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1. 发明申请

WO2007014154A3 10-SUBSTITUTED TETRACYCLINES AND METHODS OF USE THEREOF 审中-公开
标题翻译： 10替代的四环素及其使用方法
公开(公告)号：WO2007014154A3
公开(公告)日：2007-08-23
申请号：PCT/US2006028676
申请日：2006-07-21
申请人： PARATEK PHARM INNC , ABATO PAUL , ASSEFA HAREGEWEIN , BERNIAC JOEL , BOWSER TODD , CHEN JACKSON , GRIER MARK , HONEYMAN LAURA
发明人： ABATO PAUL , ASSEFA HAREGEWEIN , BERNIAC JOEL , BOWSER TODD , CHEN JACKSON , GRIER MARK , HONEYMAN LAURA
IPC分类号： C07C237/26 , A61K31/65 , C07D239/26 , C07D265/12 , C07D295/14 , C07D307/77 , C07F7/08
CPC分类号： C07D295/155 , C07C237/26 , C07C309/65 , C07D207/06 , C07D211/14 , C07D239/26 , C07D263/58 , C07D265/12 , C07D307/77 , C07D307/81
摘要： 10-Substituted tetracycline compounds are described.
摘要翻译：描述了10-取代的四环素化合物。

2. 发明申请

WO2006047756A3 SUBSTITUTED TETRACYCLINE COMPOUNDS 审中-公开
公开(公告)号：WO2006047756A3
公开(公告)日：2006-07-20
申请号：PCT/US2005039014
申请日：2005-10-25
申请人： PARATEK PHARM INNC , ABATO PAUL , ASSEFA HAREGEWEIN , BERNIAC JOEL , BHATIA BEENA , BOWSER TODD , CHEN JACKSON , GRIER MARK , HONEYMAN LAURA , ISMAIL MOHAMED Y , NELSON MARK , KWASI OHEMENG , PAN JINGWEN
发明人： ABATO PAUL , ASSEFA HAREGEWEIN , BERNIAC JOEL , BHATIA BEENA , BOWSER TODD , CHEN JACKSON , GRIER MARK , HONEYMAN LAURA , ISMAIL MOHAMED Y , NELSON MARK , KWASI OHEMENG , PAN JINGWEN
IPC分类号： C07C237/26 , A61K31/65 , A61P25/28 , A61P31/04 , A61P31/12 , A61P33/06 , C07D295/155 , C07D307/54 , C07D405/06
CPC分类号： C07D471/04 , C07C237/26 , C07C251/48 , C07C255/59 , C07C259/10 , C07C271/18 , C07C271/22 , C07C271/24 , C07C2601/02 , C07C2603/46 , C07D207/335 , C07D207/337 , C07D211/70 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/84 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/30 , C07D295/096 , C07D295/155 , C07D295/192 , C07D307/46 , C07D307/52 , C07D307/54 , C07D309/14 , C07D333/20 , C07D333/24 , C07D333/38 , C07D403/06 , C07D405/06 , C07D405/12 , C07D413/12 , C07D487/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.

