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1. 发明申请

WO2010144044A1 USE OF A COMPOSITION FOR THE TREATMENT OF MUCOSITIS 审中-公开
标题翻译：使用组合物治疗肌瘤
公开(公告)号：WO2010144044A1
公开(公告)日：2010-12-16
申请号：PCT/SE2010/050650
申请日：2010-06-10
申请人： EXTHERA AB , ADOLFSSON, Lars , LARM, Olle , WESTERMARK, Anders
发明人： ADOLFSSON, Lars , LARM, Olle , WESTERMARK, Anders
IPC分类号： A61K31/727 , A61K31/722 , A61K31/737 , A61P1/04 , A61P29/00
CPC分类号： A61K31/722 , A61K9/006 , A61K9/10 , A61K31/721 , A61K31/727 , A61K31/737 , A61K47/36 , A61K2300/00
摘要： The present invention relates to a composition comprising an ionic complex of chitosan and a negatively charged polysaccharide, selected from the group consisting of heparin, heparan sulfate and dextran sulfate, for use in the treatment of mucositis in a mammalian subject, to a method of preventing or treating mucositis ina mammalian subject, by applying topically a compositioncomprising an ionic complex of chitosan and a negatively charged polysaccharide, selected from the group consisting of heparin, heparan sulfate and dextran sulfate. The present invention further relates to a pharmaceutical composition for topical administration comprising an ionic complex of chitosan and heparin.
摘要翻译：本发明涉及一种组合物，其包含壳聚糖和带负电荷的多糖的离子络合物，所述多糖选自用于治疗哺乳动物受试者的粘膜炎的肝素，硫酸乙酰肝素和硫酸葡聚糖，以防止或治疗哺乳动物受试者中的粘膜炎，通过局部施用组合物，其包含选自由肝素，硫酸乙酰肝素和硫酸葡聚糖组成的组的壳聚糖和带负电荷的多糖的离子络合物。本发明还涉及一种用于局部给药的药物组合物，其包含壳聚糖和肝素的离子络合物。

2. 发明申请

WO1996018423A1 COATING PROCESS 审中-公开
标题翻译：涂装工艺
公开(公告)号：WO1996018423A1
公开(公告)日：1996-06-20
申请号：PCT/SE1995001459
申请日：1995-12-05
申请人： MEDICARB AB , LARM, Olle , GOUDA, Ibrahim
发明人： MEDICARB AB
IPC分类号： A61L27/00
CPC分类号： A61L33/08 , A61F2/16 , A61L27/34 , A61L33/0029 , A61F2/14 , C08L79/00 , C08L5/10 , C08L5/08 , C08L5/00
摘要： A process for the coating of an intraocular lens to impart tissue compatibility thereto, comprising the steps: a) priming said lens using a solution of a polyamine; b) coating the lens treated in step a) above with a solution of a periodate-oxidized polysaccharide selected from heparin, heparan sulphate, and chondroitin sulphate to stabilize said polyamine by covalent and/or ionical cross-linking; c) coating the lens treated in step b) above with a solution of a polyamine; and d) coating the lens treated according to step c) above with a solution of a periodate-oxidized polysaccharide selected from heparin, heparan sulphate, and chondroitin sulphate in the presence of a cyanoborohydride to convert formed labile Schiff's bases to stable secondary amines.
摘要翻译：一种用于涂覆眼内透镜以赋予组织相容性的方法，包括以下步骤：a）使用多胺溶液引发所述镜片; b）用选自肝素，硫酸乙酰肝素和硫酸软骨素的高碘酸盐氧化多糖的溶液涂覆在上述步骤a）中处理的晶状体以通过共价和/或离子交联稳定所述多胺; c）用多胺溶液涂覆上述步骤b）中处理的晶状体; 和d）在氰基硼氢化钠存在下，用选自肝素，硫酸乙酰肝素和硫酸软骨素的高碘酸盐氧化多糖溶液涂覆根据上述步骤c）处理的晶状体，以将形成的不稳定希夫碱转化成稳定的仲胺。

