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1. 发明申请

WO2003031588A2 HEPATITIS C VIRUS VACCINE 审中-公开
标题翻译： HEPATITIS C病毒疫苗
公开(公告)号：WO2003031588A2
公开(公告)日：2003-04-17
申请号：PCT/US2002/032512
申请日：2002-10-10
申请人： MERCK & CO., INC. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI, S.P.A. , EMINI, Emilio, A. , KASLOW, David, C. , BETT, Andrew, J. , SHIVER, John, W. , NICOSIA, Alfredo , LAHM, Armin , LUZZAGO, Alessandra , CORTESE, Riccardo , COLLOCA, Stefano
发明人： EMINI, Emilio, A. , KASLOW, David, C. , BETT, Andrew, J. , SHIVER, John, W. , NICOSIA, Alfredo , LAHM, Armin , LUZZAGO, Alessandra , CORTESE, Riccardo , COLLOCA, Stefano
IPC分类号： C12N
CPC分类号： C07K14/005 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/57 , C12N15/86 , C12N2710/10343 , C12N2770/24222 , C12N2770/24234 , C12N2800/108 , C12N2810/6018 , C12N2830/003 , C12N2840/20 , C12N2840/203
摘要： The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.
摘要翻译：本发明的特征在于Ad6载体和编码含有失活的NS5B RNA依赖性RNA聚合酶区域的Met-NS3-NS4A-NS4B-NS5A-NS5B多肽的核酸。核酸特别可用作腺病毒载体或DNA质粒疫苗的组分，其提供广泛的抗原用于产生针对HCV的HCV特异性细胞介导免疫（CMI）应答。

2. 发明申请

WO1994026886A2 PROCESS FOR THE PREPARATION OF IMMUNOGENS OR DIAGNOSTIC REAGENTS, AND IMMUNOGENS OR DIAGNOSTIC REAGENTS THEREBY OBTAINABLE 审中-公开
标题翻译：制备免疫原或诊断试剂的方法，以及可获得的免疫原或诊断试剂
公开(公告)号：WO1994026886A2
公开(公告)日：1994-11-24
申请号：PCT/IT1994000054
申请日：1994-05-05
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , FELICI, Franco , LUZZAGO, Alessandra , NICOSIA, Alfredo , MONACI, Paolo , CORTESE, Riccardo
发明人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.
IPC分类号： C12N15/10
CPC分类号： C40B40/02 , A61K39/00 , C07K14/005 , C07K14/4713 , C07K16/32 , C07K2319/40 , C07K2319/735 , C12N15/1037 , C12N2730/10122 , C12N2770/24222 , Y10S436/811
摘要： A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations: identification of at least one antibody that reacts with the antigen or pathogenic organism specific to the disease; construction of phage libraries which display on the surface of the capsid oligopeptides, expressed from random sequence oligonucleotidic inserts introduced into a gene coding for a phage capsid protein using genetic manipulation techniques (for example using a plasmid engineered for the purposes of the invention, the genetic map of which is shown in the figure); selection of the phages that display on the surfaces of the capsid antigenic oligopeptides recognized by said antibody; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of diagnostic kits for the specific pathogenic agent, or in general for the diseases, including immunological disorders typical of so-called autoimmune diseases, with known or unknown etiology and/or pathogenesis; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of an antagonist of the antigen-antibody reactions for treatment of the disease induced by said antigen; optional use of the selected phages and/or fragments thereof and/or their derivatives to induce a tolerance of the phenomena of hypersensitivity and/or allergy to compounds and/or natural or synthetic preparations; optional immunization of an organism by means of the selected phages and/or fragments thereof and/or their derivatives; and optional verification of the presence, in the serum of the immunized organism, of antibodies that recognize the above antigen or organism specific to the disease.
摘要翻译：一种制备模拟抗原或疾病特异性的致病生物的免疫原或诊断试剂的方法，其基本特征在于以下操作：鉴定与该疾病特异性的抗原或致病生物反应的至少一种抗体; 构建在衣壳寡肽的表面上显示的噬菌体文库，其由使用遗传操作技术引入到编码噬菌体衣壳蛋白的基因中的随机序列寡核苷酸插入物表达（例如使用为本发明目的而设计的质粒，遗传地图如图所示）; 选择在所述抗体识别的衣壳抗原寡肽的表面上显示的噬菌体; 任选使用所选择的噬菌体和/或其片段和/或其衍生物用于制备用于特定病原体的诊断试剂盒，或一般用于包括已知或未知的所谓自身免疫性疾病典型的免疫学疾病的疾病病因和/或发病机制; 任选使用所选择的噬菌体和/或其片段和/或其衍生物用于制备用于治疗由所述抗原诱导的疾病的抗原 - 抗体反应的拮抗剂; 任选使用所选择的噬菌体和/或其片段和/或其衍生物以诱导对化合物和/或天然或合成制剂的过敏和/或过敏现象的耐受性; 通过所选择的噬菌体和/或其片段和/或其衍生物任选地免疫生物体; 并且可选地验证在免疫生物体的血清中存在识别上述对该疾病特异性的抗原或生物体的抗体。

