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1. 发明申请

WO2006112714A3 URONIC ACID AND PROBIOTICS 审中-公开
标题翻译：尿酸和微生物
公开(公告)号：WO2006112714A3
公开(公告)日：2007-03-29
申请号：PCT/NL2006050088
申请日：2006-04-18
申请人： NUTRICIA NV , VRIESEMA ADRIANUS JOHANNES MAR , KNOL JAN , STAHL BERND
发明人： VRIESEMA ADRIANUS JOHANNES MAR , KNOL JAN , STAHL BERND
IPC分类号： A61K35/74 , A61K31/702 , A61P31/00
CPC分类号： A61K31/702 , A23L33/135 , A61K35/745 , A61K35/747 , A61K2300/00
摘要： The present invention relates to compositions containing probiotic bacteria and uronic acid oligosaccharides. The compositions can suitably be used as infant nutrition and advantageously reduce the incidence of infection.
摘要翻译：本发明涉及含有益生菌和糖醛酸寡糖的组合物。组合物可适当地用作婴儿营养，并有利地降低感染的发生率。

2. 发明申请

WO2007105945A2 USE OF NON-DIGESTABLE SACHARIDES FOR GIVING AN INFANT THE BEST START AFTER BIRTH 审中-公开
标题翻译：使用不可食用的沙发提供婴儿是出生后最好的开始
公开(公告)号：WO2007105945A2
公开(公告)日：2007-09-20
申请号：PCT/NL2007050094
申请日：2007-03-09
申请人： NUTRICIA NV , BEERMANN CHRISTOPHER , KNOL JAN , ALLES MARTINE SANDRA , STAHL BERND , BOEHM GUENTHER
发明人： BEERMANN CHRISTOPHER , KNOL JAN , ALLES MARTINE SANDRA , STAHL BERND , BOEHM GUENTHER
IPC分类号： A61K35/74 , A61P11/00 , A61P37/00
CPC分类号： A61K31/702 , A23L33/115 , A23L33/21 , A23L33/30 , A23V2002/00 , A23V2200/324 , A23V2250/28 , A23V2250/1882 , A61K2300/00
摘要： A food or supplement for pregnant women comprising water soluble, non-digestible saccharides is described. The composition is used to improve the flora and/or immune system o f the pregnant women, to improve the immune system of the infant and to improve the intestinal flora of the infant after birth.
摘要翻译：描述了包含水溶性，不可消化的糖的孕妇的食物或补充剂。该组合物用于改善孕妇的植物和/或免疫系统，改善婴儿的免疫系统并改善婴儿在出生后的肠道菌群。

3. 发明申请

WO2009065905A3 COMPOSITION WITH SYNBIOTICS 审中-公开
标题翻译：与SYNBIOTICS组合
公开(公告)号：WO2009065905A3
公开(公告)日：2009-09-17
申请号：PCT/EP2008065936
申请日：2008-11-20
申请人： NUTRICIA NV , KNOL JAN , STAHL BERND
发明人： KNOL JAN , STAHL BERND
IPC分类号： A23L1/29 , A23L1/09 , A23L1/30
CPC分类号： A23L33/135 , A23L29/30 , A23L33/125 , A23L33/17 , A23L33/21 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K35/745 , A61K35/747 , A61K2035/115 , A23V2200/3202 , A23V2200/3204 , A23V2250/28 , A23V2250/5062 , A23V2250/54252 , A23V2250/612 , A23Y2220/17 , A23Y2300/21 , A23V2250/061 , A23V2250/242 , A23V2250/2482 , A23V2250/5072 , A23V2250/5118
摘要： Nutritional compositions with health benefits comprising bacterial strains and galactooligosaccharides are disclosed.
摘要翻译：公开了包含细菌菌株和低聚半乳糖的具有健康益处的营养组合物。

