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1. 发明申请

WO2011003191A1 COMPOSITIONS AND METHODS FOR ENHANCING VIRUS EFFICACY 审中-公开
标题翻译：用于增强病毒效能的组合物和方法
公开(公告)号：WO2011003191A1
公开(公告)日：2011-01-13
申请号：PCT/CA2010/001057
申请日：2010-07-07
申请人： Ottawa Hospital Research Institute , BELL, John , DIALLO, Jean-Simon
发明人： BELL, John , DIALLO, Jean-Simon
IPC分类号： C07D307/58 , A61K31/00 , A61K35/76 , A61K45/06 , A61P35/00 , C07C335/16 , C07C335/40 , C07D213/75 , C07D233/90 , C07D257/04 , C07D319/20 , C07D333/04 , C07D403/12 , C07D409/12 , C12N7/00
CPC分类号： A61K35/766 , A61K31/275 , A61K31/341 , A61K31/365 , A61K38/00 , A61K45/06 , C07C49/675 , C07C49/747 , C07C205/37 , C07C217/84 , C07C233/32 , C07C233/38 , C07C243/38 , C07C255/37 , C07C311/44 , C07C323/42 , C07C323/60 , C07C335/16 , C07C337/06 , C07C337/08 , C07C2601/02 , C07C2601/14 , C07C2603/26 , C07C2603/34 , C07D213/75 , C07D233/90 , C07D257/04 , C07D307/58 , C07D319/20 , C07D333/04 , C07D403/12 , C07D409/12 , C12N7/00 , C12N2760/20232 , C12N2760/20251 , A61K2300/00
摘要： Provided are viral sensitizing compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the cytotoxicity of virus to cells. Other uses, compositions and methods of using same are also provided.
摘要翻译：提供的病毒敏化化合物通过增加病毒在细胞中的扩散，增加病毒在细胞中的滴度或增加病毒对细胞的细胞毒性而增强病毒的功效。还提供了其他用途，组合物和使用方法。

2. 发明申请

WO2012122649A1 RECOMBINANT ORF VIRUS 审中-公开
标题翻译：重组ORF病毒
公开(公告)号：WO2012122649A1
公开(公告)日：2012-09-20
申请号：PCT/CA2012/050153
申请日：2012-03-14
申请人： OTTAWA HOSPITAL RESEARCH INSTITUTE , RINTOUL, Julia , LAPORTE, Aimée, Nicole , KOMAR, Monica , BELL, John
发明人： RINTOUL, Julia , LAPORTE, Aimée, Nicole , KOMAR, Monica , BELL, John
IPC分类号： C12N7/01 , A61K35/76 , A61P35/00 , A61P35/04 , C12N15/86 , C12N15/863 , C12N5/10 , C12N5/09
CPC分类号： A61K35/768 , C12N2710/24122 , C12N2710/24232 , C12N2710/24243 , Y02A50/465
摘要： The present invention relates to recombinant orf virus, and use and methods involving such recombinant orf virus in the treatment of hyperproliferative disorders. The recombinant orf virus contains one or more heterologous host range genes. Advantageously, such engineering allows the orf virus to better replicate in human cells, while still maintaining the orf virus' unique immune stimulatory profile.
摘要翻译：本发明涉及重组orf病毒，以及涉及这种重组orf病毒用于治疗过度增殖性疾病的用途和方法。重组orf病毒含有一个或多个异源宿主范围基因。有利的是，这种工程允许orf病毒在人类细胞中更好地复制，同时仍保持orf病毒独特的免疫刺激特征。

