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1. 发明申请

WO2008079339A3 TETRACYCLINE DERIVATIVES FOR THE TREATMENT OF BACTERIAL, VIRAL AND PARASITIC INFECTIONS 审中-公开
标题翻译：用于治疗细菌，病毒和寄生虫感染的四环素衍生物
公开(公告)号：WO2008079339A3
公开(公告)日：2008-12-18
申请号：PCT/US2007026178
申请日：2007-12-21
申请人： PARATEK PHARM INNC , ABATO PAUL , ASSEFA HAREGEWEIN , BERNIAC JOEL , BHATIA BEENA , BOWSER TODD , GRIER MARK , HONEYMAN LAURA , ISMAIL MOHAMED , KIM OAK K , NELSON MARK , PAN JINGWEN , VERMA ATUL
发明人： ABATO PAUL , ASSEFA HAREGEWEIN , BERNIAC JOEL , BHATIA BEENA , BOWSER TODD , GRIER MARK , HONEYMAN LAURA , ISMAIL MOHAMED , KIM OAK K , NELSON MARK , PAN JINGWEN , VERMA ATUL
IPC分类号： C07D207/50 , A61K31/65 , A61P31/04 , A61P33/06 , C07C237/26 , C07D231/12 , C07D239/20 , C07D241/12 , C07D261/02 , C07D261/04 , C07D263/32 , C07D265/02
CPC分类号： C07C237/26 , C07C2603/46 , C07D207/20 , C07D207/50 , C07D211/14 , C07D231/12 , C07D239/20 , C07D239/26 , C07D241/12 , C07D261/02 , C07D261/04 , C07D263/32 , C07D265/02 , C07D265/30 , C07D295/13 , C07D307/52
摘要： The present invention pertains, at least in part, to a substituted tetracycline compound of Formula (I): wherein X is CHC(R13VY), CR6 R6, C=CR6 R6, S, NR6, or O; E is NR7dR7ß, OR7f or (CH2)o.iC(=W)WR7s; W is O, S, NR711 or CR75R7*; W is O, S or NR7*; These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.
摘要翻译：本发明至少部分地涉及式（I）的取代四环素化合物：其中X是CHC（R13VY），CR6R6，C = CR6R6，S，NR6或O; E为NR7dR7β，OR7f或（CH2）o.iC（= W）WR7s; W是O，S，NR711或CR75R7 *; W是O，S或NR7 *; 这些四环素化合物可用于治疗许多四环素化合物反应状态，如细菌感染和赘生物。

2. 发明申请

WO2006047756A3 SUBSTITUTED TETRACYCLINE COMPOUNDS 审中-公开
公开(公告)号：WO2006047756A3
公开(公告)日：2006-07-20
申请号：PCT/US2005039014
申请日：2005-10-25
申请人： PARATEK PHARM INNC , ABATO PAUL , ASSEFA HAREGEWEIN , BERNIAC JOEL , BHATIA BEENA , BOWSER TODD , CHEN JACKSON , GRIER MARK , HONEYMAN LAURA , ISMAIL MOHAMED Y , NELSON MARK , KWASI OHEMENG , PAN JINGWEN
发明人： ABATO PAUL , ASSEFA HAREGEWEIN , BERNIAC JOEL , BHATIA BEENA , BOWSER TODD , CHEN JACKSON , GRIER MARK , HONEYMAN LAURA , ISMAIL MOHAMED Y , NELSON MARK , KWASI OHEMENG , PAN JINGWEN
IPC分类号： C07C237/26 , A61K31/65 , A61P25/28 , A61P31/04 , A61P31/12 , A61P33/06 , C07D295/155 , C07D307/54 , C07D405/06
CPC分类号： C07D471/04 , C07C237/26 , C07C251/48 , C07C255/59 , C07C259/10 , C07C271/18 , C07C271/22 , C07C271/24 , C07C2601/02 , C07C2603/46 , C07D207/335 , C07D207/337 , C07D211/70 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/73 , C07D213/74 , C07D213/84 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/30 , C07D295/096 , C07D295/155 , C07D295/192 , C07D307/46 , C07D307/52 , C07D307/54 , C07D309/14 , C07D333/20 , C07D333/24 , C07D333/38 , C07D403/06 , C07D405/06 , C07D405/12 , C07D413/12 , C07D487/04
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.

