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1. 发明申请

WO2012032402A1 SYSTEM FOR THE AUTOMATIC DETECTION OF RESPIRATORY DISEASES AND FOR THE PREDICTION OF FUTURE ACUTE AIRWAY INSTABILITIES 审中-公开
标题翻译：呼吸系统疾病自动检测系统及预测未来急性空气不稳定
公开(公告)号：WO2012032402A1
公开(公告)日：2012-03-15
申请号：PCT/IB2011/002103
申请日：2011-09-09
申请人： POLITECNICO DI MILANO , GOBBI, Alessandro , POMPILIO, Pasquale, Pio , DELLACA', Raffaele , PEDOTTI, Antonio
发明人： GOBBI, Alessandro , POMPILIO, Pasquale, Pio , DELLACA', Raffaele , PEDOTTI, Antonio
IPC分类号： A61B5/085
CPC分类号： A61B5/085 , A61B5/087 , A61B5/4842 , A61B5/7275
摘要： A system for automatically predicting acute airway events in patients, comprising: a device for measuring the respiratory impedance of a human subject during a plurality of respiratory cycles of said human subject; said respiratory impedance comprising a real part and an imaginary part; said device measuring said respiratory impedance two times per day to provide a plurality of measurements; means for calculating the relative variation of said plurality of measurements; means for evaluating the probability of respiratory pathology presence in the subject under examination when the value of the imaginary part of said impedance is greater than 35%; means for predicting a relapse in the patent under examination within an established future time window, once the presence of the pathology has been ascertained, if the variation coefficient of the real part of said impedance is greater than 0.4.
摘要翻译：一种用于自动预测患者急性呼吸道事件的系统，包括：用于在所述人类受试者的多个呼吸循环期间测量人类受试者的呼吸阻抗的装置; 所述呼吸阻抗包括实部和虚部; 所述装置每天测量两次呼吸阻力以提供多个测量; 用于计算所述多个测量的相对变化的装置; 当所述阻抗的虚部的值大于35％时，用于评估在检查对象中呼吸道病理学存在概率的方法; 如果所述阻抗的实部的变化系数大于0.4，则在确定的病理学存在之后，在已建立的未来时间窗口内预测在检查中的专利复发的手段。

2. 发明申请

WO2012014024A1 SYSTEM AND METHOD FOR MEASURING THE MECHANICAL IMPEDANCE OF THE RESPIRATORY SYSTEM 审中-公开
标题翻译：用于测量呼吸系统的机械阻抗的系统和方法
公开(公告)号：WO2012014024A1
公开(公告)日：2012-02-02
申请号：PCT/IB2011/001070
申请日：2011-05-17
申请人： RESTECH S.R.L. - SPIN OFF DEL POLITECNICO DI MILANO , POMPILIO, Pasquale, Pio , GOBBI, Alessandro , DELLACA', Raffaele , PEDOTTI, Antonio
发明人： POMPILIO, Pasquale, Pio , GOBBI, Alessandro , DELLACA', Raffaele , PEDOTTI, Antonio
IPC分类号： A61B5/085 , A61M16/00 , A61M16/06 , A61B5/087
CPC分类号： A61B5/085 , A61B5/087 , A61M16/0006 , A61M2016/0027 , A61M2016/0036 , A61M2230/46
摘要： A system for measuring the mechanical impedance of a patient's respiratory system during spontaneous respiratory activity, characterised by comprising a fan; a motor which operates said fan; said motor and said fan being positioned within a cavity; said cavity comprising an initial end and a final end, both providing access to the outside; said cavity presenting an impedance between said initial and said final end of less than 1 cm H 2 O/L/s; said fan withdrawing air from said final end and providing pressure variations of small amplitude and of frequency > 2 Hz to said initial end; said initial end comprising air pressure and air flow measurement means and a connection directly connected to the airway opening.
摘要翻译：一种用于在自发呼吸活动期间测量患者呼吸系统的机械阻抗的系统，其特征在于包括风扇; 操作所述风扇的电动机; 所述马达和所述风扇位于空腔内; 所述腔包括初始端和最终端，两者都提供通向外部的通路; 所述空腔在所述初始和所述最终端之间呈现小于1cm H 2 O / L / s的阻抗; 所述风扇从所述最终端抽出空气，并向所述初始端提供小振幅和频率> 2Hz的压力变化; 所述初始端包括空气压力和空气流量测量装置以及直接连接到气道开口的连接。

