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1. 发明申请

WO2011068563A1 USES OF HYPOXIA-INDUCIBLE FACTOR INHIBITORS 审中-公开
标题翻译： HYPOXIA诱导因子抑制剂的使用
公开(公告)号：WO2011068563A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/039910
申请日：2010-06-25
申请人： ONCOIMMUNE INC. , SUNVITA THERAPEUTICS, LLC. , LIU, Yang , WANG, Yin , LIU, Yan , MALEK, Sami, N. , ZENG, Pan
发明人： LIU, Yang , WANG, Yin , LIU, Yan , MALEK, Sami, N. , ZENG, Pan
IPC分类号： A61K31/00
CPC分类号： A61K38/07 , A61K31/00 , A61K31/395 , A61K31/4355 , A61K31/498 , A61K31/565 , A61K38/08 , A61K45/06 , A61K2300/00
摘要： The present invention relates to treating a hematologic cancer using a Hypoxia- Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.
摘要翻译：本发明涉及使用缺氧诱导因子（HIF抑制剂）治疗血液癌症。本发明还涉及使用HIF抑制剂诱导急性骨髓性白血病缓解。本发明还涉及使用HIF抑制剂抑制癌症干细胞（CSC）的维持或存活功能。

2. 发明申请

WO2008141282A2 MATERIALS AND METHODS FOR FOXP3 TUMOR SUPPRESSION 审中-公开
标题翻译： FOXP3肿瘤抑制的材料与方法
公开(公告)号：WO2008141282A2
公开(公告)日：2008-11-20
申请号：PCT/US2008/063419
申请日：2008-05-12
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , LIU, Yan , ZHENG, Pan , CHANG, Xing , WANG, Lizhong , LIU, Runhua , WANG, Yin , LIU, Yang , ZUO, Tao
发明人： LIU, Yan , ZHENG, Pan , CHANG, Xing , WANG, Lizhong , LIU, Runhua , WANG, Yin , LIU, Yang , ZUO, Tao
CPC分类号： G01N33/57415 , A61K31/7088 , A61K38/1709 , A61K45/06 , G01N33/57434 , A61K2300/00
摘要： Provided herein are methods of treating a cancer in a subject comprising administering a F0XP3 protein, a nucleic acid encoding a F0XP3 protein, or an inducing compound which induces FOXP3 protein expression. Methods of altering a phenotype of a cancer cell or tumor cell, methods of inhibiting growth of such cells, and methods of inducing apoptosis of these cells are also provided herein. These methods comprise contacting the cell with a F0XP3 protein, a nucleic acid encoding a F0XP3 protein, or an inducing compound which induces F0XP3 protein expression. Further provided herein are diagnostic methods, comprising comparing the expression or structure of a F0XP3 protein or F0XP3 gene in a test sample to that of a normal or prior sample. A method of screeing a test compound for anti-cancer activity comprising administering to cells the test compound and measuring F0XP3 protein or F0XP3 gene expression is moreover provided herein.
摘要翻译：本文提供了治疗受试者中的癌症的方法，包括施用F0XP3蛋白，编码F0XP3蛋白的核酸或诱导FOXP3蛋白表达的诱导化合物。本文还提供了改变癌细胞或肿瘤细胞表型的方法，抑制细胞生长的方法和诱导细胞凋亡的方法。这些方法包括使细胞与F0XP3蛋白，编码F0XP3蛋白的核酸或诱导F0XP3蛋白表达的诱导化合物接触。本文进一步提供了诊断方法，其包括将测试样品中F0XP3蛋白或F0XP3基因的表达或结构与正常或先前样品的表达或结构进行比较。本发明提供了一种筛选测试化合物用于抗癌活性的方法，其包括向细胞施用测试化合物并测量F0XP3蛋白或F0XP3基因表达。

