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1. 发明申请

WO2010014676A1 COMPOSITION AND METHOD FOR TREATMENT OF MRSA 审中-公开
标题翻译：用于治疗MRSA的组合物和方法
公开(公告)号：WO2010014676A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/052059
申请日：2009-07-29
申请人： ONDINE INTERNATIONAL LTD. , STREET, Cale , LOEBEL, Nicolas , PEDIGO, Lisa
发明人： STREET, Cale , LOEBEL, Nicolas , PEDIGO, Lisa
IPC分类号： A61K31/155 , A61K41/00 , A61P31/00
CPC分类号： A61K31/155 , A61K41/0057 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： The present invention provides a photosensitizing composition for treatment of MRSA comprising a photosensitizer and chlorhexidine and a pharmaceutically acceptable carrier. The present invention also provides a method for reducing disease causing microbes comprising: applying the composition comprising a photosensitizer, chlorhexidine at a concentration of more than about 0.01% and less than about 2% v/v, and a pharmaceutically acceptable carrier to a treatment site; and applying light to the treatment site at a wavelength absorbed by the photosensitizer so as to reduce the microbes at the treatment site.
摘要翻译：本发明提供了一种用于治疗MRSA的光敏组合物，其包含光敏剂和洗必太和药学上可接受的载体。本发明还提供了一种减少引起疾病的微生物的方法，其包括：将含有浓度大于约0.01％且小于约2％v / v的光敏剂，洗必泰和包含药学上可接受的载体的组合物施用于治疗部位 ; 并以由光敏剂吸收的波长向处理部位施加光，以便减少处理部位的微生物。

2. 发明申请

WO2010107454A1 COMPOSITION FOR PHOTODYNAMIC DISINFECTION 审中-公开
标题翻译：用于光化学消毒的组合物
公开(公告)号：WO2010107454A1
公开(公告)日：2010-09-23
申请号：PCT/US2009/061442
申请日：2009-10-21
申请人： ONDINE INTERNATIONAL LTD. , STREET, Cale , PEDIGO, Lisa , LOEBEL, Nicolas
发明人： STREET, Cale , PEDIGO, Lisa , LOEBEL, Nicolas
IPC分类号： A61K41/00 , A61P31/04
CPC分类号： A61K41/0057
摘要： The present invention includes a composition for enhancing the antimicrobial efficacy of photodynamic disinfection against Gram-negative organism that is receptive to paraben potentiation using a composition comprising a photosensitizer and at least one paraben. The present invention also includes a method for photodynamic disinfection comprising applying the composition to a desired treatment area and applying light to the desired treatment area at a wavelength absorbed by the photosensitizer so as to inhibit Gram-negative organism located within the treatment area wherein the Gram-negative organism is receptive to paraben potentiation.
摘要翻译：本发明包括用于增强光动力消毒对抗革兰氏阴性生物的抗微生物效能的组合物，其使用包含光敏剂和至少一种对羟基苯甲酸酯的组合物接受对羟基苯甲酸酯增强。本发明还包括一种光动力消毒方法，包括将组合物施加到所需的治疗区域，并以光敏剂吸收的波长将光照射到所需的治疗区域，以便抑制位于治疗区域内的革兰氏阴性生物体，其中革兰氏 - 阴性生物体接受对羟基苯甲酸酯增强。