3. 发明申请

WO2012122629A1 A METHOD OF VACCINATION COMPRISING A HISTONE DEACETYLASE INHIBITOR 审中-公开
标题翻译：包含脱乙酰壳多糖酶抑制剂的疫苗接种方法
公开(公告)号：WO2012122629A1
公开(公告)日：2012-09-20
申请号：PCT/CA2012/000212
申请日：2012-03-09
申请人： MCMASTER UNIVERSITY , BRIDLE, Bryam , LICHTY, Brian , WAN, Yonghong , DIALLO, Jean-Simon , LEMAY, Chantal , BELL, John
发明人： BRIDLE, Bryam , LICHTY, Brian , WAN, Yonghong , DIALLO, Jean-Simon , LEMAY, Chantal , BELL, John
IPC分类号： A61K39/39 , A61K35/76 , A61P37/04
CPC分类号： A61K39/29 , A61K31/165 , A61K31/167 , A61K31/18 , A61K31/19 , A61K31/192 , A61K31/4045 , A61K31/4406 , A61K31/4745 , A61K31/506 , A61K31/713 , A61K35/766 , A61K38/12 , A61K38/15 , A61K38/164 , A61K39/0011 , A61K39/02 , A61K39/04 , A61K39/12 , A61K39/165 , A61K39/17 , A61K39/205 , A61K39/285 , A61K45/06 , A61K2039/545 , C12N2710/10343 , C12N2760/20232 , C12N2760/20243 , A61K2300/00
摘要： A vaccination method is provided. The method comprises administering to a mammal a histone deacytelase inhibitor in conjunction with a vaccine that expresses an antigen to which the mammal has a pre-existing immunity.
摘要翻译：提供疫苗接种方法。该方法包括向哺乳动物施用组蛋白deacytelase抑制剂与表达哺乳动物具有预先存在的免疫力的抗原的疫苗。

4. 发明申请

WO2022251960A1 EXPRESSION OF BACTERIAL DINUCLEOTIDE CYCLASES 审中-公开
公开(公告)号：WO2022251960A1
公开(公告)日：2022-12-08
申请号：PCT/CA2022/050878
申请日：2022-06-01
申请人： MCMASTER UNIVERSITY , OTTAWA HOSPITAL RESEARCH INSTITUTE
发明人： LICHTY, Brian , WANG, Fuan , ATHERTON, Matthew , BELL, John , SINGARAVELU, Ragunath , ILKOW, Carolina
IPC分类号： C12N15/86 , A61K35/76 , A61K35/768 , A61K38/43 , A61P35/00 , C12N1/21 , C12N7/01 , C12N9/00 , C12N15/52 , C12N15/85 , C12P21/00
摘要： A method of constitutively expressing a bacterial dinucleotide cyclase in a mammalian cell is provided. The method comprises transfecting the mammalian cell with a transgene encoding the bacterial dinucleotide cyclase and subjecting the mammalian cell to suitable growth conditions. In an embodiment, the bacterial dinucleotide cyclase is expressed in a tumour or cancer cell and is useful to treat cancer.

5. 发明申请

WO2012094386A1 GENERATION OF ANTIBODIES TO TUMOR ANTIGENS AND GENERATION OF TUMOR SPECIFIC COMPLEMENT DEPENDENT CYTOTOXICITY BY ADMINISTRATION OF ONCOLYTIC VACCINIA VIRUS 审中-公开
标题翻译：抗肿瘤抗生素的产生和肿瘤特异性补体的产生依赖于毒理性疫苗病毒的依赖性细胞毒性
公开(公告)号：WO2012094386A1
公开(公告)日：2012-07-12
申请号：PCT/US2012/020173
申请日：2012-01-04
申请人： JENNEREX INC. , KIRN, David , BELL, John , BREITBACH, Caroline , MOON, Anne , HWANG, Tae-Ho , LEE, Yu Kyoung , KIM, Mi-kyung , INSTITUTE FOR RESEARCH & INDUSTRY COOPERATION, PUSAN NATIONAL UNIVERSITY
发明人： KIRN, David , BELL, John , BREITBACH, Caroline , MOON, Anne , HWANG, Tae-Ho , LEE, Yu Kyoung , KIM, Mi-kyung
IPC分类号： A61K39/12
CPC分类号： A61K39/285 , A61K35/26 , A61K35/76 , A61K35/761 , A61K35/763 , A61K35/768 , A61K39/0011 , A61K39/12 , A61K39/125 , A61K39/145 , A61K39/165 , A61K39/17 , A61K39/205 , A61K39/235 , A61K39/245 , A61K39/395 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/55522 , C07K16/18 , C07K16/30 , C07K2317/14 , C07K2317/734 , C12N7/00 , C12N2710/10034 , C12N2710/16632 , C12N2710/16634 , C12N2710/24034 , C12N2710/24132 , C12N2720/12232 , C12N2750/14034 , C12N2760/16034 , C12N2760/18134 , C12N2760/18434 , C12N2760/18734 , C12N2760/20034 , C12N2760/20232 , C12N2770/32034 , C12N2770/32334 , C12N2770/36034 , G01N33/574
摘要： The present invention relates to methods and compositions for use in inducing tumor-specific antibody mediated complement-dependent cytotoxic response in an animal having a tumor comprising administering to said animal a composition comprising a replication competent oncolytic virus wherein administration of the composition induces in the animal production of antibodies that mediate a CDC response specific to said tumor.
摘要翻译：本发明涉及用于在具有肿瘤的动物中诱导肿瘤特异性抗体介导的补体依赖性细胞毒性应答的方法和组合物，包括向所述动物施用包含复制能力的溶瘤病毒的组合物，其中组合物在动物中的诱导产生介导对所述肿瘤特异性的CDC反应的抗体。