3. 发明申请

WO2006052911A3 LAFORIN EXPRESSION IN DIAGNOSIS AND TREATMENT OF CANCER AND OTHER DISEASES 审中-公开
公开(公告)号：WO2006052911A3
公开(公告)日：2006-05-18
申请号：PCT/US2005/040338
申请日：2005-11-07
申请人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , ZHENG, Pan , LIU, Yang , WANG, Yin , LIU, Yan
发明人： ZHENG, Pan , LIU, Yang , WANG, Yin , LIU, Yan
IPC分类号： C12Q1/68 , A61K38/00 , A61K48/00
摘要： Methods of characterizing the etiology of a cancer and other human diseases comprising testing at least one cell for the presence of at least one of a) methylation of EPM2A gene; b) reduced expression of EPM2A gene; and c) mutation of EPM2A gene. Methods of treating cancer and other diseases are also provided.

4. 发明申请

WO2007002733A2 CELLUOSIC PRODUCTS COMPRISING SUBSTANTIALLY VOC-FREE COMPOSITIONS 审中-公开
标题翻译：包含非挥发性无挥发成分的细胞产品
公开(公告)号：WO2007002733A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/025109
申请日：2006-06-27
申请人： CHEMCO, INC. , WANG, Yin , JIANG, Wenbo
发明人： WANG, Yin , JIANG, Wenbo
IPC分类号： B32B29/06
CPC分类号： C08L97/02 , B27K3/15 , B27K5/02 , B27K5/065 , C08L61/24 , Y10T428/249924
摘要： Embodiments of a composition useful for forming cellulosic products are disclosed, as well as products made using disclosed compositions. One disclosed composition comprises effective amount of dihydroxyethylene urea(s), dihydroxypropanol ureas, glycoluril(s), or combinations thereof. Such compositions can be cross linked, or not. The compositions can include other materials, such as methylol melamine; maltodextrin, where the DE of the maltodextrin can vary from about 4 to about 25, optional auxiliary additives, including a surfactant; a trialkanolamine, a preservative, a fire retardant; an aesthetic material, such as a dye that, in certain embodiments, substantially completely penetrates the cross section of the board product; a hardness enhancer; and any and all combinations of such materials. One embodiment of a disclosed method for making a cellulosic product comprises first providing a disclosed composition and applying it to cellulosic material, such as by substantially immersing cellulosic material in desired compositions in an autoclave.
摘要翻译：公开了用于形成纤维素产品的组合物的实施方案，以及使用所公开的组合物制备的产品。一种公开的组合物包含有效量的二羟基亚乙基脲，二羟基丙基脲，甘脲或其组合。这样的组合物可以是交联的或不交联的。组合物可以包括其它材料，例如羟甲基三聚氰胺; 麦芽糖糊精，其中麦芽糖糊精的DE可以在约4至约25之间变化，任选的辅助添加剂，包括表面活性剂; 三烷醇胺，防腐剂，阻燃剂; 美学材料，例如染料，其在某些实施方案中基本上完全渗透板产品的横截面; 硬度增强剂以及这些材料的任何和所有组合。公开的制造纤维素产品的方法的一个实施方案包括首先提供所公开的组合物并将其施加到纤维素材料上，例如通过将高分子化合物中的纤维素材料基本上浸入所需的组合物中。

5. 发明申请

WO2009012190A1 WOOD-DRYING SOLAR GREENHOUSE 审中-公开
标题翻译：木材干燥太阳能温室
公开(公告)号：WO2009012190A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/069905
申请日：2008-07-13
申请人： WANG, Yin
发明人： WANG, Yin
IPC分类号： A01G9/14
CPC分类号： A01G9/22 , A01G9/243 , F26B3/28 , F26B21/06 , F26B25/08 , F26B2210/16 , Y02A40/258 , Y02A40/266 , Y02P60/124 , Y10T428/249924 , Y10T428/662
摘要： A method of drying comprises placing a moist material inside a substantially enclosed solar greenhouse. The greenhouse comprises at least one light transmission roof and/or wall panel that is substantially transparent to solar radiation, but resistant to convective and conductive heat transfer. The interior temperature and humidity of the greenhouse are maintained within their pre-determined ranges while the interior moisture of the greenhouse is effectively reduced to allow a controlled drying of the material. A solar greenhouse for the drying process is also disclosed.
摘要翻译：一种干燥方法包括将湿物质放置在基本封闭的太阳能温室内。温室包括至少一个对太阳辐射基本透明但耐对流和传导热传递的光透射屋顶和/或墙板。温室的内部温度和湿度保持在其预定范围内，同时温室的内部水分被有效地减少以允许受控的材料干燥。还公开了一种用于干燥过程的太阳能温室。

