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1. 发明申请

WO2011047197A8 MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS 审中-公开
标题翻译： MR光谱系统及其诊断方法，用于诊断阴性和非阴性椎间盘
公开(公告)号：WO2011047197A8
公开(公告)日：2011-11-10
申请号：PCT/US2010052737
申请日：2010-10-14
申请人： NOCIMED LLC , UNIV CALIFORNIA , PEACOCK JAMES C III , CLAUDE JOHN P , KANE PAUL H , LOTZ JEFFREY C
发明人： PEACOCK JAMES C III , CLAUDE JOHN P , KANE PAUL H , LOTZ JEFFREY C
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/407 , A61B5/4514 , A61B5/4824 , A61B5/7203 , G01R33/34069 , G01R33/3415 , G01R33/4616 , G01R33/485 , G01R33/565 , G01R33/56527
摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2 -weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.
摘要翻译：提供MR光谱（MRS）系统和方法用于诊断慢性，严重腰痛患者（DDD-MRS）中的疼痛和非疼痛的椎间盘。 DDD-MRS脉冲序列产生并获得椎间盘核内的DDD-MRS光谱，用于后续信号处理和诊断分析。接口DDD-MRS信号处理器接收所获得的DDD-MRS光谱的输出信号，并配置为通过选择性地进行最佳信道选择，相位和频率校正以及帧编辑的自动化系统来优化信噪比（SNR）适用于给定的采集系列。诊断处理器基于加权因子集合来计算盘的诊断值，该加权因子集合使用从与获得和处理的MRS光谱中提取的MRS数据沿着与多个化学物质相关联的区域，所述化学物质与疼痛与非痛苦盘相关。诊断显示提供缩放的颜色编码的图例和针对被诊断为患者的腰椎的中矢状T2加权MRI图像分析的每个椎间盘的结果的指示。实施例的临床应用提供了通过简单地扩展和增强腰椎否则的标准MRI检查的实用性来诊断疼痛与非痛性椎间盘的非侵入性，客观，无痛，可靠的方法。

2. 发明申请

WO2011047197A3 MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS 审中-公开
标题翻译： MR光谱系统和用于诊断疼痛和非疼痛椎间盘的方法
公开(公告)号：WO2011047197A3
公开(公告)日：2011-09-22
申请号：PCT/US2010052737
申请日：2010-10-14
申请人： NOCIMED LLC , UNIV CALIFORNIA , PEACOCK JAMES C , CLAUDE JOHN P , KANE PAUL H , LOTZ JEFFREY C
发明人： PEACOCK JAMES C , CLAUDE JOHN P , KANE PAUL H , LOTZ JEFFREY C
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/407 , A61B5/4514 , A61B5/4824 , A61B5/7203 , G01R33/34069 , G01R33/3415 , G01R33/4616 , G01R33/485 , G01R33/565 , G01R33/56527
摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2 -weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.
摘要翻译：磁共振波谱仪（MRS）系统和方法可用于诊断慢性严重腰痛患者（DDD-MRS）中的疼痛和非疼痛椎间盘。 DDD-MRS脉冲序列在椎间盘核内产生并获取DDD-MRS光谱，用于稍后的信号处理和诊断分析。接口DDD-MRS信号处理器接收所获取的DDD-MRS谱的输出信号，并被配置为通过选择性地进行最佳信道选择，相位和频率校正和帧编辑的自动化系统来优化信噪比（SNR）适用于特定的收购系列。诊断处理器基于加权因子集合来计算盘片的诊断值，所述加权因子集合使用MRS数据，所述MRS数据从与已经与疼痛与非疼痛盘片相关的多种化学物质相关联的区域获取并处理MRS光谱中提取。诊断显示器提供缩放的颜色编码的图例和每个椎间盘的结果指示，作为覆盖到被诊断患者的腰椎的中间矢状T2加权MRI图像上的覆盖物。实施例的临床应用通过简单地扩展和增强对腰椎的其他标准MRI检查的实用性提供了非侵入性，客观，无痛，可靠的方法来诊断疼痛与非疼痛椎间盘。