3. 发明申请

WO2009107008A2 AUTOMATED NON-MAGNETIC MEDICAL MONITOR USING PIEZOELECTRIC CERAMIC DIAPHRAGM DEVICES 审中-公开
标题翻译：使用压电陶瓷隔膜装置的自动化非磁性医疗监测仪
公开(公告)号：WO2009107008A2
公开(公告)日：2009-09-03
申请号：PCT/IB2009050418
申请日：2009-02-02
申请人： KONINKL PHILIPS ELECTRONICS NV , NELSON MARK
发明人： NELSON MARK
IPC分类号： G01R33/20 , A61B5/022
CPC分类号： A61B5/022 , A61B5/02141 , A61B5/055 , G01R33/288
摘要： In magnetic resonance imaging (MRI), the powerful magnetic fields can interfere with, damage, cause premature failure in, and attract certain non-MR safe instruments. Electromagnetic ally sensitive components are eliminated in favor of MR safe components, such as ceramic piezoelectric components and bi-metallic components. Instruments that previously had to be kept a safe distance away from the main magnet (12), e.g., beyond the 5 Gauss line, while a patient was being scanned are now allowed near the patient without fear of damage to the instrument (40) or danger to the patient and medical staff or the MRI device (10).
摘要翻译：在磁共振成像（MRI）中，强大的磁场会干扰，损坏，引起过早失效，并吸引某些非MR安全仪器。消除电磁敏感元件有利于MR安全元件，如陶瓷压电元件和双金属元件。当患者正在扫描时，先前必须与主磁体（12）保持安全距离（例如超过5高斯线）的器械现在允许靠近患者，而不用担心器械损坏（40）或对患者和医务人员或MRI设备（10）的危险。

4. 发明申请

WO2009091862A2 COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM LEPIDOPTERA 审中-公开
标题翻译：用于抑制来自LEPIDOPTERA的目标多核苷酸的组合物和方法
公开(公告)号：WO2009091862A2
公开(公告)日：2009-07-23
申请号：PCT/US2009031055
申请日：2009-01-15
申请人： PIONEER HI BRED INT , DU PONT , HERRMANN RAFAEL , LASSNER MICHAEL , LU ALBERT L , NELSON MARK , PRESNAIL JAMES K , RICE JANET A
发明人： HERRMANN RAFAEL , LASSNER MICHAEL , LU ALBERT L , NELSON MARK , PRESNAIL JAMES K , RICE JANET A
IPC分类号： C12N15/82
CPC分类号： C12N15/8286 , A01N65/20 , A01N65/44 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12N2320/32 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Spodoptera frugiperda. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉积元件的方法和组合物，当沉积元件在被害虫如来自鳞翅目序列的害虫中摄取时，它们能够降低害虫中靶序列的表达。在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。本发明提供编码来自特定蛋白质家族的多肽的多核苷酸和SEQ ID NO：1,2,3,4,5,6,7,8,9,10,11,12,13,14中所示的各种靶多核苷酸的靶多核苷酸，15，16，17，18，19，20，21，22，23，24，25，26，27，28，29，30，31，32，33，34，35，36，37，38，39 ，40,41,42,43,44,45,46,47,48,49或50个或其活性变体和片段，其中目标害虫中一个或多个序列的表达降低控制害虫（即，具有杀虫活性）。进一步提供的是沉积元件，当被害虫摄入时，降低靶多肽的水平，从而控制害虫。在具体实施方案中，害虫是草地夜蛾（Spodoptera frugiperda）。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。

5. 发明申请

WO2007061863A3 ELECTRONIC SURVEYING METHOD AND SYSTEM 审中-公开
标题翻译：电子测量方法与系统
公开(公告)号：WO2007061863A3
公开(公告)日：2009-04-30
申请号：PCT/US2006044710
申请日：2006-11-17
申请人： NELSON MARK
发明人： NELSON MARK
IPC分类号： G09B7/00
CPC分类号： G06Q30/00 , G09B7/02
摘要： The present invention provides a method for providing a survey to an individual by displaying a video, audio, or audio/video presentation and collecting responses to the information display. The survey responses are collected over duration of the presentation and can be displayed along with the information display in a synchronized fashion.
摘要翻译：本发明提供一种通过显示视频，音频或音频/视频呈现并且收集对信息显示的响应来向个人提供调查的方法。调查回答是在演示的持续时间内收集的，并且可以以同步的方式与信息显示一起显示。

