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1. 发明申请

WO2004023147A2 MALDI-MATRIX 审中-公开
标题翻译： MALDI MATRIX
公开(公告)号：WO2004023147A2
公开(公告)日：2004-03-18
申请号：PCT/EP0308435
申请日：2003-07-30
申请人： NUTRICIA NV , STAHL BERND , BOEHM GUENTHER , MANK MARKO
发明人： STAHL BERND , BOEHM GUENTHER , MANK MARKO
IPC分类号： G01N27/64 , G01N27/447 , G01N27/62 , G01N30/72 , G01N33/68 , H01J49/16
CPC分类号： H01J49/164 , G01N33/6848 , G01N33/6851 , Y10T436/10
摘要： The invention relates to matrixes for ultraviolet matrix-assisted laser desorption-ionisation mass spectrometry made of the salt of an amine which reacts as a proton acceptor and an organic substance which reacts as a proton donator. Either the amine or the organic substance absorbs UV light. Said matrixes are characterised in that they represent an ionic liquid at room temperature and in that the amine is selected from the group which is made up of 3-aminoquinoline, pyridine, a primary amine whose N-Atom is bound to a phenyl radical or a straight or branched, saturated C1-C11-alkyl radical which can be substituted by an OH-group, a secondary and tertiary amine whose N-Atoms are bound to two or three radicals which can be the same or different and represent a straight or branched, saturated C1-C8-alkyl radical which can be substituted by an OH-group and a phenyl radical, imidazole and the C and/or N-alkylated imidazole derivatives and also characterised in that the organic substance is selected from the group which is made up of 2,5-dihydroxybenzoic acid and the isomers thereof, 2-hydroxy-5-methoxy-benzoic acid and the isomers thereof, picolinic-acid, 3-hydroxypicolinic acid, nicotinic acid, 5-chloro-2-mercapto-benzo-thiazole, 6-aza-2-thiothymine, 2',4',6'-trihydroxyacetophenone-monohydrate, 2',6'-di-hydroxyaceto-phenone, 9H-pyridol[3,4-b]indole, dithranole, trans-3-indolacrylic acid, osazones, ferulic acid, 2,5-dihydroxyacetophenone, 1-nitrocarbazole, 7-amino-4-methylcumarine, 2-(p-hdroxyphenylazo)-benzoic acid, 8-aminopyrene-2,3,4-trissulfonic acid, 2-[2E-3-(4-tert-butylphenyl)-2-methylprop-2-enylidene]malonitril (DCTB), 4-methoxy-3-hydroxycinnamic acid and 3,4-dihydroxycinnamic acid. Said liquid matrixes enable reproducible, error-free analysis values to be obtained. The combination of pure mass spectrometric analysis with additional knowledge of enzymatic reactions/modifications with the possible monitoring is also described.
摘要翻译：提供矩阵作为对质子受体和胺作为质子供体反应性有机物质，其特征在于，无论是胺或有机物质吸收的UV光反应的盐的紫外线基质辅助激光解吸电离质谱分析法。这些矩阵的特征在于，该矩阵代表在室温下的离子液体，使得所述胺选自由3-氨基喹啉，吡啶，伯胺组成的组中，选择在N原子的苯基烷基或直链或支链的，其可通过一个OH基团取代的饱和的C1-C11的烷基键合，一个仲和叔胺，在N原子，两个或三个基团所连接，其可以是相同的或不同的，并且它们将成为其可被OH基团取代的直链或支链的，饱和的C1-C8烷基，和苯基是，咪唑和C-和/或N-烷基化的咪唑衍生物和有机物质选自由的组中选择从2,5-二羟基苯甲酸和它们的异构体，2-羟基-5-甲氧基 - 苯甲酸和它们的异构体，甲基吡啶酸，3-Hydroxypicolin酸，烟酸，5-氯-2- 巯基苯并噻唑，6-氮杂-2-硫代胸腺嘧啶，2 '4' ，6'-三羟基苯乙酮一水合物，2'，6'-二 - hydroxyaceto基二苯酮，-9H-吡啶并[3,4-B] 吲哚，蒽三酚，反式-3-吲哚丙烯酸，osazones，阿魏酸，2,5-二羟基苯乙酮，1- nitrocarbazole，7-氨基-4-甲基香豆素，2-（对 - Hdroxyphenylazo）苯甲酸，8-氨基芘-2,3-， 4-trissulfonsäure，2- [2E-3-（4-叔丁基苯基）-2-甲基丙-2-烯亚基]丙二腈（DCTB），4-甲氧基-3-羟基肉桂酸和3,4-二羟基肉桂酸。与这些液体基质无差错和可再现的分析值可以得到，特别是与酶反应的附加知识纯质谱分析的组合/设置有监测的可能性修改。