6. 发明申请

WO2002059165A3 POLYMERIZATION OF OLEFINIC COMPOUNDS 审中-公开
公开(公告)号：WO2002059165A3
公开(公告)日：2002-08-01
申请号：PCT/US2002/003088
申请日：2002-01-25
申请人： E.I. DUPONT DE NEMOURS AND COMPANY , BROOKHART, Maurice, S. , KUNITSKY, Keith , MALINOSKI, Jon, M. , WANG, Lin , WANG, Yin , LIU, Weijun , JOHNSON, Lynda, Kaye , KREUTZER, Kristina, A. , ITTEL, Steven, Dale
发明人： BROOKHART, Maurice, S. , KUNITSKY, Keith , MALINOSKI, Jon, M. , WANG, Lin , WANG, Yin , LIU, Weijun , JOHNSON, Lynda, Kaye , KREUTZER, Kristina, A. , ITTEL, Steven, Dale
IPC分类号： C08F10/00
摘要： Certain complexes containing ligands having a phosphino group, amino group or an imino group, and a second functional group such as amide, ester or ketone, when complexed to transition metals, catalyze the (co)polymerization of olefinic compounds such as ethylene, α-olefins and/or acrylates. A newly recognized class of ligands for making copolymer containing polar monomers using late transition metal complexes is described.

7. 发明申请

WO2012092880A1 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS 审中-公开
标题翻译： 2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物，以FAK / Pyk2抑制剂
公开(公告)号：WO2012092880A1
公开(公告)日：2012-07-12
申请号：PCT/CN2012/070122
申请日：2012-01-07
申请人： CENTAURUS BIOPHARMA CO., LTD. , XIAO, Dengming , CHENG, Liang , LIU, Xijie , HU, Yuandong , XU, Xinhe , LIU, Zhihua , ZHANG, Lipeng , WU, Wei , WANG, Shulong , SHEN, Yu , LI, Gen , WANG, Yin , ZHAO, Sheng , LI, Chonglong , TANG, Jia , YU, Honghao
发明人： XIAO, Dengming , CHENG, Liang , LIU, Xijie , HU, Yuandong , XU, Xinhe , LIU, Zhihua , ZHANG, Lipeng , WU, Wei , WANG, Shulong , SHEN, Yu , LI, Gen , WANG, Yin , ZHAO, Sheng , LI, Chonglong , TANG, Jia , YU, Honghao
IPC分类号： C07D487/04 , A61K31/505 , A61P35/00 , A61P29/00 , A61P31/00 , A61P37/02
CPC分类号： C07D487/04 , A61K31/4523 , A61K31/519 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D413/12 , C07D417/12 , C07D493/12
摘要： The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/ or Pyk2 mediated disorder or disease.
摘要翻译：本发明涉及一种新型的作为FAK和/或Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物，其制备方法和组合物以及该化合物用于抑制FAK和/或Pyk2的方法和用于治疗FAK和/或Pyk2介导的病症或疾病的方法。

