专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2023082021A1 MAGNETIC MICROGEL BEADS, METHODS OF MAKING AND USES THEREOF 审中-公开
公开(公告)号：WO2023082021A1
公开(公告)日：2023-05-19
申请号：PCT/CA2022/051679
申请日：2022-11-14
申请人： MCMASTER UNIVERSITY
发明人： SOLEYMANI, Leyla , HOARE, Todd , LI, Yingfu , LU, Yang , PANDEY, Richa
IPC分类号： G01N33/553 , C12Q1/68 , G01N33/531 , G01N21/66 , G01N21/76 , G01N27/416
摘要： This disclosure relates to magnetic microgel beads, and in particular to magnetic microgel beads for biofunctionalization and methods of making and uses thereof, for example, in biosensing assays. In an embodiment, a magnetic microparticle comprising a magnetic nanoparticle encapsulated by a polymer hydrogel. In another embodiment, an assay for detecting the presence of a target analyte in a sample comprising a) the magnetic microparticle disclosed herein, wherein the biorecognition agent further comprises a reporter moiety; b) an electrochemical chip comprising a working electrode, a counter electrode and a reference electrode; and c) a capture probe functionalized on the working electrode; wherein binding of the biorecognition agent to the target analyte results in production of an electrochemical, electroluminescent or photoelectrochemical signal.

2. 发明申请

WO2022178633A1 ANTIBODY RECRUITMENT MOLECULES AND METHODS OF TREATING COVID-19 USING SAME 审中-公开
公开(公告)号：WO2022178633A1
公开(公告)日：2022-09-01
申请号：PCT/CA2022/050262
申请日：2022-02-24
申请人： MCMASTER UNIVERSITY
发明人： RULLO, Anthony , WAN, Yonghong , MCNULTY, James , LAKE, Benjamin , ZHANG, Ruijia , KAPCAN, Eden , WALSH, Scott
IPC分类号： C07K7/08 , A61K39/385 , A61P31/14 , A61P37/02
摘要： The present disclosure relates generally to the field of antiviral immunotherapy. More particularly, the present disclosure provides Antibody Recruitment Molecules (ARMs) for targeted recruitment of endogenous antibodies to virions and/or virus-infected cells, pharmaceutical compositions comprising same and methods of treating Coronavirus Disease 2019 (COVID-19) using same.

3. 发明申请

WO2022006660A1 GENETICALLY MODIFIED BOVINE HERPESVIRUS TYPE 1 (BHV-1) FOR USE TO TREAT CANCER 审中-公开
公开(公告)号：WO2022006660A1
公开(公告)日：2022-01-13
申请号：PCT/CA2021/050915
申请日：2021-07-06
申请人： MCMASTER UNIVERSITY
发明人： MOSSMAN, Karen , DAVOLA, Maria , COLLINS, Susan , CUDDINGTON, Breanne
IPC分类号： C12N7/01 , A61K35/763 , A61K39/245 , A61P35/00 , A61P37/04 , C07K14/52 , C12N15/12 , C12N15/19 , C12N15/38 , C12N15/869 , C12N7/00
摘要： A recombinant BHV-1 oncolytic virus is provided comprising a BHV-1 mutant with enhanced cancer selectivity and/or enhance immunostimulatory activity as compared to wildtype BHV-1. The BHV-1 mutant is genetically modified to express one or more immunomodulatory molecules that induce an anti-tumor immune response. A method of generating the recombinant BHV-1 oncolytic virus is also provided.

4. 发明申请

WO2021051195A1 CHIMERIC COSTIMULATORY RECEPTORS AND METHODS AND USES THEREOF 审中-公开
公开(公告)号：WO2021051195A1
公开(公告)日：2021-03-25
申请号：PCT/CA2020/051245
申请日：2020-09-16
申请人： MCMASTER UNIVERSITY
发明人： BRAMSON, Jonathan , MARVYN, Phillip
IPC分类号： C12N15/62 , A61K35/17 , A61P35/00 , C07K14/705 , C07K14/715 , C07K19/00 , C12N15/85 , C12N5/0783 , C12N5/10
摘要： Described herein is a chimeric costimulatory receptor (CCR) molecule having an extracellular domain of a Tumor Necrosis Factor Superfamily member, a transmembrane domain and a cytosolic costimulatory signaling domain from a Tumor Necrosis Factor Receptor Superfamily member is provided. Also provided are pharmaceutical compositions having a T cell expressing CCR and methods and uses of such T cells to treat cancers.

5. 发明申请

WO2021012048A1 CATALYST FREE, RAPID CURE SILICONE ELASTOMERS 审中-公开
公开(公告)号：WO2021012048A1
公开(公告)日：2021-01-28
申请号：PCT/CA2020/051013
申请日：2020-07-22
申请人： MCMASTER UNIVERSITY
发明人： BROOK, Michael A. , BUI, Robert
IPC分类号： C08G77/388 , C08J3/24 , C08K5/07 , C08L83/08
摘要： The present application provides a method for the rapid, catalyst-free, preparation of silicone elastomers using aminoalkylsilicones and aliphatic aldehydes that can dissolve in water at a concentration of at least 2 wt.%, in air or under water. The elastomers prepared by this method have good hydrolytic stability and can be used as hydrophobic adhesives or sealants under water.

