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1. 发明申请

WO2008109424A1 COMPOSITION, THERAPY AND DEVICE FOR TREATMENT OF NAIL INFECTIONS 审中-公开
标题翻译：用于治疗指甲感染的组合物，治疗和装置
公开(公告)号：WO2008109424A1
公开(公告)日：2008-09-12
申请号：PCT/US2008/055473
申请日：2008-02-29
申请人： ONDINE INTERNATIONAL LTD. , LOEBEL, Nicholas, G. , MCKENZIE, Fergus, R. , STREET, Cale , ANDERSEN, Roger , SCOTT, Robert
发明人： LOEBEL, Nicholas, G. , MCKENZIE, Fergus, R. , STREET, Cale , ANDERSEN, Roger , SCOTT, Robert
IPC分类号： A61K9/10 , A61K31/125 , A61K31/045 , A61K41/00
CPC分类号： A61K31/045 , A61K31/125 , A61K41/0057 , A61N5/062 , A61N2005/0645 , A61N2005/0652
摘要： The present invention includes a composition for treating fungal infections, particularly onychomycosis. The composition includes a photosensitizer, an effective amount of' antifungal agent, and a pharmaceutically acceptable delivery system. The present invention also includes use of an antifungal, composition and/or a photosensitizer in the manufacture of a medicament for treating dermatophytic fungal infection comprising applying a composition includes a photosensitizer, an effective amount of antifungal agent, and a pharmaceutically acceptable delivery system to a locus and irradiating the locus with a light source at a wavelength absorbed by the photosensitizer so as to destroy microbes at the locus.
摘要翻译：本发明包括用于治疗真菌感染，特别是甲真菌病的组合物。该组合物包括光敏剂，有效量的“抗真菌剂”和药学上可接受的递送系统。本发明还包括抗真菌剂，组合物和/或光敏剂在制备用于治疗皮肤真菌性真菌感染的药物中的应用，包括将组合物包括光敏剂，有效量的抗真菌剂和药学上可接受的递送系统并用光敏元件吸收的波长照射该场所，从而破坏该场所的微生物。

2. 发明申请

WO2009018205A1 PHOTODISINFECTION OF ORAL CAVITY 审中-公开
标题翻译：口腔光致发光
公开(公告)号：WO2009018205A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/071328
申请日：2008-07-28
申请人： ONDINE INTERNATIONAL LTD. , LOEBEL, Nicholas, G. , STREET, Cale
发明人： LOEBEL, Nicholas, G. , STREET, Cale
IPC分类号： A61C19/06 , A61K8/11 , A61N5/06
CPC分类号： A61N5/0603 , A61K8/11 , A61K8/49 , A61K2800/412 , A61K2800/81 , A61N5/0601 , A61N5/062 , A61N5/0624 , A61N2005/0606 , A61Q11/00
摘要： A composition for photodisinfection of the oral cavity comprising toothpaste and a photosensitizing composition encapsulated within microspheres, wherein the microspheres release the photosensitizing composition into the oral cavity upon contact with liquid and/or force and the photosensitizing composition includes a photosensitizer that upon irradiation of at least one predetermined wavelength will reduce and/or eliminate microbes in the oral cavity. The present invention also includes a method of applying the composition into the oral cavity and applying irradiation to the oral cavity at a wavelength or wavelengths absorbed by the photosensitizing composition so as to reduce or eliminate microbes in the oral cavity.
摘要翻译：一种用于口腔光学消毒的组合物，其包含牙膏和包封在微球内的光敏组合物，其中所述微球体在与液体和/或力接触时将光敏组合物释放到口腔中，并且光敏组合物包含光敏剂，一个预定波长将减少和/或消除口腔中的微生物。本发明还包括将组合物施用到口腔中并以由光敏组合物吸收的波长或波长对口腔照射以减少或消除口腔中的微生物的方法。

