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1. 发明申请

WO9426886A3 PROCESS FOR THE PREPARATION OF IMMUNOGENS OR DIAGNOSTIC REAGENTS, AND IMMUNOGENS OR DIAGNOSTIC REAGENTS THEREBY OBTAINABLE 审中-公开
标题翻译：制备免疫原或诊断试剂的方法，以及可获得的免疫原或诊断试剂
公开(公告)号：WO9426886A3
公开(公告)日：1995-03-16
申请号：PCT/IT9400054
申请日：1994-05-05
申请人： ANGELETTI P IST RICHERCHE BIO , FELICI FRANCO , LUZZAGO ALESSANDRA , NICOSIA ALFREDO , MONACI PAOLO , CORTESE RICCARDO
发明人： FELICI FRANCO , LUZZAGO ALESSANDRA , NICOSIA ALFREDO , MONACI PAOLO , CORTESE RICCARDO
IPC分类号： G01N33/53 , A61K35/76 , A61K39/00 , C07K7/08 , C07K14/02 , C07K14/18 , C07K14/47 , C07K16/32 , C09K8/38 , C12N7/00 , C12N15/09 , C12N15/10 , C40B30/06 , C40B40/02 , G01N33/569 , G01N33/576 , A61K39/12 , C12N15/36 , C12N15/51 , C12N15/62 , G01N33/577
CPC分类号： C40B40/02 , A61K39/00 , C07K14/005 , C07K14/4713 , C07K16/32 , C07K2319/40 , C07K2319/735 , C12N15/1037 , C12N2730/10122 , C12N2770/24222 , Y10S436/811
摘要： A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations: identification of at least one antibody that reacts with the antigen or pathogenic organism specific to the disease; construction of phage libraries which display on the surface of the capsid oligopeptides, expressed from random sequence oligonucleotidic inserts introduced into a gene coding for a phage capsid protein using genetic manipulation techniques (for example using a plasmid engineered for the purposes of the invention, the genetic map of which is shown in the figure); selection of the phages that display on the surfaces of the capsid antigenic oligopeptides recognized by said antibody; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of diagnostic kits for the specific pathogenic agent, or in general for the diseases, including immunological disorders typical of so-called autoimmune diseases, with known or unknown etiology and/or pathogenesis; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of an antagonist of the antigen-antibody reactions for treatment of the disease induced by said antigen; optional use of the selected phages and/or fragments thereof and/or their derivatives to induce a tolerance of the phenomena of hypersensitivity and/or allergy to compounds and/or natural or synthetic preparations; optional immunization of an organism by means of the selected phages and/or fragments thereof and/or their derivatives; and optional verification of the presence, in the serum of the immunized organism, of antibodies that recognize the above antigen or organism specific to the disease.
摘要翻译：一种制备模拟抗原或疾病特异性的致病生物的免疫原或诊断试剂的方法，其基本特征在于以下操作：鉴定与该疾病特异性的抗原或致病生物反应的至少一种抗体; 在使用遗传操作技术（例如，使用为本发明的目的而工程设计的质粒）的引入到编码噬菌体衣壳蛋白的基因的随机序列寡核苷酸插入物表达的衣壳寡肽的表面上显示的噬菌体文库的构建遗传图谱如图所示）; 选择在所述抗体识别的衣壳抗原寡肽的表面上显示的噬菌体; 任选使用选定的噬菌体和/或其片段和/或其衍生物用于制备用于特定病原体的诊断试剂盒，或一般用于该疾病，包括典型的所谓自身免疫性疾病的免疫学疾病，具有已知或未知的病因和/或发病机制; 任选使用所选择的噬菌体和/或其片段和/或其衍生物以诱导对化合物和/或天然或合成制剂的过敏和/或过敏现象的耐受性; 通过所选择的噬菌体和/或其片段和/或其衍生物任选地免疫生物体; 并且可选地验证在免疫生物体的血清中存在识别上述对该疾病特异性的抗原或生物体的抗体。