6. 发明申请

WO2008054526A1 SEAT BELT SYSTEM FOR A VEHICLE 审中-公开
标题翻译：汽车座椅系统
公开(公告)号：WO2008054526A1
公开(公告)日：2008-05-08
申请号：PCT/US2007/010996
申请日：2007-05-07
申请人： KEY SAFETY SYSTEMS, INC. , BELL, John , PALLISER, Martyn
发明人： BELL, John , PALLISER, Martyn
IPC分类号： B60R22/00 , B60R22/20
CPC分类号： B60R22/26 , B60N2/688 , B60R22/024 , B60R2022/1818
摘要： A vehicle seat (1) provides location and fixing points on the vehicle seat that will take crash loads and can be used to position a webbing path adapter (14) to serve as a guide for placing a seat belt (4) in a suitable position for when a child is occupying the seat. The vehicle seat (1) includes a seat backrest (2) having an upholstered part overlying a load-bearing plate (15). A first plurality of holes (11) pass through the upholstered part and a second, aligned, plurality of holes (11A) pass through the load-bearing plate (15). A webbing path adapter (14) has a passageway (19) for receiving the seat belt in a removable manner. A pin (16) connects the webbing path adapter (14) to the seat back (2) in a removable manner via a pair of aligned holes (11, 11A) in the upholstered part and the load-bearing plate (15).
摘要翻译：车辆座椅（1）提供车辆座椅上的位置和固定点，该位置和固定点将承受碰撞载荷，并可用于定位织带路径适配器（14）以用作将安全带（4）放置在适当位置因为当一个孩子占据座位时。车辆座椅（1）包括座椅靠背（2），其具有覆盖承重板（15）的软垫部分。第一多个孔（11）穿过软垫部分，并且第二对准的多个孔（11A）穿过承载板（15）。一种织带路径适配器（14）具有用于以可拆卸的方式接收座椅安全带的通道（19）。销（16）通过软垫部分和承载板（15）中的一对对齐的孔（11,11A）以可拆卸的方式将织带路径适配器（14）连接到座椅靠背（2）。

7. 发明申请

WO2007050780A3 NEUROLOGIC SYSTEM AND ASSOCIATED METHODS 审中-公开
公开(公告)号：WO2007050780A3
公开(公告)日：2007-05-03
申请号：PCT/US2006/041826
申请日：2006-10-24
申请人： BELL, John
发明人： BELL, John
IPC分类号： A61B5/04
摘要： The present invention includes systems and methods for assessing stimulatory effects on a neurologic system. One method may include steps of stimulating the neurologic system, monitoring at least one neurologic state for effects of the stimulation to the neurologic system, gathering multi-dimensional data from the monitoring of the at least one neurological state, and analyzing the multi-dimensional data to determine multi-dimensional interactions between the stimulation and the effects on the at least one neurological state. Various neurologic states are considered to be within the scope of the present invention, including, without limitation, hypnotic, analgesia, relaxation, stress, depression, anxiety, allostasis, immune response, and combinations thereof.

