , WARD ROBERT S , MCCREA KEITH R , TIAN YUAN , PARAKKA JAMES P , WANG SHANGER
发明人： WARD ROBERT S , MCCREA KEITH R , TIAN YUAN , PARAKKA JAMES P , WANG SHANGER
IPC分类号： A61K47/00
CPC分类号： A61K31/785 , C08G18/0895 , C08G18/2875 , C08G18/288 , C08G18/44 , C08G18/6266
摘要： Polymers having the formula R(LE) x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain, having at least 5 identical repeat units, capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE) x in the polymer may be the same as or different from one another. Design of monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer. Use of the polymer to fabricate a configured article from the surface-modified polymer or a coating or topical treatment on an article made from another material.
摘要翻译：具有式R（LE）x X的聚合物其中R是数均分子量为5000-7,000,000道尔顿并具有x个端基的聚合物芯，E是通过共价键与聚合物芯R共价连接的端基连接L，L是具有至少5个相同重复单元的二价低聚链，其能够与聚合物的相邻分子上的L链自组装，并且聚合物中的部分（LE）x < 可以彼此相同或不同。单体，低聚物或其它类似于已知的自组装单层的单体，低聚物或其它反应性结构的设计，但具有至少一个能够将它们结合到聚合物末端的反应性化学基团，使得无硫醇的SAM类似物变成自组装表面修饰该聚合物的端基。使用聚合物从表面改性的聚合物制造配置的制品，或者对由另一种材料制成的制品进行包衣或局部处理。

3. 发明申请

WO2009073401A4 SILICONE HYDROGELS FOR TISSUE ADHESIVES AND TISSUE DRESSING APPLICATIONS 审中-公开
标题翻译：有机硅水凝胶用于组织粘合剂和组织敷料应用
公开(公告)号：WO2009073401A4
公开(公告)日：2009-12-03
申请号：PCT/US2008084306
申请日：2008-11-21
申请人： DSM IP ASSETS BV , MCCREA KEITH , WARD ROBERT S , TIAN YUAN
发明人： MCCREA KEITH , WARD ROBERT S , TIAN YUAN
IPC分类号： A61L26/00
CPC分类号： A61L15/60 , A61L15/225 , A61L15/26 , A61L26/0019 , A61L26/0076 , A61L26/008 , C08L83/04
摘要： A silicone hydrogel formulation may contains random and/or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethylacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS).
摘要翻译：硅酮水凝胶制剂可含有无规和/或嵌段共聚物或低聚物或大分子单体。硅氧烷共聚物与其他聚合物或单体或大分子单体共聚或共混以获得最终配方。硅酮水凝胶可以含有交联基团以提供完全或部分交联的最终结构。硅酮水凝胶制剂可以预先形成为膜或其他结构，或者可以在施用期间如在粘合剂制剂的情况下那样聚合。 1.一种创伤敷料，其包含作为膜形成的硅酮水凝胶，所述硅酮水凝胶在应用于伤口之前或原位置于伤口上，所述膜具有气体渗透性，透湿性和高含水量，其中所述硅酮水凝胶由可聚合硅酮如双官能聚二甲基硅氧烷甲基丙烯酸酯和交联剂如N，N-二甲基丙烯酰胺（DMA），甲基丙烯酸2-羟乙酯（HEMA）和三甲基甲硅烷氧基硅烷（TRIS）。

4. 发明申请

WO2009148880A2 ANTIMICROBIAL POLYMERS AND THEIR USES 审中-公开
标题翻译：抗微生物聚合物及其用途
公开(公告)号：WO2009148880A2
公开(公告)日：2009-12-10
申请号：PCT/US2009045140
申请日：2009-05-26
申请人： DSM IP ASSETS BV , WANG SHANGER , WARD ROBERT S , TIAN YUAN , LI LI , MCCREA KEITH , PARAKKA JAMES , JONES ROBERT L JR
发明人： WANG SHANGER , WARD ROBERT S , TIAN YUAN , LI LI , MCCREA KEITH , PARAKKA JAMES , JONES ROBERT L JR
IPC分类号： A01N33/12 , A01N25/10
CPC分类号： A01N33/12 , A01N47/44 , A01N25/10 , A01N2300/00
摘要： Polymers with non-leaching antimicrobial activity and their use as surface coatings or bulk resins for medical devices. The antimicrobial polymers are prepared with antimicrobial moieties covalently bonded to a polymer chain end or to a polymer backbone at a side chain end. The antimicrobial moiety-containing endgroups include surface active (or surface assembling) moieties which promote enrichment of antimicrobial endgroups at the polymer surface and thus formation of an antimicrobially active surface. Polymers with built-in antimicrobial endgroups can be used as bulk resins, as antimicrobial additives, or as infection preventative coatings in the manufacture of medical devices (e.g., catheters, vascular access devices, peripheral lines, IV sites, drains, gastric feeding and tubes, and other implantable devices). Such materials can also be used as antimicrobial and antifouling coatings on structures in contact with microorganism in environments that require control of biofilm formation, such as marine products.
摘要翻译：具有非浸出抗菌活性的聚合物及其用作医疗器械的表面涂层或体积树脂。抗微生物聚合物通过共价键合到聚合物链末端的抗微生物部分或在侧链末端与聚合物主链一起制备。含抗微生物部分的端基包括表面活性（或表面组装）部分，其促进抗微生物端基在聚合物表面的富集，从而形成抗微生物活性表面。具有内置抗微生物端基的聚合物可用作散装树脂，作为抗微生物添加剂，或作为医疗器械制造中的感染预防性涂层（例如，导管，血管通路装置，外围线，IV部位，下水道，胃饲和管，和其他可植入装置）。在需要控制生物膜形成的环境中，例如海产品，这样的材料也可以用作与微生物接触的结构上的抗微生物和防污涂料。