2. 发明申请

WO2004101799A3 BROADENING ADENOVIRUS TROPISM 审中-公开
标题翻译：广播腺病毒TROPISM
公开(公告)号：WO2004101799A3
公开(公告)日：2006-03-23
申请号：PCT/EP2004004999
申请日：2004-05-10
申请人： ANGELETTI P IST RICHERCHE BIO , FONTANA LAURA , MONACI PAOLO
发明人： FONTANA LAURA , MONACI PAOLO
IPC分类号： A61K48/00 , C07K14/075 , C12N15/861 , C07K7/00 , C12N5/10 , C12N15/10 , C12N15/62
CPC分类号： C07K14/005 , A61K48/00 , C07K2319/00 , C07K2319/735 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/40 , C12N2810/80 , C12N2840/20
摘要： Recombinant adenoviruses comprising modified fiber proteins which expand the tropism of the adenovirus in comparison to wild-type virus are disclosed. The modified fiber proteins described herein contain a peptide ligand for a cell surface binding site other than CAR comprising a 14 amino acid core sequence containing both fixed and variable amino acid residues. The invention includes isolated nucleic acid molecules encoding the modified adenovirus fiber proteins disclosed, as well as recombinant vectors and host cells containing said nucleic acid molecules. Methods of identifying peptide ligands that bind to cell binding sites other than CAR are included comprising screening a phage-display library of peptide ligands expressed within an adenovirus fiber knob context on CAR-negative cells. Recombinant adenoviruses of the present invention will increase the ability of an adenovirus to transduce important cell and tissue targets as part of a gene therapy/gene vaccination regime that have been shown to be refractory to adenoviral infection.
摘要翻译：公开了包含与野生型病毒相比扩展腺病毒嗜性的修饰的纤维蛋白质的重组腺病毒。本文所述的修饰的纤维蛋白质包含除CAR之外的细胞表面结合位点的肽配体，其包含含有固定和可变氨基酸残基的14个氨基酸核心序列。本发明包括编码公开的修饰的腺病毒纤维蛋白的分离的核酸分子，以及含有所述核酸分子的重组载体和宿主细胞。包括鉴定结合除CAR以外的细胞结合位点的肽配体的方法包括筛选在CAR阴性细胞上的腺病毒纤维旋钮上下文中表达的肽配体的噬菌体展示文库。本发明的重组腺病毒将增加腺病毒转导重要细胞和组织靶标的能力，作为已被证明对腺病毒感染难治的基因治疗/基因疫苗接种方案的一部分。

3. 发明申请

WO2005012527A9 SYNTHETIC GENE ENCODING HUMAN EPIDERMAL GROWTH FACTOR 2/NEU ANTIGEN AND USES THEREOF 审中-公开
标题翻译：合成基因编码人类生殖因子2 / NEU抗原及其用途
公开(公告)号：WO2005012527A9
公开(公告)日：2006-03-02
申请号：PCT/EP2004008234
申请日：2004-07-20
申请人： LETTI SPA ISTITUTO DI RICERCHE , GALLO PASQUALE , MONACI PAOLO , NUZZO MAURIZIO
发明人： GALLO PASQUALE , MONACI PAOLO , NUZZO MAURIZIO
IPC分类号： C07K14/71 , C12N5/10 , C12N7/00 , C12N15/12 , C12N15/86
CPC分类号： C07K14/71 , C07K16/32 , C12N7/00 , C12N2710/10043
摘要： Synthetic polynucleotides encoding human HER2/neu or a truncated form thereof, are provided, the synthetic polynucleotides being codon-optimized for expression in a human cellular environment. The gene encoding hHER2 is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the hHER2 tumor-associated antigen, wherein aberrant hHER2 expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector and plasmid constructs carrying codon-optimized human HER2 and codon-optimized truncated HER2, and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
摘要翻译：提供了编码人HER2 / neu或其截短形式的合成多核苷酸，所述合成多核苷酸被密码子优化用于在人细胞环境中表达。编码hHER2的基因通常与人类癌的发展有关。本发明提供了引发或增强对由hHER2肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常hHER2表达与癌症或其发展相关。本发明具体提供携带密码子优化的人HER2和密码子优化的截短的HER2的腺病毒载体和质粒构建体，并公开了它们用于预防和治疗癌症的疫苗和药物组合物中。

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