3. 发明申请

WO2008015222A1 DUAL BODY PLETHYSMOGRAPHY APPARATUS AND PROCESS FOR MEASURING BLOOD FLOW BETWEEN THE THORAX AND ABDOMEN (THE TRUNK) AND THE BODY PERIPHERY 审中-公开
标题翻译：双体动物测量仪器和测量THORAX和ABDOMEN（TRUNK）和身体外周血液流量的方法
公开(公告)号：WO2008015222A1
公开(公告)日：2008-02-07
申请号：PCT/EP2007/057919
申请日：2007-07-31
申请人： POLITECNICO DI MILANO , ALIVERTI, Andrea , DELLACA', Raffaele , PEDOTTI, Antonio , MACKLEM, Peter T.
发明人： ALIVERTI, Andrea , DELLACA', Raffaele , PEDOTTI, Antonio , MACKLEM, Peter T.
IPC分类号： A61B5/08 , A61B5/103
CPC分类号： A61B5/0806 , A61B5/026 , A61B5/0295 , A61B5/0535 , A61B5/1073 , A61B5/6888
摘要： An apparatus is described (1) for measuring the blood flow (Vb) between the trunk and the extremities. Such an apparatus (1) comprises a whole body plethysmograph (102; 4, 12, 15, 40) for measuring the variations of gas volume in the lungs (ΔVL), a thoraco-abdominal plethysmograph (101, 2, 3) for measuring the volume variations of the trunk (ΔVCW) and a system for processing (20) allowing measurement of the said variations of gas volume of the lungs (ΔVL) and the volume variations of the trunk (ΔVCW) so as to compute the volume of blood shifted between the trunk and the extremities (Vb). Further a process is described for measuring the volume of blood shifted between the trunk and the extremities (Vb). Such a process comprises: a measurement (121) of the volume variations of the trunk (ΔVCW) by means of thoraco-abdominal plethysmography, a measurement (104) (performed at the same time as the previous measurement) of the variations of gas volume of the lungs (ΔVL) by means of whole body plethysmography; a processing (120) of said volume variations of the trunk (ΔVCW) and of said volume variations of the lungs in order to measure the volume of blood shifted between the trunk and the extremities (Vb).
摘要翻译：描述了用于测量躯干和四肢之间的血流量（Vb）的装置（1）。这种装置（1）包括用于测量肺中的气体体积变化（ΔVL）的全身体积描记图（102; 4,12,15,40），用于测量肺中的气体容积的变化（ΔVLV）的胸腔积血积分仪（101,2,3）测量中继线（... VCW）的体积变化和用于处理（20）的系统，允许测量所述肺的气体体积变化（ΔVL）和躯体的体积变化（ΔVCW），以便计算血液在躯干和四肢之间移动的体积（Vb）。此外，描述了用于测量在躯干和四肢之间移位的血液的体积（Vb）的过程。这样的方法包括：通过胸腹部体积描记法测量（121）体积变化（→VCW），测量（104）（与之前的测量同时进行）气体变化通过全身体积描记术检查肺的容积（△VL）; 为了测量在躯干和四肢之间移位的血液的体积（Vb），所述体积变化（→VCW）和所述肺的体积变化的处理（120）。

4. 发明申请

WO2006008300A1 APPARATUS FOR NAVIGATION AND FOR FUSION OF ECOGRAPHIC AND VOLUMETRIC IMAGES OF A PATIENT WHICH USES A COMBINATION OF ACTIVE AND PASSIVE OPTICAL MARKERS 审中-公开
标题翻译：用于导航和融合患者的生物和体积图像的装置，其使用有源和被动光标记的组合
公开(公告)号：WO2006008300A1
公开(公告)日：2006-01-26
申请号：PCT/EP2005/053490
申请日：2005-07-19
申请人： POLITECNICO DI MILANO , DELLACA', Raffaele , ALIVERTI, Andrea , PEDOTTI, Antonio
发明人： DELLACA', Raffaele , ALIVERTI, Andrea , PEDOTTI, Antonio
IPC分类号： A61B19/00
CPC分类号： A61B8/5238 , A61B5/055 , A61B5/1127 , A61B6/03 , A61B6/5247 , A61B8/00 , A61B8/0833 , A61B8/0841 , A61B8/14 , A61B8/4245 , A61B8/4263 , A61B34/20 , A61B2034/2051 , A61B2034/2055 , A61B2034/2072 , A61B2090/364 , A61B2090/365 , A61B2090/378
摘要： The invention concerns an apparatus for fusion and navigation of ecographic and volumetric images of a patient (1) and for localization of an ecographic probe (2) connected with an ecographer (7) and/or of a surgical instrument (3) operating on the same patient. The unit comprises a plurality of passive or active optical markers (4) positionable on the body of the patient and a plurality of active optical markers (5, 6) located on the ecographic probe and/or on the surgical instrument, sensors of optical signal (8) provided with devices (9) for activation of said passive markers, which sensors (8) are suitable for reception of optical signals produced by reflect ion of said passive markers and/or coming from said active markers, a turning on device (11) for said active markers and said devices for the activation of the passive markers, a movement analysis device (10) suitable to process the signals emitted by said sensors (8) as a function of the optical signals received in order to obtain from them the coordinates of said markers, a decoding device (12) suitable to distinguish the coordinates of the active markers from the ones of the passive markers, a data processing device (13) for localization of the ecographic probe (2) and/or the surgical instrument (3) and for definition of the movement of the patient, a device (14) for acquisition of the ecographic images in synchronism with the posit ion of the ecographic probe (2) and/or the surgical instrument (3) and a device (15) for fusion and the navigation of the ecographic images with volumetric images coming from other systems (16) for acquisition of images.
摘要翻译：本发明涉及用于患者（1）的生态图像和体积图像的融合和导航的装置，以及用于与在其上操作的生态学家（7）和/或手术器械（3）连接的生态探针（2）的定位的装置。同样的病人该单元包括可定位在患者身体上的多个被动或主动光学标记（4）和位于环境探针上和/或外科手术器上的多个有源光学标记（5,6），光学信号的传感器（8），其设置有用于激活所述被动标记的装置（9），所述传感器（8）适于接收由所述被动标记的反射和/或来自所述有源标记产生的光信号， 11），用于激活被动标记的所述活动标记和所述装置，适于处理由所述传感器（8）发射的信号的运动分析装置（10）作为接收的光信号以便从它们获得的函数所述标记的坐标，适于区分活动标记的坐标与被动标记的坐标的解码装置（12），用于定位环境探针（2）和/或手术的数据处理装置（13）（3）并且用于定义患者的运动，用于与环境探针（2）和/或手术器械（3）的定位同步地获取生态图像的装置（14）和用于融合的设备（15）以及来自用于获取图像的其他系统（16）的体积图像的生态图像的导航。