5. 发明申请

WO0238197A3 DEVICES THAT CHANGE SIZE/SHAPE VIA OSMOTIC PRESSURE 审中-公开
标题翻译：通过动态压力改变尺寸/形状的装置
公开(公告)号：WO0238197A3
公开(公告)日：2002-10-10
申请号：PCT/US0143036
申请日：2001-11-09
申请人： POLYMER TECHNOLOGY GROUP INC , WARD ROBERT S , COVIELLO SALLIE K
发明人： WARD ROBERT S , COVIELLO SALLIE K
IPC分类号： A61F2/00 , A61F2/02 , A61F2/44 , A61L27/16 , A61L27/18 , A61L27/50 , B01D61/00 , B01D69/02 , B01D71/54 , B01D71/80 , C02F1/44 , A61L27/14
CPC分类号： C02F1/44 , A61F2/441 , A61F2002/30062 , A61F2002/30075 , A61F2002/444 , A61F2210/0004 , A61F2210/0061 , A61L27/16 , A61L27/18 , A61L27/50 , B01D61/002 , B01D69/02 , B01D71/54 , B01D71/80 , Y02A20/131 , C08L33/26 , C08L75/00
摘要： Devices implantable in animal bodies, possibly configured as self-inflating spinal disc prostheses. Alternatively, non-implantable water-desalination and/or purification devices. The devices include specified types of water-absorbing solute encapsulated by non-porous, water-permeable polymer membranes having specified properties. Also, methods of using the devices in biomedical applications or water treatment.
摘要翻译：可植入动物体内的装置，可能构成自充气脊椎椎间盘假体。或者，非植入式脱水和/或净化装置。这些装置包括由具有特定性质的无孔，透水的聚合物膜包封的特定类型的吸水溶质。此外，在生物医学应用或水处理中使用该装置的方法。

6. 发明申请

WO2011068897A1 METHOD FOR REMOVING CYTOKINES FROM BLOOD WITH SURFACE IMMOBILIZED POLYSACCHARIDES 审中-公开
标题翻译：用表面固定化多糖从血液中去除细胞因子的方法
公开(公告)号：WO2011068897A1
公开(公告)日：2011-06-09
申请号：PCT/US2010058596
申请日：2010-12-01
申请人： EXTHERA MEDICAL LLC , WARD ROBERT S , MCCREA KEITH R , LARM OLLE , ADOLFSSON LARS
发明人： WARD ROBERT S , MCCREA KEITH R , LARM OLLE , ADOLFSSON LARS
IPC分类号： A61K31/70 , A61M1/36
CPC分类号： A61M1/362 , A61K31/60 , A61K31/722 , A61K31/727 , A61K31/728 , A61M1/3472 , A61M1/3496 , A61M1/36 , A61M1/3621 , A61M1/3673 , A61M1/3679 , A61M1/3687 , A61M1/38 , A61M2202/0057
摘要： The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
摘要翻译：本发明涉及通过使血液与已经用肝素，硫酸乙酰肝素和/或表面处理的固体，基本上非微孔的底物接触，从血液或血清（血液）中除去细胞因子和/或病原体的方法对待除去的细胞因子或病原体（吸附物）具有结合亲和力的其它分子或化学基团（吸附介质或介质），并且其中所述介质中的间质通道的大小与介质的量平衡表面积和培养基上结合位点的表面浓度，以提供足够的吸附能力，同时还允许血液通过吸附介质的相对较高的流速。

7. 发明申请

WO2008157570A3 DEVICE AND METHOD FOR RESTORATION OF THE CONDITION OF BLOOD 审中-公开
标题翻译：用于恢复血液条件的装置和方法
公开(公告)号：WO2008157570A3
公开(公告)日：2009-07-16
申请号：PCT/US2008067271
申请日：2008-06-18
申请人： EXTHERA AB , LARM OLLE , BERGSTROEM THOMAS , AXELSSON JONAS , ADOLFSSON LARS , WARD ROBERT S , MCCREA KEITH
发明人： LARM OLLE , BERGSTROEM THOMAS , AXELSSON JONAS , ADOLFSSON LARS , WARD ROBERT S , MCCREA KEITH
IPC分类号： A61M1/36
CPC分类号： A61M1/3679 , A61K31/70 , B01J20/3272 , B01J20/3274
摘要： The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate.
摘要翻译：本发明涉及一种用于从血液或血液成分体外去除有害物质的装置，其包括通过共价终点附着固定在固体基质上的全长肝素。本发明还涉及从哺乳动物血液或血液成分体外去除有害物质的方法。本发明还涉及将全长肝素与固体底物共价连接的方法。

