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1. 发明申请

WO2012156963A2 IMMUNOGLOBULIN REDUCED IN THROMBOGENIC AGENTS AND PREPARATION THEREOF 审中-公开
标题翻译：免疫球蛋白减少在血液中的代谢物及其制备
公开(公告)号：WO2012156963A2
公开(公告)日：2012-11-22
申请号：PCT/IL2012/000189
申请日：2012-05-14
申请人： OMRIX BIOPHARMACEUTICALS LTD. , MINTZ, Roni , BELYAEV, Oleg , NUR, Israel , BAR, Liliana , MEIDLER, Roberto
发明人： MINTZ, Roni , BELYAEV, Oleg , NUR, Israel , BAR, Liliana , MEIDLER, Roberto
IPC分类号： C07K1/18
CPC分类号： C07K16/065 , A61K39/39591 , A61K2039/505 , C07K1/18 , C07K2317/10 , Y10S530/83 , Y10S530/831
摘要： The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
摘要翻译：本发明涉及减少血栓形成剂的免疫球蛋白组合物及其制备方法。一种方法包括在高于3.8至等于或低于5.3的pH范围内使含免疫球蛋白的溶液进行负阳离子交换层析。该溶液也可以在7至8.2范围内的pH下进行阴离子交换层析。

2. 发明申请

WO2010095128A3 DEVICE FOR ADMINISTERING AN AT LEAST TWO-COMPONENT SUBSTANCE 审中-公开
公开(公告)号：WO2010095128A3
公开(公告)日：2010-08-26
申请号：PCT/IL2010/000137
申请日：2010-02-17
申请人： OMRIX BIOPHARMACEUTICALS LTD. , ILAN, Erez , MERON, Moti , REGEV, Kfir , BAR, Liliana , NUR, Israel
发明人： ILAN, Erez , MERON, Moti , REGEV, Kfir , BAR, Liliana , NUR, Israel
IPC分类号： A61B17/00 , A61M5/158 , A61M25/00
摘要： The device for administering an at least two-component substance comprises a concentric lumen arrangement including (i) an inner cannula having a lumen with an inlet opening at a first end and a tip with an outlet opening at a second end opposite its first end, and (ii) an outer sheath having opposite first and second ends facing the respective first and second ends of the inner cannula, and surrounding the inner cannula along an axial length between the first and second ends of the inner cannula, wherein the outer sheath at its second end is sealingly and fixedly connected to the inner cannula and defining an outer lumen around the inner cannula, and wherein the inner cannula is provided with at least one opening for providing fluid communication between the outer lumen around the inner cannula and the lumen of the inner cannula.

3. 发明申请

WO2013001524A1 METHOD FOR REMOVING A LYTIC ENZYME FROM A HETEROGENEOUS MIXTURE 审中-公开
标题翻译：从异构混合物中除去乳酸酶的方法
公开(公告)号：WO2013001524A1
公开(公告)日：2013-01-03
申请号：PCT/IL2012/000258
申请日：2012-06-26
申请人： OMRIX BIOPHARMACEUTICALS LTD. , MEIDLER, Roberto , RAVER-SHAPIRA, Nina , BAR, Liliana , BELYAEV, Oleg , NUR, Israel
发明人： MEIDLER, Roberto , RAVER-SHAPIRA, Nina , BAR, Liliana , BELYAEV, Oleg , NUR, Israel
IPC分类号： C07K1/22 , C12N9/50 , C12N9/64 , C07K14/81
CPC分类号： C12N9/50 , C07K1/22 , C07K14/81 , C07K14/811 , C12N9/6435 , C12Y304/21007
摘要： The invention relates to purification of an intact, non-degraded macromolecule from a biological mixture comprising the macromolecule in the presence of its lytic enzyme. The method comprises providing the biological mixture as a heterogeneous mixture comprising the lytic enzyme, at least partially, in soluble form and the macromolecule, at least partially, in non-soluble form; batch-wise contacting the heterogeneous mixture with an immobilized inhibitor of the lytic enzyme; increasing the solubility of the macromolecule in the mixture; and removing the immobilized inhibitor from the mixture.
摘要翻译：本发明涉及在其溶解酶存在下从包含大分子的生物混合物中纯化完整的未降解的大分子。该方法包括提供生物混合物作为非均质混合物，其包含溶解酶，至少部分可溶形式和大分子，至少部分为非溶解形式; 将非均相混合物与溶解酶的固定化抑制剂分批接触; 增加大分子在混合物中的溶解度; 并从混合物中除去固定化的抑制剂。