2. 发明申请

WO2007105945A2 USE OF NON-DIGESTABLE SACHARIDES FOR GIVING AN INFANT THE BEST START AFTER BIRTH 审中-公开
标题翻译：使用不可食用的沙发提供婴儿是出生后最好的开始
公开(公告)号：WO2007105945A2
公开(公告)日：2007-09-20
申请号：PCT/NL2007050094
申请日：2007-03-09
申请人： NUTRICIA NV , BEERMANN CHRISTOPHER , KNOL JAN , ALLES MARTINE SANDRA , STAHL BERND , BOEHM GUENTHER
发明人： BEERMANN CHRISTOPHER , KNOL JAN , ALLES MARTINE SANDRA , STAHL BERND , BOEHM GUENTHER
IPC分类号： A61K35/74 , A61P11/00 , A61P37/00
CPC分类号： A61K31/702 , A23L33/115 , A23L33/21 , A23L33/30 , A23V2002/00 , A23V2200/324 , A23V2250/28 , A23V2250/1882 , A61K2300/00
摘要： A food or supplement for pregnant women comprising water soluble, non-digestible saccharides is described. The composition is used to improve the flora and/or immune system o f the pregnant women, to improve the immune system of the infant and to improve the intestinal flora of the infant after birth.
摘要翻译：描述了包含水溶性，不可消化的糖的孕妇的食物或补充剂。该组合物用于改善孕妇的植物和/或免疫系统，改善婴儿的免疫系统并改善婴儿在出生后的肠道菌群。

3. 发明申请

WO2006018314A3 IMMUNE STIMULATORY INFANT NUTRITION 审中-公开
标题翻译：免疫刺激性哺乳动物营养
公开(公告)号：WO2006018314A3
公开(公告)日：2006-06-29
申请号：PCT/EP2005008999
申请日：2005-08-19
申请人： NUTRICIA NV , BOEHM GUENTHER , BEERMANN CHRISTOPHER , STAHL BERND , M RABET LAURA , GARSSEN JOHAN
发明人： BOEHM GUENTHER , BEERMANN CHRISTOPHER , STAHL BERND , M RABET LAURA , GARSSEN JOHAN
IPC分类号： A61K35/20 , A61K31/201 , A61K31/702 , A61P29/00 , A61P37/08
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： The invention provides a nutritional or pharmaceutical composition containing a fat component, a protein component and a carbohydrate component and comprising whey and casein. Said composition is characterized in that, the weight ratio of casein to whey is 1:1 to 1:2.4 and that the composition contains: a) at least 3 grams arginine per 100 grams protein; b) at least 10 wt.% linoleic acid based on total fatty acids; c) at least 1 wt.% alpha linolenic acid based on total fatty acids; d) at least one long chain-polyunsaturated fatty acid in an amount exceeding 0.1 wt.% based on total fatty acids, said long chain polyunsaturated fatty acid being selected from the group consisting of docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid; e) 5 to 25 wt.% of at least one polyunsaturated fatty acid based on total fatty acids; and f) 2 to 12 grams indigestible oligosaccharides having a degree of polymerisation of 2 to 100 per 100 gram dry weight of the composition. The composition of the invention reduces -among others- the risks attached to feeding whey dominant infant formula.
摘要翻译：本发明提供含有脂肪组分，蛋白质组分和碳水化合物组分并包含乳清和酪蛋白的营养或药物组合物。所述组合物的特征在于，酪蛋白与乳清的重量比为1:1至1:2.4，组合物含有：a）每100克蛋白质至少3克精氨酸; b）基于总脂肪酸至少10重量％的亚油酸; c）基于总脂肪酸的至少1重量％的α-亚麻酸; d）至少一种长链多不饱和脂肪酸，其量超过基于总脂肪酸的0.1重量％，所述长链多不饱和脂肪酸选自二十二碳六烯酸，花生四烯酸和二十碳五烯酸; e）5至25重量％的基于总脂肪酸的至少一种多不饱和脂肪酸; 和f）2至12克不可消化的寡糖，其组合物的每100克干重具有聚合度2至100。本发明的组合物减少了其他人 - 与喂食乳清主要婴儿配方奶粉相关的风险。