4. 发明申请

WO2007067053A9 COMPOSITION CONTAINING OLIGOSACCHARIDES FOR THE TREATMENT / PREVENTION OF INFECTIONS 审中-公开
标题翻译：含有治疗/预防感染的低聚糖的组合物
公开(公告)号：WO2007067053A9
公开(公告)日：2007-10-04
申请号：PCT/NL2006050304
申请日：2006-12-05
申请人： NUTRICIA NV , POTAPPEL-VAN T LAND BELINDA , GARSSEN JOHAN , BOEHM GUNTHER , STAHL BERND
发明人： POTAPPEL-VAN T LAND BELINDA , GARSSEN JOHAN , BOEHM GUNTHER , STAHL BERND
IPC分类号： A61K31/70 , A23L1/09
CPC分类号： A61K31/702 , A23L29/231 , A23L29/244 , A23L33/40 , A23V2002/00 , A61K31/70 , A23V2200/324 , A23V2250/28 , A23V2250/5072
摘要： The present invention relates to the use of oligosaccharide mixtures for the treatment and/or prevention of infections, in particular for reducing the severity of childhood infection or the treatment and/or prevention of childhood infection.
摘要翻译：本发明涉及寡糖混合物用于治疗和/或预防感染的用途，特别是用于降低儿童感染的严重性或治疗和/或预防儿童感染。

5. 发明申请

WO2006018314A3 IMMUNE STIMULATORY INFANT NUTRITION 审中-公开
标题翻译：免疫刺激性哺乳动物营养
公开(公告)号：WO2006018314A3
公开(公告)日：2006-06-29
申请号：PCT/EP2005008999
申请日：2005-08-19
申请人： NUTRICIA NV , BOEHM GUENTHER , BEERMANN CHRISTOPHER , STAHL BERND , M RABET LAURA , GARSSEN JOHAN
发明人： BOEHM GUENTHER , BEERMANN CHRISTOPHER , STAHL BERND , M RABET LAURA , GARSSEN JOHAN
IPC分类号： A61K35/20 , A61K31/201 , A61K31/702 , A61P29/00 , A61P37/08
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： The invention provides a nutritional or pharmaceutical composition containing a fat component, a protein component and a carbohydrate component and comprising whey and casein. Said composition is characterized in that, the weight ratio of casein to whey is 1:1 to 1:2.4 and that the composition contains: a) at least 3 grams arginine per 100 grams protein; b) at least 10 wt.% linoleic acid based on total fatty acids; c) at least 1 wt.% alpha linolenic acid based on total fatty acids; d) at least one long chain-polyunsaturated fatty acid in an amount exceeding 0.1 wt.% based on total fatty acids, said long chain polyunsaturated fatty acid being selected from the group consisting of docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid; e) 5 to 25 wt.% of at least one polyunsaturated fatty acid based on total fatty acids; and f) 2 to 12 grams indigestible oligosaccharides having a degree of polymerisation of 2 to 100 per 100 gram dry weight of the composition. The composition of the invention reduces -among others- the risks attached to feeding whey dominant infant formula.
摘要翻译：本发明提供含有脂肪组分，蛋白质组分和碳水化合物组分并包含乳清和酪蛋白的营养或药物组合物。所述组合物的特征在于，酪蛋白与乳清的重量比为1:1至1:2.4，组合物含有：a）每100克蛋白质至少3克精氨酸; b）基于总脂肪酸至少10重量％的亚油酸; c）基于总脂肪酸的至少1重量％的α-亚麻酸; d）至少一种长链多不饱和脂肪酸，其量超过基于总脂肪酸的0.1重量％，所述长链多不饱和脂肪酸选自二十二碳六烯酸，花生四烯酸和二十碳五烯酸; e）5至25重量％的基于总脂肪酸的至少一种多不饱和脂肪酸; 和f）2至12克不可消化的寡糖，其组合物的每100克干重具有聚合度2至100。本发明的组合物减少了其他人 - 与喂食乳清主要婴儿配方奶粉相关的风险。