4. 发明申请

WO2012020412A3 FIBRIN BASED SCAFFOLD, PREPARATION AND USE THEREOF 审中-公开
公开(公告)号：WO2012020412A3
公开(公告)日：2012-02-16
申请号：PCT/IL2011/000653
申请日：2011-08-10
申请人： OMRIX BIOPHARMACEUTICALS LTD, , ATLAS, Roee , NUR, Israel , MEIDLER. Roberto , BAR, Liliana , BUENSUCESO, Charito , KIHM, Anthony J. , DHANARAJ, Sridevi
发明人： ATLAS, Roee , NUR, Israel , MEIDLER. Roberto , BAR, Liliana , BUENSUCESO, Charito , KIHM, Anthony J. , DHANARAJ, Sridevi
IPC分类号： A61L17/00 , A61L27/22 , A61K9/00
摘要： The invention relates to a fibrin-based scaffold suitable for supporting a population of cells comprising mesenchymal stem cells (MSC) and/or umbilical tissue derived cells (UTC) at the site of administration for a prolonged period of time. The scaffold is capable of supporting at least 1 x 106 cells/ml scaffold. The invention also relates to the preparation of the scaffold and to its use. Preparation of the scaffold is carried out with a fibrinogen component comprising fibrinogen having a final concentration of higher than 17.5 mg/ml scaffold. The scaffold and the embedded MSC and/or UTC can be used for increasing vascularization and/or wound healing at the site of administration.

5. 发明申请

WO2009004573A1 KITS, FORMULATIONS AND SOLUTIONS HAVING ENZYMATICALLY-PERMISSIVE AMOUNTS OF VISUALIZATION AGENTS AND USES THEREOF 审中-公开
标题翻译：具有可视化代理商的酶学性质的组合，配方和解决方案及其用途
公开(公告)号：WO2009004573A1
公开(公告)日：2009-01-08
申请号：PCT/IB2008/052636
申请日：2008-07-01
申请人： OMRIX BIOPHARMACEUTICALS LTD. , NUR, Israel , MEIDLER, Roberto , BAR, Liliana
发明人： NUR, Israel , MEIDLER, Roberto , BAR, Liliana
IPC分类号： A61L24/10 , A61L31/04 , A61L24/04
CPC分类号： A61L24/106 , A61L24/043 , A61L24/108 , A61L31/046 , C08L89/00
摘要： The invention relates to a proteolytic enzyme which is capable of forming fibrin when it reacts with fibrinogen, a fibrin-glue kit and a fibrin-glue formulation comprising an enzymatically-permissive concentration of a visualization agent and to their use in methods for prevention and/or reduction of adhesions and/or methods for promotion of blood coagulation sealing or filling body surfaces.
摘要翻译：本发明涉及当与纤维蛋白原反应时能够形成纤维蛋白的蛋白水解酶，纤维蛋白胶试剂盒和包含酶允许浓度的可视化试剂的纤维蛋白胶制剂，以及它们在预防和/ 或减少用于促进血液凝固密封或填充体表面的粘合和/或方法。

6. 发明申请

WO2014087394A1 THROMBIN SOLUTION AND METHODS OF USE THEREOF 审中-公开
标题翻译： THROMBIN解决方案及其使用方法
公开(公告)号：WO2014087394A1
公开(公告)日：2014-06-12
申请号：PCT/IL2013/000088
申请日：2013-11-28
申请人： OMRIX BIOPHARMACEUTICALS LTD.
发明人： MEIDLER, Roberto , BELYAEV, Oleg , BAR, Liliana , NUR, Israel
IPC分类号： A61K38/48 , A61K9/19
CPC分类号： C12N9/96 , A61K9/19 , A61K38/4833 , A61K47/26 , A61K47/42 , C12N9/6429 , C12Y304/21005
摘要： Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
摘要翻译：提供冻干凝血酶水溶液，用于这种冻干方法的凝血酶溶液，以及通过这些方法制备的固体凝血酶组合物的方法。