3. 发明申请

WO2009048868A1 PHOTODYNAMIC THERAPY PROCESS AND PHOTOSENSITIZER COMPOSITIONS 审中-公开
标题翻译：光化疗法和光敏剂组合物
公开(公告)号：WO2009048868A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079050
申请日：2008-10-07
申请人： ONDINE INTERNATIONAL LTD. , LOEBEL, Nicholas , STREET, Cale
发明人： LOEBEL, Nicholas , STREET, Cale
IPC分类号： A61K31/5415 , A61K41/00 , A61P31/04 , A61K35/00
CPC分类号： A61K31/5415 , A61K41/0057 , Y02A50/473
摘要： Use of a photosensitizer composition in the manufacture of a medicament for photodynamic therapy and a process for photodynamic therapy are provided along with a photosensitizer composition suitable for the use and the process. The photosensitizer composition comprises at least one photoactive ingredient in a chemically reduced state. According to the use, the photosensitizer composition having at least one photoactive ingredient in a chemically reduced state is provided. The photosensitizer composition is applied to tissue or other substrate such that the at least one photoactive ingredient is at or travels to a location adjacent a target medium and the at least one photoactive ingredient is then altered to a photoactive state. The at least one photoactive ingredient is then exposed to light energy for assisting in inhibiting at least one pathogen at the target medium. The prefered photosensitizer is methylene blue. It is preferably reduced by ascorbic acid.
摘要翻译：提供光敏剂组合物在制造用于光动力疗法的药物中的用途以及光动力疗法的方法以及适合于使用和过程的光敏剂组合物。光敏剂组合物包含至少一种化学还原状态的光活性成分。根据该用途，提供具有化学还原状态的至少一种光活性成分的光敏剂组合物。将光敏剂组合物施用于组织或其他底物，使得至少一种光活性成分处于或移动到与靶介质相邻的位置，然后将至少一种光活性成分改变为光活性状态。然后将至少一种光活性成分暴露于光能以帮助抑制目标培养基上的至少一种病原体。优选的光敏剂是亚甲基蓝。优选由抗坏血酸还原。

4. 发明申请

WO2010014676A1 COMPOSITION AND METHOD FOR TREATMENT OF MRSA 审中-公开
标题翻译：用于治疗MRSA的组合物和方法
公开(公告)号：WO2010014676A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/052059
申请日：2009-07-29
申请人： ONDINE INTERNATIONAL LTD. , STREET, Cale , LOEBEL, Nicolas , PEDIGO, Lisa
发明人： STREET, Cale , LOEBEL, Nicolas , PEDIGO, Lisa
IPC分类号： A61K31/155 , A61K41/00 , A61P31/00
CPC分类号： A61K31/155 , A61K41/0057 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： The present invention provides a photosensitizing composition for treatment of MRSA comprising a photosensitizer and chlorhexidine and a pharmaceutically acceptable carrier. The present invention also provides a method for reducing disease causing microbes comprising: applying the composition comprising a photosensitizer, chlorhexidine at a concentration of more than about 0.01% and less than about 2% v/v, and a pharmaceutically acceptable carrier to a treatment site; and applying light to the treatment site at a wavelength absorbed by the photosensitizer so as to reduce the microbes at the treatment site.
摘要翻译：本发明提供了一种用于治疗MRSA的光敏组合物，其包含光敏剂和洗必太和药学上可接受的载体。本发明还提供了一种减少引起疾病的微生物的方法，其包括：将含有浓度大于约0.01％且小于约2％v / v的光敏剂，洗必泰和包含药学上可接受的载体的组合物施用于治疗部位 ; 并以由光敏剂吸收的波长向处理部位施加光，以便减少处理部位的微生物。

5. 发明申请

WO2010107454A1 COMPOSITION FOR PHOTODYNAMIC DISINFECTION 审中-公开
标题翻译：用于光化学消毒的组合物
公开(公告)号：WO2010107454A1
公开(公告)日：2010-09-23
申请号：PCT/US2009/061442
申请日：2009-10-21
申请人： ONDINE INTERNATIONAL LTD. , STREET, Cale , PEDIGO, Lisa , LOEBEL, Nicolas
发明人： STREET, Cale , PEDIGO, Lisa , LOEBEL, Nicolas
IPC分类号： A61K41/00 , A61P31/04
CPC分类号： A61K41/0057
摘要： The present invention includes a composition for enhancing the antimicrobial efficacy of photodynamic disinfection against Gram-negative organism that is receptive to paraben potentiation using a composition comprising a photosensitizer and at least one paraben. The present invention also includes a method for photodynamic disinfection comprising applying the composition to a desired treatment area and applying light to the desired treatment area at a wavelength absorbed by the photosensitizer so as to inhibit Gram-negative organism located within the treatment area wherein the Gram-negative organism is receptive to paraben potentiation.
摘要翻译：本发明包括用于增强光动力消毒对抗革兰氏阴性生物的抗微生物效能的组合物，其使用包含光敏剂和至少一种对羟基苯甲酸酯的组合物接受对羟基苯甲酸酯增强。本发明还包括一种光动力消毒方法，包括将组合物施加到所需的治疗区域，并以光敏剂吸收的波长将光照射到所需的治疗区域，以便抑制位于治疗区域内的革兰氏阴性生物体，其中革兰氏 - 阴性生物体接受对羟基苯甲酸酯增强。

