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1. 发明申请

WO9911660A3 IMMUNOGENIC POLYPEPTIDES THAT MIMIC A SURFACE POLYSACCHARIDE ANTIGEN OF A PATHOGENIC MICROORGANISM, METHOD FOR OBTAINING THE SAME, AND THEIR USE IN VACCINE COMPOSITIONS 审中-公开
标题翻译：免疫原性多肽，其模拟致病微生物的表面多糖抗原，其获得方法以及它们在疫苗组合物中的用途
公开(公告)号：WO9911660A3
公开(公告)日：1999-05-27
申请号：PCT/EP9805575
申请日：1998-09-03
申请人： PASTEUR INSTITUT , INST NAT SANTE RECH MED , PHALIPON ARMELLE , SANSONETTI PHILIPPE , FELICI FRANCO , CORTESE RICCARDO , KRAEHENBUHL JEAN PIERRE
发明人： PHALIPON ARMELLE , SANSONETTI PHILIPPE , FELICI FRANCO , CORTESE RICCARDO , KRAEHENBUHL JEAN-PIERRE
IPC分类号： A61K39/00 , C07K14/25 , C07K16/12 , C12Q1/02 , G01N33/569 , C07K7/06 , C07K16/08 , C12N15/10 , G01N33/53 , G01N33/532
CPC分类号： C12Q1/025 , A61K39/00 , A61K2039/525 , C07K14/25 , C07K16/1228 , C07K2317/34 , G01N33/56911 , G01N33/56983 , G01N2333/25
摘要： A purified immunogenic polypeptide comprises an epitope unit recognized by a protective monoclonal antibody having a high affinity and a high specificity for a surface polysaccharide of a pathogenic microorganism of bacterial, viral, or fungal origin. The polypeptide is capable of inducing an immune response in vivo against the pathogenic microorganism. The immune response confers protection in mice against challenge with the virulent microorganisms.
摘要翻译：纯化的免疫原性多肽包含被对细菌，病毒或真菌来源的病原微生物的表面多糖具有高亲和力和高特异性的保护性单克隆抗体识别的表位单元。该多肽能够在体内诱导针对致病微生物的免疫应答。免疫应答赋予小鼠抵抗有毒微生物攻击的保护作用。