7. 发明申请

WO2010032246A3 IMPLANTABLE DEVICE COMPRISING A SUBSTRATE PRE-COATED WITH STABILIZED FIBRIN 审中-公开
公开(公告)号：WO2010032246A3
公开(公告)日：2010-03-25
申请号：PCT/IL2009/000909
申请日：2009-09-21
申请人： OMRIX BIOPHARMACEUTICALS LTD. , SHEETRIT, Eyal , NUR, Israel , BAR, Liliana , WEISSMAN, Lior
发明人： SHEETRIT, Eyal , NUR, Israel , BAR, Liliana , WEISSMAN, Lior
IPC分类号： A61L31/10 , A61L31/14
摘要： The invention relates to a prosthetic for repairing an opening or a defect in a soft tissue, to its preparation and use. The prosthetic of the invention comprises a substrate viscerally-coated with stabilized and non-completely dry fibrin. The prosthetic displays reduced postoperative complications following its implantation.

8. 发明申请

WO2009109963A1 A GELATIN SPONGE COMPRISING AN ACTIVE INGREDIENT, ITS PREPARATION AND USE 审中-公开
标题翻译：包括活性成分，其制备和使用的香奈儿海绵
公开(公告)号：WO2009109963A1
公开(公告)日：2009-09-11
申请号：PCT/IL2009/000236
申请日：2009-03-02
申请人： OMRIX BIOPHARMACEUTICALS LTD. , NUR, Israel , BAR, Liliana , TOMER, Guy , SHEETRIT, Eyal
发明人： NUR, Israel , BAR, Liliana , TOMER, Guy , SHEETRIT, Eyal
IPC分类号： A61L15/32 , A61L15/44 , A61L15/64
CPC分类号： A61L15/425 , A61K9/70 , A61K38/4833 , A61L15/32 , A61L15/325 , A61L15/44 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04
摘要： The invention relates to an improved dry cross-linked gelatin sponge comprising a layer of an active ingredient, to methods of its preparation and uses thereof.
摘要翻译：本发明涉及包含活性成分层的改进的干交联明胶海绵，其制备方法及其用途。

9. 发明申请

WO2008053475A1 METHOD OF MICRONIZATION 审中-公开
标题翻译：微波方法
公开(公告)号：WO2008053475A1
公开(公告)日：2008-05-08
申请号：PCT/IL2007/001318
申请日：2007-10-30
申请人： OMRIX BIOPHARMACEUTICALS LTD. , NUR, Israel , BAR, Liliana
发明人： NUR, Israel , BAR, Liliana
IPC分类号： B02C19/06 , A61K9/14
CPC分类号： B02C19/061 , A61K9/14 , A61K9/19 , A61K38/363 , A61K38/4833
摘要： A method for micronization of a dispersion of particles comprising a protein having a predetermined level of biological activity. The method comprises introducing the dispersion into a vortex chamber milling apparatus under milling conditions which result in a protein powder having a particle size distribution of 5 to 100 µm and/or exhibiting a 30 to 400 fold size reduction of the protein particle dispersion from its original size, and retaining at least 80% of the predetermined level of biological activity of the protein. The milling conditions include one or more parameters selected from the following: input pressure between 1 and 7 Bars; injector pressure between 0.2 and 5 Bars; loading rate between 0.1 and 5 kg/hour; and gas flow between 30 and 100 m 3 /hour.
摘要翻译：包含具有预定水平生物活性的蛋白质的颗粒分散体的微粉化方法。该方法包括在研磨条件下将分散体引入涡流室研磨装置中，其导致蛋白质粉末的粒度分布为5至100μm，和/或显示蛋白质颗粒分散体从其原始的30至400倍大小的尺寸并且保留蛋白质的预定水平的生物活性的至少80％。研磨条件包括从以下选择的一个或多个参数：1和7条之间的输入压力; 注射器压力在0.2和5条之间; 装载速度在0.1到5公斤/小时之间; 并且气体流动在30和100m 3 /小时之间。

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