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1. 发明申请

WO2007142683A3 SELF-ASSEMBLING MONOMERS AND OLIGOMERS AS SURFACE-MODIFYING ENDGROUPS FOR POLYMERS 审中-公开
标题翻译：自组装单体和低聚物作为表面修饰聚合物的终端
公开(公告)号：WO2007142683A3
公开(公告)日：2008-10-30
申请号：PCT/US2006046586
申请日：2006-12-07
申请人： POLYMER TECHNOLOGY GROUP INC , WARD ROBERT S , MCCREA KEITH R , TIAN YUAN , PARAKKA JAMES P , WANG SHANGER
发明人： WARD ROBERT S , MCCREA KEITH R , TIAN YUAN , PARAKKA JAMES P , WANG SHANGER
IPC分类号： A61K47/00
CPC分类号： A61K31/785 , C08G18/0895 , C08G18/2875 , C08G18/288 , C08G18/44 , C08G18/6266
摘要： Polymers having the formula R(LE) x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain, having at least 5 identical repeat units, capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE) x in the polymer may be the same as or different from one another. Design of monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer. Use of the polymer to fabricate a configured article from the surface-modified polymer or a coating or topical treatment on an article made from another material.
摘要翻译：具有式R（LE）x X的聚合物其中R是数均分子量为5000-7,000,000道尔顿并具有x个端基的聚合物芯，E是通过共价键与聚合物芯R共价连接的端基连接L，L是具有至少5个相同重复单元的二价低聚链，其能够与聚合物的相邻分子上的L链自组装，并且聚合物中的部分（LE）x < 可以彼此相同或不同。单体，低聚物或其它类似于已知的自组装单层的单体，低聚物或其它反应性结构的设计，但具有至少一个能够将它们结合到聚合物末端的反应性化学基团，使得无硫醇的SAM类似物变成自组装表面修饰该聚合物的端基。使用聚合物从表面改性的聚合物制造配置的制品，或者对由另一种材料制成的制品进行包衣或局部处理。

2. 发明申请

WO2006102050A2 PROCESS FOR THE PRODUCTION OF MONODISPERSE AND NARROW DISPERSE MONOFUNCTIONAL SILICONES 审中-公开
标题翻译：单分散和单分散单功能硅生产工艺
公开(公告)号：WO2006102050A2
公开(公告)日：2006-09-28
申请号：PCT/US2006009666
申请日：2006-03-16
申请人： JOHNSON & JOHNSON VISION CARE , PARAKKA JAMES P , TIAN YUAN , WARD ROBERT S , WANG SHANGER , MAHADEVAN SHIVKUMAR , MOLOCK FRANK
发明人： PARAKKA JAMES P , TIAN YUAN , WARD ROBERT S , WANG SHANGER , MAHADEVAN SHIVKUMAR , MOLOCK FRANK
CPC分类号： C08G77/045 , C07F7/0874 , C08G77/06 , C08G77/08 , C08G77/20 , C08G77/36 , C08G77/38 , G02B1/043 , C08L83/06
摘要： Synthesis and purification of mono and narrow disperse monofunctional polydimethylsiloxane methacrylate derivatives with different molecular weights are disclosed.
摘要翻译：公开了具有不同分子量的单分散和单分散单官能聚二甲基硅氧烷甲基丙烯酸酯衍生物的合成和纯化。

3. 发明申请

WO2009148880A2 ANTIMICROBIAL POLYMERS AND THEIR USES 审中-公开
标题翻译：抗微生物聚合物及其用途
公开(公告)号：WO2009148880A2
公开(公告)日：2009-12-10
申请号：PCT/US2009045140
申请日：2009-05-26
申请人： DSM IP ASSETS BV , WANG SHANGER , WARD ROBERT S , TIAN YUAN , LI LI , MCCREA KEITH , PARAKKA JAMES , JONES ROBERT L JR
发明人： WANG SHANGER , WARD ROBERT S , TIAN YUAN , LI LI , MCCREA KEITH , PARAKKA JAMES , JONES ROBERT L JR
IPC分类号： A01N33/12 , A01N25/10
CPC分类号： A01N33/12 , A01N47/44 , A01N25/10 , A01N2300/00
摘要： Polymers with non-leaching antimicrobial activity and their use as surface coatings or bulk resins for medical devices. The antimicrobial polymers are prepared with antimicrobial moieties covalently bonded to a polymer chain end or to a polymer backbone at a side chain end. The antimicrobial moiety-containing endgroups include surface active (or surface assembling) moieties which promote enrichment of antimicrobial endgroups at the polymer surface and thus formation of an antimicrobially active surface. Polymers with built-in antimicrobial endgroups can be used as bulk resins, as antimicrobial additives, or as infection preventative coatings in the manufacture of medical devices (e.g., catheters, vascular access devices, peripheral lines, IV sites, drains, gastric feeding and tubes, and other implantable devices). Such materials can also be used as antimicrobial and antifouling coatings on structures in contact with microorganism in environments that require control of biofilm formation, such as marine products.
摘要翻译：具有非浸出抗菌活性的聚合物及其用作医疗器械的表面涂层或体积树脂。抗微生物聚合物通过共价键合到聚合物链末端的抗微生物部分或在侧链末端与聚合物主链一起制备。含抗微生物部分的端基包括表面活性（或表面组装）部分，其促进抗微生物端基在聚合物表面的富集，从而形成抗微生物活性表面。具有内置抗微生物端基的聚合物可用作散装树脂，作为抗微生物添加剂，或作为医疗器械制造中的感染预防性涂层（例如，导管，血管通路装置，外围线，IV部位，下水道，胃饲和管，和其他可植入装置）。在需要控制生物膜形成的环境中，例如海产品，这样的材料也可以用作与微生物接触的结构上的抗微生物和防污涂料。

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