2. 发明申请

WO9426886A3 PROCESS FOR THE PREPARATION OF IMMUNOGENS OR DIAGNOSTIC REAGENTS, AND IMMUNOGENS OR DIAGNOSTIC REAGENTS THEREBY OBTAINABLE 审中-公开
标题翻译：制备免疫原或诊断试剂的方法，以及可获得的免疫原或诊断试剂
公开(公告)号：WO9426886A3
公开(公告)日：1995-03-16
申请号：PCT/IT9400054
申请日：1994-05-05
申请人： ANGELETTI P IST RICHERCHE BIO , FELICI FRANCO , LUZZAGO ALESSANDRA , NICOSIA ALFREDO , MONACI PAOLO , CORTESE RICCARDO
发明人： FELICI FRANCO , LUZZAGO ALESSANDRA , NICOSIA ALFREDO , MONACI PAOLO , CORTESE RICCARDO
IPC分类号： G01N33/53 , A61K35/76 , A61K39/00 , C07K7/08 , C07K14/02 , C07K14/18 , C07K14/47 , C07K16/32 , C09K8/38 , C12N7/00 , C12N15/09 , C12N15/10 , C40B30/06 , C40B40/02 , G01N33/569 , G01N33/576 , A61K39/12 , C12N15/36 , C12N15/51 , C12N15/62 , G01N33/577
CPC分类号： C40B40/02 , A61K39/00 , C07K14/005 , C07K14/4713 , C07K16/32 , C07K2319/40 , C07K2319/735 , C12N15/1037 , C12N2730/10122 , C12N2770/24222 , Y10S436/811
摘要： A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations: identification of at least one antibody that reacts with the antigen or pathogenic organism specific to the disease; construction of phage libraries which display on the surface of the capsid oligopeptides, expressed from random sequence oligonucleotidic inserts introduced into a gene coding for a phage capsid protein using genetic manipulation techniques (for example using a plasmid engineered for the purposes of the invention, the genetic map of which is shown in the figure); selection of the phages that display on the surfaces of the capsid antigenic oligopeptides recognized by said antibody; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of diagnostic kits for the specific pathogenic agent, or in general for the diseases, including immunological disorders typical of so-called autoimmune diseases, with known or unknown etiology and/or pathogenesis; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of an antagonist of the antigen-antibody reactions for treatment of the disease induced by said antigen; optional use of the selected phages and/or fragments thereof and/or their derivatives to induce a tolerance of the phenomena of hypersensitivity and/or allergy to compounds and/or natural or synthetic preparations; optional immunization of an organism by means of the selected phages and/or fragments thereof and/or their derivatives; and optional verification of the presence, in the serum of the immunized organism, of antibodies that recognize the above antigen or organism specific to the disease.
摘要翻译：一种制备模拟抗原或疾病特异性的致病生物的免疫原或诊断试剂的方法，其基本特征在于以下操作：鉴定与该疾病特异性的抗原或致病生物反应的至少一种抗体; 在使用遗传操作技术（例如，使用为本发明的目的而工程设计的质粒）的引入到编码噬菌体衣壳蛋白的基因的随机序列寡核苷酸插入物表达的衣壳寡肽的表面上显示的噬菌体文库的构建遗传图谱如图所示）; 选择在所述抗体识别的衣壳抗原寡肽的表面上显示的噬菌体; 任选使用选定的噬菌体和/或其片段和/或其衍生物用于制备用于特定病原体的诊断试剂盒，或一般用于该疾病，包括典型的所谓自身免疫性疾病的免疫学疾病，具有已知或未知的病因和/或发病机制; 任选使用所选择的噬菌体和/或其片段和/或其衍生物以诱导对化合物和/或天然或合成制剂的过敏和/或过敏现象的耐受性; 通过所选择的噬菌体和/或其片段和/或其衍生物任选地免疫生物体; 并且可选地验证在免疫生物体的血清中存在识别上述对该疾病特异性的抗原或生物体的抗体。

3. 发明申请

WO2007144771A3 PEPTIDES THAT MIMIC NON-HUMAN CROSS-REACTIVE PROTECTIVE EPITOPES OF THE GROUP B MENINGOCOCCAL CAPSULAR POLYSACCHARIDE 审中-公开
标题翻译：本组B型肉毒杆菌多糖的MIMIC非人类交叉反应性保护性抗原肽
公开(公告)号：WO2007144771A3
公开(公告)日：2008-05-22
申请号：PCT/IB2007002668
申请日：2007-06-12
申请人： TETI GIUSEPPE , FELICI FRANCO
发明人： FELICI FRANCO
IPC分类号： C07K7/06 , A61K39/095
CPC分类号： A61K39/095 , A61K2039/53
摘要： Peptides that mimic the antigenic features of non human-cross-reactive protective epitopes of the MenB CP and nucleic acids encoding the peptide mimetics are disclosed. Antibodies elicited by these peptides do not bind to polysialic acid in host tissue and thus provide a safe and efficacious method for the treatment and/or prevention of Meningitis B.
摘要翻译：公开了模拟MenB CP的非人交叉反应性保护性表位的抗原特征和编码肽模拟物的核酸的肽。由这些肽引发的抗体不与宿主组织中的聚唾液酸结合，因此提供了治疗和/或预防脑膜炎B的安全有效的方法。

4. 发明申请

WO2010028096A2 PEPTIDES PRESENTING AN EPITOPE OF AN A DOMAIN OF FACTOR H BINDING PROTEIN AND METHODS OF USE 审中-公开
标题翻译：表达因子H结合蛋白的蛋白质的表达及其使用方法
公开(公告)号：WO2010028096A2
公开(公告)日：2010-03-11
申请号：PCT/US2009055795
申请日：2009-09-02
申请人： CHILDRENS HOSP & RES CT OAK , BEERNINK PETER , FELICI FRANCO , GRANOFF DAN M , NOVARTIS VACCINES & DIAGNOSTIC
发明人： BEERNINK PETER , FELICI FRANCO , GRANOFF DAN M
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K2039/55566 , A61K2039/6018 , A61K2039/6081 , C07K14/22
摘要： Polypeptides that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis, and methods of use, are provided.
摘要翻译：提供了可引发针对脑膜炎奈瑟氏球菌的不同fHbp变异株的杀菌性抗体的多肽，以及使用方法。