6. 发明申请

WO2009091864A3 COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM LYGUS 审中-公开
标题翻译：抑制淋巴瘤靶向多核苷酸的组合物和方法
公开(公告)号：WO2009091864A3
公开(公告)日：2009-12-10
申请号：PCT/US2009031057
申请日：2009-01-15
申请人： PIONEER HI BRED INT , DU PONT , HERRMANN RAFAEL , LASSNER MICHAEL , LU ALBERT L , NELSON MARK , PRESNAIL JAMES K , RICE JANET A
发明人： HERRMANN RAFAEL , LASSNER MICHAEL , LU ALBERT L , NELSON MARK , PRESNAIL JAMES K , RICE JANET A
IPC分类号： C12N15/82
CPC分类号： C12N15/8286 , A01N57/16 , C12N15/113 , C12N15/8218 , C12N2310/141 , C12N2310/531 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lygus genus, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides from specific polypeptide families as disclosed herein, and further provides target polynucleotides set forth in SEQ ID NOS:1-21 or active variants thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Lygus Hesperus. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉默元件的方法和组合物，所述沉默元件当被有害生物如来自草盲蝽属的害虫摄入时，能够降低害虫中靶序列的表达。在具体的实施方案中，靶序列表达的降低控制害虫，并且由此该方法和组合物能够限制对植物的损害。本发明提供了来自本文公开的特定多肽家族的各种靶多核苷酸，并且还提供了SEQ ID NO：1-21中列出的靶多核苷酸或其活性变体，其中靶害虫中一个或多个序列的表达降低控制害虫（即具有杀虫活性）。进一步提供了沉默元件，其在被害虫摄入时降低靶多肽的水平并由此控制害虫。在具体的实施方案中，害虫是草盲蝽（Lygus Hesperus）。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其他宿主细胞。

7. 发明申请

WO2009091860A3 COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM THE FAMILY APHIDIDAE 审中-公开
标题翻译：用于抑制来自家庭蚜虫目标多核苷酸的组合物和方法
公开(公告)号：WO2009091860A3
公开(公告)日：2009-11-05
申请号：PCT/US2009031053
申请日：2009-01-15
申请人： PIONEER HI BRED INT , DU PONT , HERRMANN RAFAEL , LASSNER MICHAEL , LU ALBERT L , NELSON MARK , PRESNAIL JAMES K , RICE JANET A
发明人： HERRMANN RAFAEL , LASSNER MICHAEL , LU ALBERT L , NELSON MARK , PRESNAIL JAMES K , RICE JANET A
IPC分类号： C12N15/82
CPC分类号： C12N15/8286 , C07K14/43563 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Aphididae family, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides for specific protein classes and also target polynucleotides as set forth in SEQ ID NOS:1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or active variants or fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Aphis glycines. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉默元件的方法和组合物，所述沉默元件当被有害生物例如来自蚜科的害虫摄取时，能够降低害虫中靶序列的表达。在具体的实施方案中，靶序列表达的降低控制害虫，并且由此该方法和组合物能够限制对植物的损害。本发明提供了特定蛋白质类别的靶多核苷酸以及如SEQ ID NO：1,2,3,4,5,6,7,8,9,10或其活性变体或片段所示的靶多核苷酸，其中a 目标害虫中一个或多个序列表达的减少控制了害虫（即，具有杀虫活性）。进一步提供了沉默元件，其在被害虫摄入时降低靶多肽的水平并由此控制害虫。在具体的实施方案中，害虫是蚜虫（Aphis）甘氨酸。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其他宿主细胞。