4. 发明申请

WO2006021335A3 PEPTIDE MIXTURE FROM PEPTIDES HAVING A MOLECULAR WEIGHT OF FROM 1000 TO 5000 DALTON 审中-公开
标题翻译：肽的分子量从1000-5000 DALTON肽混合物
公开(公告)号：WO2006021335A3
公开(公告)日：2006-04-20
申请号：PCT/EP2005008805
申请日：2005-08-12
申请人： NUTRICIA NV , BOEHM GUENTHER , BEERMANN CHRISTOPHER , GEORGI GILDA , STAHL BERND , SCHMITT JOACHIM , BOCK NADINE , KELM SOERGE
发明人： BOEHM GUENTHER , BEERMANN CHRISTOPHER , GEORGI GILDA , STAHL BERND , SCHMITT JOACHIM , BOCK NADINE , KELM SOERGE
IPC分类号： A61K38/02 , A23L1/305 , A61K35/20 , A61K36/18 , A61P35/00 , A61P37/00
CPC分类号： A23J3/346 , A23J3/344 , A23L33/18 , A23L33/40 , A61K35/20 , A61K36/06 , A61K36/31 , A61K36/48 , A61K36/88 , A61K38/168 , A61K38/1709 , A61K2300/00
摘要： The invention relates to the use of a peptide mixture from peptides having a molecular weight of from 1000 to 5000 Dalton for use in the prevention and/or treatment of cancers, of diseases associated with the developmental disturbance of the immune system, diseases of the immune system, autoimmune responses, allergies and inflammations in humans. The invention also relates to a protein component containing said peptide mixture and to formula foodstuff containing said peptide mixture. The peptides are preferably obtained from non-human proteins that are suitable for consumption, especially by enzymatic or hydrolytic cleavage of the proteins.
摘要翻译：本发明涉及使用具有从1000到5000道尔顿的肿瘤疾病的预防和/或治疗时，与免疫系统的发育障碍相关的免疫系统的疾病，自身免疫反应，变态反应和，疾病的分子量的肽的肽混合物的炎症在人类中，含有这样的肽混合物中的蛋白质组分，并且这种肽混合物含有配方食品。所述肽优选从食用合适的非人类蛋白由这些蛋白质的酶或水解裂解获得的，特别是。

5. 发明申请

WO2005039597A3 IMMUNEMODULATING OLIGOSACCHARIDES 审中-公开
标题翻译：免疫调节低密度脂蛋白
公开(公告)号：WO2005039597A3
公开(公告)日：2005-07-14
申请号：PCT/NL2004000750
申请日：2004-10-25
申请人： NUTRICIA NV , STAHL BERND , M RABET LAURA , VOS ARJAN PAUL , GARSSEN JOHAN , BOEHM GUENTHER
发明人： STAHL BERND , M RABET LAURA , VOS ARJAN PAUL , GARSSEN JOHAN , BOEHM GUENTHER
IPC分类号： A61K31/70 , A61K31/702 , A61K31/732 , A61P37/00
CPC分类号： A61K31/732 , A23L29/30 , A23L33/10 , A23L33/40 , A23V2002/00 , A61K31/70 , A61K31/702 , A23V2200/324 , A23V2250/28
摘要： The present invention relates to a method for enhancing the immune system and the treatment and/or prevention of immune system related disorders in a mammal, particularly newborns, said method comprising the administration of acid oligosaccharide and neutral oligosaccharide. Food compositions suitable for use in the above method are also provided.
摘要翻译：本发明涉及增强哺乳动物，特别是新生儿免疫系统和治疗和/或预防免疫系统相关疾病的方法，所述方法包括施用酸性寡糖和中性寡糖。还提供了适用于上述方法的食品组合物。

6. 发明申请

WO03063882A8 CYCLOGLYCANS SUITABLE TO INHIBIT MAMMALIAN INFECTION 审中-公开
标题翻译： CYCLOGLYCANE SUITABLE感染了哺乳动物体内预防
公开(公告)号：WO03063882A8
公开(公告)日：2004-12-29
申请号：PCT/EP0300505
申请日：2003-01-20
申请人： NUTRICIA NV , STAHL BERND , FINKE BERNDT , SCHMITT JOACHIM , GOEBEL WERNER , SLAGHIUS JOERG , BOEHM GUENTHER
发明人： STAHL BERND , FINKE BERNDT , SCHMITT JOACHIM , GOEBEL WERNER , SLAGHIUS JOERG , BOEHM GUENTHER
IPC分类号： A61K31/715
CPC分类号： A61K31/715
摘要： The use of, in particular homopolymeric, cycloglycans with an annular base structure of 2 to 40 monosaccharides in the ring for the prevention of the invasion and infection of mammalian cells by pathogens. The treatment of diseases caused by said pathogens and foodstuffs and dietetic and pharmaceutical products comprising said cycloglycans.