5. 发明申请

WO2008031822A1 APPARATUS FOR RESPIRATORY SUPPORT AND NON-INVASIVE DETECTION OF ALVEOLAR DERECRUITMENT FOR PATIENTS SUFFERING FROM RESPIRATORY FAILURE 审中-公开
标题翻译：用于呼吸困难的患者的呼吸道支持和非侵入性检测的装置
公开(公告)号：WO2008031822A1
公开(公告)日：2008-03-20
申请号：PCT/EP2007/059534
申请日：2007-09-11
申请人： POLITECNICO DI MILANO , DELLACA', Raffaele , ALIVERTI, Andrea , PEDOTTI, Antonio
发明人： DELLACA', Raffaele , ALIVERTI, Andrea , PEDOTTI, Antonio
IPC分类号： A61M16/00 , A61B5/085
CPC分类号： A61M16/0006 , A61B5/085 , A61M16/024 , A61M2016/0021 , A61M2016/0027 , A61M2016/0036 , A61M2230/65 , A61M2230/005
摘要： There is described an apparatus (1) for respiratory support and non- invasive detection of alveolar derecruitment for patients suffering from respiratory failure. Such an apparatus (1) generally comprises a mechanical ventilator (3) for inspiration/expiration functions and means (15) allowing to impose an additional periodic pressure component (Pstim) having a higher frequency than the spectral content of the inspiration/expiration pressure component (Presp). There are provided computing means (12) to obtain the inspiratory average reactance (Xrs) of the respiratory system of the patient (2) as the positive end-expiratory pressure (PEEP) varies, in order to detect the presence of alveolar derecruitment. There is also described a procedure allowing to obtain an optimal positive end-expiratory pressure.
摘要翻译：描述了一种用于呼吸支持和无创检测用于患有呼吸衰竭的患者的肺泡瘫痪的装置（1）。这种装置（1）通常包括用于吸气/呼气功能的机械呼吸机（3）和允许施加具有比吸气/呼气压力分量的频谱含量更高的频率的附加周期压力分量（Pstim）的装置（15）（Presp）。提供了计算装置（12），以便随着正呼气末压力（PEEP）的变化，获得患者（2）的呼吸系统的吸气平均电抗（Xrs），以便检测肺泡瘫痪的存在。还描述了允许获得最佳的正呼气末正压的程序。