3. 发明申请

WO2009154878A1 METHOD AND DEVICE FOR ELIMINATING MICROBES WITHIN INDUSTRIAL PIPELINES 审中-公开
标题翻译：用于消除工业管道中微生物的方法和装置
公开(公告)号：WO2009154878A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/041928
申请日：2009-04-28
申请人： BIOCORROSION SOLUTIONS INC. , STREET, Cale , RIDGE, Joe , LOEBEL, Nicolas , ANDERSEN, Roger
发明人： STREET, Cale , RIDGE, Joe , LOEBEL, Nicolas , ANDERSEN, Roger
IPC分类号： B08B9/04 , C23G3/04 , A61L2/16 , A61L2/18
CPC分类号： A61L2/084 , A61L2/18 , B08B9/0553
摘要： The present invention provides a method to inhibit microbes located within a pipeline comprising: applying a photosensitizer composition to a predetermined interior surface area of the pipeline where microbes are located; and applying light to the area at a wavelength that is absorbed by the photosensitizer composition so as to inhibit or eliminate the microbes; wherein the light is applied by a photodynamic disinfection device adapted to provide light to the area. The present invention also provided a photodynamic disinfection device comprising a pipeline inspection gauge (pig) adapted to include a circumferential high energy light source and an energy source wherein the light source is in communication with and powered by the energy source via communication means.
摘要翻译：本发明提供一种抑制位于管线内的微生物的方法，包括：将光敏剂组合物施用到微生物所在管道的预定内表面区域; 以及在由所述光敏剂组合物吸收的波长处对所述区域施加光，以抑制或消除所述微生物; 其中所述光通过适于向所述区域提供光的光动力消毒装置施加。本发明还提供了一种光动力消毒装置，其包括适于包括周向高能光源和能量源的管线检查计（pig），其中光源通过通信装置与能源通信并由其供电。

4. 发明申请

WO2006019510A1 METHOD OF MAKING A FIBER OPTIC PROBE TIP FOR USE IN A MEDICAL DEVICE 审中-公开
标题翻译：制造用于医疗设备的光纤探头提示的方法
公开(公告)号：WO2006019510A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/022336
申请日：2005-06-23
申请人： ONDINE INTERNATIONAL LTD. , LOEBEL, Nicolas
发明人： LOEBEL, Nicolas
IPC分类号： A61B18/22
CPC分类号： G02B6/262 , A61B18/22 , A61B2018/2261 , Y10T29/4902
摘要： The invention described here is an improved fiber optic probe (10). The tip of the probe (10) is made from a transparent fill material (18) that is connected to the end (14) of a conventional optical fiber (12). The optical fiber (12) is tapered, the fill material (18) is connected thereto, and typically extends outwardly from the fiber (12) as though it is a continuous part of the fiber (12). The outer diameter of the fill material (18) is preferably essentially the same as the optical fiber (12). The fill material (18) may contain light-scattering elements that disperse light as it exits the fiber (12).
摘要翻译：这里描述的发明是改进的光纤探针（10）。探针（10）的尖端由连接到常规光纤（12）的端部（14）的透明填充材料（18）制成。光纤（12）是锥形的，填充材料（18）连接到其上，并且通常从纤维（12）向外延伸，就好像它是纤维（12）的连续部分。填充材料（18）的外径优选与光纤（12）基本相同。填充材料（18）可以包含在其离开纤维（12）时分散光的光散射元件。

5. 发明申请

WO2006022970A1 SONOPHOTODYNAMIC THERAPY FOR DENTAL APPLICATIONS 审中-公开
标题翻译：用于牙科应用的SONOPHOTODYNAMIC治疗
公开(公告)号：WO2006022970A1
公开(公告)日：2006-03-02
申请号：PCT/US2005/019707
申请日：2005-06-03
申请人： ONDINE INTERNATIONAL LTD. , LOEBEL, Nicolas , MARTIN, Roy, Wallace , ROSE, Andreas
发明人： LOEBEL, Nicolas , MARTIN, Roy, Wallace , ROSE, Andreas
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61C1/088 , A61C17/02 , A61C17/20 , A61N5/0601 , A61N2005/0606
摘要： The present invention includes methods for killing microbes in an oral cavity or wound comprising: applying a photosensitizing composition to a locus or a wound (102); applying a fluid and sonic energy to the locus or wound (104); and irradiating the locus or wound with a light source at a wavelength absorbed by the photosensitizing composition so as to destroy microbes at the locus or wound (106). The present invention also include methods for killing microbes in an oral cavity or wound comprising: applying a photosensitizing composition to a locus or a wound (202); and applying sufficient sonic energy to the locus or wound in order to provide acoustic cavitation so as to destroy microbes at the locus or wound (204). The present invention further provides an apparatus for providing sonophotodynamic therapy includes one or more members (12) in communication with one or more of the following: a sonic energy source (20); a therapeutic fluid source (26) and a light source (22).
摘要翻译：本发明包括杀死口腔或伤口中的微生物的方法，包括：将光敏组合物施用于场所或伤口（102）; 向所述场所或伤口施加流体和声波能量（104）; 用光敏组合物吸收的波长的光源照射所述轨迹或者伤口，以破坏所述场所或伤口处的微生物（106）。本发明还包括在口腔或伤口中杀死微生物的方法，包括：将光敏组合物施用于场所或伤口（202）; 并向轨迹或伤口施加足够的声能，以提供声空化，从而破坏位点或伤口处的微生物（204）。本发明还提供一种用于提供超声波动力疗法的装置，包括与以下一种或多种相通的一个或多个构件（12）：声能量源（20）; 治疗流体源（26）和光源（22）。

