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1. 发明申请

WO2007047854A2 METHODS AND SYSTEMS FOR ESTABLISHING PARAMETERS FOR NEURAL STIMULATION 审中-公开
标题翻译：用于建立神经刺激参数的方法和系统
公开(公告)号：WO2007047854A2
公开(公告)日：2007-04-26
申请号：PCT/US2006040910
申请日：2006-10-18
申请人： NORTHSTAR NEUROSCIENCE INC , WYLER ALLEN , GLINER BRADFORD EVAN , SLOAN LEIF R
发明人： WYLER ALLEN , GLINER BRADFORD EVAN , SLOAN LEIF R
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/0539
摘要： Methods and systems for establishing parameters for neural stimulation are disclosed. A method in accordance with one embodiment includes applying a first stimulus to a first neural population associated with a first neural function, using a first set of stimulation parameters. The method can further include detecting a response to the first stimulus at least proximate to the patient's central nervous system and, based at least in part on the response to the first stimulus and on the first set of stimulation parameters, applying a second stimulus to a second neural population. The second neural population can be associated with a second neural function different than the first neural function and can be stimulated using a second set of stimulation parameters. In a further embodiment, evidence of a neural activity can be detected at the patient's central nervous system, and electromagnetic stimulation of a target neural population at the patient's central nervous system can be automatically triggered, based at least in part on the detected evidence.
摘要翻译：公开了建立神经刺激参数的方法和系统。根据一个实施例的方法包括使用第一组刺激参数将第一刺激应用于与第一神经功能相关联的第一神经群体。该方法还可以包括至少接近患者的中枢神经系统检测对第一刺激的响应，并且至少部分地基于对第一刺激的响应和第一组刺激参数，对第一刺激施加第二刺激第二神经人群。第二神经群体可以与不同于第一神经功能的第二神经功能相关联，并且可以使用第二组刺激参数来刺激。在另一实施例中，可以在患者的中枢神经系统处检测到神经活动的证据，并且至少部分地基于检测到的证据，可以自动触发患者中枢神经系统上的目标神经群体的电磁刺激。

2. 发明申请

WO2007047852A3 SYSTEMS AND METHODS FOR PATIENT INTERACTIVE NEURAL STIMULATION AND/OR CHEMICAL SUBSTANCE DELIVERY 审中-公开
标题翻译：用于患者交互神经刺激和/或化学物质递送的系统和方法
公开(公告)号：WO2007047852A3
公开(公告)日：2007-11-29
申请号：PCT/US2006040908
申请日：2006-10-18
申请人： NORTHSTAR NEUROSCIENCE INC , FIRLIK ANDREW D , GLINER BRADFORD EVAN , SHEFFIELD W DOUGLAS , SLOAN LEIF R
发明人： FIRLIK ANDREW D , GLINER BRADFORD EVAN , SHEFFIELD W DOUGLAS , SLOAN LEIF R
IPC分类号： A61N1/00
CPC分类号： A61N1/36067 , A61B5/16 , A61B5/18 , A61B5/7275 , A61F2002/704 , A61M5/14276 , A61M5/1723 , A61M2205/05 , A61M2205/50 , A61M2230/63 , A61N1/0531 , A61N1/36003 , A61N1/36014 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N1/372 , G06F19/3481
摘要： Systems and methods for patient interactive neural stimulation and/or chemical substance delivery are disclosed. A method in accordance with one embodiment of the invention includes affecting a target neural population of the patient by providing to the patient at least one of an electromagnetic signal and a chemical substance. The method can further include detecting at least one characteristic of the patient, with the characteristic at least correlated with the patient's performance of an adjunctive therapy task that is performed in association with affecting the target neural population. The method can still further include controlling at least one parameter in accordance with which the target neural population is affected, based at least in part on the detected characteristic.
摘要翻译：公开了用于患者交互式神经刺激和/或化学物质递送的系统和方法。根据本发明的一个实施例的方法包括通过向患者提供电磁信号和化学物质中的至少一个来影响患者的目标神经群体。该方法还可以包括检测患者的至少一个特征，其特征至少与患者执行与影响目标神经群体相关联的辅助治疗任务的执行相关。该方法还可以进一步包括至少部分地基于所检测到的特征来控制与目标神经群体受影响相关的至少一个参数。

