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1. 发明申请

WO2014146001A2 EXPANDABLE BODY DEVICE AND METHOD OF USE 审中-公开
标题翻译：可扩展身体装置及其使用方法
公开(公告)号：WO2014146001A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/030869
申请日：2014-03-17
申请人： NOVITA THERAPEUTICS, LLC , FRANANO, F. Nicholas , LOREE, Howard M., II. , BRUNELL, Steven , STEPHENSON, Katherine
发明人： FRANANO, F. Nicholas , LOREE, Howard M., II. , BRUNELL, Steven , STEPHENSON, Katherine
IPC分类号： A61B17/12
CPC分类号： A61B17/12113 , A61B17/12031 , A61B17/12136 , A61B17/1214 , A61B17/12172 , A61B17/12186 , A61B2017/00526 , A61B2017/00853 , A61B2017/00867 , A61B2017/00876 , A61B2017/00893 , A61B2017/00929 , A61B2017/1205 , A61B2017/12063 , A61B2090/376 , A61B2090/3966
摘要： Disclosed herein are medical devices comprising a single-lobed, thin-walled, expandable body and a flexible, elongated delivery device for treating saccular vascular aneurysms and occluding segments of blood vessels and other biological conduits. The expandable bodies may include gold and other metals that can be compressed, positioned in the lumen of an aneurysm, or other biological conduit and expanded. The external surface of the expandable bodies can be configured to promote local thrombosis and to promote the growth of tissue into and around the surface in order to reduce migration of the expandable body and to occlude and seal the aneurysm or biological conduit. For the treatment of saccular aneurysms, the expandable body may be deployed in combination with one or more coiled wires that contact both the wall of the aneurysm and the expandable body and exert force on the expandable body to aid in sealing the aneurysm neck.
摘要翻译：本文公开了包括单裂片，薄壁，可扩张体和用于治疗囊状血管动脉瘤和闭塞血管和其他生物管道段的柔性细长递送装置的医疗装置。可膨胀体可以包括金和其它可被压缩的金属，定位在动脉瘤的内腔或其他生物导管中并膨胀。可扩张体的外表面可以被构造成促进局部血栓形成并促进组织进入和周围的生长，以减少可膨胀体的迁移并阻塞和密封动脉瘤或生物导管。对于治疗囊状动脉瘤，可扩张体可以与一个或多个与动脉瘤壁和可膨胀体接触的线圈组合地展开，并且对可扩张体施加力以帮助密封动脉瘤颈部。

2. 发明申请

WO2012099910A3 BALLSTENT DEVICE AND METHODS OF USE 审中-公开
公开(公告)号：WO2012099910A3
公开(公告)日：2012-07-26
申请号：PCT/US2012/021621
申请日：2012-01-17
申请人： NOVITA THERAPEUTICS, LLC , FRANANO, F. Nicholas
发明人： FRANANO, F. Nicholas
IPC分类号： A61F2/06
摘要： What is disclosed are medical devices comprising a rounded, thin-walled, expandable metal structure ("ballstent") and a flexible, elongated delivery device ("delivery catheter") and systems and methods of use for treating saccular vascular aneurysms with the medical devices. Ballstents comprised of gold, platinum, or silver that can be compressed, positioned in the lumen of an aneurysm, and expanded to conform to the shape of the aneurysm are disclosed. The external surface of ballstents can be configured to promote local thrombosis and to promote the growth of tissue into and around the wall of the ballstent in order to seal the aneurysm and fix the ballstent in place in the aneurysm. The wall of the ballstent can also be configured to release drugs or pharmacologically active molecules, such as those that promote thrombosis, cell proliferation, extracellular matrix deposition, and tissue growth.

3. 发明申请

WO2011103356A1 SYSTEM AND METHOD TO INCREASE THE OVERALL DIAMETER OF VEINS 审中-公开
标题翻译：增加VEINS的整体直径的系统和方法
公开(公告)号：WO2011103356A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025331
申请日：2011-02-17
申请人： NOVITA THERAPEUTICS, LLC , FRANANO, F. Nicholas
发明人： FRANANO, F. Nicholas
IPC分类号： A61N1/362
CPC分类号： A61M1/101 , A61M1/10 , A61M1/1008 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3655 , A61M1/367 , A61M2205/0205 , A61M2205/3334 , A61M2206/10
摘要： A system (10) and method (100) for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein (30) for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein (30) is provided. The method (100) includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein (30) in order to optimize the rate and extent of dilation of the peripheral vein (30).
摘要翻译：一种用于在足够的时间段内增加外周静脉（30）中的血液速度和壁剪切应力（WSS）的系统（10）和方法（100），导致总直径和管腔直径的持续增加提供静脉（30）。方法（100）包括以期望的速率和搏动来抽血。根据需要监测和调整泵送，以维持外周静脉（30）中所需的血液速度，WSS和脉动，以优化外周静脉（30）的扩张速率和程度。

