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1. 发明申请

WO2014146001A3 EXPANDABLE BODY DEVICE AND METHOD OF USE 审中-公开
标题翻译：可扩展身体装置及其使用方法
公开(公告)号：WO2014146001A3
公开(公告)日：2015-01-08
申请号：PCT/US2014030869
申请日：2014-03-17
申请人： NOVITA THERAPEUTICS LLC , FRANANO F NICHOLAS , LOREE HOWARD M II , BRUNELL STEVEN , STEPHENSON KATHERINE
发明人： FRANANO F NICHOLAS , LOREE HOWARD M II , BRUNELL STEVEN , STEPHENSON KATHERINE
IPC分类号： A61F2/02 , A61F2/06 , A61M25/04 , A61M29/02
CPC分类号： A61B17/12113 , A61B17/12031 , A61B17/12136 , A61B17/1214 , A61B17/12172 , A61B17/12186 , A61B2017/00526 , A61B2017/00853 , A61B2017/00867 , A61B2017/00876 , A61B2017/00893 , A61B2017/00929 , A61B2017/1205 , A61B2017/12063 , A61B2090/376 , A61B2090/3966
摘要： Disclosed herein are medical devices comprising a single-lobed, thin-walled, expandable body and a flexible, elongated delivery device for treating saccular vascular aneurysms and occluding segments of blood vessels and other biological conduits. The expandable bodies may include gold and other metals that can be compressed, positioned in the lumen of an aneurysm, or other biological conduit and expanded. The external surface of the expandable bodies can be configured to promote local thrombosis and to promote the growth of tissue into and around the surface in order to reduce migration of the expandable body and to occlude and seal the aneurysm or biological conduit. For the treatment of saccular aneurysms, the expandable body may be deployed in combination with one or more coiled wires that contact both the wall of the aneurysm and the expandable body and exert force on the expandable body to aid in sealing the aneurysm neck.
摘要翻译：本文公开了包括单裂片，薄壁，可扩张体和用于治疗囊状血管动脉瘤和闭塞血管和其他生物管道段的柔性细长递送装置的医疗装置。可膨胀体可以包括金和其它可被压缩的金属，定位在动脉瘤的内腔或其他生物导管中并膨胀。可扩张体的外表面可以被构造成促进局部血栓形成并促进组织进入和周围的生长，以减少可膨胀体的迁移并阻塞和密封动脉瘤或生物导管。对于治疗囊状动脉瘤，可扩张体可以与一个或多个与动脉瘤壁和可膨胀体接触的线圈组合地展开，并且对可扩张体施加力以帮助密封动脉瘤颈部。

2. 发明申请

WO2013025821A2 SYSTEM AND METHOD TO INCREASE THE OVERALL DIAMETER OF VEINS AND ARTERIES 审中-公开
标题翻译：增加航空和航空器整体直径的系统和方法
公开(公告)号：WO2013025821A2
公开(公告)日：2013-02-21
申请号：PCT/US2012/050978
申请日：2012-08-15
申请人： NOVITA THERAPEUTICS, LLC , FRANANO, M.D., F. Nicholas
发明人： FRANANO, M.D., F. Nicholas
IPC分类号： A61M1/10 , A01N1/02
CPC分类号： A61M1/32 , A61B17/11 , A61B2017/00778 , A61B2017/00969 , A61B2017/1107 , A61B2017/1135 , A61M1/3655
摘要： A system and method for increasing the speed of blood and the wall shear stress in a peripheral artery or peripheral vein to a sufficient level and for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the artery or vein is provided. The method includes systems and methods to effect the movement of blood at the desired rate and in the desired direction. The movement of blood is monitored and adjusted, as necessary, to maintain the desired blood speed and wall shear stress in the peripheral artery or vein in order to optimize the rate and extent of persistent diameter increase of the peripheral artery or peripheral vein.
摘要翻译：一种用于将外周动脉或外周静脉中的血液速度和壁剪切应力提高到足够的水平并足够的时间段以导致动脉的总直径和内腔直径持续增加的系统和方法，或提供静脉。该方法包括以期望的速率和期望的方向实现血液运动的系统和方法。根据需要监测和调整血液的运动，以维持周围动脉或静脉中所需的血液速度和壁剪切应力，以优化外周动脉或外周静脉持续直径增加的速率和程度。