3. 发明申请

WO2007090054A3 SYSTEMS AND METHODS FOR VARYING ELECTROMAGNETIC AND ADJUNCTIVE NEURAL THERAPIES 审中-公开
标题翻译：改变电磁和相关神经治疗的系统和方法
公开(公告)号：WO2007090054A3
公开(公告)日：2009-03-26
申请号：PCT/US2007061125
申请日：2007-01-26
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN , BALZER JEFFREY , FOWLER BRAD , SLOAN LEIF R
发明人： GLINER BRADFORD EVAN , BALZER JEFFREY , FOWLER BRAD , SLOAN LEIF R
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/37247
摘要： Systems and methods for varying electromagnetic and adjunctive neural therapies are disclosed. A method in accordance with one embodiment includes applying electromagnetic signals to a target neural population of a patient over a first period of time in accordance with a first mode (e.g., including signal delivery to the central nervous system or peripheral nervous system, via implanted or non-implanted devices). The method can further include applying electromagnetic stimulation to the patient over a second period of time in accordance with a second mode different than the first mode. Varying the mode between the first period of time and second period of time can increase the efficacy and/or longevity of the stimulation. Systems in accordance with other embodiments can support multiple signal delivery devices.
摘要翻译：公开了用于改变电磁和辅助神经疗法的系统和方法。根据一个实施例的方法包括根据第一模式（例如，包括通过植入的或通过植入的中枢神经系统或周围神经系统的信号传递）向第一时间段的患者的目标神经群体施加电磁信号非植入设备）。该方法还可以包括根据与第一模式不同的第二模式在第二时间段内向患者施加电磁刺激。改变第一时间段和第二时间段之间的模式可以增加刺激的功效和/或寿命。根据其他实施例的系统可以支持多个信号传递装置。

4. 发明申请

WO2008017055A3 METHODS FOR TREATING NEUROLOGICAL DISORDERS, INCLUDING NEUROPSYCHIATRIC AND NEUROPSYCHOLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS 审中-公开
标题翻译：治疗神经病变的方法，包括神经病学和神经病学疾病及相关系统
公开(公告)号：WO2008017055A3
公开(公告)日：2008-12-18
申请号：PCT/US2007075129
申请日：2007-08-02
申请人： NORTHSTAR NEUROSCIENCE INC , FOWLER BRAD , GLINER BRADFORD EVAN , SHEFIELD W DOUGLAS , SLOAN LEIF R
发明人： FOWLER BRAD , GLINER BRADFORD EVAN , SHEFIELD W DOUGLAS , SLOAN LEIF R
IPC分类号： A61N1/00
CPC分类号： A61N1/36082
摘要： Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure. The method can further include applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient- specific measure and the target measure.
摘要翻译：公开了治疗神经系统疾病，包括神经精神和神经心理障碍以及相关系统的方法。一种这样的方法包括鉴定与神经病症相关的一个或多个神经群体，包括皮质靶神经群体。该方法还可以包括将针对所选择的一个神经群体的特征参数的患者特异性测量与相同参数的目标测量进行比较。如果患者特异性测量与目标测量值不同至少目标量，则该方法可以包括至少部分地基于患者特异性测量值与患者特异性测量值之间的差异来选择电信号极性，频率或极性和频率两者目标措施。该方法还可以包括以选定的信号极性，频率或极性和频率将电信号施加到目标神经群体，以减少患者特异性测量与目标测量之间的差异。