5. 发明申请

WO03011903A2 IDENTIFICATION OF SPECIFIC TUMOR ANTIGENS BY MEANS OF THE SELECTION OF CDNA LIBRARIES WITH SERA AND THE USE OF SAID ANTIGENA IN THE TREATMENT OF TUMORS 审中-公开
标题翻译：通过使用SERA选择CDNA文库和在治疗肿瘤中使用抗原抗体鉴定特异性肿瘤抗原
公开(公告)号：WO03011903A2
公开(公告)日：2003-02-13
申请号：PCT/IT0200490
申请日：2002-07-25
申请人： KENTON S R L , FELICI FRANCO , MINENKOVA OLGA
发明人： FELICI FRANCO , MINENKOVA OLGA
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P35/00 , C07K14/47 , C07K14/82 , C07K16/32 , C12N15/10 , C40B40/02 , C07K16/18
CPC分类号： C40B40/02 , A61K38/00 , A61K39/00 , C07K14/4748 , C12N15/1037
摘要： A method is described for the identification of specific tumour antigens by means of the selection of CND display libraries by using sera, characterised in that said selection is accomplished with the phage display technique, and in particular said selection is accomplished by means of the SEREX technique (serological analysis of autologous tumor antigens through the expression of recombinant cDNA). The method according to the invention described herein advantageously combines the SEREX approach with the potency of the phage display technique defined above, at the same time avoiding the drawbacks characteristic of the SEREX technique. The so identified antigens are useful for the preparation of medicaments for the treatment of tumors.
摘要翻译：描述了通过使用血清来选择CND显示文库来鉴定特异性肿瘤抗原的方法，其特征在于所述选择用噬菌体展示技术完成，特别是所述选择通过SEREX技术（通过重组cDNA的表达对自体肿瘤抗原进行血清学分析）。本文所述的根据本发明的方法有利地将SEREX方法与上文定义的噬菌体展示技术的效力相结合，同时避免了SEREX技术的缺点。如此鉴定的抗原可用于制备用于治疗肿瘤的药物。

6. 发明申请

WO2009115509A3 ANTIGENIC PROTEIN FRAGMENTS OF STREPTOCOCCUS PNEUMONIAE 审中-公开
标题翻译：白色肺炎链球菌的抗原蛋白片段
公开(公告)号：WO2009115509A3
公开(公告)日：2009-12-10
申请号：PCT/EP2009053121
申请日：2009-03-17
申请人： BENINATI CONCETTA , FELICI FRANCO , UNIV SIENA , OGGIONI MARCO , POZZI GIANNI , RICCI SUSANNA
发明人： BENINATI CONCETTA , FELICI FRANCO , OGGIONI MARCO , POZZI GIANNI , RICCI SUSANNA
IPC分类号： C07K14/315 , A61K39/09 , C12N15/31 , C12Q1/04
CPC分类号： C07K16/1275 , A61K39/00 , C07K14/3156
摘要： Antigenic protein fragments of Streptococcus pneumoniae to be used for the preparation of a medicament for the prevention and the treatment of bacterial infections and a method for the detection thereof, and related compositions using said epitopes, are disclosed.
摘要翻译：公开了用于制备用于预防和治疗细菌感染的药物的肺炎链球菌的抗原性蛋白片段及其检测方法，以及使用所述表位的相关组合物。