6. 发明申请

WO2006004644A1 OPTICAL SCANNER 审中-公开
标题翻译：光学扫描仪
公开(公告)号：WO2006004644A1
公开(公告)日：2006-01-12
申请号：PCT/US2005/022694
申请日：2005-06-28
申请人： LOEBEL, Nicolas , ROSE, Andreas , GITLIN, Mark , MELVILLE, David
发明人： LOEBEL, Nicolas , ROSE, Andreas , GITLIN, Mark , MELVILLE, David
IPC分类号： G02B7/182 , G02B26/10
CPC分类号： G02B26/105 , G02B7/1821 , G02B26/10 , H02K33/12 , H02K33/16
摘要： An optical scanner 100 comprising stators 38, 40 spaced apart from each other but ferromagnetically coupled together; a magnet 9 positioned relative to the stators 38, 40 such that axis of symmetry of a magnetic field created by the magnet 9 is substantially equidistant from and passes in between the stators 38, 40; and a flexure element 11 positioned relative to the stators 38, 40 and the magnet 9 such that its center point substantially intersects axis of symmetry of the magnet's 9 magnetic field, wherein the flexure element 11 is not in physical contact with either the stators 38, 40 or the magnet 9. A method for oscillating an optical scanner's flexure element comprising using a magnet 9 disposed between two stators 38, 40 and beneath the flexure element 11 to create two magnetic circuits 30, 31 that are generally symmetric and coplanar with one another, wherein a portion of the circuits share a common magnetic path through the magnet 9 and remaining, non-common paths of the circuits 30, 31 through the stators 38, 40 are counter-directional relative to each other; applying electromagnetic flux to such circuits 30, 31 via stator electrical coils 5, 6 enhancing flux through one circuit 30 or 31 while impeding flux through the other circuit 30 or 31 and keeping the stator-induced flux vector through the magnet 9 unchanged; and reversing polarity of the stator-induced electromagnetic flux at a regular frequency in order to oscillate the flexure element 11.
摘要翻译：光学扫描器100包括彼此间隔开但铁磁耦合在一起的定子38,40; 相对于定子38,44定位的磁体9，使得由磁体9产生的磁场的对称轴线基本上与定子38,40之间等距并且通过定子38,40; 以及相对于定子38,40和磁体9定位的挠曲元件11，使得其中心点基本上与磁体9的磁场的对称轴线相交，其中，挠曲元件11不与定子38,34,40和 40或磁体9.一种用于振荡光学扫描仪的挠曲元件的方法，包括使用设置在两个定子38,40之间的磁体9并且在挠曲元件11下方形成两个彼此大致对称和共面的磁路30,31 其中一部分电路共享通过磁体9的公共磁路，并且电路30,31的剩余的非公共路径通过定子38,40相对于彼此是相反方向的; 通过定子电线圈5,6向这种电路30,31施加电磁通量，增强通过一个电路30或31的磁通，同时阻碍通过另一个电路30或31的磁通，并且使定子感应的磁通矢量保持不变; 并以正常频率反转定子感应电磁通量的极性，以便使挠曲元件11振荡。