6. 发明申请

WO2003103493A1 SYSTEM AND METHOD FOR THE AUTOMATIC DETECTION OF THE EXPIRATORY FLOW LIMITATION 审中-公开
标题翻译：用于自动检测通气流量限制的系统和方法
公开(公告)号：WO2003103493A1
公开(公告)日：2003-12-18
申请号：PCT/EP2003/006119
申请日：2003-06-10
申请人： POLITECNICO DI MILANO , DELLACA', Raffaele , ALIVERTI, Andrea , PEDOTTI, Antonio
发明人： DELLACA', Raffaele , ALIVERTI, Andrea , PEDOTTI, Antonio
IPC分类号： A61B5/085
CPC分类号： A61B5/085
摘要： The present invention refers to a system and a method for the automatic detection of the expiratory flow limitation of a subject. In an embodiment thereof the system for the automatic detection of expiratory flow limitation of a subject comprises: means for determining the respiratory impedance of said subject composed of an imaginary component and, eventually, of a real part or, at least, means to apply a forcing signal with one or more spectral components to the airway opening of a subject combined with means to measure time courses of pressure and flow at the airway opening; means for determining at least one index linked to said respiratory impedance or pressure and flow time courses; means for indicating the positioning of said at least one index in relation to a preset threshold value.
摘要翻译：本发明涉及一种用于自动检测受试者的呼气流量限制的系统和方法。在其一个实施例中，用于自主检测受试者的呼气流量限制的系统包括：用于确定所述对象的呼吸阻抗的装置，所述呼吸阻抗由虚部和最终实际部分组成，或至少应用将具有一个或多个光谱分量的信号与对象的气道开口结合在一起测量气道开口处的压力和流量的时间进程的装置; 用于确定与所述呼吸阻抗或压力和流动时间过程相关联的至少一个指标的装置; 用于指示所述至少一个索引相对于预设阈值的定位的装置。

7. 发明申请

WO2010109298A1 ABDOMINAL CIRCULATORY PUMP DEVICE 审中-公开
标题翻译： ABDOMINAL循环泵装置
公开(公告)号：WO2010109298A1
公开(公告)日：2010-09-30
申请号：PCT/IB2010/000646
申请日：2010-03-23
申请人： POLITECNICO DI MILANO , ALIVERTI, Andrea , PEDOTTI, Antonio , MACKLEM, Peter, Tiffany , LOOMAS, Bryan, Eugene
发明人： ALIVERTI, Andrea , PEDOTTI, Antonio , MACKLEM, Peter, Tiffany , LOOMAS, Bryan, Eugene
IPC分类号： A61N1/40 , A61N1/36 , A61H31/00
CPC分类号： A61N2/02 , A61H11/00 , A61H2011/005 , A61H2203/0456 , A61H2205/083 , A61N1/3601 , A61N2/006
摘要： The abdominal circulatory pump uses expulsive manoeuvres performed by contraction of the diaphragm while stabilizing, contracting or compressing the abdominal wall to increase abdominal pressure and pump blood. At the same time, it can be used to lower pleural pressure around the surface of the lung to provide ventilation. In humans the blood in the splanchnic circulation; i.e., the blood in the abdominal contents, is a reservoir of about 20% to 25% of the whole body blood volume. The increase in abdominal pressure forces this blood to flow out of the abdomen and through the body.
摘要翻译：腹腔循环泵使用由隔膜收缩进行的排出动作，同时稳定，收缩或压缩腹壁以增加腹压并抽血。同时，它可以用于降低肺表面周围的胸膜压，以提供通气。在人类中，内脏流通中的血液; 即腹部内容物中的血液，是全身体积的约20％至25％的储存器。腹部压力的增加迫使血液从腹部流出并穿过身体。

8. 发明申请

WO2004086968A1 INTEGRATED STRUCTURE FOR DETECTING PHYSIOLOGICAL SIGNALS 审中-公开
标题翻译：用于检测生理信号的综合结构
公开(公告)号：WO2004086968A1
公开(公告)日：2004-10-14
申请号：PCT/EP2004/003319
申请日：2004-03-29
申请人： FONDAZIONE DON CARLO GNOCCHI - ONLUS , DI RIENZO, Marco , PICCINI, Luca , CASTIGLIONI, Paolo , ANDREONI, Guiseppe , PEDOTTI, Antonio
发明人： DI RIENZO, Marco , PICCINI, Luca , CASTIGLIONI, Paolo , ANDREONI, Guiseppe , PEDOTTI, Antonio
IPC分类号： A61B5/0408
CPC分类号： A61N1/08 , A61B5/04085 , A61B5/6805 , A61B5/6806 , A61B5/6831 , A61B5/6887 , A61N1/0408 , A61N1/0484
摘要： An integrated structure (1) for acquiring physiological signals comprises a fabric (2) composed of conducting fibers and non-conducting fibers, a plurality of electrodes (5) provided by means of the conducting fibers, a plurality of conducting elements (6) for connection between the electrodes and the inputs of a control and preprocessing device; the control and preprocessing device (10); the control and èreèrocessing device is provided with means for selective processing of electrical signals, particularly biological or physiological signals, that originate from the electrodes and are acquired by them.
摘要翻译：用于获取生理信号的集成结构（1）包括由导电纤维和非导电纤维组成的织物（2），通过导电纤维提供的多个电极（5），多个导电元件（6），用于电极与控制和预处理装置的输入之间的连接; 控制和预处理装置（10）; 控制和处理装置具有用于选择性地处理源自电极并由它们获取的电信号，特别是生物或生理信号的装置。

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