3. 发明申请

WO2013025821A3 SYSTEM AND METHOD TO INCREASE THE OVERALL DIAMETER OF VEINS AND ARTERIES 审中-公开
标题翻译：增加静脉和动脉的整体直径的系统和方法
公开(公告)号：WO2013025821A3
公开(公告)日：2013-05-10
申请号：PCT/US2012050978
申请日：2012-08-15
申请人： NOVITA THERAPEUTICS LLC , FRANANO M D F NICHOLAS
发明人： FRANANO M D F NICHOLAS
IPC分类号： A61M5/00
CPC分类号： A61M1/32 , A61B17/11 , A61B2017/00778 , A61B2017/00969 , A61B2017/1107 , A61B2017/1135 , A61M1/3655
摘要： A system and method for increasing the speed of blood and the wall shear stress in a peripheral artery or peripheral vein to a sufficient level and for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the artery or vein is provided. The method includes systems and methods to effect the movement of blood at the desired rate and in the desired direction. The movement of blood is monitored and adjusted, as necessary, to maintain the desired blood speed and wall shear stress in the peripheral artery or vein in order to optimize the rate and extent of persistent diameter increase of the peripheral artery or peripheral vein.
摘要翻译：一种系统和方法，用于将外周动脉或外周静脉中的血液和壁面剪切应力的速度提高到足够的水平和足够的时间周期以导致动脉的总体直径和内腔直径的持续增加或提供静脉。该方法包括以期望的速率和期望的方向实现血液运动的系统和方法。必要时监测和调整血液的运动，以维持外周动脉或静脉中所需的血液速度和壁剪切应力，以便优化外周动脉或外周静脉持续直径增加的速率和程度。

4. 发明申请

WO2012099910A2 BALLSTENT DEVICE AND METHODS OF USE 审中-公开
标题翻译： BALLSTENT装置及其使用方法
公开(公告)号：WO2012099910A2
公开(公告)日：2012-07-26
申请号：PCT/US2012021621
申请日：2012-01-17
申请人： NOVITA THERAPEUTICS LLC , FRANANO F NICHOLAS
发明人： FRANANO F NICHOLAS
IPC分类号： A61M25/10
CPC分类号： A61F2/958 , A61B17/12031 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B2017/00526 , A61B2017/00893 , A61B2017/12054 , A61B2017/12059 , A61B2017/12063 , A61B2017/12068 , A61B2090/037 , A61F2/06 , A61M25/1029 , Y10T29/49826
摘要： What is disclosed are medical devices comprising a rounded, thin-walled, expandable metal structure ("ballstent") and a flexible, elongated delivery device ("delivery catheter") and systems and methods of use for treating saccular vascular aneurysms with the medical devices. Ballstents comprised of gold, platinum, or silver that can be compressed, positioned in the lumen of an aneurysm, and expanded to conform to the shape of the aneurysm are disclosed. The external surface of ballstents can be configured to promote local thrombosis and to promote the growth of tissue into and around the wall of the ballstent in order to seal the aneurysm and fix the ballstent in place in the aneurysm. The wall of the ballstent can also be configured to release drugs or pharmacologically active molecules, such as those that promote thrombosis, cell proliferation, extracellular matrix deposition, and tissue growth.
摘要翻译：公开的是包括圆形，薄壁，可扩展金属结构（“球状液体”）和柔性细长输送装置（“输送导管”）的医疗装置以及用于用医疗装置治疗囊状血管动脉瘤的系统和方法。公开了可以压缩的位于动脉瘤内腔中的金，铂或银的球状体，并且膨胀以符合动脉瘤的形状。球形体的外表面可以被配置为促进局部血栓形成并促进组织在球状体壁中和周围的生长，以便密封动脉瘤并将球状体固定在动脉瘤中的适当位置。球状体的壁还可以被配置为释放药物或药理活性分子，例如促进血栓形成，细胞增殖，细胞外基质沉积和组织生长的分子。