3. 发明申请

WO1996002258A1 ANTI-ADHESION AGENT 审中-公开
标题翻译：抗粘连剂
公开(公告)号：WO1996002258A1
公开(公告)日：1996-02-01
申请号：PCT/SE1995000856
申请日：1995-07-13
申请人： ASTRA AKTIEBOLAG , HANSSON, Hans-Arne , JOHANSSON-RUDEN, Gunilla , LARM, Olle
发明人： ASTRA AKTIEBOLAG
IPC分类号： A61K31/725
CPC分类号： A61K31/722 , A61K31/727 , A61K31/721 , A61K2300/00
摘要： The use of chitosan and a polysaccharide immobilized thereto selected from heparin, heparan sulphate and dextran sulphate for the manufacture of an agent capable of preventing or substantially reducing undesirable adhesion of damaged tissue with adjacent or surrounding tissues in connection with wound healing; and a process for the use of such agent.
摘要翻译：使用壳聚糖和固定在其上的多糖选自肝素，硫酸乙酰肝素和硫酸葡聚糖，用于制造能够预防或基本上减少与伤口愈合相关的相邻或周围组织的损伤组织的不期望的粘附的试剂; 以及使用这种药剂的方法。

4. 发明申请

WO1994026399A1 SURFACE MODIFIED BIOCOMPATIBLE MEMBRANES 审中-公开
标题翻译：表面改性生物成膜
公开(公告)号：WO1994026399A1
公开(公告)日：1994-11-24
申请号：PCT/NO1994000088
申请日：1994-05-09
申请人： NORSK HYDRO A.S. , SCHOLANDER, Elisabeth , WERYNSKI, Andrzej , JÖZWLAK, Andrzej , LARM, Olle
发明人： NORSK HYDRO A.S.
IPC分类号： B01D71/06
CPC分类号： B01D67/0093 , A61L33/0029 , B01D67/0011 , B01D67/0016 , B01D2323/08 , B01D2323/12
摘要： The present invention concerns surface modified biocompatible membranes used in contact with body fluids or tissue and a method of preparing polymer surface modified biocompatible membranes with functional groups incorporated into the membrane material thus to immobilize compounds that confer biocompatibility to the surface, where the incorporation of the surface modifying polymer takes place during formation of the membranes and the physical properties of the membranes are not affected by immobilisation of the bioactive molecules.
摘要翻译：本发明涉及用于与体液或组织接触的表面改性的生物相容性膜，以及制备聚合物表面改性的生物相容性膜的方法，其具有并入膜材料中的官能团，从而固定赋予表面生物相容性的化合物，表面改性聚合物在膜的形成期间发生，并且膜的物理性质不受生物活性分子的固定的影响。

5. 发明申请

WO1994016750A1 SOLID SUBSTRATE 审中-公开
标题翻译：固体基板
公开(公告)号：WO1994016750A1
公开(公告)日：1994-08-04
申请号：PCT/SE1994000022
申请日：1994-01-14
申请人： MEDICARB AB , GOUDA, Ibrahim , LARM, Olle
发明人： MEDICARB AB
IPC分类号： A61L33/00
CPC分类号： C08J7/047 , A61L27/34 , A61L33/0076 , C08J2403/00 , C08J2405/00 , C08L5/08
摘要： A solid substrate, the surface of which has been modified to introduce reactive groups of a hydrophilic nature thereon, the modification being provided by a primer comprising a first polysaccharide containing as reactive groups amino and hydroxyl groups; and a process for the preparation of such solid substrate.
摘要翻译：一种固体基质，其表面已经被修饰以在其上引入亲水性反应性基团，该修饰由包含含有作为反应性基团的第一多糖的引物包含氨基和羟基的引物提供; 以及制备这种固体基质的方法。