3. 发明申请

WO03061756A3 IMPLANTABLE THERMAL TREATMENT METHOD AND APPARATUS 审中-公开
标题翻译：可植入热处理方法和装置
公开(公告)号：WO03061756A3
公开(公告)日：2003-10-16
申请号：PCT/US0302211
申请日：2003-01-23
申请人： UNIV CALIFORNIA , DIEDERICH CHRIS J , LOTZ JEFFREY C , NAU WILL , BRADFORD DAVID S , O'BANION JOHN P , PEACOCK JAMES C III
发明人： DIEDERICH CHRIS J , LOTZ JEFFREY C , NAU WILL , BRADFORD DAVID S , O'BANION JOHN P , PEACOCK JAMES C III
IPC分类号： A61B17/00 , A61B19/00 , A61N7/00 , A61N7/02 , A61B18/04
CPC分类号： A61B18/04 , A61B8/56 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2018/00339 , A61B2090/374 , A61N7/00 , A61N7/02 , A61N7/022 , A61N2007/0078
摘要： A long-term implantable ultrasound therapy system (11) and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer (16) is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs (1), or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C, and in particular 75 degrees C, are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.
摘要翻译：提供了长期植入式超声治疗系统（11）和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。将超声发射器或换能器（16）输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。用于超声换能器放置的这样的位置可以包括例如在椎间盘（1）中或周围，或者诸如椎骨体或后椎体元件（例如小关节）的骨结构。各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，该范围受到诸如体内椎间盘之类的预应力组织的显着影响。特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度达到其他响应而没有明显的重塑。

4. 发明申请

WO2007035906A3 SYSTEMS AND METHODS FOR IMAGING-TREATMENT OF PAIN 审中-公开
标题翻译：用于成像治疗疼痛的系统和方法
公开(公告)号：WO2007035906A3
公开(公告)日：2009-04-23
申请号：PCT/US2006036943
申请日：2006-09-21
申请人： UNIV CALIFORNIA , BRADFORD DAVID S , LOTZ JEFFREY C
发明人： BRADFORD DAVID S , LOTZ JEFFREY C
IPC分类号： A61B5/00 , A61K51/00
CPC分类号： A61K51/1096 , A61B5/4041 , A61B5/4824 , A61B6/506 , A61B18/14 , A61B2018/00339 , A61B2018/00577 , A61B2018/00642 , A61K49/0002 , A61M5/007 , A61M5/1723 , A61M2230/005 , A61N7/02
摘要： Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission. The labeled pain factors allow spatial differentiation in the imaging sufficient to specify the location of the pain so as to drive therapeutic decisions and techniques in order to treat the pain. Pain factors labeled and imaged in this manner may include one or more of nerve factors, blood vessel factors, cellular factors, and inflammation factors. Labeled markers may include for example radioactive materials (e.g. tritiated or iodinated molecules) or other materials such as metal (e.g. gold) nanoparticles. Intermediary binding materials may be used, such as for example bi-specific antibodies. Therapeutic components of the system and method include for example localized energy delivery or ablation treatments, or local drug or other chemical delivery. Locations containing pain factor selectively bound by targeted agents are selectively treated with directed energy into a region containing the targeted agent bound to the pain factor.
摘要翻译：疼痛因素用传递到体内的靶向药物或标记进行标记。标记的疼痛因子以适当的成像工具以允许选择性识别和定位疼痛源或传播区域的方式成像。标记的疼痛因子允许成像中的空间分化足以指定疼痛的位置，以便驱动治疗决定和技术以治疗疼痛。以这种方式标记和成像的疼痛因子可包括神经因子，血管因子，细胞因子和炎症因子中的一种或多种。标记的标记可以包括例如放射性材料（例如氚化或碘化分子）或其它材料，例如金属（例如金）纳米颗粒。可以使用中间结合材料，例如双特异性抗体。该系统和方法的治疗组件包括例如局部能量递送或消融治疗，或局部药物或其它化学物质递送。选择性地由靶向药物结合的含有疼痛因子的位置被选择性地用定向能量处理到含有与疼痛因子结合的靶向药剂的区域中。