5. 发明申请

WO2012099704A3 BLOCKSTENT DEVICE AND METHODS OF USE 审中-公开
标题翻译：块式设备及其使用方法
公开(公告)号：WO2012099704A3
公开(公告)日：2013-12-12
申请号：PCT/US2012000030
申请日：2012-01-17
申请人： NOVITA THERAPEUTICS LLC , FRANANO F NICHOLAS , STEPHENSON KATHERINE
发明人： FRANANO F NICHOLAS , STEPHENSON KATHERINE
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61B17/12031 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B2017/00526 , A61B2017/00893 , A61B2017/12054 , A61B2017/12059 , A61B2017/12063 , A61B2017/12068 , A61B2090/037 , A61F2/06 , A61M25/1029 , Y10T29/49826
摘要： What is disclosed is a medical device comprising a compressed, cylindrical or oblong, thin-walled, expandable metal structure (a "blockstent") and a flexible, elongated device (a "delivery catheter") to position the compressed blockstent into the lumen of a blood vessel segment to be treated, and methods of use for occlusion of treated blood vessel segments. A blockstent can be made with ductile meta!s such that the blockstent will conform to the shape of the lumen of the treated blood vessel segment during expansion and allow for the shape of the blockstent to be permanently changed by the application of an external force. The surface of the blockstent can be configured to promote local thrombus on the external surface of the blockstent and to promote the growth of tissue into the wall of the blockstent in order to occlude the treated blood vessel and fix the blockstent in place.
摘要翻译：所公开的是包括压缩的，圆柱形或长圆形的薄壁可膨胀金属结构（“块状物”）和柔性细长装置（“输送导管”）的医疗装置，以将压缩块状物置于待治疗的血管段，以及用于闭塞经处理的血管段的方法。块状物可以用延性元件制成，使得块状物在膨胀期间将符合经处理的血管段的内腔的形状，并且允许通过施加外力来永久改变块状物的形状。阻塞物的表面可以构造成促进块状物的外表面上的局部血栓，并促进组织生长到阻塞物的壁中，以封闭经处理的血管并将块状物固定就位。

6. 发明申请

WO2012099704A2 BLOCKSTENT DEVICE AND METHODS OF USE 审中-公开
标题翻译：块式设备及其使用方法
公开(公告)号：WO2012099704A2
公开(公告)日：2012-07-26
申请号：PCT/US2012/000030
申请日：2012-01-17
申请人： NOVITA THERAPEUTICS, LLC , FRANANO, F., Nicholas
发明人： FRANANO, F., Nicholas
IPC分类号： A61M25/16
CPC分类号： A61F2/958 , A61B17/12031 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B2017/00526 , A61B2017/00893 , A61B2017/12054 , A61B2017/12059 , A61B2017/12063 , A61B2017/12068 , A61B2090/037 , A61F2/06 , A61M25/1029 , Y10T29/49826
摘要： What is disclosed is a medical device comprising a compressed, cylindrical or oblong, thin-walled, expandable metal structure (a "blockstent") and a flexible, elongated device (a "delivery catheter") to position the compressed blockstent into the lumen of a blood vessel segment to be treated, and methods of use for occlusion of treated blood vessel segments. A blockstent can be made with ductile metals such as gold, platinum, or silver such that the blockstent will conform to the shape of the lumen of the treated blood vessel segment during expansion and allow for the shape of the blockstent to be permanently changed by the application of an external force. The surface of the blockstent can be configured to promote local thrombus on the external surface of the blockstent and to promote the growth of tissue into the wall of the blockstent in order to occlude the treated blood vessel and fix the blockstent in place. The wall of the blockstent can also be configured to release drugs or pharmacologically active molecules such as those that promote thrombosis, cell proliferation, extracellular matrix deposititon to promote this thrombus formation and tissue growth.
摘要翻译：所公开的是包括压缩的，圆柱形或长圆形的薄壁可膨胀金属结构（“块状物”）和柔性细长装置（“输送导管”）的医疗装置，以将压缩块状物置于待治疗的血管段，以及用于闭塞经处理的血管段的方法。块状物可以用诸如金，铂或银的延性金属制成，使得块状物将在膨胀期间符合经处理的血管段的内腔的形状，并且允许块状物的形状被永久地改变外力的应用阻塞物的表面可以构造成促进块状物的外表面上的局部血栓，并促进组织生长到阻塞物的壁中，以阻塞经处理的血管并将块状物固定就位。阻滞剂的壁还可以被配置为释放药物或药理活性分子，例如促进血栓形成，细胞增殖，细胞外基质沉积物以促进该血栓形成和组织生长的分子。