6. 发明申请

WO2004023147A2 MALDI-MATRIX 审中-公开
标题翻译： MALDI MATRIX
公开(公告)号：WO2004023147A2
公开(公告)日：2004-03-18
申请号：PCT/EP0308435
申请日：2003-07-30
申请人： NUTRICIA NV , STAHL BERND , BOEHM GUENTHER , MANK MARKO
发明人： STAHL BERND , BOEHM GUENTHER , MANK MARKO
IPC分类号： G01N27/64 , G01N27/447 , G01N27/62 , G01N30/72 , G01N33/68 , H01J49/16
CPC分类号： H01J49/164 , G01N33/6848 , G01N33/6851 , Y10T436/10
摘要： The invention relates to matrixes for ultraviolet matrix-assisted laser desorption-ionisation mass spectrometry made of the salt of an amine which reacts as a proton acceptor and an organic substance which reacts as a proton donator. Either the amine or the organic substance absorbs UV light. Said matrixes are characterised in that they represent an ionic liquid at room temperature and in that the amine is selected from the group which is made up of 3-aminoquinoline, pyridine, a primary amine whose N-Atom is bound to a phenyl radical or a straight or branched, saturated C1-C11-alkyl radical which can be substituted by an OH-group, a secondary and tertiary amine whose N-Atoms are bound to two or three radicals which can be the same or different and represent a straight or branched, saturated C1-C8-alkyl radical which can be substituted by an OH-group and a phenyl radical, imidazole and the C and/or N-alkylated imidazole derivatives and also characterised in that the organic substance is selected from the group which is made up of 2,5-dihydroxybenzoic acid and the isomers thereof, 2-hydroxy-5-methoxy-benzoic acid and the isomers thereof, picolinic-acid, 3-hydroxypicolinic acid, nicotinic acid, 5-chloro-2-mercapto-benzo-thiazole, 6-aza-2-thiothymine, 2',4',6'-trihydroxyacetophenone-monohydrate, 2',6'-di-hydroxyaceto-phenone, 9H-pyridol[3,4-b]indole, dithranole, trans-3-indolacrylic acid, osazones, ferulic acid, 2,5-dihydroxyacetophenone, 1-nitrocarbazole, 7-amino-4-methylcumarine, 2-(p-hdroxyphenylazo)-benzoic acid, 8-aminopyrene-2,3,4-trissulfonic acid, 2-[2E-3-(4-tert-butylphenyl)-2-methylprop-2-enylidene]malonitril (DCTB), 4-methoxy-3-hydroxycinnamic acid and 3,4-dihydroxycinnamic acid. Said liquid matrixes enable reproducible, error-free analysis values to be obtained. The combination of pure mass spectrometric analysis with additional knowledge of enzymatic reactions/modifications with the possible monitoring is also described.
摘要翻译：提供矩阵作为对质子受体和胺作为质子供体反应性有机物质，其特征在于，无论是胺或有机物质吸收的UV光反应的盐的紫外线基质辅助激光解吸电离质谱分析法。这些矩阵的特征在于，该矩阵代表在室温下的离子液体，使得所述胺选自由3-氨基喹啉，吡啶，伯胺组成的组中，选择在N原子的苯基烷基或直链或支链的，其可通过一个OH基团取代的饱和的C1-C11的烷基键合，一个仲和叔胺，在N原子，两个或三个基团所连接，其可以是相同的或不同的，并且它们将成为其可被OH基团取代的直链或支链的，饱和的C1-C8烷基，和苯基是，咪唑和C-和/或N-烷基化的咪唑衍生物和有机物质选自由的组中选择从2,5-二羟基苯甲酸和它们的异构体，2-羟基-5-甲氧基 - 苯甲酸和它们的异构体，甲基吡啶酸，3-Hydroxypicolin酸，烟酸，5-氯-2- 巯基苯并噻唑，6-氮杂-2-硫代胸腺嘧啶，2 '4' ，6'-三羟基苯乙酮一水合物，2'，6'-二 - hydroxyaceto基二苯酮，-9H-吡啶并[3,4-B] 吲哚，蒽三酚，反式-3-吲哚丙烯酸，osazones，阿魏酸，2,5-二羟基苯乙酮，1- nitrocarbazole，7-氨基-4-甲基香豆素，2-（对 - Hdroxyphenylazo）苯甲酸，8-氨基芘-2,3-， 4-trissulfonsäure，2- [2E-3-（4-叔丁基苯基）-2-甲基丙-2-烯亚基]丙二腈（DCTB），4-甲氧基-3-羟基肉桂酸和3,4-二羟基肉桂酸。与这些液体基质无差错和可再现的分析值可以得到，特别是与酶反应的附加知识纯质谱分析的组合/设置有监测的可能性修改。