5. 发明申请

WO2008073420A3 SYSTEMS AND METHODS FOR TREATING PATIENT HYPERTONICITY 审中-公开
标题翻译：用于治疗患者HYPERONICITY的系统和方法
公开(公告)号：WO2008073420A3
公开(公告)日：2008-10-09
申请号：PCT/US2007025311
申请日：2007-12-11
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN , FOWLER BRAD , HULVERSHORN JUSTIN , SLOAN LEIF R
发明人： GLINER BRADFORD EVAN , FOWLER BRAD , HULVERSHORN JUSTIN , SLOAN LEIF R
IPC分类号： A61N1/05
CPC分类号： A61N1/36082 , A61N1/0531 , A61N2/006
摘要： Systems and methods for treating patient hypertonicity are disclosed. A method in accordance with one embodiment includes identifying a cortical target neural population associated with hypertonicity in a patient, and reducing or eliminating patient hypertonicity by applying electromagnetic signals to the target neural population. In further particular embodiments, the electromagnetic signals are first electromagnetic signals, and the method can further include reducing or eliminating an additional patient dysfunction by applying second electromagnetic signals.
摘要翻译：公开了用于治疗患者高渗性的系统和方法。根据一个实施例的方法包括：识别与患者中的高渗性相关的皮层目标神经群体;以及通过将电磁信号应用于目标神经群体来减少或消除患者高张性。在进一步的特定实施例中，电磁信号是第一电磁信号，并且该方法还可以包括通过施加第二电磁信号来减少或消除额外的患者功能障碍。

6. 发明申请

WO2007121129A3 SYSTEM AND METHODS FOR APPLYING SIGNALS TO NEURAL POPULATIONS 审中-公开
标题翻译：将信号应用于神经人口的系统和方法
公开(公告)号：WO2007121129A3
公开(公告)日：2008-07-03
申请号：PCT/US2007066213
申请日：2007-04-09
申请人： NORTHSTAR NEUROSCIENCE INC , PASCUAL-LEONE ALVARO , GLINER BRADFORD EVAN , HIMES DAVID , SLOAN LEIF R
发明人： PASCUAL-LEONE ALVARO , GLINER BRADFORD EVAN , HIMES DAVID , SLOAN LEIF R
IPC分类号： A61N1/00 , A61B5/05 , G06N3/12
CPC分类号： A61N1/36171 , A61N1/36082 , A61N1/36103 , A61N1/3615
摘要： Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.
摘要翻译：公开了将信号（包括对数电磁信号）应用于神经群体的系统和方法。具体方法可以涉及在脑的第一（例如ipsilesional）半球中治疗具有受试者神经群体的患者，其中受试者神经群体具有或预先具有能够改善的功能。该方法可以包括将电磁信号的应用引导至少接近于脑的第二（例如，对抗性）半球处的目标神经群体，以至少约束目标神经群体的功能，其与第一半球具有蜕皮通讯。

7. 发明申请

WO2007048000A3 NEURAL STIMULATION SYSTEM AND OPTICAL MONITORING SYSTEMS AND METHODS 审中-公开
标题翻译：神经刺激系统与光学监测系统与方法
公开(公告)号：WO2007048000A3
公开(公告)日：2007-10-11
申请号：PCT/US2006041171
申请日：2006-10-19
申请人： NORTHSTAR NEUROSCIENCE INC , SLOAN LEIF R
发明人： SLOAN LEIF R
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/36021 , A61N1/36071 , A61N1/36082
摘要： Neural stimulation and optical monitoring systems and methods are disclosed. In one embodiment, an apparatus for treating a neural condition includes a signal delivery device configured to be implanted into a patient proximate to a skull of the patient and positioned to apply electromagnetic signals to one or more target sites within the patient. The apparatus also includes an implantable optical monitoring assembly configured to monitor optical properties at one or more optical monitoring sites within the patient. The apparatus further includes a controller configured to be implanted into the patient. The controller is operatively coupled to the signal delivery device and the optical monitoring assembly and programmed to control both the signal delivery device and the optical monitoring assembly. The controller also includes a power source to power both the signal delivery device and the optical monitoring assembly.
摘要翻译：公开了神经刺激和光学监测系统和方法。在一个实施例中，用于治疗神经病症的装置包括信号传递装置，其被配置成植入患者头骨附近的患者体内并且被定位成将电磁信号施加到患者体内的一个或多个目标部位。该设备还包括可植入式光学监测组件，其被配置成监测患者体内一个或多个光学监测位置处的光学性质。该设备还包括配置成植入患者体内的控制器。控制器可操作地耦合到信号传递装置和光学监测组件，并且被编程为控制信号传递装置和光学监测组件。控制器还包括为信号传输设备和光学监测组件两者供电的电源。

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