7. 发明申请

WO0142263A3 OLIGOSACCHARIDE MIXTURE 审中-公开
标题翻译：寡糖
公开(公告)号：WO0142263A3
公开(公告)日：2001-11-01
申请号：PCT/EP0012345
申请日：2000-12-07
申请人： NUTRICIA NV , STAHL BERND , BOEHM GUENTHER , FINKE BERNDT , GEORGI GILDA , JELINEK JUERGEN , SCHMITT JOACHIM J
发明人： STAHL BERND , BOEHM GUENTHER , FINKE BERNDT , GEORGI GILDA , JELINEK JUERGEN , SCHMITT JOACHIM J
IPC分类号： A23L29/30 , A23L33/10 , A61K31/702 , A61K35/20 , A61K45/06 , A61P1/00 , A61P1/14 , C07H3/06 , A23L1/09 , A61K31/70
CPC分类号： A61K45/06 , A23L29/30 , A23L33/10 , A23V2002/00 , A61K31/702 , A61K35/20 , A61K2300/00 , A23V2250/28
摘要： The invention relates to an oligosaccharide mixture based on oligosaccharides produced from one or several animal milks and which are composed of two or more monosaccharide units. Said oligosaccharide mixture is characterized in that it comprises at least two oligosaccharide fractions which are each composed of at least two different oligosaccharides. The invention is further cahracterized in that lactose does not pertain thereto and the total spectrum of the oligosaccharides present in the oligosaccharide mixture differs from those present in animal milk or animal milks, wherefrom the oligosaccharide fractions are extracted and that a) if said oligosaccharides are extracted from only one animal milk, the proportion of neutral oligosaccharides to acidic oligosaccharides is 90 -60: 10 - 40 weight %, or b) if said oligosaccharides are extracted from at least two animal milks, the oligosaccharides extracted from two different animal milks each make up 10 weight % of the total amount of oligosaccharides present in the oligosaccharide mixture. The oligosaccharide mixture according to the invention approximates to human milk with respect to its positive properties and in particular its anti-infective activity.
摘要翻译：提供了一种基于由一种或多种动物乳获得并由两种或更多种单糖单元组成的低聚糖的寡糖混合物。此寡糖混合物的特征在于，它包括至少两个寡糖级分的每一个在至少两个不同的寡糖组成，其中游离的乳糖不与其相关的，即，存在于所述寡糖混合物的寡糖与从动物乳或动物乳的总频谱到或从其中获得的寡糖级分，而不同，并且如果所述寡糖只有一个是从中性寡糖的酸性寡糖90-60的比率获得动物牛奶）：10 - 40重量％，或b），其中从至少两个动物乳获得的寡糖，从每两个不同的动物乳中提取的寡糖占至少10重量存在于所述寡糖混合物的寡糖总量的％。该erfingungsgemässe寡糖在他们的积极作用方面，特别是人乳，其抗感染作用近似。

8. 发明申请

WO2006019300A3 IMMUNE STIMULATORY INFANT NUTRITION 审中-公开
标题翻译：免疫刺激性哺乳动物营养
公开(公告)号：WO2006019300A3
公开(公告)日：2006-06-01
申请号：PCT/NL2005000609
申请日：2005-08-22
申请人： NUTRICIA NV , BEERMANN CHRISTOPHER , BOEHM GUENTHER , STAHL BERND
发明人： BEERMANN CHRISTOPHER , BOEHM GUENTHER , STAHL BERND
IPC分类号： A61K35/20 , A61K31/702 , A61K31/7052 , A61K31/715 , A61P29/00
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： The present invention relates to a nutritional composition containing protein, fat and carbohydrate; and a. a nucleotide component selected from the group consisting of nucleic acid, nucleic acid derivatives, nucleotides, nucleoside polyphosphates, polynucleotides, nucleosides, ribose, desoxyribose, and dinucleosidpolyphosphates (Np X N); and b. a non-proteinaceous negatively charged, glycan or glycoconjugate component with a molecular weight between 200 and 20.000 dalton. The present nutritional composition is particularly suited for feeding infants as it mimics the protective effects of human milk, in particular against allergies and infections.
摘要翻译：本发明涉及含有蛋白质，脂肪和碳水化合物的营养组合物; 和a。选自核酸，核酸衍生物，核苷酸，核苷多磷酸盐，多核苷酸，核苷，核糖，脱氧核糖和二核苷酸多磷酸盐的核苷酸成分（Np×N N）; 和b。分子量在200至20.000道尔顿之间的非蛋白质带负电的聚糖或糖缀合物组分。目前的营养组合物特别适用于喂养婴儿，因为它模仿人乳的保护作用，特别是针对过敏和感染。