8. 发明申请

WO2003053967A1 AROYL PYRIDINONES 审中-公开
公开(公告)号：WO2003053967A1
公开(公告)日：2003-07-03
申请号：PCT/EP2002/013930
申请日：2002-12-09
申请人： BAYER AKTIENGESELLSCHAFT , ALONSO-ALIJA, Cristina , MICHELS, Martin , SCHIROK, Hartmut , SCHLEMMER, Karl-Heinz , DODD, Sara , FITZGERALD, Mary , BELL, John , GILL, Andrew
发明人： ALONSO-ALIJA, Cristina , MICHELS, Martin , SCHIROK, Hartmut , SCHLEMMER, Karl-Heinz , DODD, Sara , FITZGERALD, Mary , BELL, John , GILL, Andrew
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D233/22 , C07D235/12
摘要： The present invention relates to pyridinones, processes for their preparation and their use in medicaments, especially for the treatment of COPD.
摘要翻译：本发明涉及吡啶酮，其制备方法及其在药物中的用途，特别是用于治疗COPD。

9. 发明申请

WO2013022764A1 METHODS AND COMPOSITIONS FOR PRODUCTION OF VACCINA VIRUS 审中-公开
标题翻译：用于生产VACCINA病毒的方法和组合物
公开(公告)号：WO2013022764A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/049550
申请日：2012-08-03
申请人： KIRN, David , BELL, John
发明人： KIRN, David , BELL, John
IPC分类号： A61K35/76 , C12N15/86
CPC分类号： C12N7/00 , A61K35/76 , C12N15/86 , C12N2710/24132 , C12N2710/24151
摘要： Certain embodiments are directed to viral production processes for the large scale production of vaccinia virus.
摘要翻译：某些实施方案涉及大规模生产痘苗病毒的病毒生产方法。

10. 发明申请

WO2013020985A1 ACTIVE COMPOUND COMBINATIONS COMPRISING SPECIFIC TETRAMIC ACID DERIVATIVES 审中-公开
标题翻译：包含特定酸性衍生物的活性化合物组合
公开(公告)号：WO2013020985A1
公开(公告)日：2013-02-14
申请号：PCT/EP2012/065469
申请日：2012-08-07
申请人： BAYER INTELLECTUAL PROPERTY GMBH , DEALL, Michael , FISCHER, Reiner , HACKER, Erwin , HUNGENBERG, Heike , BELL, John , STEFFENS, Robert
发明人： DEALL, Michael , FISCHER, Reiner , HACKER, Erwin , HUNGENBERG, Heike , BELL, John , STEFFENS, Robert
IPC分类号： A01N47/06 , A01N57/20 , A01P5/00 , A01P7/02 , A01P7/04
CPC分类号： A01N43/38 , A01N25/32 , A01N47/06 , A01N57/20 , A01N2300/00
摘要： The invention provides combinations of insecticides/acaricides and herbicides comprising an effective amount of components (A) and (B), where component (A) is one or more of the tetramic acid derivatives listed in the description, and (B) one or more herbicides from the group of the herbicides likewise listed in the description, where the combninations may optionally additionally comprise crop plant compatibility-increasing substances (safeners). The invention also relates to the use of the combinations for controlling animal pests and unwanted vegetation and to the corresponding methods.
摘要翻译：本发明提供了包含有效量的组分（A）和（B）的杀虫剂/杀螨剂和除草剂的组合，其中组分（A）是说明书中列出的一种或多种四酸衍生物，和（B）一种或多种来自同一列举在描述中的除草剂组的除草剂，其中组合可任选地另外包含作物植物相容性增加物质（安全剂）。本发明还涉及用于控制动物害虫和不想要的植物的组合的用途以及相应的方法。

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