3. 发明申请

WO2005009943A3 SUBSTITUTED TETRACYCLINE COMPOUNDS 审中-公开
标题翻译：取代的四环素化合物
公开(公告)号：WO2005009943A3
公开(公告)日：2005-06-16
申请号：PCT/US2004020249
申请日：2004-06-25
申请人： PARATEK PHARM INNC , NELSON MARK L , OHEMENG KWASI , AMOO VICTOR , KIM OAK , ABATO PAUL , ASSEFA HAREGEWEIN , BERNIAC JOEL , BHATIA BEENA , BOWSER TODD , CHEN JACKSON , GRIER MARK , HOHOS AARON , HONEYMAN LAURA , ISMAIL MOHAMED Y , MECHICHE RACHID , NIHLAWI MOHAMMED , SIZENSKY EMMANUELLE
发明人： NELSON MARK L , OHEMENG KWASI , AMOO VICTOR , KIM OAK , ABATO PAUL , ASSEFA HAREGEWEIN , BERNIAC JOEL , BHATIA BEENA , BOWSER TODD , CHEN JACKSON , GRIER MARK , HOHOS AARON , HONEYMAN LAURA , ISMAIL MOHAMED Y , MECHICHE RACHID , NIHLAWI MOHAMMED , SIZENSKY EMMANUELLE
IPC分类号： C07C237/26 , C07C271/22 , C07C271/54 , C07C275/28 , C07C275/30 , A61K31/65
CPC分类号： C07C237/48 , A61K31/65 , C07C237/26 , C07C271/22 , C07C271/54 , C07C275/28 , C07C275/30 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2603/46
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译：本发明至少部分涉及新的取代的四环素化合物。这些四环素化合物可用于治疗许多四环素化合物反应性状态，例如细菌感染和肿瘤，以及四环素化合物的其他已知应用，例如阻断四环素外排和调节基因表达。

4. 发明申请

WO2008079339A3 TETRACYCLINE DERIVATIVES FOR THE TREATMENT OF BACTERIAL, VIRAL AND PARASITIC INFECTIONS 审中-公开
标题翻译：用于治疗细菌，病毒和寄生虫感染的四环素衍生物
公开(公告)号：WO2008079339A3
公开(公告)日：2008-12-18
申请号：PCT/US2007026178
申请日：2007-12-21
申请人： PARATEK PHARM INNC , ABATO PAUL , ASSEFA HAREGEWEIN , BERNIAC JOEL , BHATIA BEENA , BOWSER TODD , GRIER MARK , HONEYMAN LAURA , ISMAIL MOHAMED , KIM OAK K , NELSON MARK , PAN JINGWEN , VERMA ATUL
发明人： ABATO PAUL , ASSEFA HAREGEWEIN , BERNIAC JOEL , BHATIA BEENA , BOWSER TODD , GRIER MARK , HONEYMAN LAURA , ISMAIL MOHAMED , KIM OAK K , NELSON MARK , PAN JINGWEN , VERMA ATUL
IPC分类号： C07D207/50 , A61K31/65 , A61P31/04 , A61P33/06 , C07C237/26 , C07D231/12 , C07D239/20 , C07D241/12 , C07D261/02 , C07D261/04 , C07D263/32 , C07D265/02
CPC分类号： C07C237/26 , C07C2603/46 , C07D207/20 , C07D207/50 , C07D211/14 , C07D231/12 , C07D239/20 , C07D239/26 , C07D241/12 , C07D261/02 , C07D261/04 , C07D263/32 , C07D265/02 , C07D265/30 , C07D295/13 , C07D307/52
摘要： The present invention pertains, at least in part, to a substituted tetracycline compound of Formula (I): wherein X is CHC(R13VY), CR6 R6, C=CR6 R6, S, NR6, or O; E is NR7dR7ß, OR7f or (CH2)o.iC(=W)WR7s; W is O, S, NR711 or CR75R7*; W is O, S or NR7*; These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.
摘要翻译：本发明至少部分地涉及式（I）的取代四环素化合物：其中X是CHC（R13VY），CR6R6，C = CR6R6，S，NR6或O; E为NR7dR7β，OR7f或（CH2）o.iC（= W）WR7s; W是O，S，NR711或CR75R7 *; W是O，S或NR7 *; 这些四环素化合物可用于治疗许多四环素化合物反应状态，如细菌感染和赘生物。