6. 发明申请

WO2008073804A3 MEDICAMENT FOR WOUND DISINFECTION AND TISSUE WELDING 审中-公开
公开(公告)号：WO2008073804A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/086630
申请日：2007-12-06
申请人： ONDINE INTERNATIONAL LTD. , STREET, Cale , LOEBEL, Nicolas, G.
发明人： STREET, Cale , LOEBEL, Nicolas, G.
IPC分类号： A61B17/00 , A61B18/20
摘要： The present invention includes a method of treating a wound, and the use of a photosensitizer composition in the manufacture of a medicament for treating a wound, that includes both disinfecting the wound using light and welding the tissue of the wound using light. In a preferred embodiment, the tissue welding occurs substantially immediately after disinfection. The method and/or use includes applying a photosensitizer to the wound, illuminating the wound with light, closing the wound, and illuminating the wound a second time. A solder is optionally applied to wound after the first illumination and before the closing of the wound.

7. 发明申请

WO2007127894A3 PHOTODISINFECTION DELIVERY DEVICES & METHODS 审中-公开
公开(公告)号：WO2007127894A3
公开(公告)日：2007-11-08
申请号：PCT/US2007/067583
申请日：2007-04-27
申请人： ONDINE INTERNATIONAL LTD. , ROSE, Andreas , LOEBEL, Nicolas, G. , HERR, Guenter , JOHNSTON, Kyle , STREET, Cale , ANDERSON, Roger
发明人： ROSE, Andreas , LOEBEL, Nicolas, G. , HERR, Guenter , JOHNSTON, Kyle , STREET, Cale , ANDERSON, Roger
IPC分类号： A61N5/06
摘要： The present invention presents devices, kits, systems and methods that can be used to deliver and activate a photosensitizing composition in a cavity. For example, a device (100) of the present invention includes a member (10) having a base portion (11), an insert portion (13) adapted for insertion into the cavity, and a pocket (12) adapted for communication with a waveguide (14) which is connected to a light source (20) for delivering light to the device (100), wherein the pocket (12) includes a light dispersing section (18) that is adapted for light communication with distal end (16) of the waveguide (14) and desired illumination pattern for photodisinfection of the cavity is provided by at least one of the elements selected from the group consisting of: surface finish of the light dispersing section (18), geometry of the light dispersing section (18), surface finish of the member (10), geometry of the member (10), and a combination thereof. The present invention can be used for humans, other animals, and inanimate objects.

8. 发明申请

WO2009154878A1 METHOD AND DEVICE FOR ELIMINATING MICROBES WITHIN INDUSTRIAL PIPELINES 审中-公开
标题翻译：用于消除工业管道中微生物的方法和装置
公开(公告)号：WO2009154878A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/041928
申请日：2009-04-28
申请人： BIOCORROSION SOLUTIONS INC. , STREET, Cale , RIDGE, Joe , LOEBEL, Nicolas , ANDERSEN, Roger
发明人： STREET, Cale , RIDGE, Joe , LOEBEL, Nicolas , ANDERSEN, Roger
IPC分类号： B08B9/04 , C23G3/04 , A61L2/16 , A61L2/18
CPC分类号： A61L2/084 , A61L2/18 , B08B9/0553
摘要： The present invention provides a method to inhibit microbes located within a pipeline comprising: applying a photosensitizer composition to a predetermined interior surface area of the pipeline where microbes are located; and applying light to the area at a wavelength that is absorbed by the photosensitizer composition so as to inhibit or eliminate the microbes; wherein the light is applied by a photodynamic disinfection device adapted to provide light to the area. The present invention also provided a photodynamic disinfection device comprising a pipeline inspection gauge (pig) adapted to include a circumferential high energy light source and an energy source wherein the light source is in communication with and powered by the energy source via communication means.
摘要翻译：本发明提供一种抑制位于管线内的微生物的方法，包括：将光敏剂组合物施用到微生物所在管道的预定内表面区域; 以及在由所述光敏剂组合物吸收的波长处对所述区域施加光，以抑制或消除所述微生物; 其中所述光通过适于向所述区域提供光的光动力消毒装置施加。本发明还提供了一种光动力消毒装置，其包括适于包括周向高能光源和能量源的管线检查计（pig），其中光源通过通信装置与能源通信并由其供电。