6. 发明申请

WO1994016714A1 THE USE OF A COMPOSITION FOR THE TREATMENT OF INFECTIONS CAUSED BY HELICOBACTER PYLORI 审中-公开
标题翻译：用于治疗由HELICOBACTER PYLORI引起的感染的组合物的使用
公开(公告)号：WO1994016714A1
公开(公告)日：1994-08-04
申请号：PCT/SE1994000021
申请日：1994-01-14
申请人： MEDICARB AB , LARM, Olle , WADSTRÖM, Torkel
发明人： MEDICARB AB
IPC分类号： A61K31/725
CPC分类号： A61K31/715
摘要： The use of a composition in the preparation of a drug for the treatment or prophylaxis of infections caused by or associated with Helicobacter pylori, said composition containing as an active constituent an immobilized, negatively charged polysaccharide selected from the group comprising: heparin, heparan sulphate and dextran sulphate; a method of treating or preventing infections caused by or associated with Helicobacter pylori in mammals including man, comprising administering to a mammal in need of such treatment or prophylaxis an effective amount of a composition containing as an active constituent an immobilized, negatively charged polysaccharide selected from the group comprising: heparin, heparan sulphate and dextran sulphate; a protein with an apparent molecular weight of not more than about 120 kDa (on SDS-PAGE) and active subfragments thereof down to a molecular weight of about 20 kDa, said protein and subfragments specifically binding to heparan sulphate and being producible from H. pylori strains 25 and 1139 as a surface protein antigen thereof; mono- and polyclonal antibodies; process for detecting H. pylori; drug compositions; reagent kit; and a vaccine.
摘要翻译：在制备用于治疗或预防由幽门螺杆菌引起或与幽门螺杆菌有关的感染的药物中的组合物的用途，所述组合物含有作为活性成分的固定化带负电荷的多糖，其选自肝素，硫酸乙酰肝素和硫酸葡聚糖; 治疗或预防包括人在内的哺乳动物中由幽门螺杆菌引起或与幽门螺杆菌有关的感染的方法，包括向需要这种治疗或预防有效量的含有作为活性成分的组合物施用有效量的选自以下的固定化带负电荷的多糖的组合物：该组包括：肝素，硫酸乙酰肝素和硫酸葡聚糖; 具有表达分子量不超过约120kDa的蛋白质（在SDS-PAGE上）及其活性亚片段分子量约为20kDa，所述蛋白质和亚片段特异性结合硫酸肝素并且可从幽门螺杆菌菌株25和1139作为其表面蛋白抗原; 单克隆和多克隆抗体; 检测幽门螺杆菌的过程; 药物组成; 试剂盒; 和疫苗。

7. 发明申请

WO2011133099A1 METHOD FOR REMOVAL OF MRSA FROM BLOOD 审中-公开
标题翻译：从血液中去除MRSA的方法
公开(公告)号：WO2011133099A1
公开(公告)日：2011-10-27
申请号：PCT/SE2011/050482
申请日：2011-04-20
申请人： EXTHERA MEDICAL LLC , LARM, Olle , MATTSBY-BALTZER, Inger , MCCREA, Keith , WARD, Robert S. , ADOLFSSON, Lars , BERGSTRÖM, Tomas
发明人： LARM, Olle , MATTSBY-BALTZER, Inger , MCCREA, Keith , WARD, Robert S. , ADOLFSSON, Lars , BERGSTRÖM, Tomas
IPC分类号： A61M1/34
CPC分类号： A61M1/3679 , A61M2202/203
摘要： The present invention relates to a method for extracorporeal removal of Methicillin-resistant Staphylococcus aureus (MRSA)from mammalian blood; use of a device comprising a carbohydrate immobilized on a solid substrate, said carbohydrate having a binding affinity for MRSA, for extracorporeal removal of MRSA from mammalian blood; use of a carbohydrate having a binding affinity for MRSA, wherein said carbohydrate is immobilized on a solid substrate, in the preparation of a device for treatment of a condition caused or aggravated by MRSA; and a method for treatment of a mammalian subject suffering from a condition caused or aggravated by MRSA.
摘要翻译：本发明涉及从哺乳动物血液中体外去除耐甲氧西林金黄色葡萄球菌（MRSA）的方法; 使用包含固定在固体基质上的碳水化合物的装置，所述碳水化合物对MRSA具有结合亲和力，用于体外从哺乳动物血液中除去MRSA; 使用对MRSA具有结合亲和力的碳水化合物，其中所述碳水化合物固定在固体基质上，用于制备用于治疗由MRSA引起或加重的病症的装置; 以及用于治疗患有由MRSA引起或加重的病症的哺乳动物受试者的方法。

8. 发明申请

WO2011068897A9 METHOD FOR REMOVING CYTOKINES FROM BLOOD WITH SURFACE IMMOBILIZED POLYSACCHARIDES 审中-公开
公开(公告)号：WO2011068897A9
公开(公告)日：2011-06-09
申请号：PCT/US2010/058596
申请日：2010-12-01
申请人： EXTHERA MEDICAL, LLC , WARD, Robert S. , McCREA, Keith R. , LARM, Olle , ADOLFSSON, Lars
发明人： WARD, Robert S. , McCREA, Keith R. , LARM, Olle , ADOLFSSON, Lars
IPC分类号： A61K31/70 , A61M1/36
摘要： The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.