4. 发明申请

WO2012099909A2 DETACHABLE METAL BALLOON DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：可拆卸的金属球囊输送装置和方法
公开(公告)号：WO2012099909A2
公开(公告)日：2012-07-26
申请号：PCT/US2012/021620
申请日：2012-01-17
申请人： NOVITA THERAPEUTICS, LLC , FRANANO, F. Nicholas
发明人： FRANANO, F. Nicholas
IPC分类号： A61M25/10
CPC分类号： A61F2/958 , A61B17/12031 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B2017/00526 , A61B2017/00893 , A61B2017/12054 , A61B2017/12059 , A61B2017/12063 , A61B2017/12068 , A61B2090/037 , A61F2/06 , A61M25/1029 , Y10T29/49826
摘要： A medical device comprising a compressed, inflatable, detachable single-lobed metal balloon attached to a catheter and methods of use for occluding blood vessels or treating vascular aneurysms are disclosed. The balloon can be made with ductile metals such as gold, platinum, or silver so that the balloon will conform to the shape of the void space during inflation and so that the balloon can be subsequently shaped by the application of an external force. The balloon can be configured such that it can be detached from the catheter by physical means or by electrolysis. The surface of the balloon can be configured to promote the growth of tissue into the wall of the balloon and to release drugs or pharmacologically active molecules, so that vessel occlusion or the sealing of an aneurysm will be maintained over time.
摘要翻译：公开了一种医疗装置，其包括附接到导管的压缩的，可膨胀的，可拆卸的单瓣金属球囊以及用于闭塞血管或治疗血管动脉瘤的方法。气球可以由延展性金属如金，铂或银制成，使得气球在充气过程中将符合空隙空间的形状，并且随后可以通过施加外力来使气球成形。球囊可以被配置为使得它可以通过物理手段或通过电解从导管分离。球囊的表面可以被配置为促进组织生长进入球囊壁并释放药物或药理学活性分子，从而随着时间的推移，血管闭塞或动脉瘤的密封将被维持。

5. 发明申请

WO2009079220A3 RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF 审中-公开
公开(公告)号：WO2009079220A3
公开(公告)日：2009-06-25
申请号：PCT/US2008/085559
申请日：2008-12-04
申请人： PROTEON THERAPEUTICS, INC. , FRANANO, F. Nicholas , BLAND, Kimberly , WONG, Marco D. , DING, Bee C.
发明人： FRANANO, F. Nicholas , BLAND, Kimberly , WONG, Marco D. , DING, Bee C.
IPC分类号： C12N9/66 , A61K38/46 , C12N15/12
摘要： The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.

6. 发明申请

WO2014028787A3 BLOOD PUMP SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2014028787A3
公开(公告)日：2014-02-20
申请号：PCT/US2013/055221
申请日：2013-08-15
申请人： NOVITA THERAPEUTICS , FRANANO, F. Nicholas , LOREE II, Howard M. , TANSLEY, Geoff , WOODARD, Steve , HUTTO, Barrett
发明人： FRANANO, F. Nicholas , LOREE II, Howard M. , TANSLEY, Geoff , WOODARD, Steve , HUTTO, Barrett
IPC分类号： A61M1/10 , A61M1/12 , A61M5/14 , A61M5/142
摘要： The present invention relates to a rotary blood pump with a double pivot contact bearing system with an operating range between about 50 mL/min and about 1500 mL/min. The rotary blood pump is part of a blood pump system that includes blood conduit(s), a control system with optional sensors, and a power source. Embodiments of the present invention may include elements such as wear resistant bearing materials, a rotor back plate for magnetic attraction of the rotor to reduce bearing pivot bearing forces and wear, a rotor size and shape and a bearing gap that combine to create a hydrodynamic bearing effect and reduce bearing pivot bearing forces and wear, improved intravascular conduits with increased resistance to thrombosis, conduit insertion site cuffs to resist infection, and conduit side ports amenable to the easy insertion of guidewire and catheter-based medical devices.

7. 发明申请

WO2009097621A1 MEDICAL DEVICE 审中-公开
标题翻译：医疗装置
公开(公告)号：WO2009097621A1
公开(公告)日：2009-08-06
申请号：PCT/US2009/032891
申请日：2009-02-02
申请人： PROTEON THERAPEUTICS, LLC , FRANANO, F. Nicholas , GOTTLIEB, Daniel Philip
发明人： FRANANO, F. Nicholas , GOTTLIEB, Daniel Philip
IPC分类号： A61M29/00
CPC分类号： A61M29/02 , A61M25/0082
摘要： A medical device for the delivery of fluids into or through the wall of a biological space or conduit is described. The medical device comprises one or more actuators, which may exist in a constrained configuration which is substantially parallel to the longitudinal axis of the device or an unconstrained configuration in which at least a portion of the one or more actuators is oriented substantially non-parallel to the longitudinal axis of the device. The device further comprises tissue penetrators, which may be attached to the actuators or contained within the actuators. Upon positioning of the device at the target treatment site within a biological space or conduit, the operator may release the actuators from their constrained position, allowing the actuators to adopt their unconstrained position and make contact with an adjacent wall of a biological space or conduit. The actuators are configured to minimize the physical contact between the device and the target tissue, thereby permitting uniform and enhanced delivery of fluids into less compressed tissue, with reduced tissue trauma.
摘要翻译：描述了用于将流体输送入或通过生物空间或导管的壁的医疗装置。医疗装置包括一个或多个致动器，其可以以约束构造存在，其基本上平行于装置的纵向轴线或非约束构造，其中，一个或多个致动器的至少一部分基本上不平行于设备的纵轴。该装置还包括组织穿透器，其可附接到致动器或包含在致动器内。在将装置定位在生物空间或导管内的目标处理部位时，操作者可以将致动器从其约束位置释放，从而允许致动器采用其无约束位置并与生物空间或导管的相邻壁接触。致动器构造成使装置和目标组织之间的物理接触最小化，从而允许均匀和增强的流体输送到较不压缩的组织中，同时减少组织损伤。

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