8. 发明申请

WO2007121180A3 BIOSENSOR MEMBRANE MATERIAL 审中-公开
标题翻译：生物传感器膜材料
公开(公告)号：WO2007121180A3
公开(公告)日：2008-10-30
申请号：PCT/US2007066332
申请日：2007-04-10
申请人： ISENSE CORP , WARD ROBERT S , TIAN YUAN , WARD WILLIAM KENNETH , ANDERSON ELLEN M , HOUSE JODY
发明人： WARD ROBERT S , TIAN YUAN , WARD WILLIAM KENNETH , ANDERSON ELLEN M , HOUSE JODY
IPC分类号： C08G77/42 , C08F283/02 , C08G77/448
CPC分类号： C08G64/18 , C08G77/448 , C08G77/458
摘要： Embodiments of the present invention provide various multipolymers and permselective membranes for use with biosensors and other implantable medical devices and prostheses. Embodiments of the present invention may provide structural strength and integrity, and further may control the influx of glucose, oxygen and/or water. Embodiments of the present invention may, for example, minimize or reduce the influx of glucose by minimizing the percentage of hydrophilic segments, which in turn minimizes the percentage of water uptake and the degree of glucose transport.
摘要翻译：本发明的实施方案提供了用于生物传感器和其它可植入医疗装置和假体的各种多聚体和选择渗透膜。本发明的实施方案可以提供结构强度和完整性，并且还可以控制葡萄糖，氧气和/或水的流入。例如，本发明的实施方案可以通过使亲水链段的百分比最小化来最小化或减少葡萄糖的流入，从而使吸水的百分比和葡萄糖转运的程度最小化。

9. 发明申请

WO2006102050A2 PROCESS FOR THE PRODUCTION OF MONODISPERSE AND NARROW DISPERSE MONOFUNCTIONAL SILICONES 审中-公开
标题翻译：单分散和单分散单功能硅生产工艺
公开(公告)号：WO2006102050A2
公开(公告)日：2006-09-28
申请号：PCT/US2006009666
申请日：2006-03-16
申请人： JOHNSON & JOHNSON VISION CARE , PARAKKA JAMES P , TIAN YUAN , WARD ROBERT S , WANG SHANGER , MAHADEVAN SHIVKUMAR , MOLOCK FRANK
发明人： PARAKKA JAMES P , TIAN YUAN , WARD ROBERT S , WANG SHANGER , MAHADEVAN SHIVKUMAR , MOLOCK FRANK
CPC分类号： C08G77/045 , C07F7/0874 , C08G77/06 , C08G77/08 , C08G77/20 , C08G77/36 , C08G77/38 , G02B1/043 , C08L83/06
摘要： Synthesis and purification of mono and narrow disperse monofunctional polydimethylsiloxane methacrylate derivatives with different molecular weights are disclosed.
摘要翻译：公开了具有不同分子量的单分散和单分散单官能聚二甲基硅氧烷甲基丙烯酸酯衍生物的合成和纯化。

10. 发明申请

WO02061515A8 REMOTE CONTROL SYSTEM 审中-公开
标题翻译：远程控制系统
公开(公告)号：WO02061515A8
公开(公告)日：2003-03-06
申请号：PCT/CA0200104
申请日：2002-01-29
申请人： AINSWORTH INC , WARD ROBERT S , LAW JAMES M , BLOOMQUIST LEIF A
发明人： WARD ROBERT S , LAW JAMES M , BLOOMQUIST LEIF A
IPC分类号： G05D1/00
CPC分类号： B60W50/02 , B60W50/08 , G05D1/0038 , G05D2201/021
摘要： The present invention comprises a system (10) and method for a control system which allows for autonomous, manual and tele-operation of underground mining vehicles (18). The control system (10) is retrofitted to existing mining vehicles (18) and has a robust system design to withstand the harsh environment of underground mines. A tele-operator (82), in a remote tele-operator station (16), uses video screens (86, 88), joysticks (84) and foot pedals (50) to remotely control the mining vehicle (18). The control system (10) also has important safety features such as supervising its operation for operational errors and providing status, warning and error information to the tele-operator station. The control system (10) also allows for remote software updates and maintenance support.
摘要翻译：本发明包括一种用于控制系统的系统（10）和方法，其允许地下采矿车辆（18）的自主，手动和远程操作。控制系统（10）被改造成现有的采矿车辆（18），并具有坚固的系统设计，可以承受地下矿井恶劣的环境。远程操作员站（16）中的远程操作员（82）使用视频屏幕（86,88），操纵杆（84）和脚踏板（50）远程控制采矿车辆（18）。控制系统（10）还具有重要的安全功能，例如监控其操作错误的操作，并向电话操作员站提供状态，警告和错误信息。控制系统（10）还允许远程软件更新和维护支持。

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