3. 发明申请

WO2006005465A1 ANTIGEN BINDING PROTEINS DIRECTED AGAINST SCAVENGER RECEPTOR B1 THAT INHIBIT HCV REPLICATION 审中-公开
标题翻译：针对禁用HCV复制的SCAVENGER受体B1指导的抗原结合蛋白
公开(公告)号：WO2006005465A1
公开(公告)日：2006-01-19
申请号：PCT/EP2005/007160
申请日：2005-07-01
申请人： ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA , CORTESE, Riccardo , LUZZAGO, Alessandra , NICOSIA, Alfredo , VITELLI, Alessandra
发明人： CORTESE, Riccardo , LUZZAGO, Alessandra , NICOSIA, Alfredo , VITELLI, Alessandra
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/565 , C07K2317/622
摘要： The present invention features antigen binding protein that bind to a SR-BI target region identified herein as a region involved in HCV E2 binding. Identified target regions are regions bound by a single-chain antibody of SEQ ID NOs: 1, 2, 3 or 4.
摘要翻译：本发明的特征在于抗原结合蛋白，其结合本文鉴定的SR-BI靶区域作为涉及HCV E2结合的区域。鉴定的靶区域是由SEQ ID NO：1,2,3或4的单链抗体结合的区域。

4. 发明申请

WO2003031588A3 HEPATITIS C VIRUS VACCINE 审中-公开
公开(公告)号：WO2003031588A3
公开(公告)日：2003-04-17
申请号：PCT/US2002/032512
申请日：2002-10-10
申请人： MERCK & CO., INC. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI, S.P.A. , EMINI, Emilio, A. , KASLOW, David, C. , BETT, Andrew, J. , SHIVER, John, W. , NICOSIA, Alfredo , LAHM, Armin , LUZZAGO, Alessandra , CORTESE, Riccardo , COLLOCA, Stefano
发明人： EMINI, Emilio, A. , KASLOW, David, C. , BETT, Andrew, J. , SHIVER, John, W. , NICOSIA, Alfredo , LAHM, Armin , LUZZAGO, Alessandra , CORTESE, Riccardo , COLLOCA, Stefano
IPC分类号： C12N15/40
摘要： The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is particularly useful as a component of an adenovector or DNA plasmid vaccine providing a broad range of antigens for generating an HCV specific cell mediated immune (CMI) response against HCV.

5. 发明申请

WO9426886A3 PROCESS FOR THE PREPARATION OF IMMUNOGENS OR DIAGNOSTIC REAGENTS, AND IMMUNOGENS OR DIAGNOSTIC REAGENTS THEREBY OBTAINABLE 审中-公开
标题翻译：制备免疫原或诊断试剂的方法，以及可获得的免疫原或诊断试剂
公开(公告)号：WO9426886A3
公开(公告)日：1995-03-16
申请号：PCT/IT9400054
申请日：1994-05-05
申请人： ANGELETTI P IST RICHERCHE BIO , FELICI FRANCO , LUZZAGO ALESSANDRA , NICOSIA ALFREDO , MONACI PAOLO , CORTESE RICCARDO
发明人： FELICI FRANCO , LUZZAGO ALESSANDRA , NICOSIA ALFREDO , MONACI PAOLO , CORTESE RICCARDO
IPC分类号： G01N33/53 , A61K35/76 , A61K39/00 , C07K7/08 , C07K14/02 , C07K14/18 , C07K14/47 , C07K16/32 , C09K8/38 , C12N7/00 , C12N15/09 , C12N15/10 , C40B30/06 , C40B40/02 , G01N33/569 , G01N33/576 , A61K39/12 , C12N15/36 , C12N15/51 , C12N15/62 , G01N33/577
CPC分类号： C40B40/02 , A61K39/00 , C07K14/005 , C07K14/4713 , C07K16/32 , C07K2319/40 , C07K2319/735 , C12N15/1037 , C12N2730/10122 , C12N2770/24222 , Y10S436/811
摘要： A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations: identification of at least one antibody that reacts with the antigen or pathogenic organism specific to the disease; construction of phage libraries which display on the surface of the capsid oligopeptides, expressed from random sequence oligonucleotidic inserts introduced into a gene coding for a phage capsid protein using genetic manipulation techniques (for example using a plasmid engineered for the purposes of the invention, the genetic map of which is shown in the figure); selection of the phages that display on the surfaces of the capsid antigenic oligopeptides recognized by said antibody; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of diagnostic kits for the specific pathogenic agent, or in general for the diseases, including immunological disorders typical of so-called autoimmune diseases, with known or unknown etiology and/or pathogenesis; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of an antagonist of the antigen-antibody reactions for treatment of the disease induced by said antigen; optional use of the selected phages and/or fragments thereof and/or their derivatives to induce a tolerance of the phenomena of hypersensitivity and/or allergy to compounds and/or natural or synthetic preparations; optional immunization of an organism by means of the selected phages and/or fragments thereof and/or their derivatives; and optional verification of the presence, in the serum of the immunized organism, of antibodies that recognize the above antigen or organism specific to the disease.
摘要翻译：一种制备模拟抗原或疾病特异性的致病生物的免疫原或诊断试剂的方法，其基本特征在于以下操作：鉴定与该疾病特异性的抗原或致病生物反应的至少一种抗体; 在使用遗传操作技术（例如，使用为本发明的目的而工程设计的质粒）的引入到编码噬菌体衣壳蛋白的基因的随机序列寡核苷酸插入物表达的衣壳寡肽的表面上显示的噬菌体文库的构建遗传图谱如图所示）; 选择在所述抗体识别的衣壳抗原寡肽的表面上显示的噬菌体; 任选使用选定的噬菌体和/或其片段和/或其衍生物用于制备用于特定病原体的诊断试剂盒，或一般用于该疾病，包括典型的所谓自身免疫性疾病的免疫学疾病，具有已知或未知的病因和/或发病机制; 任选使用所选择的噬菌体和/或其片段和/或其衍生物以诱导对化合物和/或天然或合成制剂的过敏和/或过敏现象的耐受性; 通过所选择的噬菌体和/或其片段和/或其衍生物任选地免疫生物体; 并且可选地验证在免疫生物体的血清中存在识别上述对该疾病特异性的抗原或生物体的抗体。

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