9. 发明申请

WO2014047399A3 DEVICE FOR STORING AND SMOKING TOBACCO AND TOBACCO-RELATED PRODUCTS IN AN INCLEMENT WEATHER ENVIRONMENT 审中-公开
公开(公告)号：WO2014047399A3
公开(公告)日：2014-03-27
申请号：PCT/US2013/060844
申请日：2013-09-20
申请人： STREET, Cale
发明人： STREET, Cale , BEHAR, Mark , SPRAGUE, Sacha
IPC分类号： A24F13/12 , A24F47/00
摘要： The present invention provides a hand worn smoking device (100) comprising a glove (2) having a burning reservoir (4) tor containing substance to be smoked (10), a reservoir closing feature (5), a smoke transport pathway (6), and an oral interface (8) wherein the burning reservoir (4) is connected to the oral interface (8) via the smoke transport pathway (6) allowing the burning reservoir (6) to be In smoke communication with the oral interface (8) during use. The present invention also includes a method of smoking the substance to be smoked (10) using this device (100).

10. 发明申请

WO2010036617A1 PORTABLE PHOTODYNAMIC DISINFECTION LIGHT DELIVERY DEVICE FOR CATHETER DISINFECTION 审中-公开
标题翻译：便携式消毒灯光消毒装置
公开(公告)号：WO2010036617A1
公开(公告)日：2010-04-01
申请号：PCT/US2009/057699
申请日：2009-09-21
申请人： ONDINE INTERNATIONAL HOLDINGS LTD. , STREET, Cale , LEDUC, Pierre , LEACY, Carol , LATHAM, Marcus, Alan
发明人： STREET, Cale , LEDUC, Pierre , LEACY, Carol , LATHAM, Marcus, Alan
IPC分类号： A61L2/08 , A61L2/10 , A61L2/26
CPC分类号： A61L2/10 , A61L2202/16 , A61L2202/24 , A61M2039/167 , A61N5/062 , A61N2005/0652
摘要： The present invention provides a portable photodynamic disinfection light delivery device (100) comprising: two opposing light sources (26, 28), an energy source (34) to supply energy to the light sources (26, 28), and a housing (8) for receiving the two light sources (26, 28) and the energy source (34); wherein (i) the housing 8 includes two members (10, 12) each having a clamp portion (14, 16) for receiving one of the two light sources (26, 28) and an attachment mean (18) connecting the clamp portions (14, 16); (ii) the clamp portions (14, 16) during photodynamic disinfection surround a catheter disinfection site (20); and (iii) the two light sources (26, 28) together provide circumferential illumination at least one wavelength that can activate at least one photosensitizer so as to reduce microbes located at the catheter disinfection site (20). The present invention provides a catheter disinfection method comprising: applying circumferential illumination at a wavelength that activates a photosensitizer located at a catheter disinfection site (20) so as to reduce microbes located at the catheter disinfection site (20) using the portable photodynamic disinfection light device (100) described above.
摘要翻译：本发明提供了一种便携式光动力消毒灯输送装置（100），包括：两个相对的光源（26,28），用于向光源（26,28）供应能量的能量源（34）），用于接收两个光源（26,28）和能量源（34）; 其中（i）壳体8包括两个构件（10,12），每个构件具有用于容纳两个光源（26,28）中的一个的夹持部分（14,16）和连接夹持部分 14，16）; （ii）光动力消毒期间的夹持部分（14,16）围绕导管消毒部位（20）; 和（iii）两个光源（26,28）一起提供至少一个波长的圆周照明，其可以激活至少一个光敏剂，以便减少位于导管消毒部位（20）处的微生物。本发明提供一种导管消毒方法，包括：以激活位于导管消毒部位（20）处的光敏剂的波长施加圆周照明，以便使用便携式光动力消毒灯装置来减少位于导管消毒部位（20）处的微生物（100）。

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