5. 发明申请

WO2006081471A3 SYSTEMS AND METHODS USING NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY TO EVALUATE PAIN AND DEGENERATIVE PROPERTIES OF TISSUE 审中-公开
标题翻译：使用核磁共振（NMR）光谱评估组织的疼痛和变性特性的系统和方法
公开(公告)号：WO2006081471A3
公开(公告)日：2007-08-23
申请号：PCT/US2006003036
申请日：2006-01-30
申请人： UNIV CALIFORNIA , MAJUMDAR SHARMILA , KURHANEWICZ JOHN , LOTZ JEFFREY C , BRADFORD DAVID S , KESHARI KAYVAN
发明人： MAJUMDAR SHARMILA , KURHANEWICZ JOHN , LOTZ JEFFREY C , BRADFORD DAVID S , KESHARI KAYVAN
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61B5/4824 , G01N24/08 , G01R33/465 , G01R33/483 , G01R33/485
摘要： NMR spectroscopy is performed on intervertebral disc tissue. Extent of degeneration is determined based on the NMR spectroscopy. Correlation between NMR spectral regions and pain are made. Accordingly, NMR spectroscopy is used to determine location and/or extent of at least one of disc degeneration, or discogenic pain.
摘要翻译：对椎间盘组织进行NMR光谱。基于NMR光谱测定退化程度。制作核磁共振谱区和疼痛之间的相关性。因此，使用NMR光谱来确定椎间盘退变或椎间盘疼痛中的至少一种的位置和/或程度。

6. 发明申请

WO2006060482A3 SYSTEMS, DEVICES AND METHODS OF TREATMENT OF INTERVERTEBRAL DISORDERS 审中-公开
标题翻译：系统，器官和治疗椎间盘疾病的方法
公开(公告)号：WO2006060482A3
公开(公告)日：2007-02-22
申请号：PCT/US2005043326
申请日：2005-12-01
申请人： UNIV CALIFORNIA , LOTZ JEFFREY C , BRADFORD DAVID S
发明人： LOTZ JEFFREY C , BRADFORD DAVID S
IPC分类号： A61F2/44
CPC分类号： A61F2/30907 , A61B17/0401 , A61B2017/044 , A61F2/30771 , A61F2/3094 , A61F2/30965 , A61F2/441 , A61F2/442 , A61F2/4611 , A61F2002/009 , A61F2002/30014 , A61F2002/30023 , A61F2002/30062 , A61F2002/30075 , A61F2002/30092 , A61F2002/302 , A61F2002/30324 , A61F2002/30565 , A61F2002/30578 , A61F2002/30579 , A61F2002/30586 , A61F2002/30601 , A61F2002/30677 , A61F2002/3092 , A61F2002/30932 , A61F2002/30971 , A61F2002/4435 , A61F2002/444 , A61F2002/4627 , A61F2002/4629 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , A61F2230/0065 , A61F2250/0018 , A61F2250/0034 , A61F2250/0036 , A61F2310/00976
摘要： A bioactive/biodegradable nucleus implant for repairing degenerated intervertebral discs that is inflated inside the nucleus space after the degenerated nucleus has been removed to re-pressurize the nuclear space within the intervertebral disc. The implant is inflated with a high molecular weight fluid, gel or combination of fluid and elastomer, preferably an under-hydrated HA hydrogel/growth factor mixture with or without host cells. The implant includes an internal, integral, self-sealing valve that allows one-way filling of the implant after it is placed within the disc, and is made from a material that allows fibrous in growth thereby stabilizing the implant. A variety of substances can be incorporated into the implant to promote healing, prevent infection, or arrest pain.
摘要翻译：用于修复退化椎间盘的生物活性/可生物降解的核植入物，其在退化的细胞核被去除之后在细胞核空间内充气以对椎间盘内的核空间重新加压。植入物用高分子量流体，凝胶或流体和弹性体的组合充气，优选含有或不含宿主细胞的水合不足的HA水凝胶/生长因子混合物。植入物包括内部的，一体式的自密封阀，其允许植入物在盘被放置在盘中之后进行单向填充，并且由允许纤维生长从而稳定植入物的材料制成。植入物中可以掺入各种物质以促进愈合，预防感染或阻止疼痛。

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