8. 发明申请

WO2013052063A1 GENERATING A NON-DETERMINISTIC MODEL OF A PROCESS FOR A GOAL 审中-公开
标题翻译：产生目标过程的非确定性模型
公开(公告)号：WO2013052063A1
公开(公告)日：2013-04-11
申请号：PCT/US2011/055390
申请日：2011-10-07
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , WANG, Yin , NAZEEM, Ahmed
发明人： WANG, Yin , NAZEEM, Ahmed
IPC分类号： G06Q10/00 , G06Q30/00
CPC分类号： G06N5/00 , G06Q10/10 , G06Q30/06
摘要： A method and a system of generating a non-deterministic model of an artifact system for a received goal are provided. A description of artifacts and services associated with an original version of a process is received. Component automata represent the artifacts and services that are automatically generated. There is one component automaton for each attribute of an artifact. States of a particular component automaton represents potential values of a particular attribute and transitions between the states represent services that operate on the values. A non-deterministic model of the process is generated by automatically generating a composite automaton, which includes the component automata, based on the received goal. The composite automaton provides the non-deterministic model of the process.
摘要翻译：提供了一种生成用于接收到的目标的伪像系统的非确定性模型的方法和系统。接收与进程的原始版本相关联的工件和服务的描述。组件自动机代表自动生成的工件和服务。工件的每个属性都有一个组件自动机。特定组件自动机的状态表示特定属性的潜在值，状态之间的转换表示对值进行操作的服务。基于接收到的目标，通过自动生成包括组件自动机的复合自动机来产生该过程的非确定性模型。复合自动机提供了非确定性的过程模型。

9. 发明申请

WO2012075215A3 LASER CHARACTERIZATION SYSTEM AND PROCESS 审中-公开
公开(公告)号：WO2012075215A3
公开(公告)日：2012-06-07
申请号：PCT/US2011/062752
申请日：2011-12-01
申请人： CORNING INCORPORATED , WANG, Yin , WYSOCKI, Gerard, P. , XIE, Feng , ZAH, Chung-En
发明人： WANG, Yin , WYSOCKI, Gerard, P. , XIE, Feng , ZAH, Chung-En
IPC分类号： H01S3/1055 , H01S3/101
摘要： A system and process for automatically characterizing a plurality of external cavity semiconductor laser chips on a semiconductor laser bar separated from a semiconductor wafer. The system includes a diffraction grating mounted on a rotary stage for rotating the diffraction grating through a range of diffraction angles; a steering mirror mounted on the rotary stage and oriented perpendicular to a surface of the diffraction grating; and a laser analyzer; and a laser bar positioning stage. The positioning stage is automatically moved to aligning each laser chip in a laser bar on the stage, one chip at a time, with the diffraction grating, such that a part of the laser beam emitted from a laser chip in a laser bar is reflected back to the same laser chip by the 1 st order diffraction of the grating to lock the lasing wavelength and the rest of the laser beam reflected by the steering mirror is received and characterized by the laser analyzer. For each laser ship, the rotary stage is automatically rotated to rotate the diffraction grating through a range of diffraction angles relative the laser beam emitted by the laser chip, and the laser analyzer automatically characterizes the laser optical properties such as spectra, power, or spatial modes at each diffraction angle.

10. 发明申请

WO2009006356A1 POLYMERIC COMPOSITION FOR CELLULOSIC MATERIALS BINDING AND MODIFICATION 审中-公开
标题翻译：用于纤维材料的聚合物组合和修饰
公开(公告)号：WO2009006356A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068691
申请日：2008-06-29
申请人： WANG, Yin
发明人： WANG, Yin
IPC分类号： C09D101/00 , C09D103/00
CPC分类号： B27K3/15 , B05D1/18 , B05D3/0493 , B05D2203/20 , B27K5/065 , B27K2200/30 , C08L29/04 , Y10T428/249954 , Y10T428/31975
摘要： A polymer composition suitable for wood treatment or binding comprises a reaction product of at least a polyol and at least a crosslinking agent. The crosslinking agent has at least 2 carboxylic acid groups per molecule. A wood product comprising a wood substrate and a polymer composition as well as a wood treatment process are also disclosed.
摘要翻译：适用于木材处理或结合的聚合物组合物包括至少多元醇和至少一种交联剂的反应产物。交联剂每分子具有至少2个羧酸基团。还公开了包含木质基材和聚合物组合物以及木材处理方法的木制品。

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