9. 发明申请

WO2011068897A1 METHOD FOR REMOVING CYTOKINES FROM BLOOD WITH SURFACE IMMOBILIZED POLYSACCHARIDES 审中-公开
标题翻译：用表面固定化多糖从血液中去除细胞因子的方法
公开(公告)号：WO2011068897A1
公开(公告)日：2011-06-09
申请号：PCT/US2010058596
申请日：2010-12-01
申请人： EXTHERA MEDICAL LLC , WARD ROBERT S , MCCREA KEITH R , LARM OLLE , ADOLFSSON LARS
发明人： WARD ROBERT S , MCCREA KEITH R , LARM OLLE , ADOLFSSON LARS
IPC分类号： A61K31/70 , A61M1/36
CPC分类号： A61M1/362 , A61K31/60 , A61K31/722 , A61K31/727 , A61K31/728 , A61M1/3472 , A61M1/3496 , A61M1/36 , A61M1/3621 , A61M1/3673 , A61M1/3679 , A61M1/3687 , A61M1/38 , A61M2202/0057
摘要： The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
摘要翻译：本发明涉及通过使血液与已经用肝素，硫酸乙酰肝素和/或表面处理的固体，基本上非微孔的底物接触，从血液或血清（血液）中除去细胞因子和/或病原体的方法对待除去的细胞因子或病原体（吸附物）具有结合亲和力的其它分子或化学基团（吸附介质或介质），并且其中所述介质中的间质通道的大小与介质的量平衡表面积和培养基上结合位点的表面浓度，以提供足够的吸附能力，同时还允许血液通过吸附介质的相对较高的流速。

10. 发明申请

WO2006078211A1 GROWTH FACTOR COMPOSITION 审中-公开
标题翻译：生长因子组成
公开(公告)号：WO2006078211A1
公开(公告)日：2006-07-27
申请号：PCT/SE2006/000077
申请日：2006-01-19
申请人： BONOSS MEDICAL AB , ARNANDER, Claes , ENGSTRAND, Thomas , LARM, Olle , VELTHEIM, Riikka
发明人： ARNANDER, Claes , ENGSTRAND, Thomas , LARM, Olle , VELTHEIM, Riikka
IPC分类号： A61K38/18 , A61K31/715 , A61K31/721 , A61K31/722 , A61K31/727 , A61L27/26 , A61P19/00
CPC分类号： A61K31/715 , A61K31/721 , A61K31/722 , A61K31/727 , A61L27/26 , A61L27/54 , A61L2300/414 , A61L2300/604 , A61L2430/02
摘要： A composition is provided, which is capable of generating hard tissue when introduced in a mammalian subject and comprises a) an ionic complex of i) chitosan and ii) a negatively charged polysaccharide selected from the group consisting of heparin, heparan sulfate and dextran sulfate, and b)a hard tissue generating growth factor, said ionic complex being a carrier for said hard tissue generating growth factor. Also provided are a method of preparation in vitro of a bone graft substitute using the composition, a kit for carrying out the method, as well as use of the composition in the preparation of a medical device for generation of hard tissue in a mammalian subject in need thereof, and a method of generation of hard tissue at a desired site in a mammalian subject in need thereof.
摘要翻译：提供组合物，其能够在引入哺乳动物受试者时产生硬组织，并且包含a）i）壳聚糖的离子络合物和ii）选自肝素，硫酸乙酰肝素和硫酸葡聚糖的带负电荷的多糖，和b）硬组织生成生长因子，所述离子复合物是所述硬组织生成生长因子的载体。还提供了使用该组合物在体外制备骨移植物替代物的方法，用于实施该方法的试剂盒，以及该组合物在哺乳动物受试者的制备用于产生硬组织的医疗装置中的用途需要，以及在有需要的哺乳动物受试者的期望部位产生硬组织的方法。

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