7. 发明申请

WO03028738A3 ANTI-INFECTIOUS CARBOHYDRATES 审中-公开
标题翻译：抗感染碳水化合物
公开(公告)号：WO03028738A3
公开(公告)日：2003-08-21
申请号：PCT/EP0210761
申请日：2002-09-25
申请人： NUTRICIA NV , STAHL BERND , FINKE BERNDT , SCHMITT JOACHIM , GOEBEL WERNER , SLAGHUIS JOERG
发明人： STAHL BERND , FINKE BERNDT , SCHMITT JOACHIM , GOEBEL WERNER , SLAGHUIS JOERG
IPC分类号： A61K31/702 , A61K31/715 , A61P31/00
CPC分类号： A61K31/702 , A61K31/715
摘要： The invention relates to the use of neutral straight-chain or branched oligosaccharides for preventing the invasion and infection of mammal cells by pathogens and for fighting diseases caused by such pathogens. The invention also relates to food, dietetic products and pharmaceutical agents containing said oligosaccharides. Said oligosaccharides consist of a base unit of general formula (I), and between 0 and 19 other units of general formula (II), which are linked directly or indirectly to the base unit. In said formulae, Gal represents a galactose monosaccharide unit; Glc represents a glucose monosaccharide unit; HexNAc represents an N-acetylated galactosamine or glucosamine monosaccharide unit (GalNAc or GlcNAc); the radicals R independently represent a beta 1-3 or beta 1-6 glycosidic link to the HexNAc monosaccharide unit of the next [Gal-HexNAc] unit of general formula (II), and on a terminal [Gal-HexNAc] unit, a deoxyhexose radical which is linked to the galactose monosaccharide unit of said terminal [Gal-HexNAc] unit, or said radicals R are not present; and a terminal [Gal-HexNAc] unit, wherein the radical(s) R represent a deoxyhexose radical, can have another deoxyhexose radical on the HexNAc monosaccharide unit.
摘要翻译：描述了一种用于预防侵袭和哺乳动物细胞的感染的使用中性直链或支链的寡糖的病原体和用于通过这些疾病病原体的控制而引起的含寡糖-这些食品，营养和药物组合物。这些寡糖是由下述通式（I）的基本单元及0〜19其它，从而直接或间接连接的下述通式（II）的单元式中，Gal是半乳糖单糖单元，GLC是葡萄糖单糖单元， HexNAc表示N-乙酰半乳糖胺或葡糖胺单糖单元（半乳糖胺或GlcNAc的），残基R各自独立地为1-3的β或β1-6糖苷键到下一[半乳糖的单糖HexNAc单元 HexNAc]通式单元（II），并在终端[Gal一HexNAc]单元代表链接到所述终端[脱氧己残基的半乳糖单糖单元中的半乳糖 - HexNAc]单元或不存在，并末端[Gal-HexNAc]部分，其中基团R是其中hexNAc单糖单元可以具有另外的脱氧己糖基团的脱氧己糖基团集。