7. 发明申请

WO2013025826A1 BLOOD PUMP SYSTEMS AND METHODS 审中-公开
标题翻译：血液泵系统和方法
公开(公告)号：WO2013025826A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/050983
申请日：2012-08-15
申请人： NOVITA THERAPEUTICS, LLC , FRANANO, M.D., F. Nicholas
发明人： FRANANO, M.D., F. Nicholas
IPC分类号： A61M1/10
CPC分类号： A61M1/1086 , A61M1/1008 , A61M1/101 , A61M1/1012 , A61M1/1013 , A61M1/1031 , A61M1/12 , A61M1/122 , A61M1/3653 , A61M1/3655 , A61M1/3659 , A61M2205/3334 , A61M2205/3344 , A61M2205/502 , A61M2205/82
摘要： A blood pump system for persistently increasing the overall diameter and lumen diameter of peripheral veins and arteries by persistently increasing the speed of blood and the wall shear stress in a peripheral vein or artery for a period of time sufficient to result in a persistent increase in the overall diameter and lumen diameter of the vessel is provided. The blood pump system includes a blood pump, blood conduit(s), a control system with optional sensors, and a power source. The pump system is configured to connect to the vascular system in a patient and pump blood at a desired rate and pulsatility. The pumping of blood is monitored and adjusted, as necessary, to maintain the desired elevated blood speed, wall shear stress, and desired pulsatility in the target vessel to optimize the rate and extent of persistent increase in the overall diameter and lumen diameter of the target vessel.
摘要翻译：一种用于通过持续增加外周静脉或动脉中的血液速度和壁剪切应力持续增加外周静脉和动脉的总直径和内腔直径的血泵系统，持续一段时间足以导致持续增加提供了容器的总直径和管腔直径。血液泵系统包括血液泵，血液导管，具有可选传感器的控制系统和电源。泵系统被配置为连接到患者中的血管系统并以期望的速率和脉动来泵血。根据需要监测和调整血液的抽吸，以维持目标血管中所需的升高的血液速度，壁剪切应力和所需的搏动，以优化靶的总体直径和内腔直径持续增加的速率和程度船只。

8. 发明申请

WO2012099910A3 BALLSTENT DEVICE AND METHODS OF USE 审中-公开
公开(公告)号：WO2012099910A3
公开(公告)日：2012-07-26
申请号：PCT/US2012/021621
申请日：2012-01-17
申请人： NOVITA THERAPEUTICS, LLC , FRANANO, F. Nicholas
发明人： FRANANO, F. Nicholas
IPC分类号： A61F2/06
摘要： What is disclosed are medical devices comprising a rounded, thin-walled, expandable metal structure ("ballstent") and a flexible, elongated delivery device ("delivery catheter") and systems and methods of use for treating saccular vascular aneurysms with the medical devices. Ballstents comprised of gold, platinum, or silver that can be compressed, positioned in the lumen of an aneurysm, and expanded to conform to the shape of the aneurysm are disclosed. The external surface of ballstents can be configured to promote local thrombosis and to promote the growth of tissue into and around the wall of the ballstent in order to seal the aneurysm and fix the ballstent in place in the aneurysm. The wall of the ballstent can also be configured to release drugs or pharmacologically active molecules, such as those that promote thrombosis, cell proliferation, extracellular matrix deposition, and tissue growth.