7. 发明申请

WO2007113598A3 PEPTIDE MIMETOPE VACCINE OF- AND ANTIBODIES AGAINST 6B PNEUMOCOCCAL POLYSACCHARIDES 审中-公开
标题翻译：肽类MIMETOPE和6B抗血清多糖的抗体
公开(公告)号：WO2007113598A3
公开(公告)日：2007-12-06
申请号：PCT/GB2007050181
申请日：2007-04-05
申请人： UNIV LEICESTER , ANDREW PETER , SMITH CLAIRE MARY , LOPASSO CARLA , BAXENDALE HELEN , GOLDBLATT DAVID , FELICI FRANCO
发明人： ANDREW PETER , SMITH CLAIRE MARY , LOPASSO CARLA , BAXENDALE HELEN , GOLDBLATT DAVID , FELICI FRANCO
IPC分类号： A61K39/395 , C07K9/00 , C07K16/12
CPC分类号： C07K16/1275 , A61K2039/505 , A61K2039/60 , G01N2333/315
摘要： The invention provides a Streptococcus pneumoniae serotype 6B pneumococcal polysaccharide (6BPP) peptide mimetope, optionally conjugated to a carrier protein, capable of stimulating a protective immune response against pneumococcal infection. The invention further provides a monoclonal antibody against a 6B pneumococcal polysaccharide, and 6BPP-binding fragments thereof, capable of conferring passive immunity against pneumococcal infection. Also provided are compositions comprising said peptide mimetope, conjugate, mAb or binding fragment thereof. Mimetic peptides, conjugates thereof, mAb and 6BPP binding fragments according to the invention are provided as medicaments and in the manufacture of medicaments for the treatment of pneumococcal infection. The invention further relates to methods for prophylactic or therapeutic treatment of pneumococcal infection.
摘要翻译：本发明提供了能够刺激针对肺炎球菌感染的保护性免疫应答的肺炎链球菌血清型6B肺炎球菌多糖（6BPP）肽mimetope，任选地与载体蛋白缀合。本发明还提供了能够赋予针对肺炎球菌感染的被动免疫的针对6B型肺炎球菌多糖及其6BPP结合片段的单克隆抗体。还提供了包含所述肽mimetope，缀合物，mAb或其结合片段的组合物。提供本发明的模拟肽，其缀合物，mAb和6BPP结合片段作为药物和制备用于治疗肺炎球菌感染的药物。本发明还涉及肺炎球菌感染的预防或治疗方法。

8. 发明申请

WO03010199A3 IDENTIFICATION OF SPECIFIC TUMOUR ANTIGENS BY MEANS OF THE SELECTION OF CDNA LIBRARIES WITH SERA AND THE USE OF SAID ANTIGENS IN DIAGNOSTIC IMAGING TECHNIQUES 审中-公开
标题翻译：通过使用SERA选择CDNA文库和在诊断成像技术中使用抗原抗体鉴定特异性肿瘤抗体
公开(公告)号：WO03010199A3
公开(公告)日：2003-10-02
申请号：PCT/IT0200491
申请日：2002-07-25
申请人： KENTON S R L , FELICI FRANCO , MINENKOVA OLGA
发明人： FELICI FRANCO , MINENKOVA OLGA
IPC分类号： C12N15/09 , A61K49/00 , A61K51/00 , C07K7/08 , C07K14/47 , C07K14/82 , C07K16/32 , C12N15/10 , C12Q1/68 , C12Q1/70 , C40B40/02 , G01N33/574 , C07K16/18
CPC分类号： C40B40/02 , C07K14/4748 , C12N15/1037 , G01N33/574 , G01N2500/20
摘要： A method is described for the identification of specific tumour antigens by means of the selection of cDNA display libraries by using sera characterised in that said selection is accomplished with the phage display technique, and in particular said selection is accomplished by means of the SEREX technique (serological analysis of autologous tumour antigens through the expression of recombinant cDNA). The method according to the invention described herein advantageously combines the SEREX approach with the potency of the phage display technique defined above, at the same time avoiding the drawbacks characteristic of the SEREX technique.
摘要翻译：描述了通过使用血清来选择cDNA显示文库来鉴定特异性肿瘤抗原的方法，其特征在于所述选择用噬菌体展示技术完成，特别是所述选择通过SEREX技术（通过重组cDNA的表达对自体肿瘤抗原进行血清学分析）。本文所述的根据本发明的方法有利地将SEREX方法与上文定义的噬菌体展示技术的效力相结合，同时避免了SEREX技术的缺点。

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