9. 发明申请

WO0160378A3 ANTIADHESIVE CARBOHYDRATES 审中-公开
标题翻译：抗粘性碳水化合物
公开(公告)号：WO0160378A3
公开(公告)日：2002-04-18
申请号：PCT/EP0101753
申请日：2001-02-16
申请人： NUTRICIA NV , STAHL BERND , BOEHM GUENTHER
发明人： STAHL BERND , BOEHM GUENTHER
IPC分类号： A61K31/7012 , A61K31/732 , A61K31/734 , A61P31/04 , A61P31/12 , A61P33/00 , A61P39/00 , A61P43/00 , A61K31/70 , A61K31/715
CPC分类号： A61K31/7012 , A23L29/231 , A23L29/256 , A23L29/30 , A23L33/00 , A23L33/10 , A61K31/702 , A61K31/715
摘要： The invention relates to a pharmaceutical or dietetic preparation which serves for reducing and/or blocking the adhesion of pathogenic substances and organisms to eucaryontic cells, especially mammal cells. Said preparation contains at least one carbohydrate having an uronic acid unit on one of the ends thereof. 10 to 100 % of the present, terminal uronic acid units pertaining to the carbohydrates are provided with a double bond that is especially situated between the C4 and the C5 atom.
摘要翻译：本发明提供，其用于降低哺乳动物细胞和/或阻断至真核细胞的致病物质和生物体的粘附性，特别是药物或饮食制剂。该制剂包含具有在其端部中的一个的糖醛酸单元至少一种碳水化合物。碳水化合物的现有终端糖醛酸单元的10〜100％，从而有一个双键，其位于特别是C4和C5之间原子。

10. 发明申请

WO0133973A3 FOOD FOR DIABETICS 审中-公开
标题翻译： DIABETIKERNÄHRUNG
公开(公告)号：WO0133973A3
公开(公告)日：2001-10-04
申请号：PCT/EP0011134
申请日：2000-11-10
申请人： NUTRICIA NV , STAHL BERND , KLIEM MICHAEL , FARWER SANDRA , SAWATZKI GUENTHER , BOEHM GUENTHER
发明人： STAHL BERND , KLIEM MICHAEL , FARWER SANDRA , SAWATZKI GUENTHER , BOEHM GUENTHER
IPC分类号： A23L29/30 , A23L33/20 , A23L33/21 , C12P19/14 , C12P19/18 , A23L1/054 , A23L1/09 , A23L1/307 , A23L1/308 , C07H3/06 , C08B37/00 , C12P19/08
CPC分类号： C12Y204/01019 , A23L29/30 , A23L33/20 , A23L33/21 , C12P19/14 , C12P19/18 , C12Y204/01024
摘要： The invention relates to a carbohydrate mixture which is provided with at least one modified carbohydrate made of a base body and a carbohydrate residue coupled therewith. The base body is a digestable, glucose-containing carbohydrate in the form of a digestable glucan or a non-digestable storage carbohydrate, skeletal carbohydrate or low-molecular component thereof. The base body is coupled to a carbohydrate residue. Glucose release from the inventive carbohydrate mixture is thus reduced by at least 10 %, detected in an in-vivo digestion system based on pancreatine and compared to a carbohydrate mixture which contains the same amount of weight of non-modified carbohydrates. The postprandial blood glucose concentration increase after eating can be moderated by means of the inventive carbohydrate mixture. The glucose can thus be metabolised by diabetics in spite of the existing lack of insulin. The inventive carbohydrate mixture can be used in food for diabetics and in pharmaceuticals.
摘要翻译：提供了一种碳水化合物混合物，其包含至少一种来自身体的修饰碳水化合物和与其偶联的碳水化合物部分。身体是可消化的，可消化葡聚糖形式的含葡萄糖的碳水化合物或不消化的储存碳水化合物，支架碳水化合物或其低分子量组分。穿过基体与糖残基的结合，从本发明的碳水化合物混合物的葡萄糖释放通过至少减少10％，在体内Verdausystem上Pankreatinbasis测定，并与重量的未经修饰的碳水化合物的含有相同量的碳水化合物混合物相比。利用根据本发明的碳水化合物混合物，可以缓解食物摄入后餐后血糖浓度的增加。结果，尽管存在胰岛素缺乏，葡萄糖可以被糖尿病患者代谢。根据本发明的碳水化合物混合物可以用于糖尿病营养和药物中。

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