5. 发明申请

WO2013181391A3 7-DISUBSTITUTED-PHENYL TETRACYCLINE DERIVATIVES 审中-公开
标题翻译： 7-取代的苯基四环素衍生物
公开(公告)号：WO2013181391A3
公开(公告)日：2014-02-27
申请号：PCT/US2013043363
申请日：2013-05-30
申请人： PARATEK PHARM INNC
发明人： BOWSER TODD , ABATO PAUL
IPC分类号： A61K31/65
CPC分类号： C07C237/34 , C07C2603/46
摘要： 7-Disubstituted-phenyl tetracycline compounds are disclosed herein. Also disclosed is a method for treatment or prevention of spinal muscular atrophy using the 7-disubstituted-phenyl tetracycline compounds. This invention also relates to a method for treating or preventing a subject having spinal muscular atrophy. The method includes administering to the subject an effective amount of a tetracycline compound of formula (1 ), such that the spinal muscular atrophy is treated or prevented. Advantageously, the tetracycline compounds used in this method of the invention have one or more of the following characteristics: 1 ) potency in modulating mRNA splicing, 2) potency in modulating SMN protein levels, 3) central nervous system (CNS) and/pr brain penetration, 4) decreased phototoxic properties and 5) decreased antibacterial properties.
摘要翻译： 7-二取代 - 苯基四环素化合物在本文中公开。还公开了使用7-二取代 - 苯基四环素化合物治疗或预防脊髓性肌肉萎缩的方法。本发明还涉及治疗或预防具有脊髓性肌肉萎缩的受试者的方法。该方法包括向受试者施用有效量的式（1）的四环素化合物，使得治疗或预防脊髓性肌萎缩。有利地，本发明方法中使用的四环素化合物具有一个或多个以下特征：1）调节mRNA剪接的效力，2）调节SMN蛋白水平的效力，3）中枢神经系统（CNS）和/ 渗透，4）光毒性降低，5）降低抗菌性能。

6. 发明申请

WO03079984A2 SUBSTITUTED TETRACYCLINE COMPOUNDS 审中-公开
标题翻译：取代的四唑化合物
公开(公告)号：WO03079984A2
公开(公告)日：2003-10-02
申请号：PCT/US0308324
申请日：2003-03-18
申请人： PARATEK PHARM INNC
发明人： NELSON MARK L , OHEMENG KWASI , FRECHETTE ROGER , ABATO PAUL , ASSEFA HAREGEWEIN , BANDARAGE UPUL , BERNIAC JOEL , BHATIA BEENA , CHEN JACKSON , ISMAIL MOHAMED Y , KIM OAK A , MATHEWS JUDE , MCINTYRE LAURA , NIHLAWI MOHAMMED , PEARSON ANDRE , REDDY LAXMA , SHEAHAN PAUL , SIZENSKY EMMANUELLE , TOURIGNY JUSTIN , VERMA ATUL K , VISKI PETER , WARCHOL TADEUSZ
IPC分类号： C07D295/20 , A61K31/65 , A61P31/04 , A61P43/00 , C07C237/26 , C07C239/18 , C07C245/20 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/06 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/52 , C07D307/54 , C07D307/68 , C07D317/54 , C07D317/60 , C07D401/04 , C07F7/10 , A61K
CPC分类号： C07D307/52 , C07C237/26 , C07C239/18 , C07C251/08 , C07C251/48 , C07C255/25 , C07C255/43 , C07C255/58 , C07C255/59 , C07C271/28 , C07C271/44 , C07C275/34 , C07C279/18 , C07C281/14 , C07C309/61 , C07C311/19 , C07C311/21 , C07C317/48 , C07C323/32 , C07C323/60 , C07C2603/46 , C07D207/16 , C07D211/58 , C07D213/30 , C07D213/61 , C07D213/65 , C07D213/75 , C07D239/26 , C07D239/30 , C07D239/42 , C07D261/10 , C07D261/18 , C07D295/108 , C07D295/155 , C07D295/215 , C07D307/28 , C07D307/68 , C07D317/54 , C07D401/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译：本发明至少部分地涉及新的取代的四环素化合物。这些四环素化合物可用于治疗多种四环素化合物反应状态，例如细菌感染和肿瘤，以及其他已知的米诺环素和四环素化合物的一般应用，例如阻断四环素外排和调节基因表达。

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