6. 发明申请

WO2020102901A8 SYNTHETIC ANTIBACTERIAL COMPOUNDS AND USES THEREOF 审中-公开
公开(公告)号：WO2020102901A8
公开(公告)日：2020-05-28
申请号：PCT/CA2019/051663
申请日：2019-11-20
申请人： MCMASTER UNIVERSITY
发明人： BROWN, Eric , ELHALFAWY, Omar M. , FARHA, Maya , MAGOLAN, Jakob , GALE, Robert
IPC分类号： C07D311/58 , A01N31/16 , A01N35/04 , A01N37/18 , A01N41/02 , A01N43/00 , A01N43/16 , A01N61/00 , A01P1/00 , A61K31/047 , A61K31/10 , A61K31/121 , A61K31/166 , A61K31/18 , A61K31/353 , A61K31/404 , A61K31/4155 , A61K31/4164 , A61K31/4178 , A61K31/4184 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/437 , A61K31/4409 , A61K31/4433 , A61K31/495 , A61K31/505 , A61K31/506 , A61K31/5375 , A61K31/04 , C07C235/46 , C07C311/29 , C07C317/22 , C07C39/08 , C07C39/24 , C07C49/245 , C07D213/30 , C07D213/50 , C07C233/64 , C07C235/18 , C07D239/26 , C07D241/12 , C07D263/32 , C07D277/24 , C07D295/192 , C07D311/80 , C07D405/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Provided herein are synthetic compounds useful for inhibiting bacterial growth and uses thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium or treating or preventing a bacterial infection.

7. 发明申请

WO2020024060A1 METHODS FOR INHIBITING MICROBE GROWTH 审中-公开
公开(公告)号：WO2020024060A1
公开(公告)日：2020-02-06
申请号：PCT/CA2019/051059
申请日：2019-08-01
申请人： MCMASTER UNIVERSITY
发明人： BROWN, Eric , FARHA, Maya , MACNAIR, Craig , CARFRAE, Lindsey
IPC分类号： A61K47/04 , A01N59/00 , A01P1/00 , A01P3/00 , A61L2/16 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00
摘要： Provided herein are methods and compositions useful for inhibiting microbe growth. The methods can comprise contacting the microbe with an antimicrobial agent and bicarbonate. In some embodiments, provided herein are methods for treating or preventing a microbial infection, comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent.

8. 发明申请

WO2018218376A1 LABELED FLUOROCARBON AGENTS FOR POSITRON EMISSION TOMOGRAPHY IMAGING 审中-公开
公开(公告)号：WO2018218376A1
公开(公告)日：2018-12-06
申请号：PCT/CA2018/050667
申请日：2018-06-04
申请人： MCMASTER UNIVERSITY , SUNNYBROOK RESEARCH INSTITUTE
发明人： VALLIANT, John , MATSUURA, Naomi
IPC分类号： C07C19/08 , A61K49/00 , A61K49/10 , C07C17/093 , G01R33/56 , G01T1/64
摘要： The present application is in the field of imaging reagents. In particular, the present application relates to labelled fluorocarbon imaging reagents, the preparation of the reagents, and their uses for imaging such as PET scanning.

9. 发明申请

WO2018161177A1 NUCLEIC ACID ENZYME-MEDIATED SIGNAL AMPLIFICATION FOR BIOSENSING 审中-公开
公开(公告)号：WO2018161177A1
公开(公告)日：2018-09-13
申请号：PCT/CA2018/050294
申请日：2018-03-12
申请人： MCMASTER UNIVERSITY
发明人： LI, Yingfu , BRENNAN, John , LIU, Meng
IPC分类号： C12Q1/6844 , C12Q1/68 , C12Q1/682
摘要： Described is an approach that takes advantage of rolling circle amplification (RCA) and an RNA-cleaving DNAzyme (RCD) to achieve massive signal amplification for biosensing via a cross-feedback mechanism. An RCA reaction generates copies of an RCD that triggers a reaction cascade designed to generate additional DNA assemblies for RCA. These cross- feedback actions work autonomously to turn limited molecular recognition events into massive amounts of DNA amplicons that can be conveniently detected. This approach was demonstrated for biosensing of a microRNA sequence and a bacterium.

10. 发明申请

WO2017185186A1 TEXTURED ELECTRODES WITH ENHANCED ELECTROCHEMICAL SENSITIVITY 审中-公开
标题翻译：具有增强的电化学敏感性的纹理电极
公开(公告)号：WO2017185186A1
公开(公告)日：2017-11-02
申请号：PCT/CA2017/050519
申请日：2017-04-28
申请人： MCMASTER UNIVERSITY
发明人： GABARDO, Christine , ADAMS-MCGAVIN, Robert Chris , SOLEYMANI, Leyla
IPC分类号： G01N27/30
摘要： An all-solution electrode fabrication process is provided, The process comprises the steps of: i) preparing and activating a shrinkable polymer substrate for deposition of a conductive film; ii) modifying the substrate to incorporate a linker; iii) immobilizing particles of a conductive material on the linkers of the substrate to form a conductive film on the substrate; and vi) heating the modified substrate to a temperature sufficient to cause contraction of the polymer substrate and to result in micro- and/or nano-texturing in the conductive film. The process advantageously yields a novel multi-scale electrode device comprising a polymer substrate; and a textured electro- conductive film linked to the substrate.
摘要翻译：本发明提供了一种全溶液电极制造工艺。该工艺包括以下步骤：i）制备并激活用于沉积导电膜的可收缩聚合物基底; ii）修饰底物以掺入接头; iii）将导电材料的颗粒固定在基底的连接体上以在基底上形成导电膜; 和vi）将改性基材加热到足以引起聚合物基材收缩并在导电膜中导致微米和/或纳米纹理化的温度。该方法有利地产生了包含聚合物基材的新型多尺度电极装置; 和连接到基板的纹理导电膜。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式