7. 发明申请

WO2015073953A1 METHOD OF SINUSITIS TREATMENT 审中-公开
标题翻译：神经细胞治疗方法
公开(公告)号：WO2015073953A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/065914
申请日：2014-11-17
申请人： SINUWAVE TECHNOLOGIES, INC. , ANDERSEN, Roger , DESROSIERS, Martin, Yvon , LOEBEL, Nicolas
发明人： ANDERSEN, Roger , DESROSIERS, Martin, Yvon , LOEBEL, Nicolas
IPC分类号： A61M29/00 , A61B17/24 , A61M25/00
CPC分类号： A61M25/10 , A61B17/24 , A61M2025/105 , A61M2025/107 , A61M2025/1084 , A61M2202/0014 , A61M2202/20 , A61M2202/203 , A61M2202/206 , A61M2210/0618 , A61M2210/0681 , A61M2210/1089
摘要： The present invention provides a method to treat sinusitis, a method for improved medication delivery to the sinus mucosa, and a method for staunching bleeding of the sinus mucosa comprising of comprising compressing sinus mucosa of a sinus of a patient against bone tissue of the sinus to a predetermined level without damaging the bone tissue. The present invention further provides a method to treat nasal polyposis comprising compressing nasal polyps contained within the nasal cavity against its lining to reduce volume of the nasal polyps. The present invention provides a method to treat chronic urethral syndrome comprising compressing interior surfaces of an urethra in order to stimulate and cause excretion out of urethral mucosa located along length of the urethra, The present invention further provides additional methods relating to drug delivery and visualization.
摘要翻译：本发明提供了一种治疗鼻窦炎的方法，改善向鼻窦粘膜的药物输送的方法，以及用于猝死窦粘膜出血的方法，包括将患者窦的窦粘膜压制成窦的骨组织，预定水平而不破坏骨组织。本发明还提供一种治疗鼻息肉病的方法，其包括将鼻腔内包含的鼻息肉压在其内衬上以减少鼻息肉的体积。本发明提供了一种治疗慢性尿道综合症的方法，其包括压缩尿道的内表面，以便刺激和排出尿道粘膜，尿道粘膜位于沿尿道长度的位置。本发明还提供了与药物递送和可视化有关的其它方法。

8. 发明申请

WO2013177043A1 CATHETER FOR PHOTODYNAMIC THERAPY 审中-公开
标题翻译：用于光电疗法的导管
公开(公告)号：WO2013177043A1
公开(公告)日：2013-11-28
申请号：PCT/US2013/041831
申请日：2013-05-20
申请人： SINUWAVE TECHNOLOGIES, INC. , LOEBEL, Nicolas , BIEL, Merrill , CALLAHAN MORGENS, Soja-Marie
发明人： LOEBEL, Nicolas , BIEL, Merrill , CALLAHAN MORGENS, Soja-Marie
IPC分类号： A61M25/00 , A61N5/06
CPC分类号： A61M3/0283 , A61M25/0026 , A61M25/003 , A61M25/0054 , A61M25/0069 , A61M25/007 , A61M25/0097 , A61M2025/0039 , A61N5/062
摘要： The present invention provides a multi-functional catheter ISO that can be used to irrigate a treatment site located within a body cavity, to suction waste materials from the treatment site, and to deliver a treatment composition in a generally uniform distribution pattern onto the treatment site. The present invention also provides a method to use this multi-functional catheter for various applications including medical applications (e.g., photodynsmic therapy treatment of chronic recurrent sinusitis).
摘要翻译：本发明提供了一种多功能导管ISO，其可用于冲洗位于体腔内的治疗部位，从处理部位抽吸废物材料，并将处于大致均匀分布模式的治疗组合物递送至治疗部位。本发明还提供了一种使用该多功能导管用于各种应用的方法，包括医疗应用（例如，慢性复发性鼻窦炎的光神经治疗治疗）。

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