8. 发明申请

WO2006021335A3 PEPTIDE MIXTURE FROM PEPTIDES HAVING A MOLECULAR WEIGHT OF FROM 1000 TO 5000 DALTON 审中-公开
标题翻译：肽的分子量从1000-5000 DALTON肽混合物
公开(公告)号：WO2006021335A3
公开(公告)日：2006-04-20
申请号：PCT/EP2005008805
申请日：2005-08-12
申请人： NUTRICIA NV , BOEHM GUENTHER , BEERMANN CHRISTOPHER , GEORGI GILDA , STAHL BERND , SCHMITT JOACHIM , BOCK NADINE , KELM SOERGE
发明人： BOEHM GUENTHER , BEERMANN CHRISTOPHER , GEORGI GILDA , STAHL BERND , SCHMITT JOACHIM , BOCK NADINE , KELM SOERGE
IPC分类号： A61K38/02 , A23L1/305 , A61K35/20 , A61K36/18 , A61P35/00 , A61P37/00
CPC分类号： A23J3/346 , A23J3/344 , A23L33/18 , A23L33/40 , A61K35/20 , A61K36/06 , A61K36/31 , A61K36/48 , A61K36/88 , A61K38/168 , A61K38/1709 , A61K2300/00
摘要： The invention relates to the use of a peptide mixture from peptides having a molecular weight of from 1000 to 5000 Dalton for use in the prevention and/or treatment of cancers, of diseases associated with the developmental disturbance of the immune system, diseases of the immune system, autoimmune responses, allergies and inflammations in humans. The invention also relates to a protein component containing said peptide mixture and to formula foodstuff containing said peptide mixture. The peptides are preferably obtained from non-human proteins that are suitable for consumption, especially by enzymatic or hydrolytic cleavage of the proteins.
摘要翻译：本发明涉及使用具有从1000到5000道尔顿的肿瘤疾病的预防和/或治疗时，与免疫系统的发育障碍相关的免疫系统的疾病，自身免疫反应，变态反应和，疾病的分子量的肽的肽混合物的炎症在人类中，含有这样的肽混合物中的蛋白质组分，并且这种肽混合物含有配方食品。所述肽优选从食用合适的非人类蛋白由这些蛋白质的酶或水解裂解获得的，特别是。

9. 发明申请

WO2005039597A3 IMMUNEMODULATING OLIGOSACCHARIDES 审中-公开
标题翻译：免疫调节低密度脂蛋白
公开(公告)号：WO2005039597A3
公开(公告)日：2005-07-14
申请号：PCT/NL2004000750
申请日：2004-10-25
申请人： NUTRICIA NV , STAHL BERND , M RABET LAURA , VOS ARJAN PAUL , GARSSEN JOHAN , BOEHM GUENTHER
发明人： STAHL BERND , M RABET LAURA , VOS ARJAN PAUL , GARSSEN JOHAN , BOEHM GUENTHER
IPC分类号： A61K31/70 , A61K31/702 , A61K31/732 , A61P37/00
CPC分类号： A61K31/732 , A23L29/30 , A23L33/10 , A23L33/40 , A23V2002/00 , A61K31/70 , A61K31/702 , A23V2200/324 , A23V2250/28
摘要： The present invention relates to a method for enhancing the immune system and the treatment and/or prevention of immune system related disorders in a mammal, particularly newborns, said method comprising the administration of acid oligosaccharide and neutral oligosaccharide. Food compositions suitable for use in the above method are also provided.
摘要翻译：本发明涉及增强哺乳动物，特别是新生儿免疫系统和治疗和/或预防免疫系统相关疾病的方法，所述方法包括施用酸性寡糖和中性寡糖。还提供了适用于上述方法的食品组合物。

10. 发明申请

WO03063882A8 CYCLOGLYCANS SUITABLE TO INHIBIT MAMMALIAN INFECTION 审中-公开
标题翻译： CYCLOGLYCANE SUITABLE感染了哺乳动物体内预防
公开(公告)号：WO03063882A8
公开(公告)日：2004-12-29
申请号：PCT/EP0300505
申请日：2003-01-20
申请人： NUTRICIA NV , STAHL BERND , FINKE BERNDT , SCHMITT JOACHIM , GOEBEL WERNER , SLAGHIUS JOERG , BOEHM GUENTHER
发明人： STAHL BERND , FINKE BERNDT , SCHMITT JOACHIM , GOEBEL WERNER , SLAGHIUS JOERG , BOEHM GUENTHER
IPC分类号： A61K31/715
CPC分类号： A61K31/715
摘要： The use of, in particular homopolymeric, cycloglycans with an annular base structure of 2 to 40 monosaccharides in the ring for the prevention of the invasion and infection of mammalian cells by pathogens. The treatment of diseases caused by said pathogens and foodstuffs and dietetic and pharmaceutical products comprising said cycloglycans.

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