8. 发明申请

WO0210673A8 LINEAR MEASUREMENT WORKPIECE GRIPPING DEVICE 审中-公开
标题翻译：线性测量工作装置
公开(公告)号：WO0210673A8
公开(公告)日：2002-06-20
申请号：PCT/US0123725
申请日：2001-07-26
申请人： NELSON MARK , SIMCOE THOMAS G
发明人： NELSON MARK , SIMCOE THOMAS G
IPC分类号： G01B3/10
CPC分类号： G01B3/1071 , G01B3/1056 , G01B2003/1076
摘要： A device (66) attachable either removably or permanently, or installed as original equipment, on the outer free end of an otherwise conventional measuring tape (50) for enhancing the ability of the outer end (58) of the tape to grip and stay in place on the far side of a workpiece being measured. The device features a generally planar body expanse having perimeter structure disposed outwardly of the long axis of an associated measuring tape, with this perimeter structure being formed with a line-like array (curved or straight, and with or without corners) of tooth-like projection elements which are intended to face, engage, and grip a surface of a workpiece being measured.
摘要翻译：一种可拆卸地或永久地安装或作为原始设备安装在另外传统的卷尺（50）的外部自由端上的装置（66），用于增强带的外端（58）抓住并保持在其中的能力放置在待测工件的远侧。该装置具有大致平面的主体宽度，其外围结构设置在相关联的测量带的长轴的外侧，该周边结构形成为具有牙齿状的线状阵列（弯曲或直的，有或没有角）旨在面对，接合和夹持正被测量的工件的表面的投影元件。

9. 发明申请

WO0041771A3 MARTIAL ARTS PHYSICAL INTERACTION DEVICE AND METHOD 审中-公开
标题翻译：武术物理交互设备和方法
公开(公告)号：WO0041771A3
公开(公告)日：2000-11-30
申请号：PCT/US0001134
申请日：2000-01-14
申请人： NELSON MARK
发明人： NELSON MARK
IPC分类号： A63B69/02 , A63B69/00 , A63B69/24 , A63B69/34
CPC分类号： A63B69/34 , A63B69/004 , A63B2208/12
摘要： A physical interaction device includes a controller (110) and one or more arms (102), such as a first arm (102) and a second arm (101). The first arm (102) is movably connected with a first support (104). The first arm includes a first flexible portion sized to physically interact with a first limb portion of a user of the device. The second arm (101) is movably connected with a second support (105). The second arm (101) includes a second flexible portion sized to physically interact with the first limb portion of the user and/or a second limb portion of the user. The controller (110) is linkable with the first arm (102), the second arm (101) and the pitch adjuster (402). The controller (110) is configured to adjust the angle of the first arm (102) and the second arm (101). The controller (110) is configured to selectively cause a first movement of the first flexible portion of the first arm (102). The controller (110) is configured to selectively cause a second movement of the second flexible portion of the second arm (101). The first movement of the first flexible portion of the first arm (102) serves to contact the first flexible portion of the first arm (102) with the user to physically imitate a first human strike toward the user. The second movement of the second flexible portion of the second arm (101) serves to contact the second flexible portion of the second arm (101) with the user to physically imitate a second human strike toward the user.
摘要翻译：物理相互作用装置包括控制器（110）和一个或多个臂（102），诸如第一臂（102）和第二臂（101）。第一臂（102）与第一支撑件（104）可移动地连接。第一臂包括尺寸适于物理地与设备的使用者的第一肢体部分相互作用的第一柔性部分。第二臂（101）与第二支撑件（105）可移动地连接。第二臂（101）包括尺寸设计成与用户的第一肢体部分和/或使用者的第二肢体部分物理地相互作用的第二柔性部分。控制器（110）可与第一臂（102），第二臂（101）和俯仰调节器（402）连接。控制器（110）被配置为调节第一臂（102）和第二臂（101）的角度。控制器（110）被配置为选择性地引起第一臂（102）的第一柔性部分的第一移动。控制器（110）被配置为选择性地引起第二臂（101）的第二柔性部分的第二移动。第一臂（102）的第一柔性部分的第一运动用于与使用者接触第一臂（102）的第一柔性部分，以物理地模仿朝向使用者的第一人行进。第二臂（101）的第二柔性部分的第二运动用于与使用者接触第二臂（101）的第二柔性部分，以物理地模拟朝向使用者的第二人类撞击。

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