9. 发明申请

WO2011103356A1 SYSTEM AND METHOD TO INCREASE THE OVERALL DIAMETER OF VEINS 审中-公开
标题翻译：增加VEINS的整体直径的系统和方法
公开(公告)号：WO2011103356A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025331
申请日：2011-02-17
申请人： NOVITA THERAPEUTICS, LLC , FRANANO, F. Nicholas
发明人： FRANANO, F. Nicholas
IPC分类号： A61N1/362
CPC分类号： A61M1/101 , A61M1/10 , A61M1/1008 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/125 , A61M1/3655 , A61M1/367 , A61M2205/0205 , A61M2205/3334 , A61M2206/10
摘要： A system (10) and method (100) for increasing the speed of blood and wall shear stress (WSS) in a peripheral vein (30) for a sufficient period of time to result in a persistent increase in the overall diameter and lumen diameter of the vein (30) is provided. The method (100) includes pumping blood at a desired rate and pulsatility. The pumping is monitored and adjusted, as necessary, to maintain the desired blood speed, WSS and pulsatility in the peripheral vein (30) in order to optimize the rate and extent of dilation of the peripheral vein (30).
摘要翻译：一种用于在足够的时间段内增加外周静脉（30）中的血液速度和壁剪切应力（WSS）的系统（10）和方法（100），导致总直径和管腔直径的持续增加提供静脉（30）。方法（100）包括以期望的速率和搏动来抽血。根据需要监测和调整泵送，以维持外周静脉（30）中所需的血液速度，WSS和脉动，以优化外周静脉（30）的扩张速率和程度。

10. 发明申请

WO2014146001A2 EXPANDABLE BODY DEVICE AND METHOD OF USE 审中-公开
标题翻译：可扩展身体装置及其使用方法
公开(公告)号：WO2014146001A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/030869
申请日：2014-03-17
申请人： NOVITA THERAPEUTICS, LLC , FRANANO, F. Nicholas , LOREE, Howard M., II. , BRUNELL, Steven , STEPHENSON, Katherine
发明人： FRANANO, F. Nicholas , LOREE, Howard M., II. , BRUNELL, Steven , STEPHENSON, Katherine
IPC分类号： A61B17/12
CPC分类号： A61B17/12113 , A61B17/12031 , A61B17/12136 , A61B17/1214 , A61B17/12172 , A61B17/12186 , A61B2017/00526 , A61B2017/00853 , A61B2017/00867 , A61B2017/00876 , A61B2017/00893 , A61B2017/00929 , A61B2017/1205 , A61B2017/12063 , A61B2090/376 , A61B2090/3966
摘要： Disclosed herein are medical devices comprising a single-lobed, thin-walled, expandable body and a flexible, elongated delivery device for treating saccular vascular aneurysms and occluding segments of blood vessels and other biological conduits. The expandable bodies may include gold and other metals that can be compressed, positioned in the lumen of an aneurysm, or other biological conduit and expanded. The external surface of the expandable bodies can be configured to promote local thrombosis and to promote the growth of tissue into and around the surface in order to reduce migration of the expandable body and to occlude and seal the aneurysm or biological conduit. For the treatment of saccular aneurysms, the expandable body may be deployed in combination with one or more coiled wires that contact both the wall of the aneurysm and the expandable body and exert force on the expandable body to aid in sealing the aneurysm neck.
摘要翻译：本文公开了包括单裂片，薄壁，可扩张体和用于治疗囊状血管动脉瘤和闭塞血管和其他生物管道段的柔性细长递送装置的医疗装置。可膨胀体可以包括金和其它可被压缩的金属，定位在动脉瘤的内腔或其他生物导管中并膨胀。可扩张体的外表面可以被构造成促进局部血栓形成并促进组织进入和周围的生长，以减少可膨胀体的迁移并阻塞和密封动脉瘤或生物导管。对于治疗囊状动脉瘤，可扩张体可以与一个或多个与动脉瘤壁和可膨胀体接触的线圈组合地展开，并且对可扩张体施加力以帮助密封动脉瘤颈部。

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